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Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural Regeneration Research 2025年第9期20卷 2591-2593页

作者： alena Salasova Anders Nykjær Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

Quantitative evaluation of LAL productivity of colloidal nanomaterials:Which laser pulse width is more productive,ergonomic,and economic?

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Chinese Physics B 2022年第7期31卷 23-33页

作者： alena Nastulyavichus Nikita Smirnov Sergey Kudryashov P.N.Lebedev Physical Institute of the Russian Academy of Sciences MoscowRussia

Near-IR(wavelength≈1μm)laser ablation of bulk,chemically-inert gold in water was compared for different laser pulse width in broad the range of 300 fs–100 ns,comparing a number of key ablation characteristics:mass loss,singleshot crater volume and extinction coefficient of the generated colloidal solutions taken in the spectral ranges of interband transitions and localized plasmon *** to related air-based ablation results,at the given fluences laser ablation in the liquid resulted in the maximum ablation yield per unit energy and maximum NP yield per pulse and per unit energy for the picosecond lasers,occurring at subcritical peak pulse powers for laser *** self-focusing effect was demonstrated to yield in incomplete,effectively weaker focusing in the water filaments of ultrashort laser pulses with supercritical peak powers,comparing to linear(geometrical)focusing at sub-critical peak *** the other,nanosecondpulse extreme the high ablation yield per pulse,but low ablation yield per unit energy and low NP yield per pulse and per unit energy were related to strong ablation plasma screening,providing mass removal according to the well-established scaling relationships for *** comparison of the ablation and nanoparticle generation efficiency versus the broad fs–ns laser pulse width range was enabled in terms of productivity,economicity,and ergonomicity,using the proposed universal quantitative criteria.

关键词： laser ablation of gold in liquid ablated mass critical power for self-focusing filamentation

Submicron particle sizing by aerodynamic dynamic focusing and electrical charge measurement

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Particuology 2015年第1期13卷 105-111页

作者： Zhongchao Tan Raheleh Givehchi alena Saprykina Department of Mechanical & Mechatronics Engineering University of Waterloo Department of Mechanical and Manufacturing Engineering University of Calgary

Principles of a novel submicron particle sizing technology are first introduced followed by experimental validation. The sizing was accomplished by coupling aerodynamic particle focusing and maximum ion measurement. Experimental results showed that the prototype could detect particle sizes down to 40 nm in diameter. Comparison between the prototype and a scanning mobility particle sizer using identical polydisperse particles showed that the measurements agreed well for the tested particles.

关键词： Submicron particle Particle sizing Aerodynamic focusing Particle charging

The dual choice of geodetic horizontal reference systems for Ukraine

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Geodesy and Geodynamics 2023年第3期14卷 254-264页

作者： Elena Novikova alena Palamar Rostyslav Lopunov Department of Geodesy State Higher Educational InstitutionKryvyi Rih National UniversityKryvyi RihUkraine

Almost all European countries use at least two horizontal reference systems, which allow them to minimize all risks when changing the coordinate system. The first system is used for the needs of the national survey in general, and also for technical applications in engineering surveys. A brief description of this system can be written by the formula: Geocentric Ellipsoid(GRS80) + Projection(UTM). More than half of the European countries for the second national systems use the GRS80 geocentric ellipsoid together with a projection other than UTM, some of them continue to use the projection of the old coordinate systems. The rest of the countries, excluding Ukraine, adapted the existing national coordinate systems to modern requirements, removing deformations from them concerning the ETRS89. A small number of European countries have implemented the GRS80 geocentric ellipsoid together with the UTM projection for cadastral surveys and topographic maps with a scale of 1:5000 and larger. Only one country, Ukraine, chose a variant for the new coordinate system(UCS2000), which is briefly written by the formula: Old Not Geocentric Ellipsoid + New Projection. The analysis of modern coordinate systems of Europe made it possible to formulate two variants of the future coordinate system of Ukraine based on a geocentric ellipsoid. It is shown that the transition to a geocentric ellipsoid will change the coordinates and heights of the points, but practically will not change the distance between the points and the area of the parcels.

关键词： UTM GRS80 Projection parameters Quantitative characteristics of land parcels UCS2000

A novel method for investigation of acoustic and elastic wave phenomena using numerical experiments

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Theoretical & Applied Mechanics Letters 2020年第5期10卷 307-314页

作者： alena Favorskaya Igor Petrov Moscow Institute of Physics and Technology DolgoprudnyMoscow regionRussian Federation Scientific Research Institute for System Analysis of the Russian Academy of Sciences MoscowRussian Federation Xi'an Jiaotong University Xi'an 710049China

The emergence of new types of composite materials,the depletion of existing hydrocarbon deposits,and the increase in the speed of trains require the development of new research methods based on wave ***,it is necessary to determine the laws of wave scattering in inhomogeneous *** propose a method that combines the advantages of a numerical simulation with an analytical study of the boundary value problem of elastic and acoustic wave *** this letter we present the results of the study using the proposed method:the formation of a response from a shear wave in an acoustic medium and the formation of shear waves when a vertically incident longitudinal wave is scattered by a vertical gas-filled *** have obtained a number of analytical expressions characterising the scattering of these wave types.

关键词： Elastic waves Acoustic waves Waves scattering Fractures Seismic prospecting

Organelle Extensions in Plant Cells

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Journal of Integrative Plant Biology 2012年第11期54卷 851-867页

作者： Jaideep Mathur alena Mammone Kiah A.Barton Laboratory of Plant Development and Interactions Department of Molecular and Cellular BiologyUniversity of Guelph50 Stone RoadGuelphOntario N1G 2W1Canada

Cell walls lock each cell in a specific position within the supraorganization of a plant. Despite its fixed location, each cell must be able to sense alterations in its immediate environment and respond rapidly to ens... 详细信息

关键词： Organelle extensions stromules peroxules fluorescent proteins homeostasis.

Robustness evaluation of cutting tool maintenance planning for soft ground tunneling projects

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Underground Space 2018年第1期3卷 72-85页

作者： alena Conrads Markus Scheffer Markus Konig Markus Thewes Inastitute of Tunneling cand Construction Management Ruhr-Universitat BochunGermany Chair of Computing in Engineering Ruhr-Universitit BochunGermany

Tunnel boring machines require extensive maintenance and inspection effort to provide a high *** cutting tools of the cutting wheel must be changed timely upon reaching a critical *** one possible maintenance strategy is to change tools only when it is absolutely necessary,tools can also be changed preventively to avoid further *** different maintenance strategies inﬂuence the maintenance duration and the overall project ***,determine downtime related to a particular mainte-nance strategy is still a challenging *** paper shows an analysis of the robustness to achieve the planned project performance of a maintenance strategy considering uncertainties of wear behavior of the cutting tools.A simulation based analysis is presented,imple-menting an empirical wear prediction *** strategies of maintenance planning are compared by performing a parameter vari-ation study including Monte-Carlo *** maintenance costs are calculated and evaluated with respect to their ***,an improved and robust maintenance strategy has been determined.

关键词： Mechanized tunneling,Maintenance Wear of cutting tools Process simulation Robustness Uncertainty modeling

Our experience with smartphone and spherical lens for the eye fundus examination during humanitarian project in Africa

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 157-160页

作者： alena Furdova Adriana Furdova Vladimtr Krcmery Department of Ophthalmology Faculty of MedicineComenius University in BratislavaBratislava 821 01Slovak Republic Tropic Team St.Elisabeth University of Health and Social SciencesBratislava 811 01Slovak Republic

To present the experience of eye fundus photo documentation by using the plus 20 diopters spherical Volk lens and a smartphone with 4.2 Mpix camera and LED flash within the screening project of eye disorders in countries where the standard ophthalmology equipment is not available. Totally 241 patients underwent ophthalmology screening examination. The documentation of the eye fundus included patients with Burkitt lymphoma, Kala Azar, malnutrition with unknown etiology, tuberculosis, HIV positive patients, Usher syndrome and hypertension. This technique as an alternative way of screening will become a standard within examination of patients with eye disorders in outfield regions of developing countries.

关键词： eye fundus examination smartphone Volk lens

New species in Aspergillus section Fumigati from reclamation sites in Wyoming (U.S.A.) and revision of A. viridinutans complex

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Fungal Diversity 2014年第1期64卷 253-274页

作者： alena Nováková Vit Hubka Zuzana Dudová Tetsuhiro Matsuzawa alena Kubátová Takashi Yaguchi Miroslav Kolařík Biology Centre AS CR v.v.i.Institute of Soil BiologyNa Sádkách 737005ČeskéBudějoviceCzech Republic Laboratory of Physiology and Genetics of Fungi Institute of Microbiology AS CRv.v.iVídeňská108314220 Prague 4Czech Republic Department of Botany Faculty of ScienceCharles University in PragueBenátská212801 Prague 2Czech Republic Medical Mycology Research Center Chiba University1-8-1InohanaChuo-kuChiba 260-8673Japan

The Aspergillus viridinutans complex includes morphologically similar,soil-inhabiting *** its species boundaries have not been fully defined,many isolates from the complex have been isolated as opportunistic human and animal *** the present study,these species were dominant in spoil sites subjected to various types of reclamation management after coal *** species were characterised using two different PCR-fingerprinting methods,sequence data from the β-tubulin(benA)and calmodulin(caM)genes,macro-and micromorphology(optical and scanning electron microscopy),maximum growth temperatures and mating *** addition,RNA polymerase II gene(RPB2),actin(act1)and ITS sequences were deposited for the ex-type isolates of newly described *** mating experiment results,phylogenetic analyses and ascospore morphology suggested the presence of five species in the *** *** aureolus(*** aureola)was the only homothallic *** species,***,***(***)and *** ***.,were heterothallic and their morphologically distinguishable teleomorph was induced by systematic mating *** viridinutans *** to be a very rare species and was represented only by the ex-type isolate in which the MAT1-1 locus was *** viridinutans and *** were typified in accordance with the rules of the new botanical *** species outside the *** complex isolated from the reclamation sites were *** and *** as well as two new sister species,*** *** *** *** were closely related each to other and to *** new species are phylogenetically distant from all anamorphic species and resemble ***,*** and *** in micromorphology and are distinguishable from each other by the slower growth of *** on all tested ***,no isolate from the

关键词： Aspergillus fumigatus Heterothallic species MAT locus Neosartorya udagawae PCR fingerprinting Soil fungi