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Nitric oxide:a newly discovered function on wound healing

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Acta Pharmacologica Sinica 2005年第3期26卷 259-264页

作者： alex F CHEN Departments of Pharmacology and Neurology and the Neuroscience Program Michigan State University East Lansing MI 48824-1317 USA

Wound healing impairment represents a particularly challenging clinical problemto which no efficacious treatment regimens currently *** factors ensuringappropriate intercellular communication during wound repair are not *** protein-type mediators are well-established players in thisprocess,emerging evidence from both animal and human studies indicates thatnitric oxide (NO) plays a key role in wound *** beneficial effects of NO onwound repair may be attributed to its functional influences on angiogenesis,inflammation,cell proliferation,matrix deposition,and *** find-ings from in vitro and in vivo studies of NO on wound repair are summarized inthis *** unveiled novel mechanisms support the use of NO-containingagents and/or NO synthase gene therapy as new therapeutic regimens for im-paired wound healing.

关键词： angiogenesis inflammation nitric oxide proliferation wound healing

System Reduction Using an LQR-Inspired Version of Optimal Replacement Variables

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Communications in Computational Physics 2012年第10期12卷 1520-1540页

作者： alex Solomonoff Camberville Research Institute SomervilleMAUSA Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong Kong

Optimal ReplacementVariables(ORV)is amethod for approximating a large system of ODEs by one with fewer equations,while attempting to preserve the essential dynamics of a reduced set of variables of *** earlier version of ORV[1]had some issues,including limited accuracy and in some rare cases,*** we present a newversion of ORV,inspired by the linear quadratic regulator problemof control theory,which provides better accuracy,a guarantee of stability and is in some ways easier to use.

关键词： System reduction optimal replacement variables resolved variables optimal prediction

Diversity of Idea Flows and Economic Growth

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Journal of Social Computing 2020年第1期1卷 71-81页

作者： alex Pentland Institute of Technology(MIT) CambridgeMA 02139-4307USA

What role does access to diverse ideas play in economic growth?New forms of geo-located communications and economic data allow measurement of human interaction patterns and prediction of economic outcomes for individuals,communities,and nations at a fine granularity,with the strongest predictors of income,productivity,and growth being measures of diversity and frequency of physical interaction between communities(clusters of interaction).This finding provides both new investment opportunities and new methods of risk *** and use of these data raise privacy and security risks,and the final section of the paper describes how these challenges can be controlled.

关键词： idea flow opportunity wealth inequality segregation foraging privacy policy

A simulation-based evaluation of the absolute and comparative approaches in a code compliance process from the energy use perspective: Cold-climate case study

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Building Simulation 2022年第8期15卷 1401-1418页

作者： Sara Gilani alex Ferguson Meli Stylianou CanmetENERGY-Ottawa Natural Resources Canada1 Haanel DrOttawaON K1A 1M1Canada

Like many countries,Canada's building code includes a performance compliance path that compares the energy use of a proposed design to that of a reference ***,provinces across Canada are contemplating an alternative absolute energy use intensity ***,the effect of adopting the absolute approach on house design is not well *** study first developed a proof-of-concept methodology for a technical simulation-based comparison of the two ***,it performed a comparative analysis between the design outcomes of the two approaches using the developed *** this end,statistically representative archetypes were configured to comply with the prescriptive requirements of the building *** characteristics of each archetype were then varied through parametric study,and the resulting energy performance under the absolute and comparative approaches were *** results of this study indicated that the two approaches had different effects on the design and energy use of houses in heating-dominated climate *** performing better under the absolute approach consumed less energy and exhibited more compact architectural *** houses were also less sensitive to improvements in airtightness and envelope than houses performing better under the comparative *** results suggest that adopting the absolute approach based on the energy use intensity metric in building codes would encourage design and construction of houses with higher energy efficiency.

关键词： performance path energy efficiency absolute target percent better than code reference building archetype

A hybrid tubular standing support for underground mines:Compressive behaviour

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International Journal of Mining Science and Technology 2021年第2期31卷 215-224页

作者： Hongchao Zhao Ting Ren alex Remennikov School of Civil Mining and Environmental EngineeringFaculty of Engineering and Information SciencesUniversity of WollongongNSW 2522Australia 2 School of Geology and Mining EngineeringXinjiang UniversityUrumqi 830000China

This paper presents the development of an innovative standing support for underground *** main feature of this standing support is its exterior container,a combination of polyvinyl chloride(PVC)with large rupture strain and fibre-reinforced polymer(FRP)with high strength-to-weight *** demonstrate the advantages of this cementitious grout filled PVC-FRP tubular(PFT)standing support,a series of compression tests were *** variables included the strength of cementitious grout infill material and the thickness of FRP *** tests were also conducted on cementitious grout-filled PVC tubular(PT)support and cementitious grout-filled FRP tubular(FT)*** tests showed that PFT support presents a typical strain-hardening behaviour together with an outstanding axial deformation ability(>20%of the overall height of the support).In addition,the maximum compressive strength of PFT support is much higher than that of the corresponding PT support and FT ***,using thicker FRP jacket or high strength cementitious grout material can enhance the load carrying capacity of PFT *** comparative results indicated that the high performance of PFT support is mainly attributed to the combination of confining constituents(*** and FRP)and infill material.

关键词： Standing support FRP PVC Confinement Composite structures Underground mines

Approaches to quantify axonal morphology for the analysis of axonal degeneration

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Neural Regeneration Research 2023年第2期18卷 309-310页

作者： alex Palumbo Marietta Zille Department of Neurobiology Harvard Medical School Department of Cancer Biology Dana-Farber Cancer InstituteBostonMAUSA Department of Pharmaceutical Sciences Division of Pharmacology and ToxicologyUniversity of ViennaViennaAustria

Morphological hallmarks of axonal degeneration(AxD):Axons transmit signals from one neuron to another and a re crucial for the proper communication in the nervous ***,the disintegration of axons,a process named AxD,ha... 详细信息

关键词： degeneration axonal Morphological

Genetic and Epigenetic Effects of Plant-Pathogen Interactions： An Evolutionary Perspective

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Molecular Plant 2011年第6期4卷 1014-1023页

作者： alex Boyko Igor Kovalchuk Institute of Plant Biology Zurich Switzerland Department of Biological Sciences University of Lethbridge Lethbridge Alberta T1K 3M4 Canada

Recent reports suggest that exposure to stress is capable of influencing the frequency and pattern of inherited changes in various parts of the genome. In this review, we will discuss the influence of viral pathogens on somatic and meiotic genome stability of Nicotiana tabacum and Arabidopsis thaliana. Plants infected with a compatible pathogen generate a systemic recombination signal that precedes the spread of pathogens and results in changes in the somatic and meiotic recombination frequency. The progeny of infected plants exhibit changes in global and locusspecific DNA methylation patterns, genomic rearrangements at transgenic reporter loci and resistance gene-like-loci, and even tolerance to pathogen infection and abiotic stress. Here, we will discuss the contribution of environmental stresses to genome evolution and will focus on the role of heritable epigenetic changes in response to pathogen infection.

关键词： Abiotic and biotic stress Arabidopsis thaliana genetic and epigenetic response genome stability genome evolution methylation pattern Nicotiana tabacum transgenerational effect.

A transition from a large open pit into a novel “macroblock variant” block caving geometry at Chuquicamata mine, Codelco Chile

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 549-561页

作者： German Flores alex Catalan Newcrest Mining Ltd. Melbourne3004Australia Codelco Chile Santiago8320000Chile

With a history of more than 100 years, Chuquicamata has become one of the largest open pits in the world. Its current depth of 1100 m, length of 4500 m and width of 3000 m, resulting in haulage distances of over 11,000 m from pit bottom to the processing plant or waste dumps, with waste/ore ratio greater than 4 and much lower grades, are effectively determining its profitable limit by the end of this decade. Currently, there are over 4300 Mt of geological resources containing 0.7% of copper and 340 ppm (1 ppm = 1 g/t) of molybdenum below the final pit shell. The corresponding orebody geometry is 3000 m northsouth, 300-800 m eastwest and the drilling campaign suggested the existence of more than 900 m of mineable ore from the final pit bottom. This is in spite of the fact that the Chuquicamata orebody is still open at depth. The business case to continue with the mining of the Chuquicamata orebody is to change from the current large open pit to a novel macroblock variant block caving geometry. This requires a production rate of 140,000 t/d (50 Mt per annum), with a continuous material handling system to achieve the 7-year ramp-up to full production. The resolution of a number of known technical, operational and logistical challenges outside current industry practises which Chuquicamata will face over its projected 40-year mine life is therefore essential. These challenges include simultaneous operations of open pit and underground macroblocks and from the initial lift to the second lift, rapid ramp-up and optimum sequencing of the planned macroblocks, early dilution from the west fault and late dilution from potential slope failures, and the potential for major operational hazards. An equally important issue to be addressed is cultural given that the mining history in the northern region of Chile, which includes Chuquicamata, is predominantly open pit. This paper presents a synopsis of the main challenges that the Chuquicamata underground project will face in order t

关键词： Macroblock variant Block caving Cave propagation Early and late dilutions Intensive preconditioning Rib pillar West fault Ore buffer

Levels of rhizome endophytic fungi fluctuate in Paris polyphylla *** as plants age

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Plant Diversity 2017年第1期39卷 60-64页

作者： Tao Liu alex Greenslade ShengchaoYang Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials Yunnan Agricultural University Kunming 650201China Biological Chemistry and Crop Protection Rothamsted Research Harpenden UK

Paris polyphylla var. yunnanensis is an important medicinal plant with abundant saponins that are widely used in the pharmaceuticals industry. It is unclear why the levels of active ingredients increase as these plants age. We speculated that the concentrations of those components in the rhizomes are mediated by fungal endophytes. To test this hypothesis, we took both culture-dependent and-independent(metagenomics) approaches to analyze the communities of endophytic fungi that inhabit those rhizomes in plants of different age classes(four, six, and eight years old). In all, 147 isolates representing 18 fungal taxa were obtained from 270 segments(90 per age class). Based on morphological and genetic characteristics, Fusarium oxysporum(46.55% frequency of occurrence) was the predominant endophyte,followed by Leptodontidium sp.(8.66%) and Trichoderma viride(6.81%). Colonization of endophytic fungi was maximized in the eight-year-old rhizomes(33.33%) when compared with four-year-old(21.21%) and six-year-old(15.15%) rhizomes. Certain fungal species were present only at particular ages. For example,Alternaria sp., Cylindrocarpon sp., Chaetomium sp., Paraphaeosphaeria sporulosa, Pyrenochaeta sp., Penicillium swiecickii, T. viride, and Truncatella angustata were found only in the oldest plants. Analysis of(metagenomics) community DNA extracted from different-aged samples revealed that, at the class level,the majority of fungi had the highest sequence similarity to members of Sordariomycetes, followed by Eurotiomycetes and Saccharomycetes. These results were mostly in accord with those we obtained using culture methods. Fungal diversity and richness also changed over time. Our investigation is the first to show that the diversity of fungi in rhizomes of P. polyphylla var. yunnanensis is altered as plants age, and our findings provide a foundation for future examinations of useful compounds.

关键词： Medicinal plants Endophytic fungi Paris polyphylla var.yunnanensis