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Non-anatomical liver resection for hepatocellular carcinoma:the SegSubTe classification to overcome the problem of heterogeneity

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 265-271页

作者： Mattia Garancini alessandro Fogliati Mauro alessandro Scotti Cristina Ciulli Francesca Carissimi Antonio Rovere luca Gianotti Fabrizio Romano Unit of Hepatobiliopancreatic Surgery Department of SurgeryASST-MonzaSan Gerardo HospitalUniversity of Milano-Bicoccavia Pergolesi 33MonzaMB 20052Italy Interventional Radiology Department of RadiologyASST-MonzaSan Gerardo HospitalMilano-Bicocca Universityvia Pergolesi 33MonzaMB 20052Italy

Background:The superiority of anatomical resection(AR)***-anatomical resection(NAR)in the surgical management of hepatocellular carcinoma(HCC)is *** are well-defined procedures,whereas the lack of NAR standardization results in heterogeneous *** study aimed to introduce the SegSubTe classification for NAR detailing the appropriateness of the level of surgical section of the Glissonean pedicles feeding the ***:A single-center retrospective analysis of pre-and postoperative imaging of consecutive patients treated with NAR for single HCC between 2012 and 2020 was *** quality of surgery was assessed classifying the type of vascular supply and the level of surgical section(segmental,subsegmental or terminal next to the tumor)of vascular pedicles feeding the HCCs;then,the population was divided in“SegSubTe-IN”or“SegSubTe-OUT”groups,and the tumor recurrence and survival were ***:Ninety-seven patients who underwent NAR were included;76%were SegSubTe-IN and 24%were *** disease recurrence,local recurrence and cut-edge recurrence in the SegSubTe-IN ***-OUT groups were 50%vs.83%(P=0.006),20%vs.52%(P=0.003)and 16%vs.39%(P=0.020),***-OUT odds ratio for local recurrence was 4.1 at univariate regression ***-,three-,and five-year disease-free survival rates in the SegSubTe-IN ***-OUT groups were 81%,58%and 35%vs.46%,21%and 11%,respectively(P<0.001).Conclusions:The SegSubTe classification is a useful tool to stratify and standardize NAR for HCC,aiming at improving long-term oncological outcomes and reducing the heterogeneity of quality of NAR for HCC.

关键词： Hepatocellular carcinoma Intraoperative ultrasound Liver surgery Computed tomography Surgical procedure

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Towards hydrometeorological thresholds of reservoir-induced landslide from subsurface strain observations

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Science China(Technological Sciences) 2024年第6期67卷 1907-1922页

作者： YE Xiao ZHU HongHu WANG Jia ZHENG WanJi ZHANG Wei SCHENATO luca PASUTO alessandro CATANI Filippo School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China department of Geosciences University of PadovaPadova35131Italy School of Geosciences and Info-Physics Central South UniversityChangsha410083China department of Information Engineering University of PadovaPadova35131Italy National Research Council-Research Institute for Geo-Hydrological Protection(CNR-IRPI) Padova35127Italy

Synergistic multi-factor early warning of large-scale landslides is a crucial component of geohazard prevention and mitigation efforts in reservoir *** forecasting and early warning based on surface displacements have been widely ***,the lack of direct subsurface real-time observations limits our ability to predict critical hydrometeorological conditions that trigger landslide *** this paper,we leverage subsurface strain data measured by high-resolution fiber optic sensing nerves that were installed in a giant reservoir landslide in the Three Gorges Reservoir(TGR)region,China,spanning a whole hydrologic year since February *** spatiotemporal strain profile has preliminarily identified the slip zones and potential drivers,indicating that high-intensity short-duration rainstorms controlled the landslide kinematics from an observation *** the time lag effect,we reexamined and quantified potential controls of accelerated movements using a data-driven approach,which reveals immediate response of landslide deformation to extreme rainfall with a zero-day *** identify critical hydrometeorological rules in accelerated movements,accounting for the dual effect of rainfall and reservoir water level variations,we thus construct a landslide prediction model that relies upon the boosting decision tree(BDT)algorithm using a dataset comprising daily rainfall,rainfall intensity,reservoir water level,water level fluctuations,and slip zone strain time *** results indicate that landslide acceleration is most likely to occur under the conditions of mid-low water levels(i.e.,57.9 mm and rainfall intensity>24.4 mm/h).Moreover,this prediction model allows us to update hydrometeorological thresholds by incorporating the latest monitoring *** on the shoulder of this landslide case,our study informs a practical and reliable path

关键词： slow-moving landslide fiber-optic monitoring subsurface strain hydrometeorological threshold extreme weather

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Economic and Technical Analysis of the Construction and Maintenance of Professional Soccer Fields

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Journal of Environmental Science and Engineering(A) 2016年第12期5卷 646-650页

作者： Laura Cevenini alessandro de luca Rino Ghelfi Ilaria Pasini Alberto Minelli department of Agricultural Sciences Faculty of Agriculture Alma Mater Studiorum University of Bologna Viale Fanin Bologna4640127 ltaly Italian Golf Federation Viale Tiziano Rome 74 00196 Italy

The aim of this analysis is to compare and contrast the differences and similarities of the construction and maintenance of soccer fields, from both technical and economic points of view. Authors studied two samples： the first with totally modified top soil following the USGA （United States Golf Association） Specifications, all new top soil, as in USGA, called the Texas method; the second sample was natural soil mixed with ammendants and sand, in order to reduce compaction. This study compares the initial investments, performance during training and finally the cost of maintenance. The drainage system was the same for both samples.

关键词： Turf grass management USGA (United States Golf Association) top-soil soccer fields.

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development of deep-learning-based autonomous agents for low-speed maneuvering in Unity

Journal of Intelligent and Connected Vehicles

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Journal of Intelligent and Connected Vehicles 2024年第3期7卷 229-244页

作者： Riccardo Berta luca Lazzaroni Alessio Capello Marianna Cossu luca Forneris alessandro Pighetti Francesco Bellotti Electrical Electronics and Telecommunication Engineering and Naval Architecture Department(DITEN)University of GenoaGenoa 16145Italy

This study provides a systematic analysis of the resource-consuming training of deep reinforcement-learning (DRL) agents for simulated low-speed automated driving (AD). In Unity, this study established two case studies: garage parking and navigating an obstacle-dense area. Our analysis involves training a path-planning agent with real-time-only sensor information. This study addresses research questions insufficiently covered in the literature, exploring curriculum learning (CL), agent generalization (knowledge transfer), computation distribution (CPU vs. GPU), and mapless navigation. CL proved necessary for the garage scenario and beneficial for obstacle avoidance. It involved adjustments at different stages, including terminal conditions, environment complexity, and reward function hyperparameters, guided by their evolution in multiple training attempts. Fine-tuning the simulation tick and decision period parameters was crucial for effective training. The abstraction of high-level concepts (e.g., obstacle avoidance) necessitates training the agent in sufficiently complex environments in terms of the number of obstacles. While blogs and forums discuss training machine learning models in Unity, a lack of scientific articles on DRL agents for AD persists. However, since agent development requires considerable training time and difficult procedures, there is a growing need to support such research through scientific means. In addition to our findings, we contribute to the R&D community by providing our environment with open sources.

关键词： automated driving autonomous agents deep reinforcement learning curriculum learning modeling and simulation

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Thermo-hydro-poro-mechanical responses of a reservoir-induced landslide tracked by high-resolution fiber optic sensing nerves

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1018-1032页

作者： Xiao Ye Hong-Hu Zhu Gang Cheng Hua-Fu Pei Bin Shi luca Schenato alessandro Pasuto School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China School of Computer Science North China Institute of Science and Technology(National Safety Training Center of Coal Mines)Beijing101601China State Key Lab of Coastal and Offshore Engineering Department of Geotechnical EngineeringDalian University of TechnologyDalian116024China National Research Council-Research Institute for Geo-Hydrological Protection(CNR-IRPI) Padova35127Italy department of Information Engineering University of PadovaPadova35131Italy

Thermo-poro-mechanical responses along sliding zone/surface have been extensively ***,it has not been recognized that the potential contribution of other crucial engineering geological interfaces beyond the slip surface to progressive ***,we aim to investigate the subsurface multiphysics of reservoir landslides under two extreme hydrologic conditions(*** and dry),particularly within sliding *** on ultra-weak fiber Bragg grating(UWFBG)technology,we employ specialpurpose fiber optic sensing cables that can be implanted into boreholes as“nerves of the Earth”to collect data on soil temperature,water content,pore water pressure,and *** Xinpu landslide in the middle reach of the Three Gorges Reservoir Area in China was selected as a case study to establish a paradigm for in situ thermo-hydro-poro-mechanical *** UWFBG-based sensing cables were vertically buried in a 31 m-deep borehole at the foot of the landslide,with a resolution of 1 m except for the pressure *** reported field measurements covering the period 2021 and 2022 and produced the spatiotemporal profiles throughout the *** show that wet years are more likely to motivate landslide motions than dry *** annual thermally active layer of the landslide has a critical depth of roughly 9 m and might move downward in warmer *** dynamic groundwater table is located at depths of 9e15 m,where the peaked strain undergoes a periodical response of leap and withdrawal to annual hydrometeorological *** interface behaviors may support the interpretation of the contribution of reservoir regulation to slope stability,allowing us to correlate them to local damage events and potential global *** paper also offers a natural framework for interpreting thermo-hydro-poro-mechanical signatures from creeping reservoir bank slopes,which may form the basis for a landslide monitoring and early warning system.

关键词： Reservoir landslide Thermo-hydro-poro-mechanical response Ultra-weak fiber bragg grating(UWFBG) subsurface evolution Engineering geological interface Geotechnical monitoring

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Final results of the first phase of the PROTO-SPHERA experiment: obtainment of the full current stable screw pinch and first evidences of the jet + torus combined plasma configuration

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Plasma Science and Technology 2024年第2期26卷 31-43页

作者： Paolo MICOZZI Franco ALLADIO alessandro MANCUSO Vincenzo ZANZA Gerarda APRUZZESE Francesca BOMBARDA luca BONCAGNI Paolo BURATTI Francesco FILIPPI Giuseppe GALATOLA TEKA Francesco GIAMMANCO Edmondo GIOVANNOZZI Andrea GROSSO Matteo IAFRATI alessandro LAMPASI Violeta LAZIC Simone MAGAGNINO Simone MANNORI Paolo MARSILI Valerio PIERGOTTI Giuliano ROCCHI alessandro SIBIO Benedetto TILIA Onofrio TUDISCO FSN Dipartimento Fusione e tecnologie per la Sicurezza Nucleare ENEA Agenzia Nazionale per Le Nuove Tecnologie Energia e lo Sviluppo Economico SostenibileFrascati(Rome)00044Italy IAPS Istituto di Astrofisica e Planetologia Spaziali INAF Istituto Nazionale di AstrofisicaRome O133Italy Physics department University of Pisa Faculty of Natural Sciences Mathematics and PhysicsPisa 56127 Italy

In astrophysics, the boundary conditions for plasma phenomena are provided by nature and the astronomer faces the problem of understanding them from a variety of observations [Hester J J et al 1996 Astrophys. J. 456 225], on the other hand, in laboratory plasma experiments the electromagnetic boundary conditions become a major problem in the set-up of the machine that produces the plasma, an issue that has to be investigated step by step and to be modified and adapted with great patience, in particular in the case of an innovative plasma confinement experiment. The PROTO-SPHERA machine [Alladio F et al 2006 Nucl. Fusion 46 S613] is a magnetic confinement experiment, that emulates in the laboratory the jet + torus plasma configurations often observed in astrophysics: an inner magnetized jet of plasma centered on the(approximate) axis of symmetry and surrounded by a magnetized plasma torus orthogonal to this jet. The PROTO-SPHERA plasma is simply connected, i.e., no metal current conducting rod is linked to the plasma torus, while instead it is the inner magnetized plasma jet(in the following always called the plasma centerpost) that is linked to the torus. It is mandatory that no spurious plasma current path modifies the optimal shape of the plasma centerpost. Moreover, as the plasma torus is produced and sustained, in absence of any applied inductive electric field, by the inner plasma centerpost through magnetic reconnections [Taylor J B and Turner M F 1989 *** 29 219], it is required as well that spurious current paths do not surround the torus on its outboard, in order not to lower the efficiency of the magnetic reconnections that maintain the plasma torus at the expense of the plasma centerpost. Boundary conditions have been corrected,up to the point that the first sustainment in steady state has been achieved for the combined plasma.

关键词： laboratory plasmas magnetic confinement astrophysical plasmas

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Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a delphi consensus project

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Asian Journal of Urology 2024年第2期11卷 271-279页

作者： Andrea Cocci Marta Pezzoli Fernando Bianco Franco Blefari Pierluigi Bove Francois Cornud Gaetano de Rienzo Paolo destefanis Danilo Di Trapani alessandro Giacobbe luca Giovanessi Antonino Laganà Giovanni Lughezzani Guglielmo Manenti Gianluca Muto Gianluigi Patelli Novello Pinzi Stefano Regusci Giorgio I.Russo Juan I.M.Salamanca Matteo Salvi Luigi Silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli alessandro Bertaccini debora Marchiori Hugo Davila Pasquale Ditonno Paolo Gontero Gennaro Iapicca Theo M de Reijke Vito Ricapito Pierluca Pellegrini Andrea Minervini Sergio Serni Francesco Sessa department of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology Section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology Section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly department of Urology San Carlo di Nancy HospitalRomeItaly department of Radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly department of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly departement of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Humanitas Clinical and Research CentereIRCCS Department of UrologyRozzanoItaly department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly department of Biomedicine and Prevention University of Rome“Tor Vergata”RomeItaly department of Diagnostic Imaging and Interventional Radiology University of Rome“Tor Vergata”RomeItaly department of Interventional Radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly department of Urology University of SienaSienaItaly Swiss International Prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland department of Urology University of CataniaItaly department of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain department of Medico-Surgical Sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly department of Urology European Institute of Oncology(IEO)IRCCSMilanItaly department of Radiology D

Objective: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta S.p.A., Calenzano, Italy) as a treatment for benign prostatic hyperplasia (BPH) and prostate cancer (PCa) using the delphi consensus ***: Italian and international experts on BPH and PCa participated in a collaborative consensus project. During two rounds, they expressed their opinions on Echolaser® TPLA for the treatment of BPH and PCa answering online questionnaires on indications, methodology, and potential complications of this technology. Level of agreement or disagreement to reach consensus was set at 75%. If the consensus was not achieved, questions were modified after each round. A final round was performed during an online meeting, in which results were discussed and ***: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreement was achieved on recommending Echolaser® TPLA as a treatment of BPH in patients with ample range of prostate volume, from 80 mL (80%), comorbidities (100%), antiplatelet or anticoagulant treatment (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). Majority of respondents agreed that Echolaser® TPLA is a potential option for the treatment of localized PCa (78%) and recommended it for low-risk PCa (90%). During the final round, experts concluded that it can be used for intermediate-risk PCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Almost all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreement among experts). Pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading t

关键词： Transperineal laser ablation Prostatecancer Benignprostatic hyperplasia delphi consensus

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Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

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Cancer Communications 2024年第2期44卷 282-286页

作者： Bianca Cesaro Alessia Iaiza Fabio Piscopo Marco Tarullo Eleonora Cesari Dante Rotili Antonello Mai Alberto Diana Michela Londero luca del Giacco Riccardo Masetti Alba Di Leone Chiara Naro Silvia Masciarelli Giulia Fontemaggi Claudio Sette Francesco Fazi alessandro Fatica department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly department of Biology and Biotechnologies“Charles Darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core Facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly department of Drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly department of BioSciences University of MilanMilanItaly Multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(METTL3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

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Gastric endoscopic submucosal dissection in Western countries:Indications,applications,efficacy and training perspective

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World Journal of Gastrointestinal Surgery 2021年第10期13卷 1180-1189页

作者： luca de luca Massimiliano Di Berardino Benedetto Mangiavillano alessandro Repici Gastroenterology and Digestive Endoscopy Unit Riuniti Marche North HospitalPesaro 61121Italy Gastrointestinal Endoscopy Unit Humanitas-Mater DominiCastellanza 21053Italy Digestive Endoscopy Unit Humanitas Clinical and Research CenterHumanitas UniversityRozzano 20089Italy

Endoscopic submucosal dissection was introduced in Japan for the mini-invasive treatment of early gastric cancer,as part of national screening program considering high prevalence of disease in these *** technique allows en-bloc curative oncological excision and to obtain in a single step R0-resection,characterization,histological staging and potential cure of the tumor with a very high cost-benefit *** the years,Western endoscopists have adopted endoscopic submucosal dissection,achieving good rates of efficacy,long-term improved outcomes and safety,with low risk of local recurrence comparable to those obtained in Asian ***,according to some authors,the excellent outcomes from East country could not be representative of the Western *** epidemiological differences of early gastric cancer,scant volume data and limitations in training opportunities between Western and Eastern countries,European Society of Gastrointestinal Endoscopy have adopted Japanese guidelines and developed a European core curriculum for endoscopic submucosal dissection *** should be able to estimate the probability of performing a curative resection by considering the benefit/risk relationship case-by-case in order to implement a correct decision-making process.

关键词： Endoscopic submucosal dissection Western experience Early gastric cancer Curative oncological excision Long-term outcome Training perspective

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Autoimmune pancreatitis not otherwise specified(NOS): Clinical features and outcomes of the forgotten type

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Hepatobiliary & Pancreatic Diseases International 2019年第6期18卷 576-579页

作者： Nicolò de Pretis Filippo Vieceli alessandro Brandolese Lorenzo Brozzi Antonio Amodio luca Frulloni Gastroenterology Unit Pancreas Center University of Verona

Background:Autoimmune pancreatitis(AIP)is a well-recognized fibroinflammatory disease of the *** the significant number of studies published on AIP type 1 and 2,no studies have been focused on AIP type not otherwise specified(NOS)and therefore very little is known about clinical features and long-term outcomes of these *** aim of this study was to investigate clinical and radiological features of AIP type ***:Patients classified as AIP type NOS at clinical onset included in our database prospectively maintained since 1995 were ***,clinical data were collected and ***:Forty-six patients were included in the *** clinical onset was mainly characterized by weight loss,jaundice and acute *** patients(17.4%)were reclassified as AIP type 2 during follow-up because of the development of ulcerative *** patients(15.2%)experienced relapse after steroid treatment but only one(2.2%)needed immunosuppressive drugs because of recurrent ***:AIP type NOS shares clinical features similar to AIP type 2 and a relevant proportion of patients was reclassified as AIP type 2 during follow-up because of the development of ulcerative *** risk of relapse is low but not irrelevant.

关键词： Autoimmune pancreatitis Not otherwise specified Outcome Follow-up Therapy

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