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Long-noncoding RNAs as epigenetic regulators in neurodegenerative diseases

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Neural Regeneration Research 2023年第6期18卷 1243-1248页

作者： paola Ruffo Francesca de Amicis Emiliano Giardina Francesca Luisa Conforti Medical Genetics Laboratory Department of PharmacyHealth and Nutritional SciencesUniversity of CalabriaRendeItaly department of Pharmacy Health and Nutritional SciencesUniversity of CalabriaRendeItaly Genomic Medicine Laboratory UILDM IRCCS Fondazione Santa LuciaRomeItaly department of Biomedicine&Prevention Tor Vergata University of RomeRomeItaly

The growing and rapid development of high-throughput sequencing technologies have allowed a greater understanding of the mechanisms underlying gene expression *** the epigenome and epitranscriptome directs the fate of the transcript influencing the functional outcome of each *** this context,non-coding RNAs play a decisive role in addressing the expression regulation at the gene and chromosomal ***-noncoding RNAs,consisting of more than 200 nucleotides,have been shown to act as epigenetic regulators in several key molecular processes involving neurodegenerative disorders,such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis and Huntington’s ***-noncoding RNAs are abundantly expressed in the central nervous system,suggesting that their deregulation could trigger neuronal degeneration through RNA *** evaluation of their diagnostic significance and therapeutic potential could lead to new treatments for these diseases for which there is no cure.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis epigenetic mechanism Huntington’s disease long-noncoding RNAs neurodegenerative disease non-coding RNAs Parkinson’s disease

Immortalized hippocampal astrocytes from 3xTg-AD mice,a new model to study disease-related astrocytic dysfunction:a comparative review

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Neural Regeneration Research 2023年第8期18卷 1672-1678页

作者： Laura Tapella Giulia dematteis Armando A Genazzani Massimiliano de paola Dmitry Lim department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly department of Neuroscience Mario Negri Institute for Pharmacological Research IRCCSMilanoItaly

Alzheimer's disease(AD)is characterized by complex etiology,long-lasting pathogenesis,and celltype-specific ***,there is no cure for AD,emphasizing the urgent need for a comprehensive understanding of cell-specific ***,principal homeostatic cells of the central nervous system,are key players in the pathogenesis of neurodegenerative diseases,including *** models greatly facilitate the investigation of cell-specific pathological alterations and the dissection of molecular mechanisms and ***-derived and immortalized astrocytic cell lines,alongside the emerging technology of adult induced pluripotent stem cells,are widely used to study cellular dysfunction in ***,no stable cell lines were available from genetic mouse AD ***,we established immortalized hippocampal astroglial cell lines from amyloid-βprecursor protein/presenilin-1/Tau triple-transgenic(3xTg)-AD mice(denominated as wild type(WT)-and 3Tg-iAstro cells)using retrovirus-mediated transduction of simian virus 40 large T-antigen and propagation without clonal selection,thereby maintaining natural heterogeneity of primary *** groups have successfully used 3Tg-iAstro cells for single-cell and omics approaches to study astrocytic AD-related alterations of calcium signaling,mitochondrial dysfunctions,disproteostasis,altered homeostatic and signaling support to neurons,and blood-brain barrier *** we provide a comparative overview of the most used models to study astrocytes in vitro,such as primary culture,tumor-derived cell lines,immortalized astroglial cell lines,and induced pluripotent stem cell-derived *** conclude that immortalized WT-and 3Tg-iAstro cells provide a noncompetitive but complementary,low-cost,easy-to-handle,and versatile cellular model for dissection of astrocyte-specific AD-related alterations and preclinical drug discovery.

关键词： Alzheimer's disease astrocytes immortalization astroglial Alzheimers's disease model blood-brain barrier calcium signaling central nervous system homeostasis disproteostasis endoplasmic reticulum-mitochondria contacts induced pluripotent stem cell-derived astrocytes protein synthesis

Proteinuria in paediatric patients with human immunodefi ciency virus infection

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World Journal of Clinical Cases 2013年第1期1卷 13-18页

作者： Vania Giacomet paola Erba Francesca Di Nello Sonia Coletto alessandra Viganò Gian Vincenzo Zuccotti department of Paediatrics L Sacco Hospital University of Milan 20157 Milan Italy

In human immunodef iciency virus(HIV)-infected people kidney disease is as an important cause of morbidity and mortality. Clinical features of kidney damage in HIV-infected patients range from asymptomatic microalbuminuria to nephrotic syndrome. The lack of specif ic clinical features despite the presence of heavy proteinuria may mask the renal involvement. Indeed, it is important in HIV patients to monitor renal function to early discover a possible kidney injury. After the introduction of antiretroviral therapy, mortality and morbidity associated to HIV-infection have shown a substantial reduction, although a variety of side effects for longterm use of highly active antiretroviral therapy, including renal toxicity, has emerged. Among more than 20 currently available antiretroviral agents, many of them can occasionally cause reversible or irreversible nephrotoxicity. At now, three antiretroviral agents, i.e., indinavir, atazanavir and tenofovir disoproxil fumarate have a well established association with direct nephrotoxicity. This review focuses on major causes of proteinuria and other pathological f indings related to kidney disease in HIV-infected children and adolescents.

关键词： Human immunodeficiency virus-infection Nephropathy Proteinuria Antiretroviral therapy Children

Distributed schemes for efficient deployment of price-responsive demand with partial flexibility

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Journal of Control and decision 2018年第2期5卷 169-194页

作者： A.de paola D.Angeli G.Strbac department of Electrical and Electronic Engineering Imperial College LondonLondonUK

This paper presents novel methodologies for efficient deployment of flexible *** populations of price-responsive loads are coordinated through a price signal and a power constraint broadcast by a central *** quantities are designed in order to minimise a global objective function(*** generation costs)and ensure a one-step convergence to a stable solution,characterised as a Nash *** for the sought equilibrium are preliminarily expressed as monotonicity of demand profiles under reordered coordinates and then they are imposed as constraints of a global optimisation,whose solution is calculated *** reduce the computational complexity of the problem in scenarios with high penetration of flexible demand,clustering of the appliances is *** global properties of the final stable solution and its optimality with respect to the task times of the appliances are analysed both theoretically and through simulation results.

关键词： Electric power network demand response game theory distributed control

Relation between skeletal muscle volume and prognosis in rectal cancer patients undergoing neoadjuvant therapy

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 423-433页

作者： paola de Nardi Alessandro Giani Giulia Maggi Marco Braga department of Gastrointestinal Surgery IRCCS San Raffaele Scientific InstituteMilano 20132Italy department of Surgery School of MedicineUniversity of Milano-BicoccaMilan ItalyMonza 20900Italy department of Oncologic Surgery Policlinico CasilinoRome 00169Italy department of Surgery San Gerardo HospitalUniversity Milano BicoccaMonza 20900Italy

The prognostic role of body composition indexes,and specifically sarcopenia,has recently been explored in different cancer ***,conflicting results have been *** in cancer type,cancer stage or oncological treatments,as well as different methodology and definition of sarcopenia,could be accounted for different conclusions retrieved from *** focusing on colorectal cancer,it clearly appears that colon and rectal cancers are often treated as a single entity though they have different behaviors and ***,patients with advanced rectal cancer represent a peculiar group of patients that according to current guidelines are treated with neoadjuvant chemotherapy and radiotherapy followed by radical *** review was restricted to a homogeneous group of patients with advanced lower rectal cancer and the aim of exploring whether there is a correlation between skeletal muscle depletion and *** was searched for articles related to patients with advanced rectal cancer undergoing neoadjuvant chemo-radiotherapy(NCRT)followed by radical surgery,in whom muscle mass and/or change in muscle mass during neoadjuvant treatment were *** full-text articles were selected and included in the present *** main findings of our review were:(1)The majority of the studies defined sarcopenia as muscle mass alone over muscle strength or physical performance;(2)There was a great deal of heterogeneity in the definition and measures of sarcopenia,in the definition of cut-off values,and in the method to measure change in muscle mass;(3)There was not full agreement on the association between sarcopenia at baseline and/or after chemoradiotherapy and prognosis,and only few studies found a significance in the multivariate analysis;and(4)It seems that a loss in skeletal muscle mass during NCRT is associated with the worst outcomes in terms of disease-free *** conclusion,analysis of muscle mass might provid

关键词： Advanced rectal cancer Sarcopenia Neoadjuvant treatment Chemoradiotherapy Surgery Muscle mass change Prognosis Survival Review

Functionalization of micropipette tips with hydrophobin-laccase chimera and application to the electrochemical determination of caffeic acid in tea samples

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Food Bioscience 2023年第2期52卷 1362-1368页

作者： Ilaria Stanzione Anna Pennacchio alessandra Piscitelli paola Giardina b Estefania Costa-Rama M.Teresa Fernandez-Abedul department of Physical and Analytical Chemistry University of OviedoSpain department of Chemical Sciences University of Naples“Federico II”Italy

Performing on-site measurements is one of the main challenges of current(bio)chemical *** tips,which are among the most common utilities in laboratories,can be useful and cheap elements for designing out-of-the-box innovative analytical ***,most of the analytical properties of these bioplatforms depend on the immobilization of the recognition element(e.g.,enzymes).In this context,we have recently designed a chimeric protein in which laccase PoxA1b from the fungus Pleurotus ostreatus has been genetically fused to the class I hydrophobin *** ability to self-assemble at hydrophobic-hydrophilic interfaces of hydrophobin,allows an easy laccase *** this work,the Vmh2-PoxA1b fusion protein was immobilized into common polypropylene micropipette tips to develop an innovative enzymatic bioplatform that can produce fast results in a simple *** proof of applicability,the platform was applied to the determination of caffeic acid by enzymatic oxidation and further electrochemical reduction of the product on a screen-printed electrode,achieving a limit of detection of 1.4-10^(-6) *** was then used for determining caffeic acid in tea samples.

关键词： Fusion protein Laccase Micropipette tips Electrochemical detection Caffeic acid

Profiling of phenol content and microbial community dynamics during pate olive cake fermentation

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Food Bioscience 2023年第2期52卷 170-178页

作者： paola Foti Nunziatina Russo Cinzia LRandazzo Altino Branco Choupina alessandra Pino Cinzia Caggia Flora V.Romeo Dipartimento di Agricoltura Alimentazione e Ambiente-Di3AUniversita degli Studi di Cataniavia S.Sofia 10095123CataniaItaly ProBioEtna srl Spin off of University of Cataniavia S.Sofia 10095123CataniaItaly Centro de Investigacao de Montanha(CIMO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BraganccPortugal Laboratorio para a Sustentabilidade e Tecnologia em Regioes de Montanha Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragançaPortugal Consiglio per la Ricerca in Agricoltura e l’Analisi dell’Economia Agraria(CREA) Centro di Ricerca OlivicolturaFrutticoltura e AgrumicolturaCorso Savoia 19095024AcirealeItaly

In this study,different microbial strains,as single and mixed-cultures,were used to ferment the pate olive cake(POC),a by-product of olive oil *** particular,strains belonging to Candida boidinii,Wickerhamomyces anomalus and Lactiplantibacillus plantarum were *** fermentation was carried out on diluted(3:2)POC without and with glucose(2%w/v)***,phenolic compounds were monitored during fermentation in POC added with glucose differetly inoculated and the microbial community,at the end of fermentation,was evaluated by Next Generation Sequencing(NGS)*** highlighted that inoculated samples showed an hydroxytyrosol content higher than the un-inoculated *** particular,during fermentation the sample inoculated with ***,both in single and in mixed culture together with ***,increased the hydroxytyrosol content by 275 and 261 mg/L,respectively,after 8 days,to reach the highest content at the end of *** analysis revealed a low abundance of 16S ribosomal RNA genes and fungal ITS in all samples at any sampling ***,at the end of fermentation,all samples exhibited a different bacterial community with a decrease in acetic acid bacteria and an increase in Lactobacillaceae ***,no effect was detected in any samples on fungal metagenomic profile,where Dipodascus geotrichum was found dominant both at initial and final *** conclusion,the present study confirmed that selected cultures can drive the fermentation and have an impact on the phenolic profile.

关键词： Olive by-products Yeast Lactic acid bacteria Fermentation Phenols Microbial dynamics

Photocatalytic activity of Eu-doped ZnO prepared by supercritical antisolvent precipitation route:When defects become virtues

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Journal of Materials Science & Technology 2022年第17期112卷 49-58页

作者： Olga Sacco paola Franco Iolanda de Marco Vincenzo Vaiano Emanuela Callone Riccardo Ceccato Francesco Parrino department of Chemistry and Biology“A.Zambelli” University of Salernovia Giovanni Paolo II13284084 Fisciano SalernoItaly department of Industrial Engineering Univerisity of SalernoVia Giovanni Paolo II 13284084 Fisciano SalernoItaly department of Industrial Engineering University of TrentoVia Sommarive 930123 TrentoItaly

The aim of this work is to determine the structural and optical properties of Eu-doped ZnO powders prepared by supercritical antisolvent precipitation route(SAS)and to correlate the physico-chemical features with the photocatalytic activity under UV *** and EPR spectroscopy highlight the introduction of novel defects(mainly singly and doubly ionized oxygen vacancies,and oxygen interstitials)on the Eu-doped ZnO samples,which confer higher hydrophilicity to the doped samples with respect to bare ZnO,as evidenced by FT-IR ***,photoluminescence spectra show that the presence of Eu^(3+) totally quenches the visible light emission typical of bare ZnO,which mainly results from the recombination of photogenerated holes at defective *** prepared samples were tested both for the photocatalytic degradation of crystal violet dye(CV)and for the partial oxidation of ferulic acid under UV *** photocatalytic activity results evidence of a higher ability of Eu-doped photocatalysts to degrade CV and ferulic acid,while higher selectivity values towards vanillin are obtained in the presence of bare *** higher activity of Eu-doped ZnO photocatalysts is linked to the stabilization of photogenerated holes and to their higher hydrophilicity,both brought by the generation of defective sites induced by the presence of Eu^(3+) ions within the ZnO lattice.

关键词： Europium doped ZnO Supercritical antisolvent precipitation Crystal violet Vanillin Photocatalysis UV light defective sites

The potentially crucial role of quasi-particle interferences for the growth of silicene on graphite

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Nano Research 2020年第9期13卷 2378-2383页

作者： Fatme Jardali Christoph Lechner Maurizio de Crescenzi Manuela Scarselli Isabelle Berbezier paola Castrucci Holger Vach LPICM CNRSEcole PolytechniqueIP ParisPalaiseau 91128France Dipartimento di Fisica Universita di Roma"Tor Vergata"Roma 00133Italy CNRS Aix-Marseille UniversiteIM2NPMarseille 13397France

A comprehensive picture of the initial stages of silicene growth on graphite is *** is shown that quasiparticle interferences play a crucial role in the formation of the observed silicene *** propose,on one hand,that the charge modulations caused by those quantum interferences serve as templates and guide the incoming Si atoms to self-assemble to the unique(√3 x√3)R30°honeycomb atomic *** the other hand,their limited extension limits the growth to about 150 Si atoms under our present deposition *** here proposed electrostatic interaction finally explains the unexpected stability of the observed silicene islands over time and with *** the robust guiding nature of those quantum interferences during the early growth phase,we demonstrate that the window of experimental conditions for silicene growth is quite narrow,making it an extremely challenging experimental ***,it is shown that the experimentally observed threedimensional silicon clusters might very well be the simple result of the end of the silicene growth resulting from the limited extent of the quasi-particle interferences.

关键词： silicene growth highly oriented pyrolytic graphite(HOPG) ab initio calculations scanning tunneling microscopy(STM) quasi-particle interferences two-dimensional(2D)self-assembly