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Are liver nested stromal epithelial tumors always low aggressive?

World Journal of Gastroenterology 2017年第46期23卷 8248-8255页

作者： Tania Meletani Luca Cantini Andrea Lanese Daniele Nicolini alessia cimadamore Andrea Agostini Giulia Ricci Stefania Antognoli Alessandra Mandolesi Maria Guido Rita Alaggio Gian Marco Giuseppetti Marina Scarpelli Marco Vivarelli Rossana Berardi Medical Oncology University Hospital and Polytechnic University Ancona Hepatobiliary and Trans-plantation Surgery Department of Clinical and Experimental MedicineUniversity Hospital and Polytechnic University Ancona Section of Pathological Anatomy Department of Biomedical Sciences and Public HealthUniversity Hospital and Polytechnic University Ancona Department of Radiology University Hospital and Polytechnic University Ancona Pathology Department Padova University

Nested stromal-epithelial tumor(NSET) is a nonhepatocytic and non-biliary tumor of the liver consisting of nests of epithelial and spindled cells with associated myofibroblastic stroma and variable intra-lesional calcification and ossification, which represents a very rare and challenging disease. Most of the reported cases have been treated with surgery, obtaining a long survival outcome. Here, we report the case of a 31-year-old Caucasian man who underwent surgery at our institution for a large, lobulated, multinodular mass of the right hemi-liver. The histological exam confirmed the diagnosis of NSET. After 6 mo from surgery, a liver recurrence was described and a chemoembolization was performed. After a further disease progression, based on the correlation between the histological features of the disease and those of the hepatoblastoma, a similar chemotherapy regimen(with cisplatin and ifosfamide/mesna chemotherapy, omitting doxorubicin due to liver impairment) was administered. However, infection of the biliary catheter required a dose modification of the treatment. No benefit was noted and a progression of disease was radiologically assessed after only four cycles. The worsening of the clinical status prevented further treatments, and the patient died a few months later. This case report documents how the NSET might have an aggressive and non-preventable behavior. No chemotherapy schedules with a proved efficacy are available, and new data are needed to shed light on this rare neoplasm.

关键词： Nested stromal epithelial tumor Liver Rare Chemotherapy Aggressive Metastatic

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Syndrome of inappropriate antidiuresis in prostate adenocarcinoma with neuroendocrine differentiation: a case report and literature review

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Journal of Cancer Metastasis and Treatment 2019年第7期4卷 69-76页

作者： Ilaria Fiordoliva Giulia Marcantognini Silvia Rinaldi alessia cimadamore Rodolfo Montironi Rossana Berardi Medical Oncology UniversitàPolitecnica delle MarcheOspedali Riuniti Umberto I-GM Lancisi-G SalesiVia Conca 71Ancona 60126Italy Section of Pathological Anatomy UniversitàPolitecnica delle MarcheSchool of MedicineOspedali Riuniti Umberto I-GM Lancisi-G SalesiVia Conca 71Ancona 60126Italy

Syndrome of inappropriate antidiuresis (SIAD) is a common paraneoplastic syndrome commonly associated with thoracic malignancies, gastrointestinal cancers and kidney tumors. It is defined as hyponatremia in euvolemic patients, often due to abnormal secretion of antidiuretic hormone by tumor cells. Tolvaptan, a vasopressin-2-receptor antagonist, is currently recommended for patients affected by SIAD with mild or moderate symptoms. Among patients with prostatic cancer, SIAD represents a rare condition but it is frequently associated with poorly differentiated adenocarcinoma or pure small-cell carcinoma histotype. We report a case of SIAD appeared at disease progression in a 60-year-old male patient with acinar adenocarcinoma with neuroendocrine differentiation together with a literature review.

关键词： Hyponatremia prostate cancer syndrome of inappropriate antidiuresis neuroendocrine differentiation

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