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Ileal loop interposition:an alternative biliary bypass technique

Hepatobiliary & Pancreatic Diseases International 2010年第6期9卷 654-657页

作者： Felipe JF Coimbra alessandro l diniz Heber SC Ribeiro Wilson l Costa Jr. Eduardo NP lima Andrél Montagnini Abdominal Surgery Department Hospital do Cncer A.C.CamargoRua Professor Antnio Prudente 211LiberdadeSo PauloSP 01509-010Brazil Nuclear Medicine Imaging Department Hospital do Cncer A.C.CamargoRua Professor Antnio Prudente 211LiberdadeSo PauloSP 01509-010Brazil

BACKGROUND:Obstructive jaundice is a common condition in advanced digestive *** procedures can improve quality of life and allow patients to attempt a systemic *** anastomosis is still the procedure of choice for patients in many *** a surgical bypass is not possible,biliary drainage can be done by placing endoscopic or transparietal stents,which are less durable methods even when an expandable stent is employed. METHODS:A 47-year-old male with an excellent clinical status and a previous cholecystectomy and an exploratory laparotomy for advanced gastric cancer was referred with obstructive jaundice.A preoperative CT scan showed a dilated bile duct and a small mass at the distal hepatic *** other signs of metastasis were found.A surgical bilioenteric anastomosis was *** surgery,a distal choledochal obstruction and a mesenteric retraction by a lymph node mass prevented the jejunum to ascend for a bilioenteric anastomosis. Surgically,an alternative bilioenteric bypass was performed by means of an ileal loop interposition between the bile duct and the jejunum. RESUlT:The recovery of the patient was uneventful and his bilirubin levels normalized after one *** patient was then referred for systemic chemotherapy. CONClUSIONS:This alternative biliary bypass can be safely and easily performed,and may be a good alternative for patients already referred for surgery because of a better life expectancy and when the jejunum is not an alternative.

关键词： biliary bypass ileal loop interposition biliary cancer

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A comprehensive review on the processing-property relationships of laser strengthened magnesium

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Journal of Magnesium and Alloys 2024年第1期12卷 1-34页

作者： alessandro M.Ralls Aaksheta Agnel Pradeep l.Menezes Department of Mechanical Engineering University of Nevada RenoRenoNV 89557United States

Among the existing series of softer metals,magnesium(Mg)has attracted much attention due to its impressive strength-to-weight ***,due to its ease of deformability,Mg tends to suffer from rapid degradation in a wide variety of abrasive and electrochemical *** method of improving its surface properties is through surface modification *** the existing techniques,laser shock peening(lSP)has been one of the most widely utilized processes due to its surface-hardening-like *** this understanding,a comprehensive review has yet to exist that encapsulates the strengthening mechanism of lSP for Mg and its influence in degradation *** review aims to encapsulate the existing research around the lSP field for ***,an understanding of the surface-strengthening effects in relation to its mechanical,tribological,corrosion,and tribo-corrosion characteristics is ***,the feasibility of lSP for Mg materials in critical industries is also *** this work,a novel understanding of lSP for Mg can be understood,which can provide a future direction for research in this field.

关键词： laser shock peening Magnesium Surface deformation Tribology Microstructure

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Spark Plasma Sintering of Mg-based Alloys:Microstructure,Mechanical Properties,Corrosion Behavior,and Tribological Performance

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Journal of Magnesium and Alloys 2024年第2期12卷 405-442页

作者： alessandro M.Ralls Mohammadreza Daroonparvar Pradeep l.Menezes Department of Mechanical Engineering University of Nevada RenoRenoNV89557United States

Within the past ten years,spark plasma sintering(SPS)has become an increasingly popular process for Mg *** the SPS process,interparticle diffusion of compressed particles is rapidly achieved due to the concept of Joule *** to traditional and additive manufacturing(AM)techniques,SPS gives unique control of the structural and microstructural features of Mg *** doing so,their mechanical,tribological,and corrosion properties can be *** great advancements in this field have been made,these pieces of knowledge are scattered and have not been contextualized into a single *** motivation of this work is to address this scientific gap and to provide a groundwork for understanding the basics of SPS manufacturing for *** do so,the existing body of SPS Mg literature was first surveyed,with a focus on their structural formation and degradation *** was found that successful Mg SPS fabrication highly depended on the processing temperature,particle size,and particle *** addition of metal and ceramic composites also affected their microstructural features due to the Zener pinning *** degradative environments,their performance depends on their structural features and whether they have secondary phased *** industrial applications,SPS'd Mg was found to have great potential in biomedical,hydrogen storage,battery,automotive,and recycling *** prospects to advance the field include using Mg as a doping agent for crystallite size refinement and using bulk metallic Mg-based glass powders for amorphous SPS *** these findings,the interactions of multi-composites on the processing-structure-property relationships of SPS Mg is not well *** total,this work will provide a useful direction in the SPS field and serve as a milestone for future Mg-based SPS manufacturing.

关键词： Spark plasma sintering Magnesium alloys Nanocrystalline Tribology Mechanical properties Corrosion

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Exploring unconventional attributes of red blood cells and their potential applications in biomedicine

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Protein & Cell 2024年第5期15卷 315-330页

作者： Alkmini T.Anastasiadi Vasiliki-Zoi Arvaniti Krystalyn E.Hudson Anastasios G.Kriebardis Constantinos Stathopoulos Angelo D’alessandro Steven l.Spitalnik Vassilis l.Tzounakas Department of Biochemistry School of MedicineUniversity of Patras26504 PatrasGreece Department of Pathology and Cell Biology Columbia University Irving Medical CenterNew York CityNY 10032USA laboratory of Reliability and Quality Control in laboratory Hematology(HemQcR) Department of Biomedical SciencesSchool of Health&Caring SciencesUniversity of West Attica(UniWA)12243 EgaleoGreece Department of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus13001 AuroraCOUSA Present address:Institute for Fundamental Biomedical Research(IFBR) Biomedical Sciences Research Center“Alexander Fleming”Vari11527 AthensGreece

We need to talk about red blood *** cells are defined as cells containing distinct nuclei and other membranous ***,red blood cells(RBCs)lack a nucleus and organelles—perhaps to limit the generation of reactive oxygen species(Zhang et al.,2011)—and are filled with hemoglobin(Hb).This oxygen carrier is limited to the cytosol by the cell membrane and cytoskeleton,which maintain cellular integrity and deformability as RBCs pass through narrow capillaries(Gratzer,1994)to perform their primary function of gas exchange.

关键词： membranous maintain

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Characterization of the molecular dysfunctions occurring in Aicardi-Goutieres syndrome patients with mutations in ADAR1

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Genes & Diseases 2024年第3期11卷 116-119页

作者： Sofan Al wardat loredana Frasinlli Elisa Orecchini Federica Rey Silvia Anna Ciafre Silvia Galardi Jessica Garau Stella Gagliardi Simona Orcesi Davide Tonduti Stephana Carelli Cristina Cereda Ernesto Picardi alessandro Michienzi Department of Biomedicine and Prevention University of Rome Tor VergataRome 00133Italy Pediatric Clinical Research Center"Romeo ed Enrica Invernizzi" Department of Biomedical and Clinical SciencesUniversity of MilanoMilano 20157Italy Center of Functional Genomics and Rare Diseases Department of PediatricsBuzzi Children's HospitalMilano20154Italy Department of Child Neurology and Psychiatry IRccs Mondino FoundationPavia 27100Italy Unit of Pediatric Neurology C.O.A.L.A(Center for Diagnosis and Treatment of Leukodystrophies)Buzzi Children's HospitalMilano 20154Italy Department of Biosciences Biotechnologies and EnvironmentUniversityof Bari"AldoMoro"Bari 70125Italy Institute of Biomembranes Bioenergetics and Molecular Biotechnologies(IBIOM)National Research Council(CNR)Bari 70126Italy Biostructures and Biosystems National Institute(INBB) Rome00136Italy Institute of Biochemistry and Cell Biology IBBC-CNRCampus Adriano Buzzati TraversoRome 00015Italy

Aicardi-Goutieres syndrome(AGS)is a systemic inflammatory disorder caused by mutations in any one of the nine different genes,whose deficiency provokes a type I(interferon)IFN response probably central to pathogenesis.^(1) ADAR1,one of the genes mutated in AGS(AGS6),encodes for an enzyme that belongs to the ADAR family(ADAR1,ADAR2,and ADAR3)that catalyzes the conversion of adenosine to inosine within double-stranded RNAs(dsRNAs)(RNA editing A-to-1).

关键词： ADAR1 interferon res

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Assessment of earthquake location uncertainties for the design of local seismic networks

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Earthquake Science 2024年第5期37卷 415-433页

作者： Antonio Fuggi Simone Re Giorgio Tango Sergio Del Gaudio alessandro Brovelli Giorgio Cassiani Isamgeo Italia S.r.l. Gallarate 21013Italy STOGIT S.p.A. UnitàGiacimentiCrema 26013Italy Dipartimento di Geoscienze Universitàdegli Studi di PadovaPadova 35131Italy

The ability to estimate earthquake source locations,along with the appraisal of relevant uncertainties,is paramount in monitoring both natural and human-induced *** this purpose,a monitoring network must be designed to minimize the location errors introduced by geometrically unbalanced *** this study,we first review different sources of errors relevant to the localization of seismic events,how they propagate through localization algorithms,and their impact on *** then propose a quantitative method,based on a Monte Carlo approach,to estimate the uncertainty in earthquake locations that is suited to the design,optimization,and assessment of the performance of a local seismic monitoring *** illustrate the performance of the proposed approach,we analyzed the distribution of the localization uncertainties and their related dispersion for a highly dense grid of theoretical hypocenters in both the horizontal and vertical directions using an actual monitoring network *** results expand,quantitatively,the qualitative indications derived from purely geometrical parameters(azimuthal gap(AG))and classical detectability *** proposed method enables the systematic design,optimization,and evaluation of local seismic monitoring networks,enhancing monitoring accuracy in areas proximal to hydrocarbon production,geothermal fields,underground natural gas storage,and other subsurface *** approach aids in the accurate estimation of earthquake source locations and their associated uncertainties,which are crucial for assessing and mitigating seismic risks,thereby enabling the implementation of proactive measures to minimize potential *** an operational perspective,reliably estimating location accuracy is crucial for evaluating the position of seismogenic sources and assessing possible links between well activities and the onset of seismicity.

关键词： network design earthquake localization detectability localization uncertainties local seismic network

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Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTl3

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Cancer Communications 2024年第2期44卷 282-286页

作者： Bianca Cesaro Alessia Iaiza Fabio Piscopo Marco Tarullo Eleonora Cesari Dante Rotili Antonello Mai Alberto Diana Michela londero luca Del Giacco Riccardo Masetti Alba Di leone Chiara Naro Silvia Masciarelli Giulia Fontemaggi Claudio Sette Francesco Fazi alessandro Fatica Department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly Department of Biology and Biotechnologies“Charles Darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core Facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly Department of Drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly Department of BioSciences University of MilanMilanItaly Multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly Department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(METTl3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

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Frequency stabilization of C-band semiconductor lasers through a SiN photonic integrated circuit

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Photonics Research 2024年第8期12卷 1619-1626页

作者： A1lESSANDRO BRUGNONI AlI EMRE KAPlAN VAlERIO VITAlI KYlE BOTTRIll MICHElE RE PERIKlIS PETROPOUlOS COSIMO lACAVA IlARIA C1RISTIANI Photonics Group Department of Electrical Computer and Biomedical Engineering University of Pavia Optoelectronics Research Centre University of Southampton Huawei Technologies Italia S.r.l Centro direzionale Milano

Integrated semiconductor lasers represent essential building blocks for integrated optical components and circuits and their stability in frequency is fundamental for the development of numerous frontier applications and engineering tasks. When dense optical circuits are considered, the stability of integrated laser sources can be impaired by the thermal cross-talk generated by the action of neighboring components, leading to a deterioration of the long-term system performance (on the scale of seconds). In this work we show the design and the experimental characterization of a silicon nitride photonic integrated circuit (PIC) that is able to frequency stabilize 16semiconductor lasers, simultaneously. A stabilized 50 GHz-spaced two-channel system is demonstrated through the detection of the related beating note and the stability of the resulting waveform is characterized via the use of artificially induced thermal cross-talk stimuli.

关键词： Fiber optic couplers laser sources Optical circuits Ring resonators Semiconductor lasers Silicon nitride

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Structure-activity relationship in Pd/CeO2 methane oxidation catalysts

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Chinese Journal of Catalysis 2020年第6期41卷 938-950页

作者： Sara Colussi Paolo Fornasiero alessandro Trovarelli Dipartimento Politecnico Universitàdi UdineUnitàdi Ricerca INSTM Udinevia del Cotonificio 10833100 UdineItaly Dipartimento di Scienze Chimiche e Farmaceutiche Unitàdi Ricerca di Trieste ICCOM-CNRINSTM TriesteUniversitàdi Triestevia L.Giorgieri134127 TriesteItaly

Palladium based catalysts are the most active for methane oxidation. The tuning of their composition, structure and morphology at macro and nanoscale can alter significantly their catalytic behavior and robustness with a strong impact on their overall performances. Among the several combinations of supports and promoters that have been utilized, Pd/CeO2 has attracted a great attention due to its activity and durability coupled with the unusually high degree of interaction between Pd/Pd O and the support. This allows the creation of specific structural arrangements which profoundly impact on methane activation characteristics. Here we want to review the latest findings in this area, and particularly to envisage how the control(when possible) of Pd-CeO2 interaction at nanoscale can help in designing more robust methane oxidation catalysts.

关键词： Palladium Ceria Methane catalytic oxidation Pd-ceria interaction Nanostructure

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The first comprehensive Milky Way stellar mock catalogue for the Chinese Space Station Telescope Survey Camera

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中国科学:物理学、力学、天文学英文版 2023年第11期66卷 206-220页

作者： Yang Chen Xiaoting Fu Chao liu Piero Dal Tio léo Girardi Giada Pastorelli alessandro Mazzi Michele Trabucchi Hao Tian Dongwei Fan Paola Marigo alessandro Bressan School of Physics and Optoelectronic Engineering Anhui UniversityHefei230601China National Astronomical Observatories Chinese Academy of SciencesBeijing100101China Purple Mountain Observatory Chinese Academy of SciencesNanjing210023China Dipartimento di Fisica e Astronomia Galileo Galilei Universitàdi PadovaPadovaI-35122Italy INAF-Osservatorio Astronomico di Padova PadovaI-35122Italy National Astronomical Data Center Beijing100101China SISSA via Bonomea 365TriesteI-34136Italy

The Chinese Space Station Telescope(CSST)is a cutting-edge two-meter astronomical space telescope currently under *** primary Survey Camera(SC)is designed to conduct large-area imaging sky surveys using a sophisticated seven-band photometric *** resulting data will provide unprecedented data for studying the structure and stellar populations of the Milky *** support the CSST development and scientific projects related to its survey data,we generate the first comprehensive Milky Way stellar mock catalogue for the CSST SC photometric system using the TRIlEGAl stellar population synthesis *** catalogue includes approximately 12.6 billion stars,covering a wide range of stellar parameters,photometry,astrometry,and kinematics,with magnitude reaching down to g=27.5 mag in the AB magnitude *** catalogue represents our benchmark understanding of the stellar populations in the Milky Way,enabling a direct comparison with the future CSST survey ***,it sheds light on faint stars hidden from current sky *** crowding limit analysis based on this catalogue provides compelling evidence for the extension of the CSST Optical Survey(OS)to cover low Galactic latitude *** strategic extension of the CSST-OS coverage,combined with this comprehensive mock catalogue,will enable transformative science with the CSST.

关键词： The Chinese Space Station Telescope(CSST) stellar content and populations Milky Way sky surveys

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