检索结果-南通市图书馆

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

The inflammasomes in health and disease:from genetics to molecular mechanisms of autoinflammation and beyond

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2011年第2期8卷 135-145页

作者： Cristina Conforti-Andreoni paola Ricciardi-Castagnoli alessandra Mortellaro Singapore Immunology Network(SIgN) Agency for ScienceTechnology and Research(A*STAR)ImmunosSingapore

Nucleotide-binding oligomerization domain(NOD)-containing protein-like receptors(NLRs)are a recently discovered class of innate immune receptors that play a crucial role in initiating the inflammatory response following pathogen *** NLRs form the framework for cytosolic platforms called inflammasomes,which orchestrate the early inflammatory process via IL-1b *** and polymorphisms in NLR-coding genes or in genetic loci encoding inflammasome-related proteins correlate with a variety of autoinflammatory ***,the activity of certain inflammasomes is associated with susceptibility to infections as well as autoimmunity and *** this review,we will discuss how identifying the genetic characteristics of inflammasomes is assisting our understanding of both autoinflammatory diseases as well as other immune system-driven disorders.

关键词： autoinflammatory diseases polymorphisms NLRs NLRP3

Multidisciplinary approach to suspected sudden unexpected infant death caused by milk-aspiration:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第18期8卷 4128-4134页

作者： Aniello Maiese Raffaele La Russa Mauro Arcangeli Gianpietro Volonnino alessandra de Matteis paola Frati Vittorio Fineschi department of Surgical Pathology MedicalMolecular and Critical AreaInstitute of Legal MedicineUniversity of PisaPisa 56126Italy department of Anatomy HistologyForensic Medicine and OrthopedicsSapienza University of RomaRoma 00185Italy department of Life Health and Environmental SciencesUniversity of L'AquilaL'Aquila 67100Italy department SAIMLAL Sapienza University of RomaRoma 00185Italy

BACKGROUND The term sudden unexpected infant death(SUID)is not always properly *** refers to a broad range of conditions that sometimes defy *** is not only a strong emotional impact on the family,but such cases are also quite *** causes may be multiple,not always readily apparent,and have potential repercussions,especially in terms of *** SUMMARY A 5-month-old male baby was pronounced dead following acute lung failure and cardiopulmonary *** parents had immediately rushed their child to the hospital,stating the baby was found prone and not ***-body postmortem computed tomography(PMCT)was performed,revealing a hypodense material of indeterminate nature within the main airways and areas of ground-glass parenchymal *** autopsy,the respiratory tract mucosa appeared edematous and was coated with a whitish stringy *** was widespread airspace reduction due to parenchymal *** sacs and bronchial openings contained abundant amorphous material admixed with white blood *** studies were performed,targeting CD15,CD68,and ***,the focus was on alpha-lactalbumin(milk protein),which showed marked immunopositivity within alveolar *** staining of macrophages was also particularly *** Postmortem investigations are thus essential to identify causes of death and surrounding *** is a useful tool in this setting,given the frequent dearth of autopsy findings and ambiguity as to cause of death in SUID *** findings,later confirmed by immunohistochemical investigations,were indicative of active pneumonia due to aspirated *** present account illustrates the importance a broad diagnostic approach to SUID in cases of forensic *** is a very valuable aid in cases of forensic interest,as it can provide useful information in all those situations in which the cause of death is uncertain or

关键词： Sudden unexpected infant death Aspiration pneumonia Postmortem computed tomography Case report Diagnosis Immunohistochemistry

How reliable is current imaging in restaging rectal cancer after neoadjuvant therapy?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第36期19卷 5964-5972页

作者： paola de Nardi Michele Carvello department of Surgery San Raffaele Scientific Institute department of Surgery Utrecht University Medical Center

In patients with advanced rectal cancer,neoadjuvant chemo radiotherapy provides tumor downstaging and downsizing and complete pathological response in up to 30%of *** proctectomy complete pathological response is associated with low rates of local recurrence and excellent long term *** authors claim a less invasive surgery or a non operative policy in patients with partial or clinical complete response respectively,however to identify patients with true complete pathological response before surgical resection remains a *** imaging techniques have been reported to be highly accurate in the primary staging of rectal cancer,however neoadjuvant therapy course produces deep modifications on cancer tissue and on surrounding structures such as overgrowth fibrosis,deep stroma alteration,wall thickness,muscle disarrangement,tumor necrosis,calcification,and inflammatory *** a result,the same imaging techniques,when used for restaging,are far less *** tumor extent may be overestimated or *** diagnostic accuracy of clinical examination,rectal ultrasound,computed tomography,magnetic resonance imaging,and positron emission tomography using 18F-fluoro-2’-deoxy-Dglucose ranges between 25%and 75%being less than 60%in most studies,both for rectal wall invasion and for lymph nodes *** particular the ability to predict complete pathological response,in order to tailor the surgical approach,remains *** to the radio-induced tissue modifications,combined with imaging technical aspects,low rate accuracy is achieved,making modern imaging techniques still unreliable in restaging rectal cancer after chemo-radiotherapy.

关键词： Rectal cancer Restaging Neoadjuvant therapies Diagnostic accuracy Complete pathological response

Endoluminal vacuum-assisted therapy to treat rectal anastomotic leakage:A critical analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第14期28卷 1394-1404页

作者： Andrea Vignali paola de Nardi department of Gastrointestinal Surgery IRCCS San Raffaele Scientific InstituteMilano 20132Italy department of Surgery Vita-Salute UniversityMilano 20132Italy

Endoluminal vacuum-assisted therapy(EVT)has been introduced recently to treat colorectal anastomotic leaks in clinically stable non-peritonitic *** application has been mainly reserved to low colorectal and colo-anal *** main advantage of this new procedure is to ensure continuous drainage of the abscess cavity,to promote and to accelerate the formation of granulation tissue resulting in a reduction of the abscess *** reported results are promising allowing a higher preservation of the anastomosis when compared to conventional treatments that include trans-anastomotic tube placement,percutaneous drainage,endoscopic clipping of the anastomotic defect or stent ***,despite this procedure is gaining acceptance among the surgical community,indications,inclusion criteria and definitions of success are not yet standardized and extremely heterogeneous,making it difficult to reach definitive conclusions and to ascertain which are the real benefits of this new ***,long-term and functional results are poorly *** present review is focused on critically analyzing the theoretical benefits and risks of the procedure,short-and long-term functional results and future direction in the application of EVT.

关键词： Anastomotic leakage Rectal surgery Endoluminal vacuum therapy Endosponge Complications

Multidisciplinary treatment of rectal cancer in 2014: Where are we going?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第32期20卷 11249-11261页

作者： Andrea Vignali paola de Nardi department of Surgery San Raffaele Scientific Institute Vita Salute University

In the present review we discuss the recent developments and future directions in the multimodal treatment of locally advanced rectal cancer, with respect to staging and re-staging modalities, to the current role of neoadjuvant chemo-radiation and to the conservative and more limited surgical approaches based on tumour response after neoadjuvant combined therapy. When initial tumor staging is considered a high accuracy has been reported for T pre-treatment staging, while preoperative lymph node mapping is still suboptimal. With respect to tumour re-staging, all the current available modalities still present a limited accuracy, in particular in defining a complete response. The role of short vs long-course radiotherapy regimens as well as the optimal time of surgery are still unclear and under investigation by means of ongoing randomized trials. Observational management or local excision following tumour complete response are promising alternatives to total mesorectal excision, but need further evaluation, and their use outside of a clinical trial is not *** preoperative selection of patients who will benefit from neoadjuvant radiotherapy or not, as well as the proper identification of a clinical complete tumour response after combined treatment modalities,will influence the future directions in the treatment of locally advanced rectal cancer.

关键词： Rectal cancer Cancer staging Cancer restaging Neoadjuvant chemoradiation Response Treatment Local control Local excision Complete pathologic response Rectal cancer surgery

A molecular phenology scale of grape berry development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2023年第5期10卷 72-84页

作者： Giovanni Battista Tornielli Marco Sandri Marianna Fasoli alessandra Amato Mario Pezzotti paola Zuccolotto Sara Zenoni department of Biotechnology University of VeronaStrada Le Grazie 1537134 VeronaItaly Big&Open Data Innovation Laboratory University of BresciaC.da S.Chiara 5025122 BresciaItaly

Fruit growth and development consist of a continuous succession of physical,biochemical,and physiological changes driven by a genetic program that dynamically responds to environmental *** recognizable stages over the whole fruit lifetime represents a fundamental requirement for research and fruit crop *** is especially relevant in perennial crops like grapevine(Vitis vinifera L.)to scale the development of its fruit across genotypes and growing *** this work,molecular-based information from several grape berry transcriptomic datasets was exploited to build a molecular phenology scale(MPhS)and to map the ontogenic development of the *** proposed statistical pipeline consisted of an unsupervised learning procedure yielding an innovative combination of semiparametric,smoothing,and dimensionality reduction *** transcriptomic distance between fruit samples was precisely quantified by means of the MPhS that also enabled to highlight the complex dynamics of the transcriptional program over berry development through the calculation of the rate of variation of MPhS stages by *** MPhS allowed the alignment of time-series fruit samples proving to be a complementary method for mapping the progression of grape berry development with higher detail compared to classic time-or phenotype-based approaches.

关键词： crops yielding lifetime

COVID-19 emergency: Changes in quality of life perception in patients with chronic liver disease-An Italian single-centre study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2022年第1期14卷 274-286页

作者： alessandra Zannella Silvia Fanella Massimo Marignani paola Begini department of Gastroenterology Sant’Andrea HospitalRome 00189Italy

BACKGROUND In december 2019,the coronavirus disease-2019(COVID-19)emerged and rapidly spread worldwide,becoming a global health threat and having a tremendous impact on the quality of life(QOL)of *** To evaluate the awareness of patients with chronic liver disease(CLD)regarding the COVID-19 emergency and how it impacted on their *** Patients with an established diagnosis of CLD(cirrhosis,autoimmune hepatitis,primary biliary cholangitis,and primary sclerosing cholangitis)who had been evaluated at our Outpatient Liver Disease Clinic during the 6-mo period preceding the start of Italian lockdown(March 8,2020)were *** were asked to complete a two-part questionnaire,administered by telephone according to governmental restrictions:The first section assessed patients’basic knowledge regarding COVID-19,and the second evaluated the impact of the COVID-19 emergency on their *** used the Italian version of the CLD questionnaire(CLDQ-I).With the aim of evaluating possible changes in the QOL items addressed,the questionnaire was administered to patients at the time of telephone contact with the specific request to recall their QOL perceptions during two different time *** detail,patients were asked to recall these perceptions first during time 0(t0),a period comprising the 2 wk preceding the date of ministerial lockdown decree(from February 23 to March 7,2020);then,in the course of the same phone call,they were asked to recall the same items as experienced throughout time 1(t1),the second predetermined time frame encompassing the 2 wk(from April 6 to April 19)preceding our telephone contact and questionnaire *** data are expressed as number(%),and continuous variables are reported as the median(interquartile range).The data were compared using the Wilcoxon paired non-parametric *** A total of 111 patients were enrolled,of whom 81 completed the ***-nine had liver cirrhosis,and all of them had c

关键词： COVID-19 Liver disease Quality of life Liver cirrhosis Chronic liver disease questionnaire

New approach to anal cancer:Individualized therapy based on sentinel lymph node biopsy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第44期18卷 6349-6356页

作者： paola de Nardi Michele Carvello Carlo Staudacher Surgical department San Raffaele Scientific Institute20132 MilanItaly

Oncological treatment is currently directed toward a tailored therapy *** cell carcinoma of the anal canal could be considered a suitable platform to test new therapeutic strategies to minimize treatment *** of care for patients with anal canal cancer consists of a combination of radiotherapy and *** treatment has led to a high rate of local control and a 60% cure rate with preservation of the anal sphincter,thus replacing surgical abdominoperineal *** node metastases represent a critical independent prognostic factor for local recurrence and *** and iliac lymph nodes are usually included in the radiation field,whereas the inclusion of inguinal regions still remains controversial because of the subsequent adverse side *** lymph node biopsies could clearly identify inguinal node-positive patients eligible for therapeutic groin irradiation.A sentinel lymph node navigation procedure is reported here to be a feasible and effective method for establishing the true inguinal node status in patients suffering from anal canal *** on the results of sentinel node biopsies,a selective approach could be proposed where node-positive patients could be selected for inguinal node irradiation while node-negative patients could take advantage of inguinal sparing irradiation,thus avoiding toxic side effects.

关键词： Anal carcinomal Lymphnode metastasis Sen-tinel lymphnode Tumor staging