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Open Journal of Medical Microbiology 2019年第1期9卷 1-7页

作者： aleksey shatalov Laboratory of Microbiology at Luanda Medical Center Luanda Angola

This prospective study was carried out to assess the sensitivity and resistance pattern of lactose non-fermenting Escherichia coli from July 2018 to December 2018 in the Laboratory of Microbiology at Luanda Medical Center, Angola. Out of 1170 patient, a total of 120 urine specimens infected with Escherichia coli (>105 CFU/ml) were collected according to the routine protocol of urinalysis. Among these 120 isolates, 25 (21%) isolates were determined as “atypical”, lactose non-fermenting E. colis trains. The twenty-five lactose non-fermenting Escherichia coli strains isolated from urine samples in Luanda Medical Center were declared as Multiple Drugs-Resistant strains with high resistance to Cefalexine (100%), Cefuroxime (100%), Ceftriaxone (92%), Gentamycin (92%), Ciprofloxacin (72%) and Amoxiciclin/Clavulanic (80%). The alarming resistance level to the first-choice drugs for the treatment of urinary tract infections caused by non-fermentative lactose E. coli was observed.

关键词： Escherichia coli Multi-Drugs Resistance (MDR) Lactose Non-Fermenting Urine Tract Infections Colony Forming Unit (CFU)

Prevalence and Antibiotic Resistance Pattern of Escherichia coliand Klebsiella pneumoniaein Urine Tract Infections at the La Paz Medical Center, Malabo, Equatorial Guinea

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Open Journal of Medical Microbiology 2015年第4期5卷 177-183页

作者： aleksey shatalov Laboratory of La Paz Medical Center Malabo Equatorial Guinea

The study was conducted to isolate and determine the antibiotic resistance in Escherichia coli and Klebsiella pneumonia from urine samples over a 2-year period (August 2013-September 2015) at the La Paz Medical Center, Malabo. A retrospective analysis of 785 urine culture samples over a 2-year period August 2013-September 2015 was carried out according to the routine protocol of urinalysis. Bacterial etiological agents were isolated from 155 (19.7%) samples with highest prevalence of Escherichia coli (55.5%) followed by Klebsiella pneumonia (23.2%), Proteus mirabilis (4.5%), Pseudomonas species (3.2%), Enterobacter species (2.6%), Enterococcus faecalis (2.6%) and others species (8.4%). The E. coli and K. pneumonia represent 78.7% of all isolated bacterial strains. The E. coli and K. pneumoniae isolates possess highly resistant to ampicillin, Trimethoprim/Sulfamethoxazole, Doxycycline, Amoxicicline/Clavulanic acid. Whereas K. pneumonia demonstrated also to be highly resistant to Gentamycin, Cefuroxime and Ceftriaxon, low level of resistance to Piperacilin/Tazobactam, Amikacin and the lowest to Imipenem. The alarming level of MDR strains to the first choice antibiotics treatment was observed.

关键词： Urine Tract Infections Antibiotic Resistance Klebsiella pneumonia Escherichia coli

First Case of Chromobacterium violaceumas Urinary Tract Infection Agent in Angola

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Open Journal of Medical Microbiology 2019年第1期9卷 37-40页

作者： aleksey shatalov Ziv Maianski Laboratory of Microbiology Luanda Medical Center Luanda Angola Urology Department Luanda Medical Center Luanda Angola

Background: Chromobacterium violaceum is a Gram-negative, a facultative anaerobe bacteria producing violacein pigment. C. violaceum is generally present as the normal flora of water and soil. The Urine Tract Infection (UTI) due to C. violaceum is very rare. Until now there was no report from Africa about UTIs caused by C. violaceum. The antimicrobial susceptibility pattern of C. violaceum is very limited due to the rarity of isolation from clinical specimens. Here, we describe the first case of urinary tract infection caused by C. violaceum in Angola. Aim: Our case report was carried out to assess the sensitivity and resistance pattern of C. violaceum as the causative agent of UTI. Results: C. violaceum was sensitive to Amoxicillin/Clavulanic acid, Ceftriaxon, Ciprofloxacin, Doxycycline, Trimethoprim/Sulfamethoxazole, Piperacilin/Tazobactam, Gentamicin, Amikacin, Aztreonam and imipenem. The bacteria showed resistance to Cefuroxime. Conclusion: Here, we report a rare case of complicate urinary tract infection caused by C. violaceum in patient, who was treated successfully with ciprofloxacin for a total duration of 7 days.

关键词： Chromobacterium violaceum Lactose Non-Fermenting Urine Tract Infection (UTI) Antibiotic Susceptibility

Low Efficiency of the Commonly Prescribed Drugs against Klebsiella pneumonia, Escherichia coli and Acinetobacter Species as the Causative Agents of Blood Stream Infection in Malabo, Equatorial Guinea

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Advances in Microbiology 2016年第3期6卷 162-168页

作者： aleksey shatalov Yaari Shilo Rizeq Nakhash Dennis Zhdanov Department of Microbiology La Paz Medical Center Malabo Equatorial Guinea Intern Medicine Department La Paz Medical Center Malabo Equatorial Guinea Department of Neonatology and Pediatria La Paz Medical Center Malabo Equatorial Guinea Intensive Care Unit Department La Paz Medical Center Malabo Equatorial Guinea

The prevalence of multi drug resistant gram-negative bacteria to commonly first line drugs in blood is a serious problem in Equatorial Guinea and other world. This is the first study describing antibiotic resistance analysis of blood stream infection in Equatorial Guinea. Our study presents alarming rate of inefficiency of the most commonly prescribed drugs to treatment Klebsiella pneumoniae, Escherichia coli and Acinetobacter species isolates as the most frequency etiologic agents in blood stream infection. Out of 1849 blood culture the bacterial etiological agents were isolated from 196 (10.6%) samples. E. coli (n = 22), K. pneumonia (n = 39) and Acinetobacter (n = 17) represent 71.6% of all gram negative bacterial isolates. Almost all isolates of K. pneumonia and Acinetobacter sp. (92.1% and 100%, respectively) and about 50% of E. coli strains possessed extended-spectrum β-lactamase activity. Alarming level of multi drug resistant gram negative strains was observed. E. coli and K. pneumonia and Acinetobacter isolates demonstrated low sensitivity to all commonly prescribed drugs such as Ampicillin, Trimethoprim/Sulfamethoxazole, Doxycycline, Gentamycin Amoxicicline/Clavulanic Acid, Cefuroxime, Ciprofloxacine. It is especially worth noting the low efficiency of third generation cephalosporins (Cefrtiaxon) against Acinetobacter and Klebsiella with their resistance rate of 94.7% and 100% respectively. Moreover, the alarming level of low sensitivity to Piperacilin/Tazobactam of K. pneumonia (22%) and Acinetobacter (29.4%) was been found. The 17.6% of Acinetobacter isolated was carbomenem resistant. Just Imipenem and Amikacin were the most sensitive drug against these bacterial strains.

关键词： Bacteremia Multi Drug Resistance ESBL Gram Negative Rods

Predominance of Multi-Drug Resistant Klebsiella pneumoniaand Other Gram Negative Bacteria in Neonatal Sepsis in Equatorial Guinea

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Open Journal of Medical Microbiology 2015年第4期5卷 254-258页

作者： aleksey shatalov Fares Awwad Pablo Mangue Rami Juden Foqahaa Department of Microbiology La Paz Medical Center Malabo Equatorial Guinea Department of Neonatology and Pediatria La Paz Medical Center Malabo Equatorial Guinea

The study was conducted on new-born babies in whom septicemia was suspected, to determine the prevalence of bacterial strains isolated and their sensitivity to antimicrobial drugs. The study was carried out at La Paz Medical Center, Microbiology section, Malabo, Equatorial Guinea from August 2013 to October 2015. Out of 293 septicemia suspected cases, 29 (10%) blood cultures were positive, 28 with bacterial growth and 1 with growth of Candida sp. The mortality rate of neonates caused by Gram negative bacterial sepsis was 34.7%. Among the Gram negative bacteria (24 isolates), the most common types were Klebsiella pneumoniae (16 = 69.6%), followed by Escherichia coli (4 = 17.4%) and Acinetobacter species (4 = 17.4%). Four Gram positive bacteria were also isolated and identified all ascoagulase-negative staphylococci. All the Klebsiella pneumoniae isolates and Acinetobacter species demonstrated Multi Drug Resistance against different antibiotics with Extended-spectrum β-lactamase (ESBL) activity. The most frequent causative agent of bacterial sepsis in new-born children was Klebsiella pneumoniae. An alarming level of Multi Drug Resistance (MDR) Klebsiella pneumoniae strains to the first choice antibiotic treatment was observed.

关键词： Sepsis New-Born Multi Drug Resistance Equatorial Guinea Klebsiella pneumoniae