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Trogocytosis of CD80 and CD86 by induced regulatory 7 cells

Cellular & Molecular Immunology 2012年第2期9卷 136-146页

作者： Peng Gu Julia Fang Gao Cheryl A D＇Souza aleksandra Kowalczyk Kuang-Yen Chou Li Zhang University of Toronto Transplant Institute Toronto General Research Institute University Health Network Toronto Ontario Canada Shanghai Institute of Immunology Shanghai Jiaotong University School of Medicine Shanghai China Department of Immunology University of Toronto Toronto Ontario Canada These authors contributed equally to this paper.

Trogocytosis is a process which involves the transfer of membrane fragments and cell surface proteins between cells. Various types of T cells have been shown to be able to acquire membrane-bound proteins from antigen-presenting cells and their functions can be modulated following trogocytosis. However, it is not known whether induced regulatory T cells （iTregs） can undergo trogocytosis, and if so, what the functional consequences of this process might entail. In this study, we show that iTregs can be generated from CD80-/-CD86-/- double knockout （DKO） mice. Using flow cytometry and confocal fluorescence microscopy, we demonstrate that iTregs generated from DKO mice are able to acquire both CD80 and CD86 from mature dendritic cells （mDCs） and that the acquisition of CD86 occurs to a higher extent than that of CD80. Furthermore, we found that after co-incubation with iTregs, dendritic cells （DCs） downregulate their surface expression of CD80 and CD86. The trogocytosis of both CD80 and CD86 occurs in a cytotoxic T lymphocyte-associated antigen-4 （CTLA-4）, CD28 and programmed death ligand-1 （PDL1）-independent manner. Importantly, we showed that iTregs that acquired CD86 from mDCs expressed higher activation markers and their ability to suppress naive CD4＋ T-cell proliferation was enhanced, compared to iTregs that did not acquire CD86. These data demonstrate, for the first time, that iTregs can acquire CD80 and CD86 from mDCs, and the acquisition of CD86 may enhance their suppressive function. These findings provide novel understanding of the interaction between iTregs and DCs, suggesting that trogocytosis may play a significant role in iTreg-mediated immune suppression.

关键词： CD80 CD86 CTLA-4 iTregs trogocytosis

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Predictors of heart rhythm disturbances in hypertensive obese patients with obstructive sleep apnea

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Journal of Geriatric Cardiology 2017年第9期14卷 553-562页

作者： Lyudmila Sergeevna Korostovtseva Nadezhda Edvinovna Zvartau Oxana Petrovna Rotar Yurii Vladimirovich Sviryaev aleksandra Olegovna Konradi Research Department for Hypertension Almazov National Medical Research Centre St Petersburg Russia Institute of TranslationalMedicine ITMO University St Petersburg Russia

Objective To assess the incidence and predictors of heart rhythm and conduction disturbances in hypertensive obese patients with andwithout obstructive sleep apnea （OSA）. Methods This is an open, cohort, prospective study. Out of 493 screened patients, we selected 279hypertensive, obese individuals without severe concomitant diseases： 75 patients without sleep-disordered breathing （non-SDB group）, and204 patients with OSA （OSA group）. At baseline, all patients underwent examination, including ECG, Holter ECG monitoring, and sleepstudy. During follow-up （on 3, 5, 7 and 10th years; phone calls once per 6 months）, information about new events, changes in therapy and lifestyle was collected, diagnostic procedures were performed. As the endpoints, we registered significant heart rhythm and conduction disordersas following： atrial fibrillation （AF）, ventricular tachycardia, atrioventricular block （AV） 2-3 degree, sinoatrial block, significant sinus pauses（〉 2000 ms）, and the required pacemaker implantation. Results The median follow-up was 108 （67.5-120） months. The frequency of heartrhythm disorders was higher in OSA patients （29 cases, X^2= 5.5; P = 0.019） compared to the non-SDB patients （three cases; OR： 3.92, 95%CI： 1.16-13.29）. AF was registered in 15 patients （n = 12 in OSA group; P = 0.77）. Heart conduction disturbance developed in 16 patients,without an association with the rate of coronary artery disease onset. Regression analysis showed that only hypertension duration was anindependent predictor olAF （OR： 1.10, 95% CI： 1.04-1.16; P = 0.001）. In case of heart conduction disturbances, apnea duration was thestrongest predictor （P = 0.002）. Conclusions Hypertensive obese patients with OSA demonstrate 4-fold higher incidence of heart rhythmand conduction disturbances than subjects without SDB. Hypertension duration is an independent predictor for AF development, while sleepapneaJhypopnea duration is the main factor for heart conduction disorders onset in hypertensiv

关键词： Atrial fibrillation Cardiovascular morbidity Cardiovascular prognosis Heart conduction disorder Obstructive sleep apnea

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放电等离子烧结和快速热压工艺制备具有低或负热膨胀系数钨酸锆块体(英文)

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硅酸盐学报 2009年第5期37卷 749-754页

作者： NEUBAUER Erich GAVRILOVIC aleksandra ANGERER Paul 奥地利研究中心(ARC) 奥地利塞伯斯多夫A-2444 电化学表面技术中心(CEST) 奥地利维也纳新城A-2700

采用快速热压工艺(放电等离子烧结和感应加热热压),利用ZrW2O5粉料制备了负热膨胀系数(coefficient of thermal expansion,CTE)钨酸锆(ZrW2O8)陶瓷体材料。这两种工艺可在烧结过程中保留负CTE材料钨酸锆所需的结构和相组成。结果表明:... 详细信息

采用快速热压工艺(放电等离子烧结和感应加热热压),利用ZrW2O5粉料制备了负热膨胀系数(coefficient of thermal expansion,CTE)钨酸锆(ZrW2O8)陶瓷体材料。这两种工艺可在烧结过程中保留负CTE材料钨酸锆所需的结构和相组成。结果表明:改变工艺参数,如热压温度和保温时间,可以调节 ZrW2O8陶瓷的CTE从-9 × 10-6/K到+9× 10-6/K变化。首次采用ZrW2O8作为填料与轻金属钛复合制备了零膨胀复合材料。

关键词：钨酸锆体材料负热膨胀材料放电等离子烧结技术感应加热热压工艺金属基复合材料

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Improving nutrition for the prevention of gestational diabetes:Current status and perspectives

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World Journal of Diabetes 2021年第9期12卷 1494-1506页

作者： Polina V Popova Evgenii A Pustozerov aleksandra S Tkachuk Elena N Grineva Institute of Endocrinology Almazov National Medical Research CentreSaint Petersburg 194156Russia Department of Faculty Therapy Saint Petersburg Pavlov State Medical UniversitySaint Petersburg 197022Russia Department of Biomedical Engineering Saint Petersburg State Electrotechnical UniversitySaint Petersburg 197341Russia

Gestational diabetes mellitus(GDM)is a common complication of pregnancy and a serious public health *** carries significant risks of short-term and longterm adverse health effects for both mothers and their *** factors,especially modifiable risk factors,must be considered to prevent GDM and its *** studies have identified several nutritional and lifestyle factors associated with the risk of *** results of intervention studies examining the effects of diet and lifestyle on the prevention of GDM are *** in the study populations,types and intensity of intervention,time frame of the intervention,and diagnostic criteria for GDM may explain the heterogeneity in the results of intervention *** review provides an overview of new diets and other factors that may help prevent *** main results of epidemiological studies assessing the risk factors for GDM,as well as the results and methodological problems of intervention studies on the prevention of GDM and their meta-analyses,are *** addition,the evidence that gene and lifestyle interactions influence the development of GDM,as well as prospects for increasing the effectiveness of interventions designed to prevent GDM,including new data on the possible uses of personalized diet therapy,are highlighted.

关键词： Gestational diabetes mellitus Risk factors Nutrition Prevention Personalized medicine Postprandial glycemic response

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Engineering Simulation of Knee Orthosis in Ansys Complex and Approbation

Engineering Simulation of Knee Orthosis in Ansys Complex and...

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作者：安心（ZIUZINA aleksandra）兰州理工大学

学位级别：硕士

人们很容易受到各种形式的伤害,包括先天性和后天性疾病。膝关节作为人体中最大和最坚固的关节之一,其发病率持续上升,目前全世界约有2.5亿人受到膝关节疾病的影响,主要表现在软骨受损。然而膝关节中的关节软骨上的动态负荷可以通过膝... 详细信息

人们很容易受到各种形式的伤害,包括先天性和后天性疾病。膝关节作为人体中最大和最坚固的关节之一,其发病率持续上升,目前全世界约有2.5亿人受到膝关节疾病的影响,主要表现在软骨受损。然而膝关节中的关节软骨上的动态负荷可以通过膝关节外力矩和冲力可靠地预测。因此,可通过设计理想的矫形器以修复、激活和纠正损坏关节,进一步恢复肢体功能。然而,目前市场上的膝关节矫形器存在许多不符合使用的要求,如治疗效率低、舒适性差、无法调节铰链弯曲角度等。因此,本文以改善活动受限群体生活质量为主题,以膝关节矫形器为主要研究对象,建立其有限元数学模型,分析塑料矫形器的临界负荷形变,基于3D打印技术,研究塑料矫形器的制造和成型工艺参数对其强度和刚度的影响,最后提出一种计算机导航操作算法。具体研究内容如下:（1）建立下肢的有限元数学模型。分别扫描膝关节和脚踝弯曲90°和伸直时的肢体位置,创建虚拟样机模型以获取数据,将获取的数据导入软件中进行数学建模,为分析肢体轴向变形时不同材料情况下矫形器塑变的临界载荷提供支撑。（2）分析肢体轴向变形导致塑变的临界载荷。考虑到肢体轴的变形,基于有限元分析方法,在ANSYS中划分网格并施加载荷,进行集中载荷作用分析及应力计算,为评价矫形器质量提供参考。初步计算表明,膝关节矫形器最容易出现问题的区域是其最小细节处。（3）研究塑料矫形器的制造和成型工艺参数对其强度及刚度影响。考虑到每个病人的腿部结构的个体特征以及特征的不同属性,借助于复合材料零件的3D打印技术,从设计制造两个方面入手,通过更换材料和打印参数研究矫形器的制造和成型工艺参数对其强度及刚度影响,发现打印过程中温度波动会导致分层。（4）提出一种计算机导航操作算法。为解决常规导航操作不能满足个性化膝关节矫形器需求和精度的不足,考虑到人体腿部形态各异,提出一种基于腿部形态特征数学模型的应用计算机导航操作技术算法,使得改善病人的治疗效果成为可能。

关键词：有限元膝关节矫形器 3D打印

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AlFe层柱粘土催化剂催化甲苯在水中的降解(英文)

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催化学报 2009年第1期30卷 14-18页

作者： Predrag BANKOVIC aleksandra MILUTINOVIC-NIKOLIC Zorica MOJOVIC aleksandra ROSIC ZeljkoUPIC Davor LONAREVIC Dusan JOVANOVIC Institute of Chemistry Technology and Metallurgy University of BelgradeDepartment of Catalysis and Chemical Engineering Faculty of Mining and Geology University of Belgrade

The catalytic wet peroxide oxidation (CWPO) of toluene on two bentonite-based AlFe-pillared clays (PILCs) with different iron contents was investigated. The PILCs were obtained using bentonite clay from Bogovina,Serbia. The change in chemical and phase composition and textural properties of the starting clay and synthesized catalysts was monitored using X-ray diffraction,inductively coupled plasma optical emission spectrometry,UV-Vis diffuse reflectance spectrometry,and physisorption of nitrogen. The catalytic performance was examined using gas chromatography. The Na-exchange process lowered the (001) smectite basal plane spacing,but the clay retained its swelling properties,while the pillaring process increased it. The surface areas of both synthesized pillared clays increased to similar values although their Fe content was different. At 37 ℃,both catalysts show significant toluene degradation,with the one richer in Fe having higher efficiency. The leaching of the active cations during reaction was negligible,and the catalysts were stable. AlFe-pillared clay catalysts can be used in CWPO for the elimination of BTEX compounds from plant effluent streams.

关键词：催化湿式过氧化物氧化法甲苯膨润土催化剂

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Machine learning in concrete science:applications,challenges,and best practices

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npj Computational Materials 2022年第1期8卷 1192-1208页

作者： Zhanzhao Li Jinyoung Yoon Rui Zhang Farshad Rajabipour Wil V.Srubar III Ismaila Dabo aleksandra Radlińska Department of Civil and Environmental Engineering The Pennsylvania State UniversityUniversity ParkPA16802USA Department of Structural Engineering Research Korea Institute of Civil Engineering and Building Technology(KICT)Goyang-si10223Republic of Korea Department of Civil Environmentaland Architectural EngineeringUniversity of Colorado BoulderBoulderCO80309USA Materials Science and Engineering Program University of Colorado BoulderBoulderCO80309USA Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA16802USA

Concrete,as the most widely used construction material,is inextricably connected with human *** conceptual and methodological progress in concrete science,concrete formulation for target properties remains a challenging task due to the ever-increasing complexity of cementitious *** the ability to tackle complex tasks autonomously,machine learning(ML)has demonstrated its transformative potential in concrete *** the rapid adoption of ML for concrete mixture design,there is a need to understand methodological limitations and formulate best practices in this emerging computational ***,we review the areas in which ML has positively impacted concrete science,followed by a comprehensive discussion of the implementation,application,and interpretation of ML *** conclude by outlining future directions for the concrete community to fully exploit the capabilities of ML models.

关键词： concrete directions autonomous

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Oral Cadmium Intake Enhances Contact Allergen-induced Skin Reaction in Rats

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Biomedical and Environmental Sciences 2022年第11期35卷 1038-1050页

作者： Dina Tucovic Jelena Kulas Ivana Mirkov Dusanka Popovic Lidija Zolotarevski Marta Despotovic Milena Kataranovski aleksandra Popov Aleksandrov Immunotoxicology Group Department of EcologyInstitute for Biological Research"Sinisa Stankovic"-National Institute of Republic of SerbiaUniversity of Belgrade142 Bulevar despota Stefana11060 BelgradeSerbia Medical College of Applied Sciences 254 Cara Dusana11080 BelgradeSerbia Centre of Research Excellence in Nutrition and Metabolism Institute for Medical ResearchUniversity of Belgrade11 Tadeusa Koscuska 111000 BelgradeSerbia

Objective The effect of oral cadmium(Cd)intake to influence contact skin allergies was examined,since it is known that Cd is a heavy metal that affects many tissues,including the skin,in which it disturbs homeostasis,thus resulting in inflammation and *** Male rats were evoked with experimental contact hypersensitivity reaction(CHS)to hapten dinitrochlorobenzene(DNCB),after prolonged(30 day)oral exposure to an environmentally relevant Cd dose(5 ppm).The ear cell population was analyzed with flow *** production by ear skin cells and the activity of skin-draining lymph node(DLN)cells were measured using enzyme-linked immunosorbent assay(ELISA).Results Orally acquired Cd(5 ppm)increased CHS intensity only in Dark Agouti(DA)rats by affecting inflammatory responses in both the sensitization(an increase of IFN-γ and IL-17 cytokine production)and challenge(an increase of CD8^(+)and CD4^(+)cell number and TNF,IFN-γ and IL-17 cytokine production)*** increased CHS reaction was seen in Albino Oxford(AO)rats only at a high Cd dose(50 ppm),during the challenge phase(an increase of CD8^(+)and CD4^(+)cell number and TNF,IFN-γ and IL-17 cytokine production).Conclusion These novel data indicate that oral Cd intensifies the skin response to sensitizing chemicals such as DNCB.

关键词： Cadmium(Cd) Contact hypersensitivity reaction(CHS) Dinitrochlorobenzene(DNCB)

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Crystal structure of SARS-CoV-2 papain-like protease

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Acta Pharmaceutica Sinica B 2021年第1期11卷 237-245页

作者： Xiaopan Gao Bo Qin Pu Chen Kaixiang Zhu Pengjiao Hou Justyna aleksandra Wojdyla Meitian Wang Sheng Cui NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China The Swiss Light Source(SLS)at the Paul Scherrer Institut Villigen 5232Switzerland

The pandemic of coronavirus disease 2019(COVID-19)is changing the world like never *** crisis is unlikely contained in the absence of effective therapeutics or *** papain-like protease(PLpro)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)plays essential roles in virus replication and immune evasion,presenting a charming drug *** the PLpro proteases of SARS-CoV-2 and SARS-CoV share significant homology,inhibitor developed for SARS-CoV PLpro is a promising starting point of therapeutic *** this study,we sought to provide structural frameworks for PLpro inhibitor *** determined the unliganded structure of SARS-CoV-2 PLpro mutant C111 S,which shares many structural features of SARS-CoV *** crystal form has unique packing,high solvent content and reasonable resolution 2.5 A°,hence provides a good possibility for fragment-based screening using crystallographic *** characterized the protease activity of PLpro in cleaving synthetic peptide harboring nsp2/nsp3 *** demonstrate that a potent SARS-CoV PLpro inhibitor GRL0617 is highly effective in inhibiting protease activity of SARSCoV-2 with the IC50 of 2.2?0.3 mmol/*** then determined the structure of SARS-CoV-2 PLpro complexed by GRL0617 to 2.6 A°,showing the inhibitor accommodates the S3 e S4 pockets of the substrate binding *** binding of GRL0617 induces closure of the BL2 loop and narrows the substrate binding cleft,whereas the binding of a tetrapeptide substrate enlarges the ***,our results suggest a mechanism of GRL0617 inhibition,that GRL0617 not only occupies the substrate pockets,but also seals the entrance to the substrate binding cleft hence prevents the binding of the LXGG motif of the substrate.

关键词： SARS-CoV-2 PLpro Proteinase inhibitor Crystal structure Antiviral drug Drug design

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Investigation of chlorinated phenols sorption mechanisms on different layers of the Danube alluvial sediment

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Journal of Environmental Sciences 2020年第12期32卷 134-142页

作者： Tamara Apostolovic Jelena Trickovic Marijana Kragulj Isakovski Branislav Jovic Snežana Maletic aleksandra Tubic Jasmina Agbaba University of Novi Sad Faculty of SciencesDepartment of ChemistryBiochemistry and Environmental ProtectionTrg Dositeja Obradovica 3Novi SadSerbia

The characteristics of the Danube river alluvial sediment are of great importance in assessing the risk for transport of pollutants to drinking water sources. Characterization of the sediment column layers has shown that the alluvial sediment, sampled near the city of Novi Sad, is a mesoporous sandy material with certain differences in the properties of individual layers. In order to investigate the sorption mechanisms of four chlorinated phenols(CPs) on the alluvial deposit, static sorption experiments were performed at pH 4, 7 and 10. The results of sorption experiments, confirmed by principal components analysis sugest different mechanisms govern the sorption process at different p H conditions. This can be attributed to the molecular characteristics of CPs, geosorbent properties and to variations in the surface charge of the sorbent at different p H conditions.

关键词： Sorption mechanisms Chlorinated phenols Alluvial sediment Principal component analysis

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