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Cervical spinal cord injury: tailoring clinical trial endpoints to reflect meaningful functional improvements

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Neural Regeneration Research 2014年第16期9卷 1493-1497页

作者： Lisa M.bond Lisa McKerracher BioAxone BioSciences Inc.Cambridge MA USA McGill University Department of Neurology and NeurosurgeryMontreal Quebec Canada

Cervical spinal cord injury （SCI） results in partial to full paralysis of the upper and lower extrem- ities. Traditional primary endpoints for acute SCI clinical trials are too broad to assess functional recovery in cervical subjects, raising the possibility of false positive outcomes in trials for cervical SCI. Endpoints focused on the recovery of hand and arm control （e.g., upper extremity motor score, motor level change） show the most potential for use as primary outcomes in upcoming trials of cervical SCI. As the field moves forward, the most reliable way to ensure meaningful clinical testing in cervical subjects may be the development of a composite primary endpoint that measures both neurological recovery and functional improvement.

关键词： spinal cord injury SCI cervical clinical trial endpoint Cethrin UEMS

Recent trends in the use of polyoxometalate-based material for efficient water oxidation

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Science China Chemistry 2011年第12期54卷 1877-1887页

作者： HAN ZhanGang bond Alan M ZHAO Chuan School of Chemistry The University of New South Wales Sydney NSW 2052 Australia School of Chemistry Monash University Clayton Victoria 3800 Australia

Polyoxometalates （POMs）, with their attractive topological and electronic properties, have been demonstrated over the last few decades to be efficient catalysts for many reactions. In a new direction, POMs having a purely inorganic framework are now being explored as efficient catalysts for water oxidation. This review focuses on very recent developments of POM-based catalysts for water oxidation to O2. In the very extensive family of POMs, tetra-core sandwich-type Ru- and Co-containing POM complexes, namely [Ru404（OH）2（H20）4（y-SiW10O36）2]10- and [CO4（H2O）2（a-PWgO34）2]10- exhibit the ability to facilitate water oxidation under electrocatalytic and/or photocatalytic conditions. However, it is concluded that much work still needs to be done to explain the catalytic mechanisms and optimize these catalytic systems. In addition, recent trends in using ionic liquids as media to modify the electrolytic environment and enhance water oxidation are highlighted.

关键词： polyoxometalate water oxidation catalysis electrochemistry photochemistry energy

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渴！渴！渴！墨西哥城即将用光最后一滴水！

环球人文地理 2024年第11期 46-55页

作者：方小白陈曦Stanley ulrikestein 欧德立 alex Wolf Leonardo fforriol

2024年春夏之交，“干渴的墨西哥城”频繁作为主角，登上其他国家的新闻：“约2100万居民面临缺水”“零日即将到来！或用光最后一滴水”“谁来给墨西哥城解渴”……电视上接受采访的墨城居民无不忧心忡忡。或许他们并不知道，此时此刻...

2024年春夏之交，“干渴的墨西哥城”频繁作为主角，登上其他国家的新闻：“约2100万居民面临缺水”“零日即将到来！或用光最后一滴水”“谁来给墨西哥城解渴”……电视上接受采访的墨城居民无不忧心忡忡。或许他们并不知道，此时此刻整个城市如此缺水，跟他们祖先之间的一场战争有关，也跟一场“杀湖案”有关—为了扩大居住面积，墨城人花几百年时间排光了一个巨湖的水，“杀死”了湖，利用湖底平整的土地建起了伟大的墨西哥城。

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Bridging academic science and clinical research in the search for novel targeted anti-cancer agents

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Cancer Biology & Medicine 2015年第4期12卷 316-327页

作者： alex Matter Experimental Therapeutics Center & D3 A*STAR

This review starts with a brief history of drug discovery & development, and the place of Asia in this worldwide effort discussed. The conditions and constraints of a successful translational R&D involving academic basic research and clinical research are discussed and the Singapore model for pursuit of open R&D described. The importance of well-characterized, validated drug targets for the search for novel targeted anti-cancer agents is emphasized, as well as a structured, high quality translational R&D. Furthermore, the characteristics of an attractive preclinical development drug candidate are discussed laying the foundation of a successful preclinical development. The most frequent sources of failures are described and risk management at every stage is highly recommended. Organizational factors are also considered to play an important role. The factors to consider before starting a new drug discovery & development project are described, and an example is given of a successful clinical project that has had its roots in local universities and was carried through preclinical development into phase I clinical trials.

关键词： Drug discovery drug development translational R&D targeted anti-cancer agents

Data Warehouse Design for Big Data in Academia

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Computers, Materials & Continua 2022年第4期71卷 979-992页

作者： alex Rudniy Department of Computing Sciences University of ScrantonScranton18510PAUSA

This paper describes the process of design and construction of a data warehouse(“DW”)for an online learning platform using three prominent technologies,Microsoft SQL Server,MongoDB and Apache *** three systems are evaluated for corpus construction and descriptive *** case also demonstrates the value of evidence-centered design principles for data warehouse design that is sustainable enough to adapt to the demands of handling big data in a variety of ***,the paper addresses maintainability-performance tradeoff,storage considerations and accessibility of big data *** this NSF-sponsored work,the data were processed,transformed,and stored in the three versions of a data warehouse in search for a better performing and more suitable *** data warehouse engines-a relational database,a No-SQL database,and a big data technology for parallel computations-were subjected to principled ***,construction and evaluation of a data warehouse were scrutinized to find improved ways of storing,organizing and extracting *** work also examines building corpora,performing ad-hoc extractions,and ensuring *** was found that Apache Hive demonstrated the best processing time followed by SQL Server and *** the aspect of analytical queries,the SQL Server was a top performer followed by MongoDB and *** paper also discusses a novel process for render students anonymity complying with Family Educational Rights and Privacy Act *** phases for DW design are recommended:1)Establishing goals at the outset based on Evidence-Centered Design principles;2)Recognizing the unique demands of student data and use;3)Adopting a model that integrates cost with technical considerations;4)Designing a comparative database and 5)Planning for a DW design that is *** for future research include attempting DW design in contexts involving larger data sets,more refined operations,and ensu

关键词： Big data data warehouse MongoDB Apache hive SQL server

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QS2025世界大学排名解析--聚焦中国

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教育国际交流 2024年第4期 56-60页

作者： Ben Sowter Alice Wei alex Berka Simona Bizzozero Sally Zhang QS

英国QS世界大学排名是目前全球的三大权威大学排名之一,每年的排名发布都会吸引全球教育界的目光。2024年6月5日,QS发布了2025版世界大学排名,中国大学整体表现亮眼。本期编辑部特邀Ben Sowter高级副总裁及QS资深学术顾问团队对此次排... 详细信息

英国QS世界大学排名是目前全球的三大权威大学排名之一,每年的排名发布都会吸引全球教育界的目光。2024年6月5日,QS发布了2025版世界大学排名,中国大学整体表现亮眼。本期编辑部特邀Ben Sowter高级副总裁及QS资深学术顾问团队对此次排名进行独家分析,对中国高校的表现作出权威解读,并就“留学中国”的品牌建设提出专业建议。

关键词：学术顾问大学排名副总裁权威解读中国大学整体表现

Peripheral Facial Paralysis in People Living with Human Immunodeficiency Virus (HIV)

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第3期13卷 168-177页

作者： Lekassa Pierrette Andjock Nkouo Yves Christian Mouinga Abayi alex Davy Assoumou Ada Prudence BiyeNgoghe Prudence Ngoma Manfoumbi Albert Brice Manfoumbi Manfoumbi Kévin Dimitri Miloundja Jerome Nzouba Léon ENT and CFS Department Omar Bongo Ondimba Army Instruction Hospital Libreville Gabon Department of Surgery and Surgical Specialties University of Health Sciences Owendo Gabon ENT and CFS Department Yaound&#233 General Hospital Yaound&#233 Cameroon Ophthalmology Department Omar Bongo Ondimba Army Instruction Hospital Libreville Gabon Ophthalmology Department Owendo University Hospital Center Libreville Gabon Internal Medicine Department Omar Bongo Ondimba Army Instruction Hospital Libreville Gabon

Introduction: Peripheral facial palsy (PFP) is a frequent reason for ENT consultations. It is a common complication of human immunodeficiency virus (HIV) infection. The aim of this study was to describe the diagnostic and therapeutic aspects and to establish the correlation between PFP and HIV in our context. Patients and Method: This was a retrospective descriptive study conducted in the ENT and CFS department of the HIAOBO, covering the medical records of patients hospitalized for taking a PFP on HIV terrain from January 1, 2016 to December 31, 2020. Results: The study involved 17 patients, 10 men (59%) and 7 women (41%), a sex ratio of 1.4. The average age was 39 years with the extremes of 11 and 69 years. Shopkeepers reported 9 cases (53%). The reason for consultation was facial asymmetry in 11 cases (100%). The delay in consultation during the first week was 82.4%. Clinical signs were unilateral facial asymmetry, the opening of the palpebral fissure and lacrimation. All patients received medical treatment for PFP and HIV. Evolution was favorable, with complete recovery and no sequelae in 82.4% of cases. Surgery was performed in one case. Conclusion: PFPs are common in HIV infection. Diagnosis is clinical and management is multidisciplinary. Progression depends on the length of time taken to treat the disease.

关键词： Peripheral Facial Paralysis HIV HIAOBO

A New Approach to Multivariate Network Traffic Analysis

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Journal of Computer Science & Technology 2019年第2期34卷 388-402页

作者： Jinoh Kim alex Sim Department of Computer Science Texas A&M University Commerce 75428 U.S.A. Computational Research Division Lawrence Berkeley National Laboratory Berkeley CA 94720 U.S.A.

Network traffic analysis is one of the core functions in network monitoring for effective network operations and *** online traffic analysis has been widely studied,it is still intensively challenging due to several *** of the primary challenges is the heavy volume of traffic to analyze within a finite amount of time due to the increasing network *** important challenge for effective traffic analysis is to support multivariate functions of traffic variables to help administrators identify unexpected network events *** this end,we propose a new approach with the multivariate analysis that offers a high-level summary of the online network *** this approach,the current state of the network will display patterns compiled from a set of traffic variables,and the detection problems in network monitoring(e.g.,change detection and anomaly detection)can be reduced to a pattern identification and classification *** this paper,we introduce our preliminary work with clustered patterns for online,multivariate network traffic analysis with the challenges and limitations we *** then present a grid-based model that is designed to overcome the limitations of the clustered pattern-based *** will discuss the potential of the new model with respect to the technical challenges including streaming-based computation and robustness to outliers.

关键词： network traffic analysis multivariate analysis time-series similarity network monitoring

Generation scenarios of anodic structures and experimental realization of turbulence in unmagnetized plasma

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Plasma Science and Technology 2020年第8期22卷 90-98页

作者： Prince alex Suraj Kumar SINHA Departimento di Fisica G.Occhialini Universita degli studi di MilanoBicoccaI-20126Italy Department of Physics Pondicherry UniversityKalapetPuducherry 605014India

In the present work,we report development of a DC glow discharge plasma(GDP)set-up to study controlled evolution of anodic structures having distinctive geometry,size and layers,generated in front of a positively biased electrode,submerged in unmagnetized *** such an anodic structure,we have also investigated the condition under which the turbulence is *** of these structures,generated in front of a positively biased electrode,depends on multiple parameters such as the ratio of anode to cathode size,electrode separation,gas pressure,biasing configuration such as anode bias,cathode bias and grounding *** attempted to classify different anodic structures observed experimentally,as anode glow,fireball,anode spot,double layer and multiple double layers(MDLs)based on its physical *** these structures the present investigation is focused on *** number of layers,observed in MDLs varied from as high as six to as low as zero,by controlling the operating discharge parameters,*** were carried out using Langmuir *** analysis of floating potential fluctuations corresponds to a multiple anodic structure showed emergence of turbulence,at its critical stage,satisfying condition for self-organized criticality(SOC).This was identified with three slopes observed in the power spectrum,resembling the sand-pile ***,the GDP is completely different from that of the magnetically confined plasma,the nature of turbulence observed with SOC,is very similar to that observed in the scrape of layer of fusion ***,the present investigation could provide new approach to study turbulence of similar nature,under an experimental condition that is free from the complexities of complicated field geometries used in confinement devices.

关键词： glow discharge plasma anode structure multiple anodic double layer turbulence unmagnetized plasma fireball