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Frontiers of Structural and Civil Engineering 2024年第1期18卷 14-29页

作者： Jing XU Xianzhi WANG Wu YAO Anna A.KULMINSKAYA Surendra p.SHAH Key Laboratory of Advanced Civil Engineering Materials(Ministry of Education) School of Materials Science and EngineeringTongji UniversityShanghai 201804China petersburg Nuclear physics Institute Named by B.p.Konstantinov of National Research Centre Kurchatov InstituteGatchina 188300Russia Center for Advanced Construction Materials University of Texas at ArlingtonArlingtonTX 76019USA

Microbially induced carbonate precipitation(MICp)is a promising technique for the autonomous healing of concrete *** this study,the effect of pH on MICp was *** results indicate that the MICp process was inhibited when the pH was higher than *** vaterite and calcite were produced when the pH wasproduced when the pH was>*** concrete aggregates(RCA)coated with sodium silicate have been proposed as protective carriers for microbial healing *** the presence of the coated RCA resulted in a loss of the splitting tension strength of the concrete,the loaded healing agents were highly efficient in self-healing *** incorporated with 20%RCA loaded with healing agents exhibited the best self-healing *** the initial crack widths were between 0.3 and 0.4 mm,the 7-d mean healing rate was approximately 90%.At 28 d,the crack area filling ratio was 86.4%,while its water tightness recovery ratio was 74.4%and 29.8%,respectively,for rapid and slow *** study suggests that RCA coated with sodium silicate is an effective method for packaging microbial healing agents and has great potential for developing cost-effective self-healing concrete.

关键词： self-healing microbial-induced carbonate precipitation water uptake recycled concrete aggregate protective carrier

Are we close to using Alzheimer blood biomarkers in clinical practice?

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Neural Regeneration Research 2024年第12期19卷 2583-2585页

作者： Bruno p.Imbimbo Simone Lista Camillo Imbimbo Robert Nisticò Department of Research&Development Chiesi FarmaceuticiParmaItaly i+HeALTH Strategic Research Group Department of Health SciencesMiguel de Cervantes European University(UEMC)ValladolidSpain Department of Brain and Behavioral Sciences University of PaviaPaviaItaly School of pharmacy University of Rome“Tor Vergata”RomeItaly Laboratory of pharmacology of Synaptic p.asticity EBRI Rita Levi-Montalcini FoundationRomeItaly

Alzheimer's disease(AD) is a progressive neurodegenerative disease histologically characterized by the presence of extraneuronal plaques,mainly formed by the 42-aminoacid isoform of amyloid-(Aβ_(1-42)),and by intraneuronal neurofibrillary to ngles,mainly formed by the tau protein and its hyperphosphorylated isoforms(p-tau).AD is the most common cause of dementia,with an estimated lifetime risk of about 1 in 10 for men and 1 in 5 for women.

关键词： Alzheimer tau Aβ

Assembly of peptide nanostructures with controllable sizes

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Nano Research 2024年第1期17卷 151-161页

作者： Dan cheng Fan Jia Yun-Bao Jiang Vincent p.Conticello Tao Jiang The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian province(IKKEM) Xiamen 361005China Department of chemistry Emory UniversityAtlanta 30033USA

Controlled peptide assembly offers significant promise to develop synthetic supramolecular nanostructures to display material and biological properties that mimic protein assemblies in *** the progress in forming peptide nanostructures of various morphology,there exists a distinct gap between natural and synthetic assembly systems in terms of size *** nanostructures with a narrow size distribution that can be tuned over a wide range of length-scales is essential for applications that require precise spacing between *** approach provides the opportunity to correlate materials and biological properties of interest with assembly *** this review,we discuss representative endeavors over the past two decades for design of size-controllable peptide nanostructures using tunable building *** mechanisms for size control,e.g.,molecular frustration,template-directed peptide assembly,and multi-component peptide co-assembly,will also be *** also demonstrate the applicable scopes of these strategies and suggest potential future avenues for scientific advances in this field.

关键词： peptide assembly controllable size template multi-component

Effect of high temperature short time infrared roasting of peanuts

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Journal of Future Foods 2024年第2期4卷 173-178页

作者： Rahi Golani chinglen Leishangthem Hongwei Xiao Qi Zhang p.p.Sutar Department of Food process Engineering National Institute of Technology RourkelaOdisha 769008India College of Engineering China Agricultural UniversityBeijing 100083China College of Mechanical Engineering Yangzhou UniversityYangzhou 225127China

Roasting is the most common processing method that enhances color,and *** this study,infrared roasting of peanuts was done using an infrared rotary *** was operated at 90%infrared power(630 W)with different rotating speed(1 and 2 r/min).The effect of roasting was studied at different moisture levels(7.66%,11.49%,and 13.72%db).From the study,the color parameter,L*value,was found to be significantly different(ppeed,and the∆E value varies from 2.32 to *** also showed that the antioxidant activity decreased with the reduction in rotating speed as lesser revolutions took longer roasting time,and the values decreased from 84.34%to 71.74%.Minimal changes in total phenolic content were found and varied from 3.62 to 2.10 mg/g GAE,an appropriate limit for good-quality roasted *** hardness of roasted peanuts ranged from 12.25 to 39.43 *** content 13.72%,and 1 r/min is the best possible treatment for infrared peanut roasting,significantly enhancing the quality of *** study concluded that high-power short-time infrared roasting could give good-quality roasted peanuts with optimum bioactive compounds.

关键词： Roasting Infrared Total phenolic content Antioxidant activity

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可编程多物理机制的力学超材料

力学进展 2024年

作者： p.Sinha T.Mukhopadhyay 印度理工学院航空工程系英国南安普顿大学工学院

力学超材料是一种有别于传统力学行为的工程材料，它源于人工可编程的微结构以及材料的固有属性。在过去的十年中，随着计算性能和复杂微观结构制造能力的巨大进步，力学超材料已经吸引了研究人员的广泛关注，因为它能够实现自然界中不... 详细信息

力学超材料是一种有别于传统力学行为的工程材料，它源于人工可编程的微结构以及材料的固有属性。在过去的十年中，随着计算性能和复杂微观结构制造能力的巨大进步，力学超材料已经吸引了研究人员的广泛关注，因为它能够实现自然界中不可能出现的多重物理属性。该领域迅速崛起的趋势之一是将材料行为和单元结构与其他不同的多种物理因素(如电场或磁场)以及温度、光或化学反应等刺激相结合，从而扩大按需主动调制力学响应的范围。在本文中，我们旨在概述有关超材料的力学和多物理性质调制的相关文献，重点介绍双能级设计的新兴趋势，着重讨论力学超材料在关键工程领域应用中的巨大潜力。本文对该领域的发展趋势、挑战和未来路线进行了系统深入分析，涵盖实时可重构性和功能编程、4D打印、纳米超材料、人工智能和机器学习、多物理折纸/剪纸、活性物质、软物质和保形超材料、复杂微结构制造、服役寿命效应和可扩展性等概念。

关键词：力学超材料按需特性调制多物理力学可编程物质双级点阵主动超材料刺激响应材料

The Value of Traditional Medicine Should not be Underestimated-Traditional chinese Medicine in Treatment of Autoimmune Diseases

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chinese Medicine and Culture 2024年第2期7卷 167-173页

作者： Yurii O Novikov Anait p Akopyan Bashkir State Medical University Republic of BashkortostanRussia 450008

Autoimmune diseases of the nervous system(ADNS)are characterized by the formation of a pronounced neurologic deficit and often lead to *** attention of doctors and researchers is increasingly attracted by complementary medicine as adjuvant or preventive therapy for various diseases,including autoimmune *** chinese medicine(TCM)is a combination of treatment methods that include acupuncture,herbal medicine,dietetics,physical exercises,and other methods that are often used in conjunction with recognized approaches of official medical *** article describes the application of TCM techniques in autoimmune diseases of the nervous system,and demonstrates clinical experience in the use of acupuncture,herbal medicine,diets and physical *** and complementary medicine is an important and often underestimated healthcare resource,especially in the prevention and treatment of autoimmune diseases of the nervous system.

关键词： Autoimmune diseases Traditional chinese medicine Nervous diseases

Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

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Science china(Life Sciences) 2024年第5期67卷 865-878页

作者： Wei Jia Yitao Li Kenneth C.p.cheung Xiaojiao Zheng School of chinese Medicine Hong Kong Baptist UniversityHong KongChina Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University School of MedicineShanghai 200233China

Bile acids(BAs)play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune *** the enterohepatic circulation,BAs are synthesized,metabolized,and reabsorbed,with a portion entering the vascular circulation and distributing *** allows BAs to interact with receptors in all major organs,leading to organ-organ interactions that regulate both local and global metabolic processes,as well as the immune *** review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation,including in the brain,heart,liver,intestine,eyes,skin,adipose tissue,and *** BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.

关键词： bile acid whole body metabolism immunity

Downstaging strategies for unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第20期30卷 2731-2733页

作者： Georgia Sofia Karachaliou Nikolaos Dimitrokallis Dimitrios p Moris Division of Gastroenterology Department of MedicineDuke University Medical CenterDurhamNC 27710United States First Department of Surgery&Organ Transplant Unit Evangelismos General HospitalAthens 10676Greece Department of Surgery Duke University Medical CenterDurhamNC 27710United States

A significant number of patients with hepatocellular carcinoma(HCC)are usually diagnosed in advanced stages,that leads to inability to achieve *** options are focusing on downstaging a locally advanced *** is wellsupported in the literature that patients with HCC who undergo successful conversion therapy followed by curative-intent surgery may achieve a significant survival benefit compared to those who receive chemotherapy alone or those who are successfully downstaged with conversion therapy but not treated with *** artery infusion chemotherapy can be a potential downstaging strategy,since recent studies have demonstrated excellent outcomes in patients with colorectal liver metastatic disease as well as primary liver malignancies.

关键词： Unresectable hepatocellular carcinoma Hepatic arterial infusion chemotherapy Downstaging Hepatocellular carcinoma

MDCN:Modified Dense Convolution Network Based Disease Classification in Mango Leaves

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Computers, Materials & Continua 2024年第2期78卷 2511-2533页

作者： chirag chandrashekar K.p.Vijayakumar K.pradeep A.Balasundaram School of Computer Science and Engineering Vellore Institute of Technology(VIT)ChennaiIndia Center for Cyber physical Systems School of Computer Science and EngineeringVellore Institute of Technology(VIT)ChennaiIndia

The most widely farmed fruit in the world is *** the production and quality of the mangoes are hampered by many *** diseases need to be effectively controlled and ***,a quick and accurate diagnosis of the disorders is *** convolutional neural networks,renowned for their independence in feature extraction,have established their value in numerous detection and classification ***,it requires large training datasets and several parameters that need careful *** proposed Modified Dense Convolutional Network(MDCN)provides a successful classification scheme for plant diseases affecting mango *** model employs the strength of pre-trained networks and modifies them for the particular context of mango leaf diseases by incorporating transfer learning *** data loader also builds mini-batches for training the models to reduce training ***,optimization approaches help increase the overall model’s efficiency and lower computing *** employed on the MangoLeafBD Dataset consists of a total of 4,000 *** the experimental results,the proposed system is compared with existing techniques and it is clear that the proposed algorithm surpasses the existing algorithms by achieving high performance and overall throughput.

关键词： Leaf disease detection deep convolutional neural networks transfer learning optimization MangoLeafBD Dataset

Investigation of Microstructure, Microhardness and Thermal properties of Ag-In Intermetallic Alloys prepared by Vacuum Arc Meltings

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 182-187页

作者： ÇELİK Erçevik ATA ESENER pınar ÖZTÜRK Esra AKSÖZ Sezen Nevşehir HacıBektaşVeli University Department of Physics50300NevşehirTurkey Erciyes University Graduate School of Natural and Applied Sciences38039KayseriTurkey Kocaeli University Department of Physics41380KocaeliTurkey

Ag-In intermetallic alloys were produced by using vacuum arc furnace. Differential Scanning Calorimetry(DSC) and Energy Dispersive X-Ray Spectrometry(EDX) were used to determine the thermal properties and chemical composition of the phases respectively. Microhardness values of Ag-In intermetallics were calculated with Vickers hardness measurement method. According to the experimental results, Ag-34 wt%In intermetallic system generated the best results of energy saving and storage compared to other intermetallic systems. Also from the microhardness results, it was observed that intermetallic alloys were harder than pure silver and Ag-26 wt%In system had the highest microhardness value with 143.45 kg/mm^(2).

关键词： thermal properties microstructure characterization microhardness alloys material characterization