检索结果-南通市图书馆

Outcomes assessment of hepatitis C virus-positive psoriatic patients treated using pegylated interferon in combination with ribavirin compared to new Direct-Acting Antiviral agents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2018年第2期10卷 329-336页

作者： Giovanni Damiani Chiara Franchi Paolo Pigatto Andrea Altomare alessia pacifico Stephen Petrou Sebastiano Leone Maria Caterina Pace Marco Fiore Study Center of Young Dermatologists Italian Network (YDIN) Gised Bergamo Italy and Clinical Dermatology IRCCS Galeazzi Orthopaedic Institute Department of Biomedical Surgical and Dental Sciences University of Milan Clinical Dermatology IRCCS Galeazzi Orthopaedic Institute San Gallicano Dermatological Institute IRCCS Department of Emergency Medicine St. George’s University Medical School Division of Infectious Diseases "San Giuseppe Moscati" Hospital Department of Anesthe-siological Surgical and Emergency Sciences University of Campania "Luigi Vanvitelli"

AIM To evaluate the outcomes in biological treatment and quality of life of psoriatic patients with chronic hepatitis C(CHC) treated with new Direct-Acting Antiviral agents(DAAs) compared to pegylated interferon-2α plus ribavirin(P/R) *** This is a retrospective study involving psoriatic patients in biological therapy who underwent anti-hepatitis C virus(HCV) treatment at the Department of Dermatology Galeazzi Orthopaedic Institute Milan, Italy from January 2010 to November 2017. The patients were divided into two groups: patients that underwent therapy with DAAs and patients that underwent HCV treatment with P/R. Patients were assessed by a dermatologist for psoriasis symptoms, collecting Psoriasis Area Severity Index(PASI) scores and the Dermatology Quality of Life Index(DLQI). PASI and DLQI scores were evaluated 24 wk after the end of HCV treatment and were assumed as an outcome of the progression of psoriasis. Switching to a different b DMARD was considered as an inadequate response to biological therapy. The dropout of HCV therapy and sustained virological response(SVR) were considered as outcomes of HCV *** Fifty-nine psoriatic patients in biological therapy underwent antiviral therapy for CHC. Of this, 27 patients were treated with DAAs and 32 with P/R. After 24 wk post treatment, the DLQI and the PASI scores were significantly lower(P < 0.001 and P < 0.005, respectively) in the DAAs group compared with P/R group. None of the patients in the DAAs group(0/27) compared to 8 patients of the P/R group(8/32) needed a shift in biological *** DAAs seem to be more effective and safe than P/R in HCV-positive psoriatic patients on biological treatment. Fewer dermatological adverse events may be due to interferon-free therapy.

关键词： Hepatitis C virus New Direct-Acting Antiviral agents Psoriasis Biological disease modifying drugs

Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2019年第4期11卷 391-401页

作者： Giovanni Damiani Sebastiano Leone Kristen Fajgenbaum Nicola L Bragazzi alessia pacifico Rosalynn RZ Conic Paolo DM Pigatto Carlo Maiorana Pierpaolo Poli Emilio Berti Maria C Pace Piergiorgio Malagoli Vincenzo Bettoli Marco Fiore Department of Dermatology Case Western Reserve University Young Dermatologists Italian Network (YDIN) Centro Studi GISED Clinical Dermatology IRCCS Galeazzi Orthopaedic Institute Department of Biomedical Surgical and Dental SciencesUniversity of Milan Division of Infectious Diseases "San Giuseppe Moscati" Hospital University of North Carolina School of Medicine School of Public Health Department of Health Sciences (DISSAL)University of Genoa San Gallicano Dermatological Institute IRCCS Center for Jawbone Atrophies Policlinico Hospital University of Milan School of Dentistry Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti Università degli Studi di Milano Unità Operativa di Dermatologia IRCCS Fondazione Ca’ GrandaOspedale Maggiore Policlinico Department of Women Child and General and Specialized SurgeryUniversity of Campania "Luigi Vanvitelli" Dermatology Unit Azienda Ospedaliera San Donato Milanese Department of Clinical and Experimental Dermatology O.C. of DermatologyAzienda Ospedaliero-Universitaria di Ferrara

BACKGROUND Nonalcoholic fatty liver disease(NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver(NAFL) and non-alcoholic steatohepatitis(NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease(ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health *** suppurativa(HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely *** To evaluate the prevalence and characteristics of NASH/NAFL in HS *** This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/*** Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients(P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index(ADDI) was significantly higher among patients with HS/NASH(5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only(2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three *** HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores.

关键词： Non-alcoholic steatohepatitis Non-alcoholic fatty liver Nonalcoholic fatty liver disease End stage liver disease Hidradenitis suppurativa

Sarcopenia and nonalcoholic fatty liver disease: a causal relationship

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2019年第2期8卷 144-147页

作者： Lucia pacifico Francesco Massimo Perla Claudio Chiesa Department of Pediatrics Sapienza University of RomeRomeItaly Institute of Translational Pharmacology National Research CouncilRomeItaly

Concurrent with the obesity epidemic,non-alcoholic fatty liver disease(NAFLD)is rapidly becoming the leading cause of chronic liver disease worldwide(1).NAFLD,particularly its histological phenotype non-alcoholic steatohepatitis(NASH),can progress to advanced liver disease,cirrhosis and hepatocellular carcinoma and indication for liver transplantation(2).Although remarkable advances have been made in the understanding of the pathophysiology of NAFLD,the exact mechanism of hepatic fat accumulation and the progression to NASH is not fully ***,in order to reduce the burden associated with these diseases,it is imperative that all major factors that contribute to the development of NAFLD are identified.

关键词： NAFLD becoming exact

Impact of healthy plant-based diet on abdominal visceral and liver fat contents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2021年第1期10卷 136-138页

作者： Lucia pacifico Francesco Massimo Perla Claudio Chiesa Department of Maternal and Child health Sapienza University of RomeRomeItaly Institute of Translational Pharmacology National Research CouncilRomeItaly

Diet is an important modifiable risk factor for obesity and obesity-related complications,and there has been growing interest in plant-based diets,mainly defined as“vegetarian”diets,which have been associated with a lower prevalence rate of overweight/obesity as well as a lower risk of coronary heart disease,type 2 diabetes,other cardiometabolic diseases,and all-cause mortality(1).Such dietary patterns are also a major determinant of environmental sustainability(1).Of note,however,vegetarian diets can include less healthy plant foods,such as refined grains and sugar-sweetened beverages which have detrimental effects on health(2).

关键词： obesity mortality diseases

Immune response to vaccines in children with celiac disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第18期23卷 3205-3213页

作者： Caterina Anania Francesca Olivero Alessandra Spagnolo Claudio Chiesa Lucia pacifico Policlinico Umberto I Sapienza University of Rome Department of Public Health and Infectious Diseases Sapienza University of Rome Institute of Translational Pharmacology National Research Council

Celiac disease(CD) is an immune-mediated systemic condition evoked by ingestion of gluten and related prolamines in genetically susceptible subjects. The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. Vaccination is the most potent intervention for infectious disease prevention. Several factors including age, gender, ethnicity, quality and quantity of vaccine antigen, doses, and route of administration can influence immune response to vaccination, although the main cause of variation in the responsiveness among vaccine recipients is host genetic variability. The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. The available literature indicates that the immunological response to vaccines in CD children does not differ markedly from that of general population and antibody titres are high enough to provide long-term protection, except for hepatitis B virus vaccine. In this article, we review and discuss the scarce literature in this field in order to provide clinical practice guidelines to achieve the most efficient monitoring of the response to vaccines in pediatric CD patients.

关键词： Celiac disease Children Infection Vaccines Hepatitis B vaccine HLA Gluten free diet

Mediterranean diet and nonalcoholic fatty liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第19期24卷 2083-2094页

作者： Caterina Anania Francesco Massimo Perla Francesca Olivero Lucia pacifico Claudio Chiesa Policlinico Umberto I Hospital Sapienza University of Rome Institute of Translational Pharmacology National Research Council

Nonalcoholic fatty liver disease(NAFLD) is emerging as the most common chronic liver disease, and is characterized by a wide spectrum of fat-liver disorders that can result in severe liver disease and cirrhosis. Inflammation and oxidative stress are the major risk factors involved in the pathogenesis of NAFLD. Currently, there is no consensus concerning the pharmacological treatment of NAFLD. However, lifestyle interventions based on exercise and a balanced diet for quality and quantity, are considered the cornerstone of NAFLD management. Mediterranean diet(MD), rich in polyunsaturated fats, polyphenols, vitamins and carotenoids, with their anti-inflammatory and antioxidant effects, has been suggested to be effective in preventing cardiovascular risk factors. In adults, MD has also been demonstrated to be efficacious in reducing the risk of metabolic syndrome. However, few studies are available on the effects of the MD in both adult and pediatric subjects with NAFLD. Thus, the aims of the present narrative review are to analyze the current clinical evidence on the impact of MD in patients with NAFLD, and to summarize the main mechanisms of action of MD components on this condition.

关键词： Mediterranean diet children Nonalcoholic fatty liver disease adults

Increased circulating zonulin in children with biopsy-proven nonalcoholic fatty liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第45期20卷 17107-17114页

作者： Lucia pacifico Enea Bonci Lidia Marandola Sara Romaggioli Stefano Bascetta Claudio Chiesa Department of Pediatrics and Child Neuropsychiatry Sapienza University of Rome Department of Experimental Medicine Sapienza University of Rome Institute of Translational Pharmacology National Research Council

AIM: To investigate the potential association of circulating zonulin with the stage of liver disease in obese children with biopsy-confirmed nonalcoholic fatty liver disease (NAFLD).

关键词： Zonulin Intestinal permeability Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Children

Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第10期23卷 1747-1757页

作者： Eleonora Poggiogalle Lorenzo Maria Donini Andrea Lenzi Claudio Chiesa Lucia pacifico Department of Experimental Medicine-Medical Pathophysiology Food Science and Endocrinology SectionSapienza University of Rome Institute of Translational Pharmacology National Research Council Policlinico Umberto I Hospital Sapienza University of Rome

The estimates of global incidence and prevalence of non-alcoholic fatty liver disease(NAFLD) are worrisome, due to the parallel burden of obesity and its metabolic complications. Indeed, excess adiposity and insulin resistance represent two of the major risk factors for NAFLD; interestingly, in the last years a growing body of evidence tended to support a novel mechanistic perspective, in which the liver is at the center of a complex interplay involving organs and systems, other than adipose tissue and glucose homeostasis. Bone and the skeletal muscle are fat- free tissues which appeared to be independently associated with NAFLD in several cross-sectional studies. The deterioration of bone mineral density and lean body mass, leading to osteoporosis and sarcopenia, respectively, are age-related processes. The prevalence of NAFLD also increases with age. Beyond physiological aging, the three conditions share some common underlying mechanisms, and their elucidations could be of paramount importance to design more effective treatment strategies for the management of NAFLD. In this review, we provide an overview on epidemiological data as well as on potential contributors to the connections of NAFLD with bone and skeletal muscle.

关键词： Non-alcoholic fatty liver disease Bone Skeletal muscle Osteoporosis Sarcopenia

Probiotics for the treatment of Helicobacter pylori infection in children

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第3期20卷 673-683页

作者： Lucia pacifico John Frederick Osborn Enea Bonci Sara Romaggioli Rossella Baldini Claudio Chiesa Department of Pediatrics and Child Neuropsychiatry Sapienza University of Rome Department of Health Sciences and Infectious Diseases Sapienza University of Rome Department of Experimental Medicine Sapienza University of Rome Department of Human Anatomy Sapienza University of Rome Institute of Translational Pharmacology National Research Council

The combination of a proton pump inhibitor and two antibiotics(clarithromycin plus amoxicillin or metronidazole)has been the recommended first-line therapy since the first guidelines for Helicobacter pylori(***)infection in children were *** recent years,the success of eradication therapies has declined,in part due to the development of *** resistant *** *** treatments are currently becoming more popular than the traditional eradication *** that may be used either as a monotherapy or,in combination with antimicrobials,resulting in a more effective *** therapy have been investigated in depth by several *** of the potential therapies is probiotic cultures;promising results have been observed in initial studies with numerous probiotic ***,many questions remain *** this article,we comprehensively review the possible mechanisms of action of probiotics on *** infection,and present the results of published studies using probiotics as possible agents to control *** infection in *** effect of the addition of probiotics to the standard *** eradication therapy for the prevention of antibiotic associated side-effects is also discussed.

关键词： Helicobacter pylori Children Probiotics Eradication treatment Prevention