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Implications of metabolism-driven myeloid dysfunctions in cancer therapy

Cellular & Molecular Immunology 2021年第4期18卷 829-841页

作者： Laura Strauss Valentina Guarneri alessandra gennari Antonio Sica Department of Immunopharmacology and Immuno Oncology EMD Serono Research&Development InstituteInc.80119545A Middlesex TurnpikeBillericaMA 01821USA Department of Surgery Oncology and GastroenterologyUniversity of PadovaPadovaItaly Veneto Institute of Oncology-IRCCS PaduaItalyPadovaItaly Division of Oncology Department of Translational MedicineUniversity of Eastern PiedmontNovaraItaly Department of Pharmaceutical Sciences University of Eastern PiedmontA.Avogadrovia Bovio 6NovaraItaly Humanitas Clinical and Research Center IRCCSVia Manzoni 56RozzanoMilanItaly

Immune homeostasis is maintained by an adequate balance of myeloid and lymphoid *** chronic inflammatory states,including cancer,this balance is lost due to dramatic expansion of myeloid progenitors that fail to mature to functional inflammatory neutrophils,macrophages,and dendritic cells(DCs),thus giving rise to a decline in the antitumor effector lymphoid ***-related inflammation orchestrates the production of hematopoietic growth factors and cytokines that perpetuate recruitment and activation of myeloid precursors,resulting in unresolved and chronic *** pathologic inflammation creates profound alterations in the intrinsic cellular metabolism of the myeloid progenitor pool,which is amplified by competition for essential nutrients and by hypoxia-induced metabolic rewiring at the tumor ***,persistent myelopoiesis and metabolic dysfunctions contribute to the development of cancer,as well as to the severity of a broad range of diseases,including metabolic syndrome and autoimmune and infectious *** aims of this review are to(1)define the metabolic networks implicated in aberrant myelopoiesis observed in cancer patients,(2)discuss the mechanisms underlying these clinical manifestations and the impact of metabolic perturbations on clinical outcomes,and(3)explore new biomarkers and therapeutic strategies to restore immunometabolism and differentiation of myeloid cells towards an effector phenotype to increase host antitumor *** propose that the profound metabolic alterations and associated transcriptional changes triggered by chronic and overactivated immune responses in myeloid cells represent critical factors influencing the balance between therapeutic efficacy and immune-related adverse effects(irAEs)for current therapeutic strategies,including immune checkpoint inhibitor(ICI)therapy.

关键词： Myelopoiesis Tumor-associated macrophages Myeloid-derived suppressor cells Metabolism Cancer therapy

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Characterization of Glycerol-Extractable Organic Matter from Etna Soils of Different Ages

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Pedosphere 2010年第1期20卷 120-128页

作者： A. BAGLIERI A. IOPPOLO M. NGRE C. ABBATE M. gennari Dipartimento di scienze Agronomiche Agrochimiche e delle Produzioni Animali Sezione di Scienze Agrochimiche Universitàdi Catania Dipartimento di Valorizzazione e protezione delle Risorse Agroforestali Settore Chimica Agraria Universitàdi Torino

We characterized humic acids （HAs） and glycerol-extractable organic fractions （GEOFs） extracted from four Andisols, taken from comparable soil-climate conditions on the east side of Mount Etna. The soils were formed on old lava （about 9000 years ago）, old tephra （about 8 700 years ago）, recent lava （about 2 600 years ago） and recent tephra （about 3600 years ago）. A part of the organic matter of the soils, deprived of HAs and fulvic acids （FAs）, was isolated by glycerol extraction. The GEOF can not be extracted with alkaline solutions, probably because it is closely bound to the mineral component of the soil. The characterization of the extracted organic fraction was carried out using elementary and functional group analysis and Fourier transform infrared （FT-IR） spectroscopy. About 20 extractions were necessary to extract the HA and FA from the older soils and about 10 extractions to extract them from the younger soils. Data showed that the CEOFs had a greater ash content and a smaller N content, as well as a greater presence of aliphatic compounds and carboxylic groups as compared to the HA extracted from the same soil. The GEOFs extracted from younger soils also had a lower yield, ash and COOH-group content, and were more aliphatic than the GEOF extracted from older soils. Finally, the GEOFs were more closely bound to the amorphous component of the soil （＇short-range＇ minerals） and consequently less subject to biodegradation.

关键词： Andisol Fourier transform infrared spectra humic substances

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Theoretical investigation of carbon dioxide adsorption on MgH_(2) with a cobalt catalyst

Industrial Chemistry & Materials

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Industrial Chemistry & Materials 2024年第4期2卷 587-599页

作者： Sara Rozas Fabiana C.gennari Mert Atilhan Alfredo Bol Santiago Aparicio Department of Chemistry University of Burgos09001 BurgosSpain National Scientific and Technical Research Council(CONICET) Bariloche Atomic Centre(CNEA)R8402AGPS.C.de BarilocheRio NegroArgentina Department of Chemical and Paper Engineering Western Michigan UniversityKalamazooMI 49008-5462USA Department of Physics University of Burgos09001 BurgosSpain International Research Center in Critical Raw Materials for Advanced Industrial Technologies(ICCRAM) University of Burgos09001 BurgosSpain

This work presents a theoretical investigation of carbon dioxide(CO_(2))adsorption on MgH_(2) and its reaction(chemisorption)with cobalt doped MgH_(2).The focus of this study is the properties and mechanisms involved in CO_(2) adsorption on clean MgH_(2) surfaces and the role of Co in enhancing the adsorption *** functional theory(DFT)calculations were performed to examine different CO_(2) adsorption sites on the MgH_(2) surface along with the adsorption distances,binding energies,and geometric *** results indicate that physical adsorption of CO_(2) occurs on MgH_(2) with similar adsorption energies at different adsorption *** coverage effect of CO_(2) molecules on MgH_(2) was also investigated,revealing an increased affinity of CO_(2) with higher surface ***,excessive coverage led to a decrease in adsorption efficiency due to competing surface adsorption and intermolecular *** orientation of adsorbed CO_(2) molecules shifted from parallel to quasiperpendicular arrangements upon adsorption,with notable deformations observed at higher coverage,which gives a hint of CO_(2) ***,the study explores the CO_(2) adsorption capacity of MgH_(2) in comparison to other materials reported in the literature,showcasing its medium to strong affinity for CO_(2).Additionally,the effectiveness of a single Co atom and Co clusters as catalysts for CO_(2) adsorption on MgH_(2) was ***,this theoretical investigation provides insights into the CO_(2) adsorption properties of MgH_(2) and highlights the potential of Co catalysts to enhance the efficiency of the methanation process.

关键词： DFT CO_(2)conversion Cobalt catalyst Charge transfer

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ZEWA——处理钢铁工业废料以获得有价值产品的冶金新工艺

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钢铁 2005年第8期40卷 80-83页

作者： A.Fleischanderl U.gennari A.Llie 奥钢联工程技术公司

ZEWA冶金新工艺将工业废料转化成铁水或矿物类产品如生产水泥用的水硬性胶结物、脱硫用冶金渣、铺路用材料等。工艺中包括专门设计的电加热反应器,用以进行高温熔融还原处理。一个包括所有必要的辅助设施在内的示范厂已在捷克共和国的V... 详细信息

ZEWA冶金新工艺将工业废料转化成铁水或矿物类产品如生产水泥用的水硬性胶结物、脱硫用冶金渣、铺路用材料等。工艺中包括专门设计的电加热反应器,用以进行高温熔融还原处理。一个包括所有必要的辅助设施在内的示范厂已在捷克共和国的Vítkovice钢厂建成,11次试验证实了利用碳钢和不锈钢生产的废料来生产铁水和有价值矿物类产品的技术和经济可行性。

关键词： ZEWA 废物处理有价值产品

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Analysis of Deformation in Ni-Cr Structures with New and Recast Alloys

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Materials Sciences and Applications 2015年第7期6卷 707-712页

作者： Humberto gennari Filho Marcelo Coelho Goiato José Vitor Quinelli Mazaro Karina Helga Leal Túrcio State Paulista University S&atilde o Paulo Brazil

The present study analyzed new and recast Ni-Cr alloys, regarding the relationship between the applied force and the deformation in cantilevered bar segments, with dimensions of 4.0 mm, 3.5 mm, 3.0 mm in thickness, 4.5 mm width and 15 mm length, on a universal testing machine “EMIC”. The bars in the tests were initially obtained acrylic resin by 4.8 mm wide × 4.3 mm thick × 4 cm long. We obtained 30 bars divided into two groups, with 15 to test new alloys and 15 with alloys recast. The alloy used was Tilite. For the application of the load, the bars were attached to “EMIC” where the active tip of 200 kgf load cell was at a specific point of the bar (15 mm) with a speed of 0.5 mm per minute. The data showed statistically significant differences in relation to alloys and thickness among the bars, and all thicknesses evaluated were different. Thus, it was concluded that there was statistically significant difference between the groups and their variables, and that the alloys recast could be reused at least 1 time, without loss of properties.

关键词： Alloys Oral Protheses Dental Materials

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乙烯氧化物对土壤微生物含量和某些土壤化学性质的影响

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土壤学进展 1990年第2期18卷 54-56页

作者： M. gennari 苏年华

我们研究了乙烯氧化物(EtO)对土壤微生物的存活和选定的砂壤土化学性质的影响。用EtO处理土壤8小时进行土壤消毒乙烯氧化物处理能提高土壤pH和有机质含量,对可提取的Mn和Fe略有增加,而P的含量却降低。全氮不受处理的影响。

关键词：土壤乙烯氧化物化学性质微生物

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Biomechanical Analysis of Implant Assisted-Overdentures with Variations in the Attachments Systems

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Materials Sciences and Applications 2015年第8期6卷 734-742页

作者： Eduardo Vedovatto Jose Vitor Quinelli Mazaro Humberto gennari Filho Paulo Sérgio Perri de Carvalho Caroline Cantieri de Mello Cleidiel Aparecido Araujo Lemos Sã o Leopoldo MandicInstituteandResearch Center Campinas Brazil Department of Prosthodontic and Dental Materials Ara&ccedil atuba School of Dentistry S&atilde o Paulo State University (UNESP) Ara&ccedil atuba Brazil Department of Surgery an Integrated Clinic Ara&ccedil atuba School of Dentistry S&atilde o Paulo State University (UNESP) Ara&ccedil atuba Brazil Departmentof Dental Materials and Prosthodontics Ara&ccedil atuba SchoolofDentistry S&atilde o Paulo StateUniversity (UNESP) Ara&ccedil atuba Brazil.

The aim of this study was to assess the stress patterns on the peri-implant zone and residual alveolar ridge in different overdenture attachment system designs by the photoelasticity method. Four attachments systems were tested: O-ring, ERA, Bar-clip, and Bar-clip/O-ring association. The prostheses were loaded with 100 N in five pre-determined points and the photoelastic model was evaluated by a circular polariscope. The anterior load, O-ring, and ERA showed better stress distribution in relation to the bars systems, which presented stress levels surrounding implants. The molar load, Bar-clip/O-ring association, presented the biggest stress concentration on the peri-implant region in relation to the others. When the second molar was loaded, there was a concentration of stress in the alveolar ridge in all situations analyzed. Within the limitation of this “in vitro” study, it could be concluded that there were biomechanical differences among the attachments systems analyzed, principally between isolated and the bars systems. The O-ring showed better stress distribution and the Bar-clip/O-ring showed higher stress concentration.

关键词： Dental Implants Complete Denture Overdentures

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微泡注射后时间-强度曲线可以用于鉴别活动性克罗恩病病人药物治疗6周后是否存在药物疗效

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国际医学放射学杂志 2017年第1期 89-90页

作者： E.Quaia M.Sozzi R.Angileri A.G.gennari M.A.Cova 李清 Departments of Radiology Cattinara HospitalUniversity of Trieste

摘要目的评估超声微泡造影是否可以用于鉴别活动性克罗恩病病人药物治疗6周后是否存在药物疗效。材料与方法本研究通过伦理委员会同意,并获得书面知情同意书。

关键词：药物疗效克罗恩病局限性回肠炎肠炎时间-强度曲线活动性药物治疗病人

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新型冠状病毒肺炎（COVID-19）疫苗接种后肿瘤病人PET/CT成像中腋窝淋巴结的18F-FDG摄取情况分析：频率、强度以及潜在临床影响

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国际医学放射学杂志 2022年第2期 242页

作者： S.Skawran A.G.gennari M.Dittli V.Treyer U.J.Muehlematter A.Maurer 刘昶

摘要目的评估接种BNT162b2（辉瑞）新型冠状病毒肺炎（COVID-19）疫苗和m RNA-1273（莫德纳）COVID-19疫苗后的肿瘤病人在FDG PET/CT成像中腋窝淋巴结摄取18F-

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刺槐单宁提取物对控制绵羊胃肠寄生虫的影响

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饲料博览 2009年第3期 39-39页

作者： Minho A P Bueno I C S Louvandini H Jackson F gennari S M Abdalla A L

试验旨在研究来源于刺槐的浓缩单宁提取物(CTE)对自然感染捻转血矛线虫和蛇形毛圆线虫羔羊的驱虫作用。选择20只Santa Ines绵羊,随机平均分配到4个处理组,每个处理组单独饲养在在一个小牧场内,试验期60d。其中两个处理组,分别在试验开... 详细信息

试验旨在研究来源于刺槐的浓缩单宁提取物(CTE)对自然感染捻转血矛线虫和蛇形毛圆线虫羔羊的驱虫作用。选择20只Santa Ines绵羊,随机平均分配到4个处理组,每个处理组单独饲养在在一个小牧场内,试验期60d。其中两个处理组,分别在试验开始的第1天和第30天后的连续两天,将绵羊全部进行CTE(***-1)淋洗。而另外两个处理组则为对照,不进行CTE淋洗。各处理组绵羊每14d称重1次,每周采集血样1次、粪便中虫卵计数(FEC)2次。在最后一次用CTE处理后的28d,即试验结束时,将所有羔羊屠宰并进行虫负荷计数。结果表明,各处理间平均体重均无显著差异。与对照组相比,在试验的第14天(P=0.043)、21天(P=0.074)、28天(P=0.026)、42天(P=0.007)和48(P=0.089),CTE处理组的球状体体积均表现出显著升高或呈升高的趋势。各处理间血红蛋白值没有差异。CTE淋洗同FEC(P=0.003)和皱胃的虫负荷(P<0.003)呈极显著相关,但是对小肠虫负荷没有影响。试验结果证实,CTE对羔羊胃肠中线虫类寄生虫的驱除效果,同时显示CTE用作驱除家畜体内寄生虫药物的潜在可能。

关键词：交替对照浓缩单宁刺槐绵羊羔羊线虫类寄生虫蛇形毛圆线虫

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