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Efficacy of current guidelines for the treatment of spontaneous bacterial peritonitis in the clinical practice

World Journal of Gastroenterology 2008年第17期14卷 2757-2762页

作者： Stefania Angeloni Cinzia Leboffe Antonella Parente Mario Venditti alessandra giordano Manuela Merli Oliviero Riggio Department of Clinical Medicine "Sapienza" University of Rome Department of Public Health "Sapienza" University of Rome

AIM： To verify the validity of the International Ascites Club guidelines for treatment of spontaneous bacterial peritonitis （SBP） in clinical practice. METHODS： All SBP episodes occurring in a group of consecutive cirrhotics were managed accordingly and included in the study. SBP was diagnosed when the ascitic fluid polymorphonuclear （PIN） cell count was 〉 250 cells/mm^3, and empirically treated with cefotaxime. RESULTS： Thirty-eight SBP episodes occurred in 32 cirrhotics （22 men/20 women; mean age： 58.6 ＋ 22.2 years）. Prevalence of SBP, in our population, was 27%. Ascitic fluid culture was positive in nine （24%） cases only. Eleven episodes were nosocomial and 71% community-acquired. Treatment with cefotaxime was successful in 59% of cases, while 41% of episodes required a modification of the initial antibiotic therapy because of a less-than 25% decrease in ascitic PMN count at 48 h. Change of antibiotic therapy led to the resolution of infection in 87% of episodes. Among the cases with positive culture, the initial antibiotic therapy with cefotaxime failed at a percentage （44%） similar to that of the whole series. In these cases, the isolated organisms were either resistant or with an inherent insufficient susceptibility to cefotaxime. CONCLUSION： In clinical practice, ascitic PMN count is a valid tool for starting a prompt antibiotic treatment andevaluating its efficacy. The initial treatment with cefotaxime failed more frequently than expected. An increase in healthcare-related infections with antibiotic-resistant pathogens may explain this finding. A different first-line antibiotic treatment should be investigated.

关键词： Spontaneous bacterial peritonitis Cefotaxi-me Antibiotic-resistant pathogens Ascitic polymorpho-nuclear count Cirrhosis

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Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 376-380页

作者： Eleonora Cella Ivan Gabrielli Gianguglielmo Zehender Marta Giovanetti alessandra Lo Presti Alessia Lai giordano Dicuonzo Silvia Angeletti Marco Salemi Massimo Ciccozzi Department of Infectious Parasitic and Immunomediated DiseasesNational Institute of Health Department of Public Health and Infectious Diseases.Sapienza University of Rome University of Rome 'La Sapienza' L.Sacco Department of Biomedical and Clinical Sciences University of Milan University of Rome 'Tor Vergata' Clinical Pathology and Microbiology Laboratory University Hospital Campus Bio-Medico of Rome Department of Pathology and Laboratory Medicine.University of Florida University Hospital Campus Bio-Medico

Objective:To study the genetic diversity of Murray Valley encephalitis virus(MVEV) in Australia and Papua New ***:MVEV envelope gene sequences were aligned using Clustal X and manual editing was performed with *** v.3.7 was used to select the simplest evolutionary model that adequately fitted the sequence *** likelihood analysis was performed using *** phylogenetic signal of the dataset wa.s investigated by the likelihood mapping *** Bayesian phylogenetic tree was built using ***:The phylogenetic trees showed two main *** clade Ⅰincluding eight strains isolated from West *** clade Ⅱ was characterized by at least four epidemic entries,three of which localized in Northern West Australia and one in Papua New *** estimated mean evolutionary rate value of the MVEV envelope gene wa.s0.407 × 10^(-3) substitution/site/year(95%HPD:0.623 × 10~4-0.780× 10^(-3)).Population dynamics defines a relative constant population until the year *** a reduction occurred,probably due to a ***:This study has been useful in supporting the probable connection between climate changes and viral evolution also by the vector point of view:multidisciplinary monitoring studies are important to prevent new viral epidemics inside and outside new endemic areas.

关键词： Murray Valley encephalitis virus Phylogeny Evolution

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Thyroid carcinoma showing thymus-like differentiation: Case presentation of a young man

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World Journal of Clinical Oncology 2014年第5期5卷 1117-1120页

作者： Chiara Abeni Chiara Ogliosi Luigina Rota Paola Bertocchi alessandra Huscher giordano Savelli Mariano Lombardi Alberto Zaniboni Department of Medical Oncology Fondazione Poliambulanza 25124 Brescia Italy Department of Radiotherapy Fondazione Poliambulanza 25124 Brescia Italy Department of Nuclear Medicine Fondazione Poliambulanza 25124 Brescia Italy Department of Pathology Fondazione Poliambulanza 25124 Brescia Italy

Ectopic thymic tissue can be present in the thyroid gland and a carcinoma showing thymus-like differentiation(CASTLE) may arise from such tissue. We are reported the case of a 26-year-old man with CASTLE, with cervical subcutaneous nodules relapse, who showed a good response to treatment with surgery, chemotherapy and radiotherapy. The problematic aspect of this case was the diagnosis; only on review were we able to make a final diagnosis. CASTLE is a very rare neoplasm. It is important to differentiate this cancer from others tumors such as primary or metastatic squamous cell carcinoma of the head and neck or squamous cell thyroid carcinoma, because the therapy and prognosis are *** is complicated and requires careful histological analysis(CD5- and P63-positive with presence of Hassall's corpuscles); unfortunately there is no gold standard treatment so, in this case, we administered a sandwich of chemotherapy and radiotherapy.

关键词： Carcinoma showing thymus-like differentiation thymic CD5 Hassall’s corpuscles Thyroidectomy Chemotherapy Radiotherapy

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Markers of bile duct tumors

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World Journal of Gastrointestinal Oncology 2011年第4期3卷 49-59页

作者： Giulia Malaguarnera Maria giordano Isabella Paladina alessandra Rando Mario Uccello Francesco Basile Antonio Biondi Santo Carnazzo Innocenza Alessandria Clorinda Mazzarino Department of Biomedical Science University of Catania Departments of Senescence Urologicaland Neurological SciencesUniversity of Catania Department of General Surgery University Medical School of CataniaHospital Vittorio Emanuele Department of General Surgery University Medical School of Catania Department of Internal Medicine University Medical School of CataniaHospital Cannizzaro

Biliary tract carcinomas are relatively rare,representing less than 1%of ***,their incidence has increased in Japan and in industrialized countries like the *** tract tumors have a poor prognosis and a high mortality rate because they are usually detected late in the course of the disease;therapeutic treatment options are often limited and of minimal *** studies have shown the importance of serum and molecularmarkers in the diagnosis and follow up of biliary tract *** review aims to introduce the main features of the most important serum and molecular markers of biliary tree *** considerable tumor markers are cancer antigen 125,carbohydrate antigen 19-9,carcinoembryonic antigen,chromogranin A,mucin 1,mucin 5,alpha-fetoprotein,claudins and cytokeratins.

关键词： Bile duct tumors Cholangiocarcinoma Tumor markers Carbohydrate antigen 19-9 Chromogranin A

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Procalcitonin and mid-regional pro-adrenomedullin as promising markers for sepsis diagnosis and prognosis

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Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 973-974页

作者： Silvia Angeletti Rossella Ottaviani Arcangela Michela Lanotte Lucia Pedicino Marina De Cesaris alessandra Lo Presti Eleonora Cella Marta Fogolari Massimo Ciccozzi giordano Dicuonzo Unit of Clinical Pathology and Microbiology Campus Bio-Medico University of Rome Department of Infectious Parasitic and Immunomediated Diseases Istituto Superiore di Sanità Public Health and Infectious Diseases Sapienza University

To the Editor,We read with great interest the recent review by Limongi et *** sepsis biomarkers[1].Recently,the combined use of two biomarkers,procalcitonin(PCT)and mid-regional proadrenomedullin(MR-pro ADM)has been reported in sepsis diagnosis and *** is a polypeptide produced as a precursor of calcitonin by thyroid C cells normally

关键词： PCT MR ADM than

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Evaluation of hot pressing parameters on the electrochemical performance of MEAs based on Aquivion^(■) PFSA membranes

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Journal of Energy Chemistry 2019年第8期28卷 168-173,I0006页

作者： Irene Gatto Ada Sacca Vincenzo Baglio Antonino Salvatore Arico Claudio Oldani Luca Merlo alessandra Carbone CNR-ITAE Institute for Advanced Energy Technologies"N. Giordano" Via S. Lucia Sopra Contesse 5Messina Italy Solvay Specialty Polymers Viale Lombardia 20 20021 Bollate MI Italy

The membrane-electrodes assembly(MEA) is the core of the Polymer Electrolyte Fuel Cell(PEFC). It consists of a membrane, catalytic(CL) and gas diffusion layers(GDL). In order to manufacture MEAs with suitable performance, a hot-pressing procedure is generally used. The relevant parameters are the temperature, pressure and time of hot-pressing. Such variables need to be adjusted as a function of the type of ionomer used in the catalytic layer and membrane. In this study, an evaluation of the temperature of hot-pressing was carried out and its influence on MEA electrochemical performance was assessed. In particular, preparation trials of MEAs were carried out with reinforced experimental membranes based on Aquivion^■ short-side-chain PFSA(by Solvay Specialty Polymers). The membranes were coupled to gas diffusion electrodes, and MEAs were manufactured using different temperatures for the hot-pressing procedure in order to evaluate their influence on the electrochemical performance of PEFCs, in the temperature range of 80–95 °C, with low relative humidity of the reactant gases. The electrochemical performance of the prepared MEAs was tested in a H2/Air 25 cm^2 single cell in terms of polarization curves and accelerated stress test(AST).

关键词： Aquivion^(■) Short-side chain PEFC Hot-pressing parameters Automotive applications

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