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An alternative,zeaxanthin epoxidase-independent abscisic acid biosynthetic pathway in plants

Molecular Plant 2022年第1期15卷 151-166页

作者： Kun-Peng Jia Jianing Mi Shawkat Ali Hajime Ohyanagi Juan C.Moreno Abdugaffor Ablazov Aparna Balakrishna Lamis Berqdar alessia fiore Gianfranco Diretto Claudio Martínez Angel R.de Lera Takashi Gojobori Salim Al-Babili Biological and Environmental Sciences and Engineering Division Center for Desert AgricultureThe BioActives LabKing Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia State Key Laboratory of Cotton Biology Henan Joint International Laboratory for Crop Multi-Omics ResearchSchool of Life SciencesHenan UniversityJinming RoadKaifeng 475004China Biological and Environmental Sciences and Engineering Division Computational Bioscience Research CenterKing Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia Italian National Agency for New Technologies Energy and Sustainable Economic Development00123 RomeItaly Universidade de Vigo Facultade de Química and CINBIO36310 VigoSpain Agriculture and Agri-Food Canada Kentville Research and Development Center32 Main StreetKentvilleNS B4N1J5Canada

Abscisic acid(ABA)is an important carotenoid-derived phytohormone that plays essential roles in plant response to biotic and abiotic stresses as well as in various physiological and developmental *** Arabidopsis,ABA biosynthesis starts with the epoxidation of zeaxanthin by the ABA DEFICIENT 1(ABA1)enzyme,leading to epoxycarotenoids;e.g.,*** oxidative cleavage of 9-cis-epoxycaro-tenoids,a key regulatory step catalyzed by 9-C/S-EPOXYCAROTENOID DIOXYGENASE,forms xanthoxin,which is converted in further *** mediated by ABA DEFICIENT 2(ABA2),ABA DEFICIENT 3(ABA3),and ABSCISIC ALDEHYDE OXIDASE 3(AAO3)into *** combining genetic and biochemical approaches,we unravel here an ABA1-independent ABA biosynthetic pathway starting upstream of *** iden-tified the carotenoid cleavage products(i.e.,apocarotenoids,β-apo-11-carotenal,9-cis-β-apo-11-carotenal,3-OH-β-apo-11-carotenal,and 9-cis-3-OH-β-apo-11-carotenal)as intermediates of this ABA1-independent ABA biosynthetic *** labeled compounds,we showed thatβ-apo-11-carotenal,9-cis-β-apo-11-carotenal,and 3-OH-β-apo-11-carotenal are successively converted into 9-cis-3-OH-β-apo-11-carotenal,xanthoxin,and finally into ABA in both Arabidopsis and *** applied to Arabidopsis,theseβ-apo-11-carotenoids exert ABA biological functions,such as maintaining seed dormancy and inducing the expression of ABA-responsive ***,the transcdptomic analysis revealed a high overlap of differentially expressed genes regulated byβ-apo-11-carotenoids and ABA,suggesting thatβ-apo-11-carot-enoids exert ABA-independent regulatory *** together,our study identifies a biological function for the common plant metabolites,β-apo-11-carotenoids,extends our knowledge about ABA biosynthesis,and provides new insights into plant apocarotenoid metabolic networks.

关键词： seed germination apocarotenoids ABA ABA biosynthesis ABA1 carotenoids ultra-high-performance liquid chromatography-mass spectrometry Arabidopsis thaliana

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Climate change and human health: Last call to arms for us

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World Journal of Clinical Cases 2024年第11期12卷 1870-1874页

作者： Antonio Corrente Maria Caterina Pace Marco fiore Department of Anaesthesiology and Intensive Care Medicine The Anastasia Guerriero HospitalMarcianise 81025CasertaItaly Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy

Climate change,now the foremost global health hazard,poses multifaceted challenges to human *** editorial elucidates the extensive impact of climate change on health,emphasising the increasing burden of diseases and the exacerbation of health *** highlights the critical role of the healthcare sector,particularly anaesthesia,in both contributing to and mitigating climate *** is a call to action for the medical community to recognise and respond to the health challenges posed by climate change.

关键词： Climate change Carbon footprint Sustainability Greenhouse gases Anaesthetic gases Environmental impact Disposable laryngoscope blades

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Correction to:Preface:Special Issue on Modeling,Simulation,and Optimization in Operational Research

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Journal of the Operations Research Society of China 2024年第2期12卷 548-548页

作者： Gerhard-Wilhelm Weber J.Joshua Thomas Jose Antonio Marmolejo Saucedo Ugo fiore Igor Litvinchev Pandian Vasant Poznan University of Technology PoznanPoland Institute of Applied Mathematics Middle East Technical UniversityAnkaraTurkey UOW Malaysia KDU Penang University CollegePetaling JayaMalaysia Facultad de Ingenieria Universidad PanamericanaMexico CityMexico Parthenope University and at Federico II University NaplesItaly Nuevo Leon State University San Nicolas de los GarzaMexico MERLIN Research Centre Ton Duc Thang UniversityHo Chi Minh CityVietnam

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Antibiotic treatment in cirrhotic patients

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World Journal of Clinical Cases 2023年第35期11卷 8242-8246页

作者： Marco fiore Sebastiano Leone Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Division of Infectious Diseases San Giuseppe Moscati HospitalAvellino 83100Italy

In this editorial,we comment on the article by Liakina V:“Antibiotic resistance in patients with liver cirrhosis:Prevalence and current approach to tackle”(World J Clin Cases 2023,11:7530-7542).In this excellent review,Liakina presents current data on bacterial complications in patients with *** infections are the most common complication in patients with liver *** focus specifically on spontaneous bacterial peritonitis(SBP)which is the most repres-entative infectious *** V suggested starting empirically,in all patients with suspected SBP,third-generation cephalosporins when the number of polymorphonuclear leukocytes(PMNs)in ascites is greater than 250/mm^(3).This statement creates some doubts in our clinical practice so we discuss on the unsolved pitfalls of diagnosis and treatment that are often encountered in patients with ascitic fluid infections,especially on bacterascites that is defined as ascitic bacterial growth with PMNs below 250/mm^(3).The severity of liver disease and overall prognosis are highly comparable for patients with bacterascites and SBP in some recent well-conducted ***,we present a brief analysis of the prevalence of antibiotic-resistant isolates with an introduction of currently approved antibiotic drug options to treat ascitic fluid infections avoiding antibiotic *** light of the most recent epidemiological data,third-generation cephalosporins should not be considered as an empirical antibiotic treatment of choice for ascitic fluid infections.

关键词： Spontaneous bacterial peritonitis Bacterascites Multidrug resistance Cirrhosis End-stage liver disease

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To metabolomics and beyond:a technological portfolio to investigate cancer metabolism

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1721-1742页

作者： Federica Danzi Raffaella Pacchiana Andrea Mafficini Maria TScupoli Aldo Scarpa Massimo Donadelli Alessandra fiore Department of Neurosciences Biomedicine and Movement SciencesSection of BiochemistryUniversity of VeronaVeronaItaly Department of Diagnostics and Public Health University of VeronaVeronaItaly Department of Neurosciences Biomedicine and Movement SciencesBiology and Genetics SectionUniversity of VeronaVeronaItaly ARC-NET Research Centre University and Hospital Trust of VeronaVeronaItaly

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support tumour initiation, progression,metastasis and resistance to therapies. These reprogrammed activities include a complete rewiring of the bioenergetic, biosyntheticand redox status to sustain the increased energetic demand of the cells. Over the last decades, the cancer metabolism field hasseen an explosion of new biochemical technologies giving more tools than ever before to navigate this complexity. Within a cell ora tissue, the metabolites constitute the direct signature of the molecular phenotype and thus their profiling has concrete clinicalapplications in oncology. Metabolomics and fluxomics, are key technological approaches that mainly revolutionized the fieldenabling researchers to have both a qualitative and mechanistic model of the biochemical activities in cancer. Furthermore, theupgrade from bulk to single-cell analysis technologies provided unprecedented opportunity to investigate cancer biology at cellularresolution allowing an in depth quantitative analysis of complex and heterogenous diseases. More recently, the advent offunctional genomic screening allowed the identification of molecular pathways, cellular processes, biomarkers and noveltherapeutic targets that in concert with other technologies allow patient stratification and identification of new treatmentregimens. This review is intended to be a guide for researchers to cancer metabolism, highlighting current and emergingtechnologies, emphasizing advantages, disadvantages and applications with the potential of leading the development ofinnovative anti-cancer therapies.

关键词： metabolism qualitative beyond

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KLOE results on light mesons

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Chinese Physics C 2010年第9期34卷 1379-1382页

作者： S.fiore Dipartimento di Fisica Sapienza Universitàdi Roma

The KLOE collaboration has recently published new results concerning scalar and pseudoscalar *** the φ → a 0 （980）γ → ηπ 0 γ decay analysis and the search for the φ → K 0 K 0 γ decay are discussed,together with the η → π ＋ π-e ＋ edecay measurements annd the new results for the pseudoscalar mixing angle and gluonium content of the η’ meson.

关键词： KLOE light mesons

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Medicinal cannabis products for the treatment of acute pain

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World Journal of Clinical Cases 2023年第12期11卷 2670-2676页

作者： Marco fiore Aniello Alfieri Sveva Di Franco Stephen Petrou Giovanni Damiani Maria Caterina Pace Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Emergency Medicine University of California San FranciscoSan FranciscoCA 94143United States Department of Biomedical Surgicaland Dental SciencesUniversity of MilanMilan 20122Italy

For thousands of years,medicinal cannabis has been used for pain treatment,but its use for pain management is still ***-analysis of the literature has shown contrasting results on the addition of cannabinoids to opioids compared with placebo/other active agents to reduce *** studies are mainly focused on medicinal cannabis use in chronic pain management,for which the analgesic effect has been proven in many *** review focuses on the potential use of medical cannabis for acute pain management in preclinical studies,studies on healthy subjects and the few pioneering studies in the clinical setting.

关键词： Cannabis Cannabinoids Endocannabinoid system 2-arachidonoylglycerol Anandamide Analgesia Acute pain

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Outcomes assessment of hepatitis C virus-positive psoriatic patients treated using pegylated interferon in combination with ribavirin compared to new Direct-Acting Antiviral agents

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World Journal of Hepatology 2018年第2期10卷 329-336页

作者： Giovanni Damiani Chiara Franchi Paolo Pigatto Andrea Altomare alessia Pacifico Stephen Petrou Sebastiano Leone Maria Caterina Pace Marco fiore Study Center of Young Dermatologists Italian Network (YDIN) Gised Bergamo Italy and Clinical Dermatology IRCCS Galeazzi Orthopaedic Institute Department of Biomedical Surgical and Dental Sciences University of Milan Clinical Dermatology IRCCS Galeazzi Orthopaedic Institute San Gallicano Dermatological Institute IRCCS Department of Emergency Medicine St. George’s University Medical School Division of Infectious Diseases "San Giuseppe Moscati" Hospital Department of Anesthe-siological Surgical and Emergency Sciences University of Campania "Luigi Vanvitelli"

AIM To evaluate the outcomes in biological treatment and quality of life of psoriatic patients with chronic hepatitis C(CHC) treated with new Direct-Acting Antiviral agents(DAAs) compared to pegylated interferon-2α plus ribavirin(P/R) *** This is a retrospective study involving psoriatic patients in biological therapy who underwent anti-hepatitis C virus(HCV) treatment at the Department of Dermatology Galeazzi Orthopaedic Institute Milan, Italy from January 2010 to November 2017. The patients were divided into two groups: patients that underwent therapy with DAAs and patients that underwent HCV treatment with P/R. Patients were assessed by a dermatologist for psoriasis symptoms, collecting Psoriasis Area Severity Index(PASI) scores and the Dermatology Quality of Life Index(DLQI). PASI and DLQI scores were evaluated 24 wk after the end of HCV treatment and were assumed as an outcome of the progression of psoriasis. Switching to a different b DMARD was considered as an inadequate response to biological therapy. The dropout of HCV therapy and sustained virological response(SVR) were considered as outcomes of HCV *** Fifty-nine psoriatic patients in biological therapy underwent antiviral therapy for CHC. Of this, 27 patients were treated with DAAs and 32 with P/R. After 24 wk post treatment, the DLQI and the PASI scores were significantly lower(P < 0.001 and P < 0.005, respectively) in the DAAs group compared with P/R group. None of the patients in the DAAs group(0/27) compared to 8 patients of the P/R group(8/32) needed a shift in biological *** DAAs seem to be more effective and safe than P/R in HCV-positive psoriatic patients on biological treatment. Fewer dermatological adverse events may be due to interferon-free therapy.

关键词： Hepatitis C virus New Direct-Acting Antiviral agents Psoriasis Biological disease modifying drugs

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Burden of severe infections due to carbapenem-resistant pathogens in intensive care unit

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World Journal of Clinical Cases 2023年第13期11卷 2874-2889页

作者： Maria Caterina Pace Antonio Corrente Maria Beatrice Passavanti Pasquale Sansone Stephen Petrou Sebastiano Leone Marco fiore Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy Department of Emergency Medicine University of California San FranciscoSan FranciscoCA 94143United States Division of Infectious Diseases “San Giuseppe Moscati”HospitalAvellino 83100Italy

Intensive care units(ICU)for various reasons,including the increasing age of admitted patients,comorbidities,and increasingly complex surgical procedures(e.g.,transplants),have become"the epicenter"of nosocomial infections,these are characterized by the presence of multidrug-resistant organisms(MDROs)as the cause of ***,the perfect match of fragile patients and MDROs,as the cause of infection,makes ICU mortality very ***,carbapenems were considered for years as last-resort antibiotics for the treatment of infections caused by MDROs;unfortunately,nowadays carbapenem resistance,mainly among Gram-negative pathogens,is a matter of the highest concern for worldwide public *** comprehensive review aims to outline the problem from the intensivist's perspective,focusing on the new definition and epidemiology of the most common carbapenem-resistant MDROs(Acinetobacter baumannii,Pseudomonas aeruginosa and Enterobacterales)to emphasize the importance of the problem that must be permeating clinicians dealing with these diseases.

关键词： Antimicrobial resistance Multidrug-resistant PDR Carbapenem-resistance Multidisciplinary critical care Intensive care unit

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Gut microbiota and nutrient interactions with skin in psoriasis:A comprehensive review of animal and human studies

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World Journal of Clinical Cases 2020年第6期8卷 1002-1012页

作者： Giovanni Damiani Nicola Luigi Bragazzi Thomas S McCormick Paolo Daniele Maria Pigatto Sebastiano Leone alessia Pacifico Danica Tiodorovic Sveva Di Franco Aniello Alfieri Marco fiore Department of Dermatology Case Western Reserve UniversityClevelandOH 44106United States Clinical Dermatology IRCCS Istituto Ortopedico GaleazziMilan 20122Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20122Italy Postgraduate School of Public Health Department of Health SciencesUniversity of GenoaGenoa 16132Italy Department of Medicine Division of Infectious diseases“San Giuseppe Moscati”HospitalAvellino 83100Italy San Gallicano Dermatological Institute IRCCSRome 00144Italy Dermatology Clinic Medical FacultyNis UniversityNis 18000Serbia Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy

The intestinal tract(i.e.,the gut),is where the body’s nutrients are absorbed,and is simultaneously inhabited by numerous *** increasing body of literature suggests a crucial role for the gut microbiome in modulating systemic inflammatory *** is a chronic systemic inflammatory disease and its pathogenesis is related to the interaction between genetic susceptibility,immune response and environmental *** omics era has allowed physicians to assess different aspects of psoriasis pathogenesis such as the microbiome,infectome,and ***,diet appears to play an important role in modulating disease activity,perhaps by influencing gut *** these observations,we aimed to summarize the current knowledge regarding skin-microbiome-gut-nutrients and psoriasis.

关键词： Gut Microbiota Nutrients Endotypes Exposome Psoriasis

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