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Comparison between hepatocellular carcinoma prognostic scores:A 10-year single-center experience and brief review of the current literature

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World Journal of Hepatology 2020年第12期12卷 1239-1257页

作者： Michele Campigotto Mauro Giuffrè Anna Colombo Alessia Visintin alessandro aversano Martina Budel Flora Masutti Cristiana Abazia Lory Saveria Croce Dipartimento Universitario Clinico di Scienze Mediche Chirurgiche e Della SaluteUniversitàdegli Studi di TriesteTrieste 34149Italy Clinica Patologie del Fegato Azienda Sanitaria Universitaria Giuliano IsontinaTrieste 34149Italy

BACKGROUND Hepatocellular carcinoma(HCC)represents the most common primitive liver malignancy.A relevant concern involves the lack of agreement on staging systems,prognostic scores,and treatment allocation *** To compare the survival rates among already developed prognostic *** We retrospectively evaluated 140 patients with HCC diagnosed between February 2006 and November *** were categorized according to 15 prognostic scoring systems and estimated median survivals were compared with those available from the current medical *** The median overall survival of the cohort of patients was 35(17;67)mo,and it was statistically different in relation to treatment choice,ultrasound surveillance,and serum *** Italian Liver Cancer(***)tumor staging system performed best in predicting survival according to stage allocation among all 15 evaluated prognostic *** the *** prognostic system,28.6%,40.7%,22.1%,and 8.6%of patients fell within stages 0-1,2-3,4-5 and>5 *** median survival was 57.9 mo for stages 0-1,43 mo for stages 2-3,21.7 mo for stages 4-5,and 10.4 mo for stage>*** 1-,3-,and 5-year survival rates were respectively 95%,65%,and 20%,for stages 0-1;94.7%,43.9%and 26.3%for stages 2-3;71%,25.8%and 16.1%for stages 4-5;and 50%,16.7%and 8.3%for stage>*** the same time,although statistically significant in prognostic stratification,the most commonly used Barcelona Clinic Liver Cancer system showed one of the most relevant differences in median survival,especially for stages A and C,when compared to the medical *** fact,10.7%,59.3%,27.1%,1.4%,and 0%of patients were stratified into stages 0,A,B,C,and D *** median survival was>81.1 mo for stage 0,44.9 mo for stage A,21.3 mo for stage B,and 3.1 mo for stage *** 1-,3-,and 5-year survival rates were respectively 86.7%,60%,and 46.7%for stage 0;91.6%,50.6%,and 20.5%for stage A;73.7%,23.7%and 13.2%for stage B;and

关键词： Hepatocellular carcinoma Prognostic score system Prognostic factors Survival analysis Barcelona Clinic Liver Cancer score system Italian Liver Cancer score system

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