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Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression

World Journal of Gastroenterology 2019年第43期25卷 6465-6482页

作者： Marina Jovanovic Bojana Simovic Markovic Nevena Gajovic Milena Jurisevic aleksandar djukic Ivan Jovanovic Nebojsa Arsenijevic Aleksandra Lukic Natasa Zdravkovic Department of Internal Medicine Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Center for Molecular Medicine and Stem Cell Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pathophysiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Dentistry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Ulcerative colitis(UC)is a chronic disease characterized by inflammation of intestinal epithelium,primarily of the *** increasing prevalence of metabolic syndrome(MetS)in patients with UC has been documented ***,there is no evidence that MetS alters the course of the *** To test the influence of the MetS on the severity of UC and the local and systemic immune *** Eighty nine patients with de novo histologically confirmed UC were divided in two groups,according to ATP III criteria:Group without MetS(no MetS)and group with *** Clinically and histologically milder disease with higher serum level of immunosuppressive cytokine interleukin-10(IL-10)and fecal content of Galectin-3(Gal-3)was observed in subjects with UC and MetS,compared to subjects suffering from UC *** was accompanied with predomination of IL-10 over pro-inflammatory cytokines tumor necrosis factorα(TNF-α),interleukin-6(IL-6),and interleukin-17(IL-17)in the sera as well as Gal-3 over TNF-αand IL-17 in feces of UC patients with ***,the patients with both conditions(UC and MetS)had higher percentage of IL-10 producing and Gal-3 expressing innate and acquired immune cells in lamina *** Local dominance of Gal-3 and IL-10 over pro-inflammatory mediators in patients with MetS may present a mechanism for limiting the inflammatory process and subsequent tissue damage in UC.

关键词： Ulcerative colitis Metabolic syndrome Galectin-3 Inflammation Interleukin-10 Systemic immune response

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