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Hepatitis B vaccine by intradermal route in non responder patients:An update

World Journal of Gastroenterology 2014年第30期20卷 10383-10394页

作者： Martina Filippelli Elena Lionetti alessia gennaro Angela Lanzafame Teresa Arrigo Carmelo Salpietro Mario La Rosa Salvatore Leonardi Department of Medical and Pediatric Science University of Catania95100 CataniaItaly Department of Pediatric Sciences University of Messina98100 MessinaItaly

Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% of general population. Individuals who develop an anti-HBs titer less than 10 mIU/mL after primary vaccination cycle are defined “no responders”. Many factors could cause a non response to the HBV vaccination, such as administration of the vaccine in buttocks, impaired vaccine storage conditions, drug abuse, smoking, infections and obesity. Moreover there are some diseases, like chronic kidney disease, human immunodeficiency virus infection, chronic liver disease, celiac disease, thalassaemia, type I diabetes mellitus, down’s syndrome and other forms of mental retardation that are characterized by a poorer response to HBV vaccination than healthy subjects. To date it is still unclear how to treat this group of patients at high risk of hepatitis B infection. Recent studies seem to indicate that the administration of HBV recombinant vaccine by the intradermal route is very effective and could represent a more useful strategy than intramuscular route. This review focuses on the use of anti hepatitis B vaccine by intradermal route as alternative to conventional intramuscular vaccine in all non responder patients. A comprehensive review of the literature using PubMed database, with appropriate terms, was undertaken for articles in English published since 1983. The literature search was undertaken in September 2013.

关键词： Hepatitis B virus Vaccine Intradermal route Non responders Update

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Impact characterization on thin structures using machine learning approaches

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Chinese Journal of Aeronautics 2024年第2期37卷 30-44页

作者： Flavio DIPIETRANGELO Francesco NICASSIO gennaro SCARSELLI Department of Engineering for Innovation University of SalentoLecce 73100Italy

Machine learning algorithms are trained and compared to identify and to characterise the impact on typical aerospace panels of different *** activities are conducted to build a proper impacts’*** regression algorithm and artificial neural network are applied and optimised to panels without stringer to test their capability to identify the ***,the algorithms are applied to panels reinforced with stringers that represent a significant increase of complexity in terms of dynamic features of the system to test:the focus is not only on the impact position’s detection but also on the event’s *** the identification of the best algorithm,the corresponding machine learning model is deployed on an ARM processor minicomputer,implementing an impact detection system,able to be installed on board an aerial vehicle,making it a smart aircraft equipped with an artificial intelligence decision-making system.

关键词： Artificial neural network Impact localisation Machine learning Polynomial regression Structural health monitoring

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Two rare cases of benign hyperlipasemia in children

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World Journal of Clinical Cases 2014年第1期2卷 16-19页

作者： Elena Lionetti Ruggiero Francavilla Salvatore Leonardi Stefania Tomarchio alessia gennaro Chiara Franzonello Mario La Rosa Department of Medical and Pediatric Science University of Catania 95123 Catania Italy Department of Paediatrics University of Bari 70100 Bari Italy

Gullo's syndrome is a newly identified condition characterized by a chronic elevation of pancreatic amylase and/or lipase in the absence of pancreatic disease. Until now, only one case of benign isolated hyperlipasemia in children has been recorded. We describe two children with benign and not familial increase of serum lipase. Case 1: a six year old girl presented with occasional discovery of serum lipase elevation. Medical history was silent for pancreatic hyperenzymemia. The screening for possible causes for elevated lipase(genetic, autoimmune and infectious diseases) was normal. The serum lipase increased three fold over the upper limit(193 U/L; reference range 0-60 U/L), with daily fluctuation of values. Both ultrasound scan and magnetic resonance imaging were normal. The genetic mutation associated with chronic pancreatitis was negative. We followed up this patient for two years with blood tests every six months and she did not show any signs or symptoms of pancreatic disease, except for the high level of lipase serum. Case 2: an eight year old girl complained of nausea, vomiting and severe abdominal pain in theepigastric region after eating for the last two weeks. Full blood count, electrolytes, C-reactive protein, liver and renal function were normal. Serum lipase was 96 U/L(reference range 0-60 U/L). The screening for the possible causes of pancreatic disease was negative. Endoscopy of the upper gastrointestinal tract, ultrasound, computed tomography scan and magnetic resonance imaging were normal. One year after the presentation of the symptoms, the patient became asymptomatic although the level of serum lipase continued to be high.

关键词： Amylase Lipase Pancreatic hyperenzymemia Gullo’s syndrome Benign hyperlipasemia

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Solid pseudopapillary tumor of the pancreas:A systematic review of clinical,surgical and oncological characteristics of 1384 patients underwent pancreatic surgery

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 331-338页

作者： gennaro Mazzarella Edoardo Maria Muttillo Diego Coletta Biagio Picardi Stefano Rossi Simone Rossi Del Monte Vito Gomes Irnerio Angelo Muttillo Division of General and Emergency Surgery San Filippo Neri Hospital00136 RomeItaly Department of Surgery“Pietro Valdoni” Sapienza University of RomeViale del Policlinico 15500161 RomeItaly Surgical and Medical Department of Translational Medicine Sant’Andrea HospitalSapienza University of Rome00185 RomeItaly Department of Surgical Sciences Umberto I University HospitalSapienza University of Rome00136 RomeItaly Department of General Surgery Ospedali Riuniti Marche Nord61121 PesaroItaly Department of Pathology San Filippo Neri Hospital00136 RomeItaly

Background:Pancreatic solid pseudopapillary tumors(SPTs)are rare clinical entity,with low malignancy and still unclear *** account for less than 2%of exocrine pancreatic *** study aimed to perform a systematic review of the main clinical,surgical and oncological characteristics of pancreatic *** sources:MEDLINE/PubMed,Web of Science and Scopus databases were systematically searched for the main clinical,surgical and oncological characteristics of pancreatic SPTs up to April 2021,in accordance with the preferred reporting items for systematic reviews and meta-analyses(PRISMA)*** endpoints were to analyze treatments and oncological ***:A total of 823 studies were recorded,86 studies underwent full-text reviews and 28 met inclusion ***,1384 patients underwent pancreatic *** age was 30 years and 1181 patients(85.3%)were *** most common clinical presentation was non-specific abdominal pain(52.6%of cases).Mean overall survival was 98.1%.Mean recurrence rate was 2.8%.Mean follow-up was 4.2 ***:Pancreatic SPTs are rare,and predominantly affect young women with unclear *** resection is the gold standard of treatment achieving good oncological impact and a favorable prognosis in a yearly life-long follow-up.

关键词： Frantz’s tumor Pancreas Pancreatic neoplasms Pancreatic surgery Solid pseudopapillary tumor

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Minimally invasive surgical therapies(MISTs)for lower urinary tract symptoms(LUTS):promise or panacea?

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Asian Journal of Andrology 2024年第2期26卷 135-143页

作者： Gian Maria Busetto Andrea Checchia Marco Recchia Edoardo Tocci Ugo G Falagario gennaro Annunziata Pasquale Annese Nicola d'Altilia Vito Mancini Matteo Ferro Felice Crocetto Octavian Sabin Tataru Luca Di Gianfrancesco Angelo Porreca Francesco Del Giudice Ettore De Berardinis Carlo Bettocchi Luigi Cormio Giuseppe Carrieri University of Foggia Foggia 71122Italy Department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Urology Unit "G.Tatarlla"HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IE0)IRCcSMilan 20141Italy University of Naples Federico Il Naples 80126Italy G.E.Palade University of Medicine PharmacyScienceand Technology of Targu MuresTargu Mures 540142Romania Department of Oncological Urology Veneto Institute of Oncology(IOv)IRccSPadua 35128Italy Department of Maternal-Infant and Urological Sciences Sapienza Rome UniversityRoma 00161Italy Urology Unit "L.Bonomo"HospitalAndria 76123Italy

The increasing importance of treatment of lower urinary tract symptoms(LUTS),while avoiding side effects and maintaining sexual function,has allowed for the development of minimally invasive surgical therapies(MiSTs).Recently,the European Association of Urology guidelines reported a paradigm shift from the management of benign prostatic hyperplasia(BPH)to the management of nonneurogenic male *** aim of the present review was to evaluate the efficacy and safety of the most commonly used MisTs:ablative techniques such as aquablation,prostatic artery embolization,water vapor energy,and transperineal prostate laser ablation,and nonablative techniques such as prostatic urethral lift and temporarily implanted nitinol device(iTIND).MiSTs are becoming a new promise,even if clinical trials with longer follow-up are still *** of them are still under investigation and,to date,only a few options have been given as a recommendation for *** cannot be considered as standard of care and are not suitable for all *** and disadvantages should be underlined,without forgetting our objective:treatment of LUTS and re-treatment avoidance.

关键词： aquablation iTIND prostatic artery embolization prostatic urethral lift transperineal prostate laser ablation water vapor energy

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Advancing prognostic understanding in hepatocellular carcinoma through the integration of genomic instability and lncRNA signatures: GILncSig model

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2774-2777页

作者： Marco Bocchetti Gabriella Misso Silvia Zappavigna Marianna Scrima Michele Caraglia Francesca Pentimalli alessia Maria Cossu Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Molecular and Precision Oncology Biogem ScarlInstitute of Genetic ResearchAriano Irpino 83031Italy Department of Medicine and Surgery LUM University Giuseppe De GennaroCasamassima 70010Italy

The recently published study by Duan et al introduces a promising method that combines genomic instability and long non-coding RNAs to improve the prognostic evaluation of hepatocellular carcinoma(HCC),a deadly cancer associated with considerable morbidity and *** editorial aims to analyze the methodology,key findings,and broader implications of the study within the fields of gastroenterology and oncological surgery,highlighting the shift towards precision medicine in the management of HCC.

关键词： Genomic instability Long non-coding RNA Hepatocellular carcinoma Prognosis

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Probing the Young＇s modulus and Poisson＇s ratio in graphene/metal interfaces and graphite： A comparative study

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Nano Research 2015年第6期8卷 1847-1856页

作者： Antonio Politano gennaro Chiarello Dipartimento di Fisica Universita della Calabria Rende (CS) 87036 Italy Consorzio Nazionale In teruniversitario per le Scienze Fisiche della Matefia (CNISM) Via della Vasca Navale 84 00146 Roma Italy

By analyzing phonon dispersion, we have evaluated the average Young＇s modulus and Poisson＇s ratio in graphite and in graphene grown on Ru（0001）, Pt（111）, Ir（111）, Ni（111）, and BC3/NbB2（0001）. In both flat and corrugated graphene sheets and in graphite, we find a Poisson＇s ratio of 0.19 and a Young＇s modulus of 342 N/m. The unique exception is graphene/Ni（111）, for which we find different values because of the stretching of C-C bonds occurring in the commensurate overstructure （0.36 and 310 N/m for the Poisson＇s ratio and Young＇s modulus, respectively）. Such findings are in excellent agreement with calculations performed for a free-standing graphene membrane. The high crystalline quality of graphene grown on metal substrates leads to macroscopic samples with high tensile strength and bending flexibility for use in technological applications such as electromechanical devices and carbon-fiber reinforcements.

关键词： Young's modulus Poisson's ration elastic properties graphene

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Insights from human sleep research on neural mechanisms of Alzheimer’s disease

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Neural Regeneration Research 2020年第7期15卷 1251-1252页

作者： Susanna Cordone Luigi De gennaro Department of Psychology University of Rome"Sapienza"RomeItaly IRCCS Fondazione Santa Lucia RomeItaly

Alzheimer's disease(AD)is considered as the major cause of dementia and affects about 50 million people in world population,with an expected increase of 27%in the coming decades,as reported by the most recent AD *** fast-growing empirical evidence is highlighting the close relationship between sleep and AD since the preclinical stage of the disease,pointing to an important role of sleep in the occurrence and progression of AD.

关键词： sleep Alzheimer clinical

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Hyperkalemia in Patients on Peritoneal Dialysis: Clinical Use Experience with New Potassium-Binders

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Open Journal of Nephrology 2024年第3期14卷 324-333页

作者： gennaro Argentino Mario Iorio Alessandra Antonia Mele Andrea Camocardi Enrica Emanuela Cascone Maria Elena Liberti Adelia Sagliocca Andrea Pota Luigi Russo Maria Luisa Sirico Germano Terzini Michele Cavasso Chiara Mennillo Francesca Nettuno Raffaele Genualdo Giuseppe Surfaro Lucia Di Micco UOC Nefrologia e Dialisi Ospedale del Mare Naples Italy UOC Chirurgia Generale Ospedale del Mare Naples Italy

Background: Patients with end-stage kidney disease (ESKD) on maintenance dialysis have a high risk of developing hyperkalemia. In addition to traditional approaches, a new option for the management of patients on dialysis includes the use of a potassium binder, sodium zirconium cyclosilicate (SZC). We evaluated the effect and safety of SZC in patients with chronic PD. Objective: To present a case series that illustrates the real-world use of new potassium-binders in hyperkalemic patients on peritoneal dialysis. Methods: This case series collected 9 patients on PD with baseline potassium values > 5.5 mmol/l and who were treated with SZC 5 g once a day. Data were collected at baseline and at 1, 2, and 3 months after initiation of treatment. Results: The median age of patients was 64.5 years and the median duration of observation was 90 ± 5 days. It was observed that median serum potassium decreased (5.8 mmol/l at baseline with a range of 5.8 mmol/L - 6.8 mmol/L versus 4.5 in the third month with a range of 3.6 mmol/L - 5.3 mmol/L) after SZC treatment. Adverse events were observed in 2 (22.2%). The unique adverse event was constipation and presented in 2 patients (22.2%). Constipation was mild and transient during the observation period. No adverse events of special interest were reported. Conclusion: Normokalemia was established and maintained in this series of patients treated with SZC. No episodes of hyper- or hypo-kalemia were observed. SCZ had a good safety profile and was well tolerated over 3 months.

关键词： SZC Sodium Zirconium Cyclosilicate Hyperkalaemia Peritoneal Dialysis

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巧用入侵物种拯救生态

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环球科学 2024年第13期 16-17页

作者：真纳罗·托马蔡雨辛(翻译) 不详

20世纪30年代,为控制当地一些有害的甲虫,澳大利亚引入了原产于南美的海蟾蜍(Rhinella marina)。自此,海蟾蜍严重破坏了澳大利亚的生态系统,并且这种破坏一直持续至今。这些入侵的两栖动物的皮肤会分泌毒素,因此宠物和其他捕食者吃了海... 详细信息

20世纪30年代,为控制当地一些有害的甲虫,澳大利亚引入了原产于南美的海蟾蜍(Rhinella marina)。自此,海蟾蜍严重破坏了澳大利亚的生态系统,并且这种破坏一直持续至今。这些入侵的两栖动物的皮肤会分泌毒素,因此宠物和其他捕食者吃了海蟾蜍后会被杀死。其中潘氏巨蜥(Varanus panoptes,一种主要分布于澳大利亚的大型蜥蜴)受到的影响尤为严重:在海蟾蜍入侵的大部分地区,潘氏巨蜥的数量下降了90%以上,进而对整个生态系统造成了影响。

关键词：生态系统蟾蜍入侵物种澳大利亚宠物捕食者两栖动物巨蜥

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