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Patients admitted in the intensive care unit after solid organ or bone marrow transplantation:Retrospective cohort study

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World Journal of Transplantation 2025年第1期15卷 95-104页

作者： Ana Vujaklija Brajkovic Iva Kosuta Lucija Batur sara sundalic Marijana Medic andro Vujevic Luka Bielen Jaksa Babel Department of Internal Medicine University Hospital Centre ZagrebZagreb 10000Croatia school of Medicine University of ZagrebZagreb 10000Croatia

BACKGROUND solid organ transplantation(sOT)and hematopoietic stem cell transplantation(HsCT)revolutionized the survival and quality of life of patients with malignant diseases,various immunologic,and metabolic disorders or those associated with a significant impairment in a patient's quality of *** To investigate admission causes and treatment outcomes of patients after sOT or HsCT treated in a medical intensive care unit(ICU).METHODs We conducted a single-center,retrospective epidemiological study in the medical ICU at the University Hospital Centre Zagreb,Croatia covering the period from January 1,2018 to December 31,*** The study included 91 patients with either sOT[28 patients(30.8%)]or HsCT[63 patients(69.2%)].The median age was 56(43.2-64.7)years,and 60.4%of the patients were *** with sOT had more comorbidities than patients after HsCT[χ^(2)(5,n=141)=18.513,Psepsis and septic shock were the most frequent reasons for admission,followed by acute respiratory insufficiency in patients following *** rate significantly differed between sOT and HsCT[χ^(2)(1,n=91)=21.767,Psurvival was 57%in the sOT and 12.7%in the HsCT *** need for mechanical ventilation[χ^(2)(1,n=91)=17.081,Psopressor therapy[χ^(2)(1,n=91)=36.803,Ps associated with *** necessity for acute renal replacement therapy did not influence patients'survival[χ^(2)(1,n=91)=0.376,P=0.54].In the subgroup of patients with infection,90%had septic shock,and the majority had positive microbiological samples,mostly Gram-negative *** ICU survival of patients with sepsis/septic shock cumulatively was 15%.The survival of sOT patients with sepsis/shock was 45%.CONCLUsION Patients with sOT or HsCT are frequently admitted to the ICU due to sepsis and septic *** advancements in critical care,the mortality rate of patients with refractory septic shock and multiorgan failure in this patient population is extremely hig

关键词： Liver transplantation Kidney transplantation Hematopoietic stem cell transplantation Critical care sepsis septic shock Mortality

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“读者”莫言的“他者”之镜

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扬子江文学评论 2021年第3期 65-70页

作者： [法]尚德兰范加慧(译) 黄荭(校) 巴黎第七大学东亚文化研究中心南京大学法语系

本文的目的不在于罗列某位中国或外国作家对莫言作品的影响,也不想指出他对某位作家的“借用”(莫言作品中某位作家的“印记”),也不谈“相似”“滋养”“挪用”,甚至对其他作家有“继承”或“剽窃”这类更有争议的说法。诚然,上述研究... 详细信息

本文的目的不在于罗列某位中国或外国作家对莫言作品的影响,也不想指出他对某位作家的“借用”(莫言作品中某位作家的“印记”),也不谈“相似”“滋养”“挪用”,甚至对其他作家有“继承”或“剽窃”这类更有争议的说法。诚然,上述研究在互文性领域十分重要,现代信息技术和数据处理手段已为研究者提供了诸多便利,确实应当对莫言作品开展此类分析。

关键词：莫言作品外国作家数据处理手段现代信息技术互文性

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PRss3/mesotrypsin in prostate cancer progression： mplications for translational medicine

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Asian Journal of andrology 2013年第4期15卷 439-440页

作者： Evette s Radisky Department of Cancer Biology Mayo Clinic ComprehensiveCancer Center Jacksonville FL 32224 USA

prostate cancer morbidity and morta lity are caused by metastasis to othervital organs and tissues. Metastatic prostate cancer is a terminal disease in need of improved therapies. Hoclda et al. have iden tified prostate cancer cell upregulation of the digestive protease PRss3/mesotrypsin in association with metastasis and recur rence. Gene silencing of PRss3 led to pronounced reductions in invasion and metastasis in cell culture and in an orthoto pic mouse model of prostate cancer. Importantly, a recently developed inhibitor of mesotrypsin was equally effective in sup pressing invasion. These results identify mesotrypsin as a potential therapeutic tar get in metastatic prostate cancer. Prostate cancer is a disease that can lie latent for decades or can progress rapidly to systemic metastasis and deathand the molecular pathways that distinguish between indolent and aggressive cancers are not well defined. Assessment of patient prognosis is therefore a critical challengewho is likely to benefit from further interventions, and who should be spared further treatment？ Prostatespecific antigen assays provide a valuable surveillance tool, but prostatespe cific antigen is not a specific marker for aggressive prostate cancers, and only a frac tion of the many men who experience pro statespecific antigen relapse after initial treatment will ever develop overt meta stasis.1＇2 Thus, there is an unmet clinical need for additional and more specific biomarkers that define subsets of patients at greatest risk of metastatic progression. An additional unmet need is encountered by patients with advanced diseasecurrent therapies are inadequate, since metastatic prostate cancerinevitably develops resistance to androgen deprivation therapy, at which time sub sequent treatment of castrationresistant pro state cancer with standard chemotherapy agent docetaxel, and even with newer regi mens incorporating agents that block andro gen signaling via alternative mechanisms, can provide only mod

关键词： PRss3/mesotrypsin progression implications

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Characterization and functions of beta defensins in the epididymis

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Asian Journal of andrology 2007年第4期9卷 453-462页

作者： susan H. Hall suresh Yenugu Yashwanth Radhakrishnan Maria Christina W. Avellar Peter Petrusz Frank s. French Laboratories for Reproductive Biology University of North Carolina at Chapel Hill NC 27599-7505 USA Department of Biochemistry and Molecular Biology Pondicherry Central University Pondicherry 605014 India section of Experimental Endocrinology Department of Pharmacology Universidade Federal de Sao Paulo SP 04044-020 Brazil

The epididymal β-defensins have evolved by repeated gene duplication and divergence to encode a family of proteins that provide direct protection against pathogens and also support the male reproductive tract in its primary function. Male tract defensins also facilitate recovery from pathogen attack. The β-defensins possess ancient conserved sequence and structural features widespread in multi-cellular organisms, suggesting fundamental roles in species survival. Primate sPAG11, the functional fusion of two ancestrally independent β-defensin genes, produces a large family of alternatively spliced transcripts that are expressed according to tissue-specific and species-specific constraints. The complexity of sPAG11 varies in different branches of mammalian evolution. Interactions of human sPAG11D with host proteins indicate involvement in multiple signaling pathways. （Asian J andro12007 July; 9： 453- 462）

关键词： defensin antibacterial male fertility

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Effect of GABA on sperm acrosome reation in antisperm antibody positive patients

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Asian Journal of andrology 2002年第4期4卷 306-306页

作者： s.L. Bian, W. Zhang, H. Zhu, et al Department of Physiology, Harbin Medical University, Harbin 150086, China

To investigate the effect of gamma-aminobutyric acid (GABA) on the rate of sperm acrosome reaction both in normal and antisperm antibody (AsAb) positive men. Methods: The sperm acrosome reaction was tested with triplestain technique in two groups of 18 men each. Results: (1) GABA increased the rate of sperm acrosome reaction both in normal and AsAb positive subjects (Psed the Na^+-K^+-ATPase activity of sperm (Psed the Ca^(2+)-ATPase activity of sperm (Psed the production of MDA and oxygen free radicals of sperm. Conclusion: GABA could regulate the rate of sperm acrosome reaction. (Chin J andro12002; 16: 355)

关键词： GABA antisperm antibody acrosome reaction

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