检索结果-南通市图书馆

Cystic echinococcosis of the liver and lung treated by radiofrequency thermal ablation:An ex-vivo pilot experimental study in animal models

引用

World Journal of Gastroenterology 2009年第26期15卷 3232-3239页

作者： Vincenzo Lamonaca Antonino Virga Marta Ida Minervini Roberta Di Stefano alessio provenzani Pietro Tagliareni Giovanna Fleres Angelo Luca Giovanni Vizzini Ugo Palazzo Bruno Gridelli ISMETT (Mediterranean Institute for Transplantation and Advanced Therapies) University of Pittsburgh Medical Center Italy Health Care Department of Region of Sicily Veterinary Service

AIM:To evaluate radiofrequency thermal ablation (RTA) for treatment of cystic echinococcosis in animal models (explanted organs).METHODS:Infected livers and lungs from slaughtered animals,10 bovine and two ovine,were *** were photographed,and their volume,cyst content,germinal layer adhesion status,wall calcification and presence of daughter or adjacent cysts were evaluated by *** cysts were treated with RTA at 150 W,80℃,7 *** was monitored inside and outside the cyst.A second needle was placed inside the cyst for pressure *** treatment,all cysts were sectioned and examined by *** were defined as alive if a preserved germinal layer at histology was evident,and as successfully treated if the germinal layer was ***:The subjects of the study were 17 cysts (nine hepatic and eight pulmonary),who were treated with *** showed 100% success rate in both hepatic (9/9) and lung cysts (8/8);immediate volume reduction of at least 65%;layer of host tissue necrosis outside the cyst,with average extension of 0.64 cm for liver and 1.57 cm for lung;and endocyst attached to the pericystium both in hepatic and lung cysts with small and focal de novo endocyst detachment in just 3/9 hepatic ***:RTA appears to be very effective in killing hydatid cysts of explanted liver and *** duct and bronchial wall necrosis,persistence of endocyst attached to pericystium,should help avoid or greatly decrease in vivo post-treatment fistula occurrence and consequent overlapping complications that are common after surgery or percutaneous aspiration,injection and *** vivo studies are required to confirm and validate this new therapeutic approach.

关键词：模型实验包虫病试验离体肺癌治疗消融射频

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Learning to become addicted,one synapse at a time

引用

Neural Regeneration Research 2024年第2期19卷 401-402页

作者： alessio Attardo Sidney B.Cambridge Leibniz Institute for Neurobiology MagdeburgGermany Institute for Anatomy II Dr.Senckenberg AnatomyGoethe-University Frankfurt am MainFrankfurtGermany

Addiction has been extensively studied on many levels:from the molecular level,with various“omics”approaches(Natividad et al.,2018;Grecco et al.,2021),to the clinical level,with psychotherapy and MRI imaging(Ceceli ... 详细信息

关键词： clinical therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pyrroloquinoline quinone:a potential neuroprotective compound for neurodegenerative diseases targeting metabolism

引用

Neural Regeneration Research 2025年第1期20卷 41-53页

作者： alessio Canovai Pete A.Williams Department of Biology University of PisaPisaItaly Department of Clinical Neuroscience Division of Eye and VisionSt.Erik Eye HospitalKarolinska InstitutetStockholmSweden

Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/*** quinone is present in the diet being available in foodstuffs,conferring the potential of this compound to be supplemented by dietary *** quinone’s nutritional role in mammalian health is supported by the extensive deficits in reproduction,growth,and immunity resulting from the dietary absence of pyrroloquinoline quinone,and as such,pyrroloquinoline quinone has been considered as a“new vitamin.”Although the classification of pyrroloquinoline quinone as a vitamin needs to be properly established,the wide range of benefits for health provided has been reported in many *** this respect,pyrroloquinoline quinone seems to be particularly involved in regulating cell signaling pathways that promote metabolic and mitochondrial processes in many experimental contexts,thus dictating the rationale to consider pyrroloquinoline quinone as a vital compound for mammalian *** the regulation of different metabolic mechanisms,pyrroloquinoline quinone may improve clinical deficits where dysfunctional metabolism and mitochondrial activity contribute to induce cell damage and *** quinone has been demonstrated to have neuroprotective properties in different experimental models of neurodegeneration,although the link between pyrroloquinoline quinone-promoted metabolism and improved neuronal viability in some of such contexts is still to be fully ***,we review the general properties of pyrroloquinoline quinone and its capacity to modulate metabolic and mitochondrial mechanisms in physiological *** addition,we analyze the neuroprotective properties of pyrroloquinoline quinone in different neurodegenerative conditions and consider future perspectives for pyrroloquinoline quinone’s potential in health and disease.

关键词： metabolism mitochondria neurodegenerative disease neuroprotection pyrroloquinoline quinone retinal diseases

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients

引用

World Journal of Gastroenterology 2013年第48期19卷 9156-9173页

作者： alessio provenzani Andrew Santeusanio Erin Mathis Monica Notarbartolo Manuela Labbozzetta Paola Poma Ambra provenzani Carlo Polidori Giovanni Vizzini Piera Polidori Natale D'Alessandro Department of Clinical Pharmacy Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) 90127 Palermo Italy School of Pharmacy University of Pittsburgh Pittsburgh PA 15261 United States G. D’Alessandro Department of Health Promotion Sciences Section of Pharmacology P Benigno University of Palermo 90127 Palermo Italy National Institute of Social Security (INPS) 90143 Palermo Italy School of Pharmacy University of Camerino 62032 Camerino Italy Department of Medicine Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) 90127 Palermo Italy

The introduction of tacrolimus in clinical practice has improved patient survival after organ ***,despite the long use of tacrolimus in clinical practice,the best way to use this agent is still a matter of intense *** start of the genomic era has generated new research areas,such as pharmacogenetics,which studies the variability of drug response in relation to the genetic factors involved in the processes responsible for the pharmacokinetics and/or the action mechanism of a drug in the *** variability seems to be correlated with the presence of genetic *** is an attractive option especially for the initiation of the dosing of tacrolimus;also,unlike phenotypic tests,the genotype is a stable characteristic that needs to be determined only once for any given ***,prospective clinical studies must show that genotype determination before transplantation allows for better use of a given drug and improves the safety and clinical efficacy of that *** present,research has been able to reliably show that the CYP3A5 genotype,but not the CYP3A4 or ABCB1 ones,can modify the pharmacokinetics of ***,it has not been possible to incontrovertibly show that the corresponding changes in the pharmacokinetic profile are linked with different patient outcomes regarding tacrolimus efficacy and *** these reasons,pharmacogenetics and individualized medicine remain a fascinating area for further study and may ultimately become the face of future medical practice and drug dosing.

关键词： Pharmacogenetics Calcineurin inhibitors Tacrolimus Liver transplant Kidney transplant Single nucleotide polymorphisms CYP3A4 CYP3A5 ABCB1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Risk of hepatitis B virus reactivation in oncological patients treated with tyrosine kinase inhibitors:A case report and literature analysis

引用

World Journal of Gastroenterology 2024年第9期30卷 1253-1256页

作者： Francesca Colapietro Nicola Pugliese Antonio Voza alessio Aghemo Stella De Nicola Department of Biomedical Sciences Humanitas UniversityMilan 20072Italy Division of Internal Medicine and Hepatology Department of GastroenterologyHumanitas Research HospitalMilan 20089Italy Department of Emergency Humanitas Research HospitalMilan 20089Italy

Hepatitis B virus(HBV)reactivation(HBVr)represents a severe and potentially life-threatening condition,and preventive measures are available through blood test screening or prophylactic therapy *** assessment of HBVr traditionally considers factors such as HBV profile,including hepatitis B surface antigen(HBsAg)and antibody to hepatitis B core antigen,along with type of medication(chemotherapy;immunomodulants).Nevertheless,consideration of possible patient’s underlying tumor and the specific malignancy type(solid or hematologic)plays a crucial role and needs to be assessed for decision-making process.

关键词： Chronic hepatitis B Reactivation Nucleoside analogue Tyrosine kinase inhibitors Onco-hematology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Use of bio-based products towards more sustainable road paving binders: A state-of-the-art review

引用

Journal of Road Engineering 2024年第2期4卷 151-162页

作者： alessio Musco Giulia Tarsi Piergiorgio Tataranni Ernesto Salzano Cesare Sangiorgi Department of Civil ChemicalEnvironmental and Materials Engineering(DICAM)Alma Mater Studiorum-University of BolognaBologna 40131Italy

Many industrial sectors exploit fossil sources to develop useful and necessary materials for our needs,such as bituminous paving ***,a key component of asphalt mixtures,is derived from oil refining and its properties are influenced by the crude oil source and refining process,resulting in a significant carbon *** growing awareness of resource depletion and environmental concerns,pavement researchers are exploring sustainable alternatives to reduce dependence on fossil *** includes a rising trend in using renewable materials like biomasses to produce bio-based binders as substitutes for bitumen,aiming for a more sustainable ***,including vegetal and animal wastes,and waste cooking oils,as substitutes for crude oil in the production of *** thermochemical conversion(TCC),such as pyrolysis,biomasses can be converted into bio-char and bio-oils,which can replace fossil-based components in *** have utilized these bio-products to reduce the dependency on fossil fuels in ***,there are no set minimum requirements for bio-components in bio-based *** the percentage of replaced bitumen increases,various types of binders are produced,including modified bitumen,extended bitumen,and alternative binders,where the fossil replacement is *** rheological tests on bio-binders,reveal that those containing biochar exhibit increased viscosity,stiffness,rutting resistance,and sometimes antioxidant ***,bio-binders with bio-oils as bitumen substitutes show poorer performance at high temperatures but improved behavior at low *** results suggest that bio-binders could provide versatile solutions for various climatic and loading conditions in road ***,the development of pavement mixtures based on bio-binders has not been studied in depth and requires further attention to unlock its full *** sustainability considerations,includin

关键词： Biomass Chemical process Bitumen replacement Bio-binder Paving material

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Venous Doppler flow patterns,venous congestion,heart disease and renal dysfunction:A complex liaison

引用

World Journal of Cardiology 2024年第1期16卷 5-9页

作者： alessio Di Maria Rossella Siligato Marta Bondanelli Fabio Fabbian Specialized Medicines Renal UnitUniversity Hospital St.Anna of FerraraFerrara I-44124Italy Department of Biomedical DentalMorphological and Functional Imaging SciencesUniversity of MessinaMessina I-98121Italy Department of Medical Sciences University of FerraraFerrara I-44124Italy Department of Medical Sciences University of FerraraFerrara 44124Italy

The World Journal of Cardiology published an article written by Kuwahara et al that we take the pleasure to comment *** focused our attention on venous *** intensive care settings,it is now widely accepted that venous congestion is an important clinical feature worthy of *** venous Doppler profile abnormalities at multiple sites could suggest adequate treatment and monitor its *** dysfunction could trigger or worsen fluid overload in heart disease,and cardio-renal syndrome is a well-characterized spectrum of disorders describing the complex interactions between heart and kidney *** overload and venous congestion,including renal venous hypertension,are major determinants of acute and chronic renal dysfunction arising in heart *** congestion from venous hypertension could be involved in the development of organ injury in several clinical situations,such as critical diseases,congestive heart failure,and chronic kidney *** and abnormal Doppler flow patterns diagnose clinically significant systemic venous *** and nephrologists might use this valuable,noninvasive,bedside diagnostic tool to establish fluid status and guide clinical choices.

关键词： Cardio-renal syndrome Fluid overload Venous congestion Acute kidney injury Ultrasound Doppler flow patterns

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Three predictive scores compared in a retrospective multicenter study of nonunion tibial shaft fracture

引用

World Journal of Orthopedics 2024年第6期15卷 560-569页

作者： Davide Quarta Marco Grassi Giuliano Lattanzi Antonio Pompilio Gigante alessio D'Anca Domenico Potena Clinical Orthopedics Department of Clinical and Molecular ScienceUniversitàPolitecnica Delle MarcheAncona 60126Italy Department of Information and Engineering UniversitàPolitecnica delle MarcheAncona 60121Italy

BACKGROUND Delayed union,malunion,and nonunion are serious complications in the healing of *** the risk of nonunion before or after surgery is *** To compare the most prevalent predictive scores of nonunion used in clinical practice to determine the most accurate score for predicting *** We collected data from patients with tibial shaft fractures undergoing surgery from January 2016 to December 2020 in three different trauma *** this retrospective multicenter study,we considered only fractures treated with intramedullary *** calculated the tibia FRACTure prediction healING days(FRACTING)score,Nonunion Risk Determination score,and Leeds-Genoa Nonunion Index(LEG-NUI)score at the time of definitive *** Of the 130 patients enrolled,89(68.4%)healed within 9 months and were classified as *** remaining patients(n=41,31.5%)healed after more than 9 months or underwent other surgical procedures and were classified as *** calculation of the three scores,LEG-NUI and FRACTING were the most accurate at predicting *** LEG-NUI and FRACTING showed the best performances by accurately predicting union and nonunion.

关键词： Trauma Bone Tibial fracture Nonunion Scores Prediction model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Management of cerebral amyloid angiopathy and atrial fibrillation:We are still far from precision medicine

引用

World Journal of Cardiology 2024年第5期16卷 231-239页

作者： Liuba Fusco Zefferino Palamà Antonio Scarà alessio Borrelli Antonio Gianluca Robles Gabriele De Masi DeLuca Silvio Romano Luigi Sciarra Department of Cardiology University Hospital of NorthamptonshireNorthampton NN15BDUnited Kingdom Department of Cardiology Casa di Cura Villa VerdeTaranto 70124Italy Department of Life Health and Environmental SciencesUniversity of l'AquilaL'Aquila 67100Italy Department of Cardiology GVM Care and ResearchSan Carlo di Nancy HospitalRome 00100Italy

The use of anticoagulation therapy could prove to be controversial when trying to balance ischemic stroke and intracranial bleeding risks in patients with concurrent cerebral amyloid angiopathy(CAA)and atrial fibrillation(AF).In fact,CAA is an age-related cerebral vasculopathy that predisposes patients to intracerebral ***,many AF patients require oral systemic dose-adjusted warfarin,direct oral anticoagulants(such as factor Xa inhibitors)or direct thrombin inhibitors to control often associated with cardioembolic stroke *** prevalence of both CAA and AF is expected to rise,due to the aging of the *** clinical dilemma is becoming increasingly *** patients with coexisting AF and CAA,the risks/benefits profile of anticoagulant therapy must be assessed for each patient individually due to the lack of a clear-cut consensus with regard to its risks in scientific *** review aims to provide an overview of the management of patients with concomitant AF and CAA and proposes the implementation of a risk-based decision-making algorithm.

关键词： Anticoagulation Atrial fibrillation Cerebral amyloid angiopathy Intracerebral hemorrhage Stroke Watchman Secondary prevention Left atrial appendage closure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

日本微热山丘

引用

城市环境设计 2024年第1期147卷 156-161页

作者：宫原贤次秋山弘明堂园有的 alessio Guarino Daici Ano Edward Caruso

我们使用了日本木结构建筑中一种叫作“地狱组”的传统连接系统，创造了一个柔和温暖的人性化空间，感觉就像森林或云朵。3D结构系统的采用使单个构件的横截面减小到60毫米×60毫米。这个用薄如树枝的木构件营造的空间，被用来品尝精心...

我们使用了日本木结构建筑中一种叫作“地狱组”的传统连接系统，创造了一个柔和温暖的人性化空间，感觉就像森林或云朵。3D结构系统的采用使单个构件的横截面减小到60毫米×60毫米。这个用薄如树枝的木构件营造的空间，被用来品尝精心挑选的食材制成的凤梨酥。

关键词：

来源：博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：