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Giant pseudoaneurysm of the splenic artery within walled of pancreatic necrosis on the grounds of chronic pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 87-89页

作者： Milica Mitrovic Jovanovic Dusan Saponjski aleksandra djuric stefanovic aleksandra Jankovic Stefan Milosevic Katarina Stosic Djordje Knezevic Jelena Kovac Department of Abdominal Radiology Center for Radiology and MRIClinical Center of SerbiaBelgradeSerbia Faculty of Medicine University of BelgradeBelgradeSerbia Clinic for Digestive Surgery–First Surgical Clinic Clinical Center of SerbiaBelgradeSerbia

Chronic pancreatitis is a long-standing inflammation of the pancreas,characterized by progressive inflammatory and fibrotic changes,resulting in permanent structural damage of pancreatic parenchyma[1].Pancreatitis(chronic or acute)is the primary risk factor for pseudo-splenic artery aneurysms,along with pancreatic pseudocysts and *** the disease progresses,patients with chronic pancreatitis may develop complications due to exocrine and endocrine pancreatic functional loss,such as fat malabsorption with steatorrhea,glucose intolerance,and ultimately diabetes mellitus[1,2].Furthermore,severe pancreatic inflammation can cause weakening of vessel walls,with subsequent formation of arterial *** artery is the most commonly affected visceral artery[2,3].Liver cirrhosis,portal hypertension,liver transplantation,atherosclerosis,hypertension,pregnancy and multiparity are main risk factors for true splenic artery aneurysms[2].Rupture and intraperitoneal bleeding is the cause of death in 30%−50%of ***,prompt diagnosis and appropriate treatment are of great clinical importance[4,5].Herein,we present a case of a giant splenic artery pseudoaneurysm within a walled of necrosis involving pancreatic parenchyma,as a complication of long standing chronic pancreatitis.

关键词： pancreatitis aneurysm inflammation

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Intraoperative endoscopy in obstructive hypopharyngeal carcinoma

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World Journal of Gastroenterology 2006年第28期12卷 4561-4564页

作者： Predrag Pesko Milos Bjelovic Predrag Sabljak Dejan Stojakov Ebrahimi Keramatollah Dejan Velickovic Bratislav Spica Branka Nenadic aleksandra djuric-stefanovic Djordjije Saranovic Vera Todorovic Department of Esophagogastric Surgery First Surgical University HospitalClinical Center of SerbiaBelgradeSerbia and Montenegro Institute of Anesthesiology First Surgical University HospitalClinical Center of SerbiaBelgradeSerbia and Montenegro Department of Radiology First Surgical University HospitalClinical Center of SerbiaBelgradeSerbia and Montenegro Institute of Medical Investigations BelgradeSerbia and Montenegro

AIM： To demonstrate the necessity of intraoperative endoscopy in the diagnosis of secondary primary tumors of the upper digestive tract in patients with obstructive hypopharyngeal carcinoma. METHODS： Thirty-one patients with hypopharyngeal squamous cell carcinoma had been operated, with radical intent, at our Institution in the period between 1978 and 2004. Due to obstructive tumor mass, in 7 （22.6%） patients, preoperative endoscopic evaluation of the esophagus and stomach could not be performed. In those patients, intraoperative endoscopy, made through an incision in the cervical esophagus, was standard diagnostic method for examination of the esophagus and stomach. RESULTS： We found synchronous foregut carcinomas in 3 patients （9.7%）. In two patients, synchronous carcinomas had been detected during preoperative endoscopic evaluation, and in one （with obstructive carcinoma） using intraoperative endoscopy. In this case, preoperative barium swallow and CT scan did not reveal the existence of second primary tumor within esophagus, despite the fact that small, but T2 carcinoma, was present. CONCLUSION： It is reasonable to use intraoperative endoscopy as a selective screening test in patients with obstructive hypopharyngeal carcinoma.

关键词： Hypopharynx Neoplasms Squamous cell Endoscopy Multiple primary Synchronous tumors

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Nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension

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World Journal of Gastroenterology 2012年第4期18卷 331-339页

作者： Andreja Vujanac Vladimir Jakovljevic Dusica Djordjevic Vladimir Zivkovic Mirjana Stojkovic Dragan Celikovic Nebojsa Andjelkovic aleksandra Jurisic Skevin Dragan djuric Department of Physiology Faculty of MedicineUniversity of Kragujevac Department of Gastroenterology and Echosonography Unit Clinical Centre of Belgrade Internal Clinic Clinical Centre "Kragujevac"Faculty of MedicineUniversity of Kragujevac Department of Physical Medicine and Rehabilitation Faculty of MedicineUniversity of Kragujevac Institute of Medical Physiology Belgrade University School of Medicine

AIM:Тo examine the effects of nitroglycerine on portal vein haemodynamics and oxidative stress in patients with portal ***:Thirty healthy controls and 39 patients with clinically verified portal hypertension and increasedvascular resistance participated in the *** di-ameters,portal diameters and portal flow velocities were recorded using color flow imaging/pulsed Doppler ***-section area,portal flow and index of vascular resistance were *** collected blood samples,superoxide anion radical (O 2-),hydrogen per-oxide (H 2 O 2),index of lipid peroxidation (measured as TBARS) and nitric oxide (NO) as a marker of endothelial response (measured as nitrite-NO 2-) were ***-dependent analysis was performed at basal state and in 10th and 15th min after nitroglycerine (sublingual 0.5 mg) ***:Oxidative stress parameters changed sig-nificantly during the study.H 2 O 2 decreased at the end of study,probably via O 2-mediated disassembling in Haber Weiss and Fenton reaction;O 2-increased signifi-cantly probably due to increased diameter and tension and decreased shear rate *** O 2-and H 2 O 2 degradation products,like hydroxyl radical,initi-ated lipid *** blood flow was to some extent lower in patients than in controls due to double paradoxes,flow velocity decreased,shear rate decreased significantly indicating non Newtonian char-acteristics of portal blood ***:This pilot study could be a starting point for further investigation and possible implemen-tation of some antioxidants in the treatment of portal hypertension.

关键词： Portal hypertension Endothelium Nitroglycerine Oxidative stress Portal vein haemodynamics

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