检索结果-南通市图书馆

Advances in Breast Cancer Research 2015年第4期4卷 109-113页

作者： Timur S. Balmukhanov Alexandra K. Khanseitova Victoria G. Nigmatova alena S. Neupokoeva Daria A. Sharafutdinova Nagima A. Aitkhozhina Department of Structural and Functional Genomics M. Aitkhozhin Institute of Molecular Biology and Biochemistry Almaty Republic of Kazakhstan

Worldwide, breast cancer (BC) is the most common invasive cancer in women. Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase receptor that is a member of the family of individually distinct fibroblast growth factor receptors involved in tumorigenesis. FGFR2 gene is amplified and over expressed in breast cancer (1 - 3). The aim of the study was to determine whether polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in FGFR2 gene are associated with breast cancer susceptibility in the population of Kazakhstan. The statistically significant associations between SNPs analyzed and breast cancer risk according χ2 and p < 0.05 criterions were not evaluated. The information describing the association of SNPs in FGFR2 with BC risk in the world populations could not be unambiguously used for Kazakhstan population.

关键词： Fibroblast Growth Factor Receptor 2 (FGFR2) Single Nucleotide Polymorphism (SNP) Association Breast Cancer (BC) Kazakhstan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

信任对支持再分配的影响

中国社会保障 2018年第8期 36-38页

作者：吴孝芹 Nazim Habibov Alex Cheung alena Auchynnikava 山东工商学院公共管理学院中国社科院研究生院

人际信任是社会资本的核心概念，可用个人对他人甚至陌生人的伙伴关系认知来反映。研究信任对支持再分配的影响，需考虑两大问题：人际信任是否会提高对再分配政策的支持力度，人际信任是否会影响个人通过多付税向穷人再分配的意愿。

关键词：再分配政策人际信任社会资本伙伴关系支持力度陌生人个人穷人

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

是否有一个晶格具有五重对称性？

数学译林 2016年第4期35卷 300-310页

作者： Michal Krizek Jakub Solc alena Solcova 郭磊磊(译) 孙宇阳(校) 捷克科学院数学研究所捷克技术大学

***镶嵌问题德国学者Kepler（开普勒，15711630），在布拉格他曾作为罗马皇帝鲁道夫二世的一个宫廷数学家，以他的天文发现闻名于世．今天我们仍然很欣赏他从Tycho Brahe（1546-1601．丹麦贵族，天文学家编注）观测的火星数据中分析出... 详细信息

***镶嵌问题德国学者Kepler（开普勒，15711630），在布拉格他曾作为罗马皇帝鲁道夫二世的一个宫廷数学家，以他的天文发现闻名于世．今天我们仍然很欣赏他从Tycho Brahe（1546-1601．丹麦贵族，天文学家编注）观测的火星数据中分析出行星运动的三大定律的能力．

关键词：对称性晶格天文发现行星运动天文学家开普勒数学家布拉格

Prognostic Significance of Comparison of Clinical Indicators with Manifestations of Genetic Polymorphism of Glutathione-S-Transferases in Non-Small Cell Lung Cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2018年第12期9卷 962-973页

作者： Mikhail N. Shapetska Evelina V. Krupnova alena P. Mikhalenka Natalia V. Chebotareva Anna N. Shchayuk Svetlana G. Pashkevich Alexander V. Prokhorov Belarusian State Medical University Minsk Republic of Belarus Institute of Genetics and Cytology of the National Academy of Sciences of Belarus Minsk Republic of Belarus Institute of Physiology of the National Academy of Sciences of Belarus Minsk Republic of Belarus

The article presented the results of comparison of polymorphic variants of the genes GSTM1, GSTT1, GSTP1 and clinical manifestations of non-small cell lung carcinoma. The association of the genotype GSTT1 (del) with the risk of developing squamous cell lung cancer has been revealed (OR = 2.54 CI: 1.13 - 5.72, p = 0.035). Analysis of patient survival rate (n = 173) in groups of various histological types of lung cancer showed that in the group of squamous cell lung cancer (n = 91) in patients with genotype GSTT1 (del), the survival rate median was significantly higher—84 months (95% CI 12.4 - 155.7) than in patients with the genotype GSTT1 (+)—36 months (95% CI 25.2 - 46.8, p = 0.045). In contrast, in the adenocarcinoma group (n = 82), the survival rate median in patients with the genotype GSTT1 (del) was 19 months. (95% CI 6.2 - 33.5), and in patients with genotype GSTT1 (+)—67 months (95% CI 50.1 - 84.0), which is the basis for continuing this comparison in an additional group of testees, as the sampling did not achieve the reliability of p = 0.12. Hypothetically, these differences may be due to differences in the gender composition of squamous cell lung cancer and adenocarcinoma and the involvement of GST enzymes in the metabolism of estrogens in adenocarcinoma in women and other hormonal background and reactivity of the male body with squamous cell carcinoma. Further research and subsequent analysis of the results will be aimed at confirming this hypothesis.

关键词： Squamous Cell Lung Carcinoma Adenocarcinoma Glutathione-S-Transferase Survival Rate

Remarkable variation of ribosomal（rDNA） DNA in gnetophytes, a distinct lineage of gymnosperms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Remarkable variation of ribosomal（rDNA） DNA in gnetophytes...

中国植物学会第十六次全国会员代表大会暨85周年学术年会

作者： Wencai Wang Tao Wan Hannes Becher alena Kuderova Ilia J.Leitch Sònia Garcia ANDrew R.Leitch Ale? Kova?ík Institute of Clinical Pharmacology Guangzhou University of Chinese Medicine School of Biological and Chemical Sciences Queen Mary University of London Key Laboratory of Southern Subtropical Plant Diversity Fairy Lake Botanical GardenShenzhen & Chinese Academy of Science Sino-Africa Joint Research Center Chinese Academy of Science Institute of Biophysics Academy of Sciences of the Czech Republic Jodrell Laboratory Royal Botanic Gardens

Gnetophytes,comprising genera Ephedra,Gnetum and Welwitschia are an understudied,enigmatic lineage of *** we examined the organization of ribosomal DNA（rDNA） across representative *** applied high throughput sequencing approaches to isolate and reconstruct rDNA units and to determine their intragenomic *** addition,fluorescent in situ hybridization（FISH） and Southern blot hybridization techniques were used to reveal the chromosome and genomic organization of *** found that:（i） the 5 S and 35 S rDNAs were separate in ***,*** and *** and linked in ***;（ii） there was huge variability variability in 5 S rDNA abundance（4,000-100,000 copies per haploid genome） and locus numbers（2-16 sites per diploid genome）;（iii） 5 S rRNA pseudogenes were interspersed between functional genes forming single unit in *** and ***;（iv） in *** internal transcribed spacers（ITS1） of 35 S rDNA were long and intrinsically repetitive while in *** and *** the ITS1 were short without *** conclusion,gnetophytes are distinctive from other gymnosperms and angiosperms as they display a surprisingly high variability in rDNA organization,rDNA copy and locus numbers between genera,with no relationship between copy numbers and genome sizes *** evolution of 5 S rDNA units seems to have led to the amplification of 5 S pseudogenes in both *** and *** patterns of rDNA show both gymnosperm and angiosperm features underlining diversity and distinctness of the group.

关键词： gnetophytes rDNA organization chromosome evolution high through-put sequencing concerted evolution pseudogenes intragenomic diversity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

斯洛伐克中医药发展现状与分析

国际中医中药杂志 2021年第3期43卷 224-228页

作者：胥静 Eugenia Bellova IvaničBoris alena Ondrejkovicova Lucia Kosikova 魏竞竞赵静许家杰曹洪欣中国中医科学院中医临床基础医学研究所2009年行业专项办公室北京100700 中国中医科学院眼科医院北京100040 斯洛伐克贝洛娃医生诊所日利纳03601 斯洛伐克平衡诊所布拉迪斯拉发83101 斯洛伐克针灸学会布拉迪斯拉发83101 斯洛伐克SHEN中医诊所布拉迪斯拉发83101 北京中医药大学 100029 中国中医科学院西苑医院北京100091 美国洛杉矶加州大学东西医学中心 90024 中华中医药学会北京100029

斯洛伐克为地处欧洲内陆中部的议会共和制国家,实行强制保险医疗制度。导致该国居民死亡的主要疾病为缺血性心脏病、脑卒中、肺癌,近年来AD和高血压性心脏病致死率呈大幅度上升。斯洛伐克传统医学以顺势医学为主,目前中医及针灸尚未纳... 详细信息

斯洛伐克为地处欧洲内陆中部的议会共和制国家,实行强制保险医疗制度。导致该国居民死亡的主要疾病为缺血性心脏病、脑卒中、肺癌,近年来AD和高血压性心脏病致死率呈大幅度上升。斯洛伐克传统医学以顺势医学为主,目前中医及针灸尚未纳入医保。中医药等传统医学相关法律法规不健全,教育体系不完善及中药使用受限,使得中医药在当地的发展受到限制;未来希望通过中斯两国合作交流,促进中医药相关立法,加强中医药教育及民众普及,从而推动中医药的传播与发展。

关键词：医学传统斯洛伐克共和国保险健康中医药学国际合作现状分析

每人支付5欧元！这是威尼斯的入城费还是逐客令？

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults:Big Data from Seven Randomized Controlled Trials Worldwide

环球人文地理 2024年第1期 46-55页

作者：蒋雨宁 Edmond Yuen 张鹏 Luca Bravo canmandawe Tao Qi Daniil Markus Nikhg Nataliia Mark alena scaliger

想去威尼斯旅行吗？进城请先支付5欧元！据路透社消息，意大利威尼斯市长路易吉·布鲁尼亚罗宣布，将在2024年4月25日开始，对进入威尼斯的游客收费。市长表示，这项措施将会让城市变得“可预约”，既能控制客流，又能保障游客的出行体...

想去威尼斯旅行吗？进城请先支付5欧元！据路透社消息，意大利威尼斯市长路易吉·布鲁尼亚罗宣布，将在2024年4月25日开始，对进入威尼斯的游客收费。市长表示，这项措施将会让城市变得“可预约”，既能控制客流，又能保障游客的出行体验。意大利时间2023年11月27日，威尼斯市长宣布，从2024年4月起，游客进入威尼斯将不再免费。

关键词：

来源：博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Health Data Science 2021年第1期2021卷 174-183页

作者： Tao Huang Zhenhuang Zhuang Yoriko Heianza Dianjianyi Sun Wenjie Ma Wenxiu Wang Meng Gao Zhe Fang Emilio Ros Liana C.Del Gobbo Jordi Salas-Salvadó Miguel A.Martínez-González Jan Polak Markku Laakso Arne Astrup Dominique Langin Jorg Hager Gabby Hul Torben Hansen Oluf Pedersen Jean-Michel Oppert Wim H.M.Saris Peter Arner Montserrat Cofán Sujatha Rajaram Jaakko Tuomilehto Jaana Lindström Vanessa D.de Mello alena Stancacova Matti Uusitupa Mathilde Svendstrup Thorkild I.A.Sørensen Christopher D.Gardner Joan Sabaté Dolores Corella J.Alfredo Martinez Lu Qi Department of Epidemiology&Biostatistics School of Public HealthPeking UniversityChina Department of Global Health School of Public HealthPeking UniversityChina Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education China Global Health Institute Peking University China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLAUSA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMAUSA Department of Endocrinology&Nutrition Institut d’Investigacions Biomèdiques August Pi SunyerHospital ClínicBarcelonaSpain CIBER Fisiopatologia de la Obesidad y Nutrición(CIBERobn) Instituto de Salud Carlos III(ISCIII)MadridSpain Stanford Prevention Research Center Stanford UniversityStanford CAUSA Human Nutrition Unit Faculty of Medicine and Health SciencesPere Virgili Health Research InstituteRovira i Virgili UniversityReusSpain University of Navarra Department of Preventive Medicine and Public HealthMedical School&IDISNAPamplonaSpain Department for the Study of Obesity and Diabetes Third Faculty of MedicineCharles UniversityPragueCzech Republic Department of Medicine University of Eastern FinlandKuopioFinland University of Copenhagen Department of NutritionExercise and SportsFaculty of ScienceCopenhagenDenmark Institut National de la Santéet de la Recherche Médicale(Inserm) UMR1048Institute of Metabolic and Cardiovascular DiseasesUniversity of Toulouse and Paul Sabatier UniversityToulouseFrance NestléInstitute of Health Sciences LausanneSwitzerland Department of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical Centre+MaastrichtNetherlands Section of Metabolic Genetics Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Sorbonne Université Institute of Cardiometabolism and Nutrition(ICAN)Department of NutritionPitié-Salpêtrière HospitalAssistance Publique-

*** strongest locus which associated with type 2 diabetes(T2D)by the common variant rs7903146 is the transcription factor 7-like 2 gene(TCF7L2).We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits,body weight,or waist circumference in overweight or obese adults in several randomized controlled trials(RCTs).*** October 2016 to May 2018,a large collaborative analysis was performed by pooling individualparticipant data from 7 *** RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese *** treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all *** the joint analysis,a total of 7 eligible RCTs were included(n=4,114).Importantly,we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting *** with the control group,diet/lifestyle interventions were related to lower fasting glucose by-3.06(95%CI,-5.77 to-0.36)mg/dL(test for heterogeneity and overall effect:I^(2)=45:1%,p<0:05;z=2:20,p=0:028)per one copy of the TCF7L2 T risk ***,regardless of genetic risk,diet/lifestyle interventions were associated with lower waist ***,there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk *** findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.

关键词： TCF7L2 weight finding

Nature：死亡的肿瘤细胞释放出胞内钾离子来阻断免疫系统

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代生物医学进展 2016年第31期16卷 I0002-I0002页

作者： Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. Pan, Douglas C. Palmer, alena Gros, Tori N. Yamamoto, Shashank J. Patel, Geoffrey C. Guittard, Zhiya Yu, David S. Schrump, W. Marston Linehan, Nicholas P. Restifo Christopher A. Klebanoff Valentina Carbonaro, Klaus Okkenhaug, Rahul Roychoudhuri National Cancer Institute National Institutes of Health (NIH) Bethesda Maryland 20892 USA Center for Cell Engineering and Department of Medicine Memorial Sloan Kettering Cancer Center New York New York 10065 USA Laboratory of Lymphocyte Signalling and Development The Babraham Institute Cambridge CB22 3AT UK

在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。... 详细信息

在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。相关研究结果在线发表在Nature期刊上。

关键词：免疫系统肿瘤细胞死亡钾离子免疫细胞无机离子肿瘤组织研究人员