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中国：向创新驱动的经济增长的转变

中国：向创新驱动的经济增长的转变

作者： alessia Pranzo 北京外国语大学

学位级别：硕士

随着 2006-2020》—(MLP)《国家中长期科技发展规划的实施,中华人民共和国采取了旨在促进国家经济创新的创新政策。根据这项政策,中国的经济目标将从以低成本制造业产品为基础的经济转变为高科技和服务业的高端产业,从而成为全球创新的... 详细信息

随着 2006-2020》—(MLP)《国家中长期科技发展规划的实施,中华人民共和国采取了旨在促进国家经济创新的创新政策。根据这项政策,中国的经济目标将从以低成本制造业产品为基础的经济转变为高科技和服务业的高端产业,从而成为全球创新的领导者。本文将评估中国推动创新政策的影响,并回答以下问题:中国的创新行动是否对其经济绩效产生了影响?如果是的话,中国是否已经度过了追赶增长的阶段,是否面临着新的增长现实?本文还将分析中国的创新环境,以及中国在这一新的经济态势中所面临的优势和挑战。最后一个问题是,中国的创新政策和行动是否足以完成从吸收现有技术和知识的发展中经济体的地位向全球创新领导者的地位的转变。最后,本文将给出一些最佳案例研究。

关键词： technological,http,renewable,companies,innovative,sector,institutions,sustainable,encourage,publications,

Mesenchymal stromal cell secretome in liver failure:Perspectives on COVID-19 infection treatment

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World Journal of Gastroenterology 2021年第17期27卷 1905-1919页

作者： Cinzia Maria Chinnici Giovanna Russelli Matteo Bulati Vitale Miceli alessia Gallo Rosalia Busà Rosaria Tinnirello Pier Giulio Conaldi Gioacchin Iannolo Department of Research Mediterranean Institute for Transplantation and Advanced Specialized Therapies(IRCCS-ISMETT)Palermo 90127Italy Department of Regenerative Medicine Fondazione Ri.MEDPalermo 90127Italy Neuroscience Unit CNR Institute of Biomedicine and Molecular ImmunologyPalermo 90146Italy

Due to their immunomodulatory potential and release of trophic factors that promote healing,mesenchymal stromal cells(MSCs)are considered important players in tissue homeostasis and *** have been widely used in clinical trials to treat multiple conditions associated with inflammation and tissue *** evidence suggests that most of the MSC therapeutic effects are derived from their secretome,including the extracellular vesicles,representing a promising approach in regenerative medicine application to treat organ failure as a result of inflammation/*** recent outbreak of respiratory syndrome coronavirus,caused by the newly identified agent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has forced scientists worldwide to use all available instruments to fight the infection,including the inflammatory cascade caused by this pandemic *** use of MSCs is a valid approach to combat organ inflammation in different *** addition to the lungs,which are considered the main inflammatory target for this virus,other organs are compromised by the *** particular,the liver is involved in the inflammatory response to SARS-CoV-2 infection,which causes organ failure,leading to death in coronavirus disease 2019(COVID-19)*** herein summarize the current implications derived from the use of MSCs and their soluble derivatives in COVID-19 treatment,and emphasize the potential of MSCbased therapy in this clinical setting.

关键词： Mesenchymal stromal cell COVID-19 SARS-CoV-2 Organ failure Inflammation Transplantation

Genetic biomarkers for hepatocellular cancer risk in a caucasian population

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World Journal of Gastroenterology 2017年第36期23卷 6674-6684页

作者： Elena De Mattia Erika Cecchin Jerry Polesel alessia Bignucolo Rossana Roncato Francesco Lupo Marina Crovatto Angela Buonadonna Claudio Tiribelli Giuseppe Toffoli Clinical and Experimental Phar-macology “Centro di Riferimento Oncologico”-National Cancer Institute Unit of Cancer Epidemiology “Centro di Riferimento Oncologico”-National Cancer Institute General Surgery 2U and Liver Transplantation Center A.O.U.Cittàdella Salute e della Scienza di TorinoUniversity of Torino Cytogenetics and Molecular Biology Unit Santa Maria degli Angeli Hospital Pordenone Medical Oncology Unit “Centro di Riferimento Oncologico”-National Cancer Institute Fondazione Italiana Fegato AREA Science Park

AIM To uncover novel genetic markers that could contribute to predicting hepatocellular carcinoma(HCC)susceptibility in Caucasians. METHODS The present retrospective case-control study compared genotype frequencies between a cohort of HCC cases and two,independent,HCC-free,age/sex-matched control *** HCC cohort comprised 192 homogeneous patients that had undergone orthotopic liver *** first control group comprised167 patients that were matched to the HCC cohort for the percentage of hepatitis B(HBV)and/or hepatitis C(HCV)infections.A second control group included192 virus-free,healthy individuals that were used to evaluate the generalizability of the identified predictive *** cases and controls were *** three study populations were characterized with a panel of 31 markers derived from 21 genes that encoded key proteins involved in hepatocarcinogenesis-related *** study end-point was to assess the association between genetic variants and HCC onset. RESULTS Five genetic markers were identified as risk factors for HCC in high-risk patients infected with HBV/*** to a dominant model,reduced HCC risk was associated with three polymorphisms:ERCC1rs3212986(OR=0.46,95%CI:0.30-0.71,P=0.0005),GST-P1 rs1138272(OR=0.41,95%CI:0.21-0.81,P=0.0097),and CYP17A1 rs743572(OR=0.50,95%CI:0.31-0.79,P=0.0032).Conversely,according to a recessive model,increased HCC risk was associated with two polymorphisms:XRCC3 rs1799794(OR=3.70,95%CI:1.02-13.39,P=0.0461)and ABCB1 rs1128503(OR=2.06,95%CI:1.18-3.61,P=0.0111).These associations remained significant in a subgroup analysis,where patients were stratified according to viral status(HBV-or HCV-positive serology).Two variants exhibited a serology-specific effect:ABCB1 rs1128503(OR=4.18,95%CI:1.55-11.29,P=0.0048)showed an effect in the HBV-positive subgroup;and ERCC1 rs3212986(OR=0.33,95%CI:0.18-0.60,P=0.0003)showed an effect in the HCV-positive *** the five markers identified,E

关键词： ERCC1 XRCC3 GST-P1 CYP17A1 MDR-1 Polymorphisms Hepatocellular carcinoma risk Early diagnosis Antiviral therapy Hepatitis B viral/hepatitis C viral

Worldwide management of hepatocellular carcinoma during the COVID-19 pandemic

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World Journal of Gastroenterology 2021年第25期27卷 3780-3789页

作者： Riccardo Inchingolo Fabrizio Acquafredda Michele Tedeschi Letizia Laera Gianmarco Surico alessia Surgo Alba Fiorentino Stavros Spiliopoulos Nicola de'Angelis Riccardo Memeo Department of Interventional Radiology Unit “F.Miulli”General Regional HospitalAcquaviva delle Fonti 70021BariItaly Unit of Hepato-Pancreatic-Biliary Surgery “F.Miulli”General Regional HospitalAcquaviva delle Fonti 70124BariItaly Gianmarco Surico Department of Oncology“F.Miulli”General Regional HospitalAcquaviva delle Fonti 70021BariItaly Department of Radiation Oncology “F.Miulli”General Regional HospitalAcquaviva delle Fonti 70021BariItaly Department of 2^(nd)Radiology National and Kapodistrian University of AthensAthens 12461Greece Unit of Minimally Invasive and Robotic Digestive Surgery “F.Miulli”General Regional HospitalAcquaviva delle Fonti 70021BariItaly

The coronavirus disease 2019(COVID-19)pandemic has impacted hospital organization,with the necessity to quickly react to face the *** management of the oncological patient has been modified by necessity due to different allocation of nurses and doctors,requiring new strategies to guarantee the correct assistance to the *** carcinoma,considered as one of the most aggressive types of liver cancer,has also required a different management during this period in order to optimize the management of patients at risk for and with this *** aim of this document is to review recommendations on hepatocellular carcinoma surveillance and management,including surgery,liver transplantation,interventional radiology,oncology,and *** and guidelines from the main scientific societies worldwide regarding the management of hepatocellular carcinoma during the COVID-19 pandemic were reviewed.

关键词： Hepatocellular carcinoma Interventional radiology Oncology Liver Management COVID-19

中国内衣行业的全球本土化——意大利Intima Moda的进入策略

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中国内衣行业的全球本土化——意大利Intima Moda的进入策略

作者： alessia Fabbri 华东理工大学

学位级别：硕士

中国时装业的发展越来越多。这是可以理解的,越来越多的西方公司正在考虑进入中国市场。本论文的目的是为那些寻求扩大其国际业务的公司的工具。本论文旨在为那些正考虑在中国市场拓展国际业务的公司提供一个可以借鉴的案例,指出这类... 详细信息

中国时装业的发展越来越多。这是可以理解的,越来越多的西方公司正在考虑进入中国市场。本论文的目的是为那些寻求扩大其国际业务的公司的工具。本论文旨在为那些正考虑在中国市场拓展国际业务的公司提供一个可以借鉴的案例,指出这类企业不仅把焦点放在财务诉求上,而且还需要关注企业战略和营销策略,以取得成功。意大利公司可以依靠的“意大利制造”的认可的质量,然而,他们必须牢记,西方消费者相比中国消费者不一样。本论文的目的是展示联合国成功的意大利内衣公司Intima Moda作为一个例子使用在地化的重要性。通过学术论文,该公司的支持和使用一个度身订造的调查研究,本文的目的是创建一个入口战略,这将有助于内膜Intima Moda的第二次尝试进入中国。在整个过程中,具体的学术文章,书籍,期刊和审查己分析。第一手材料,帮助本研究感谢该公司的直接参与,共享有关其业务的重要信息。终于,一个特定的问问卷被提交给潜在客户,以了解消费者的个人资料,购买行为和市场潜力。这个研究的主要目是,从该公司以前的错误中学习,理解和为Intima Moda命题进入战略。这项工作是公司的建议,目的是帮助他们更好地了解如何处理源上下文高度不同的目标背景。在推出自己的品牌和产品的时候,内衣企业应该考虑的分化成功的一个关键的重要性。

关键词：国际营销全球本土化内衣行业

Adalimumab efficacy in enteropathic spondyloarthritis: A 12-mo observational multidisciplinary study

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World Journal of Gastroenterology 2017年第39期23卷 7139-7149页

作者： Michele Maria Luchetti Devis Benfaremo Francesco Ciccia Laura Bolognini Monia Ciferri alessia Farinelli Matteo Rossini Piergiorgio Mosca Giovanni Triolo Armando Gabrielli Dipartimento Scienze Cliniche e Molecolari Clinica MedicaUniversità Politecnica delle Marche Dipartimento Biomedico di Medicina Interna e Specialistica Sezione di Reumatologia Università degli Studi di Palermo Dipartimento Gastro-enterologico e dei Trapianti Polo Ospedaliero--Universitario 'Umberto I-G.M. Lancisi- G. Salesi'

AIM To report adalimumab(Ada) efficacy on articulargastrointestinal disease and health-related quality of life(HRQo L) in patients with enteropathic spondyloarthritis(ES).METHODS A cohort of 52 patients with ES was evaluated in the departments of gastroenterology and internal medicine. At baseline, all patients underwent assessment by an integrated gastro-rheumatologic evaluation of articular and gastrointestinal activity, as well patient reported outcomes(PROs) of the HRQo L questionnaires. After this integrated evaluation and following a specific working flowchart, the Ada anti-tumor necrosis factor(TNF)-inhibitor was assigned to a cohort of 30 patients and its clinical efficacy was evaluated at baseline and after 6-mo and 12-mo treatment by the following tests:(1) Ankylosing Spondylitis Disease Activity ScoreC-Reactive Protein(ASDAS-CRP); Bath Ankylosing Spondylitis Disease Activity Index(BASDAI), Bath Ankylosing Spondylitis Functional Index(BASFI) and Bath Ankylosing Spondylitis Metrology Index(BASMI) for articular activity;(2) Inflammatory Bowel Disease Questionnaire(IBDQ), Crohn's Disease Activity Index(CDAI) and partial Mayo(p Mayo) score for gastrointestinal symptoms and activity; and(3) Health Assessment Questionnaire(HAQ), Patient Global Assessment(PGA) and Short Form-36 health survey(SF-36) questionnaires for PROs of the HRQo *** Integrated evaluation and management of the patients affected by ES, carried out simultaneously by a gastroenterologist and a rheumatologist, allowed clinicians to choose the optimal therapeutic strategy. In a cohort of 30 ES patients affected by active articular and gastrointestinal disease, or axial active articular inflammation, Ada led to fast and sustained improvement of both articular and gastrointestinal disease activities. In fact, all the clinimetric evaluation tests exploring articular or gastrointestinal activity, as well as all the HRQo L scores, showed a significant improvement having been achieved at the earli

关键词： Clinimetric 评价耐心的报导结果煽动性的肠疾病 Enteropathic spondyloarthritis 肿瘤坏死因素禁止者多学科的评估

Children's Rights and Business Principles:Empirical Evidences from Italy

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Children's Rights and Business Principles:Empirical Evidence...

作者： alessia DESTEFANI 复旦大学

学位级别：硕士

本文旨在研究意大利公司对于儿童及其权利的敏感度。2012年3月,联合国儿童基金会和联合国全球契约组织共同发布了10条《儿童权利及商业准则》。该准则详细地规范了企业在生产场所、营销场所和社区应该如何尊重和保护儿童权利。如此详细... 详细信息

本文旨在研究意大利公司对于儿童及其权利的敏感度。2012年3月,联合国儿童基金会和联合国全球契约组织共同发布了10条《儿童权利及商业准则》。该准则详细地规范了企业在生产场所、营销场所和社区应该如何尊重和保护儿童权利。如此详细的准则之前从未出现过。此商业准则进一步确定了联合国保护儿童公约中的条款,并将成为企业社会责任的一部分。企业社会责任是全新的企业管理战略方向,关注企业和社会的关系。本实证研究的目的是分析意大利公司在尊重和保护儿童权利方面的表现。本研究采用了内容分析法,样本包括58家意大利公司发布的可持续发展报告,其中大多数是上市公司。学界尚未形成通用的报告格式,也无儿童敏感度的评估模型。根据十条《儿童权利及商业准则》,参考联合国儿童基金会的指导文件和全球通用的可持续发展报告的格式,我创建了详细而完备的测量儿童敏感度的变量体系。该体系包括19个定性变量。因为除第一条之外的其余9条商业准则在尊重和保护儿童权利的执行过程中程度有所不同,我在定义变量的时候也采取了相同的方法。在分析结果时,我首先测量在不同商业情境下的企业儿童敏感度。这些情境包括生产场所、营销场所、社区和环境。其次,根据10条《儿童权利及商业准则》,我逐条分析了企业儿童敏感度。最后,我根据不同的行业分析企业的儿童敏感度。我始终对“尊重儿童”和“保护儿童”做了区分。研究表明,意大利企业十分关注儿童在生产场所(包括工人、雇员家属、商业设施和员工)受尊重和保护的情况。意大利企业尤其关注政府和社区在保护和实现儿童权利方面的努力。然而,意大利企业对于营销场所如何尊重和保护儿童权利关注不够,比如在紧急情况下应该如何保护儿童权利,包括相关的安全措施等。除此以外,研究发现意大利企业在保护儿童权利方面做得远不如尊重儿童权利做得好,因此在保护儿童权利方面依然有很大的努力空间,可以采取更积极的、实际的和立足长远的措施。最后,研究发现关注企业社会责任的大企业相对更关注儿童权利的保护。类似的,尽管在统计方面并不显著,国际化程度高的企业也相对更关注儿童权利的保护。从另一方面来说,企业儿童敏感度和其对企业社会责任的投入,以及董事会中女性成员的比例并无统计学上的显著关系。

关键词：企业社会责任儿童权利及商业准则意大利

Application of the Soft X-Ray TSI Advanced Aerosol Neutralizer to Aerosol Measurements Made by a Grimm SMPS

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Atmospheric and Climate Sciences 2014年第4期4卷 636-641页

作者： alessia Nicosia Franco Belosi Brais Vazquez Institute of Atmospheric Sciences and Climate (ISAC) Italian National Research Council Bologna Italy

Scanning Mobility Particle Sizer (SMPS) spectrometers are subject to several restrictions when a radioactive source is employed to bring the aerosol to a steady-state charge distribution. An alternative solution, commercially available, is represented by the soft X-ray neutralizer. The present study investigates the outcome of a combination of a Grimm SMPS, which employs a 241Am radioactive source, with the soft X-ray advanced aerosol neutralizer (TSI model 3087). To date, the latter device has been interfaced only with TSI’s Electrostatic Classifiers. Particle size distribution of sodium chloride aerosol was measured with both neutralizers and it was found that the particle number concentration agreed to be within 9% for the 10 - 700 nm range. This difference mainly corresponds to the bias reported by TSI, when the X-ray device is mounted on a TSI spectrometer. It was concluded that the X-ray neutralizer could be usefully employed, as a standalone device, in combination with Grimm Electrostatic Classifiers.

关键词： Aerosol Neutralizer SMPS Particle Size Distribution

Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 376-380页

作者： Eleonora Cella Ivan Gabrielli Gianguglielmo Zehender Marta Giovanetti Alessandra Lo Presti alessia Lai Giordano Dicuonzo Silvia Angeletti Marco Salemi Massimo Ciccozzi Department of Infectious Parasitic and Immunomediated DiseasesNational Institute of Health Department of Public Health and Infectious Diseases.Sapienza University of Rome University of Rome 'La Sapienza' L.Sacco Department of Biomedical and Clinical Sciences University of Milan University of Rome 'Tor Vergata' Clinical Pathology and Microbiology Laboratory University Hospital Campus Bio-Medico of Rome Department of Pathology and Laboratory Medicine.University of Florida University Hospital Campus Bio-Medico

Objective:To study the genetic diversity of Murray Valley encephalitis virus(MVEV) in Australia and Papua New ***:MVEV envelope gene sequences were aligned using Clustal X and manual editing was performed with *** v.3.7 was used to select the simplest evolutionary model that adequately fitted the sequence *** likelihood analysis was performed using *** phylogenetic signal of the dataset wa.s investigated by the likelihood mapping *** Bayesian phylogenetic tree was built using ***:The phylogenetic trees showed two main *** clade Ⅰincluding eight strains isolated from West *** clade Ⅱ was characterized by at least four epidemic entries,three of which localized in Northern West Australia and one in Papua New *** estimated mean evolutionary rate value of the MVEV envelope gene wa.s0.407 × 10^(-3) substitution/site/year(95%HPD:0.623 × 10~4-0.780× 10^(-3)).Population dynamics defines a relative constant population until the year *** a reduction occurred,probably due to a ***:This study has been useful in supporting the probable connection between climate changes and viral evolution also by the vector point of view:multidisciplinary monitoring studies are important to prevent new viral epidemics inside and outside new endemic areas.

关键词： Murray Valley encephalitis virus Phylogeny Evolution