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Refining the surgical playbook for treating colorectal cancer liver metastases

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 397-400页

作者： Luis I.Ruffolo Roberto hernandez-alejandro Koji Tomiyama Division of Transplantation and Hepatobiliary Surgery Department of SurgeryUniversity of Rochester Medical CenterRochesterNYUSA

Adenocarcinoma of the colon and rectum(CRC)is the second leading cause of cancer-related *** resection of disease offers the best long-term ***,>50%of patients have liver metastases at the time of diagnosis,or develop colorectal cancer liver metastases(CRLM)subsequent to treatment of primary *** of CRLM has proven to extend survival.

关键词： metastases colorectal cancer

Assessing resectability for colorectal liver metastases: agreeing that we disagree

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 797-800页

作者： Luis I.Ruffolo Koji Tomiyama Roberto hernandez-alejandro Division of Abdominal Transplantation and Hepatobiliary Surgery Department of SurgeryUniversity of Rochester Medical CenterRochesterNYUSA

Colorectal cancer(CRC)is the second leading cause of cancer related mortality,though improvements in CRC screening,systemic and local treatment,and surgical technique have steadily won victories in the battle against CRC,and the rate of mortality from CRC is steadily declining(1).However,perhaps no clinical-oncologic scenario is as unstandardized as the management of colorectal-liver metastases(CRLM)and their evaluation for consideration of resectability.

关键词： mortality colorectal metastases

Exercise benefits meet the esophagus

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Journal of Sport and Health Science 2024年第5期13卷 685-686页

作者： alejandro Santos-Lozano Pedro L.Valenzuela Carmen Fiuza-Luces alejandro Lucia i+HeALTH European University Miguel de CervantesValladolid 47012Spain Research Institute of the Hospital 12 de Octubre(“imas12”) Madrid 28041Spain Department of Systems Biology University of AlcalaAlcala de Heranes 28801Spain Faculty of Sport Sciences Universidad Europea de MadridVillaviciosa de Odon(Madrid)28670Spain

Gastroesophageal reflux disease(GERD)is defined by recurrent and troublesome heartburn and effortless regurgitation or by the specific complications of this condition—that is,esophagitis,esophageal peptic strictures,and Barrett esophagus.1Although GERD is caused by gastric contents'reaching the esophagus,gastric juices can also reach other anatomical locations(pharynx,mouth,larynx,and airways),leading to(or worsening)extra-esophageal conditions(notably asthma)or symptoms(e.g.,wheezing,cough).1 Together with obesity,GERD is the main risk factor for gastroesophageal malignancies.

关键词： esophagus esophageal Barrett

Targeting autophagy by polyphenols to prevent glycative stress-toxicity in the brain

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Neural Regeneration Research 2024年第5期19卷 941-942页

作者： alejandro Ponce-Mora Eloy Bejarano Department of Biomedical Sciences School of Health Sciences and Veterinary SchoolUniversidad Cardenal Herrera-CEUCEU UniversitiesValenciaSpain

Glycative stress-a pathological hub in brain dysfunction:The nervous system is an intricate network that requires precise and complex *** recent years,growing evidence highlights the detrimental impact of glycative stress on brain homeostasis,which disables a network of vital processes,necessary for optimal function(Gómez et al.,2021).

关键词： homeostasis stress

Evaluation of the updated definition of early allograft dysfunction in donation after brain death and donation after cardiac death liver allografts

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 372-376页

作者： Kris P Croome William Wall Douglas Quan Sai Vangala Vivian McAlister Paul Marotta Roberto hernandez-alejandro Multi-Organ Transplant Program London Health Sciences CentreThe University of Western OntarioLondonCanada Department of Surgery Division of General SurgeryThe University of Western OntarioLondonCanada Division of Gastroenterology The University of Western OntarioLondonCanada

BACKGROUND:An updated definition of early allograft dysfunction(EAD) was recently validated in a multicenter study of 300 deceased donor liver transplant *** analysis did not differentiate between donation after brain death(DBD) and donation after cardiac death(DCD) allograft ***:We reviewed our prospectively entered database for all DBD(n=377) and DCD(n=38) liver transplantations between January 1,2006 and October 30,*** incidence of EAD as well as its ability to predict graft failure and survival was compared between DBD and DCD ***:EAD was a valid predictor of both graft and patient survival at six months in DBD allograft recipients,but in DCD allograft recipients there was no significant difference in the rate of graft failure in those with EAD(11.5%) compared with those without EAD(16.7%)(P=0.664) or in the rate of death in recipients with EAD(3.8%) compared with those without EAD(8.3%)(P=0.565).The graft failure rate in the first 6 months in those with international normalized ratio ≥1.6 on day 7 who received a DCD allograft was 37.5% compared with 6.7% for those with international normalized ratio <1.6 on day 7(P=0.022).CONCLUSIONS:The recently validated definition of EAD is a valid predictor of patient and graft survival in recipients of DBD *** initial assessment,it does not appear to be a useful predictor of patient and graft survival in recipients of DCD allografts,however a study with a larger sample size of DCD allografts is needed to confirm these *** high ALT/AST levels in most recipients of DCD livers as well as the predisposition to biliary complications and early cholestasis make these parameters as poor predictors of graft *** alternative definition of EAD that gives greater weight to the INR on day 7 may be more relevant in this population.

关键词： donor risk index model for end-stage liver disease early allograft dysfunction donation after brain death

Surgical vs percutaneous radiofrequency ablation for hepatocellular carcinoma in dangerous locations

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World Journal of Gastroenterology 2011年第1期17卷 123-129页

作者： Ji-Wei Huang Roberto hernandez-alejandro Kristopher P Croome Lu-Nan Yan Hong Wu Zhe-Yu Chen Pankaj Prasoon Yong Zeng Department of Hepato-Biliary-Pancreatic Surgery Division of Liver Transplantation West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Surgery University of Western Ontario Hepatobiliary and Liver Transplant Surgery London Health Sciences Centre London Ontario N6A 4S2 Canada

AIM:To compare the long-term outcome of percutaneous vs surgical radiofrequency ablation(RFA) for hepatocellular carcinoma(HCC) in dangerous ***:One hundred and sixty-two patients with HCC in dangerous locations treated with percutaneous or surgical RFA were enrolled in this *** patients were divided into percutaneous RFA group and surgical RFA *** the patients were regularly followed up for a long time,their curative rate,hospital stay time,postoperative complications and 5-year local tumor progression were compared and ***:No significant difference was observed in curative rate between the two groups(91.3% vs 96.8%,P = 0.841).The hospital stay time was longer and more analgesics were required while the incidence of bile duct injury and RFA-related hemorrhage was lower in surgical RFA group than in percutaneous RFA group(P < 0.05).The local progression rate of HCC in dangerous locations was significantly lower in surgical RFA group than in percutaneous RFA group(P = 0.05).The relative risk of local tumor progression was 14.315 in percutaneous RFA ***:The incidence of severe postoperative complications and local tumor progression is lower after surgical RFA than after percutaneous RFA.

关键词：手术治疗射频消融危险地点肝癌 VS RFA 肝细胞癌治愈率

Weather influenced nestling growth of an insectivorous but not a granivorous grassland passerine in Argentina

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Avian Research 2024年第2期15卷 156-162页

作者： Martín alejandro Colombo Adrian Jauregui Luciano N.Segura Laboratorio de Ecología de Aves.Institute“Dr.Raúl A.Ringuelet”(ILPLA)-UNLP/CONICET Boulevard 1201437La PlataB1900Buenos AiresArgentina

Nestling growth of birds can be affected by weather *** general,it is expected that higher temper-atures favor growth by improving food availability and nestling metabolism,while rain hinders it by reducing foraging ***,most of these patterns have been described in insectivorous cavity-nesting birds in temperate *** tested these predictions in two neotropical grassland ground-nesting birds with contrasting nestling diets and therefore potentially different responses to *** measured nestlings of the Hellmayr’s Pipit(Anthus hellmayri,an insectivorous passerine)and the Grassland Yellow-Finch(Sicalis luteola,which feeds its nestlings exclusively with seeds)during three breeding seasons(2017-2020)in central-eastern *** took measurements of tarsus and body mass,modeled growth curves using nonlinear mixed-effects models,and evaluated the effects of minimum daily temperature and precipitation during the growth period and the 30 days prior to *** pipits(60 nestlings from 21 nests),minimum temperatures during the growth period were positively associated with tarsus and body mass ***,there was a positive association between precipitation during the pre-hatching period and tarsus ***,none of the weather variables analyzed had significant effects on nestling growth of finches(131 nestlings from 35 nests).Dietary contrast between species may explain the different *** activity and abundance can be affected by weather variations within the span of a breeding season,whereas seeds may depend on conditions from previous years,making the effects harder to *** with reduced asymptotic size can have reduced chances of ***,pipit populations could be impacted if they experience cold and dry conditions during their breeding season,which is of major relevance in the current context of climate change.

关键词： Finches Grassland birds Neotropical birds Pipits Precipitation Temperature

A comparison of survival and pathologic features of non-alcoholic steatohepatitis and hepatitis C virus patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第31期18卷 4145-4149页

作者： Roberto hernandez-alejandro Kris P Croome Martin Drage Nathalie Sela Jeremy Parfitt Natasha Chandok Paul Marotta Cheryl Dale William Wall Douglas Quan Multi-Organ Transplant Program Department of SurgeryLondon Health Sciences CentreOntario N6A 5A5Canada Department of Pathology London Health Sciences CentreOntario N6A 5A5Canada

AIM:To compare the clinical outcome and pathologic features of non-alcoholic steatohepatitis(NASH) patients with hepatocellular carcinoma(HCC) and hepatitic C virus(HCV) patients with HCC(another group in which HCC is commonly seen) undergoing liver ***:Patients transplanted for HCV and NASH at our institution from January 2000 to April 2011 were *** explanted liver histology and pre-transplant liver biopsies were examined by two specialist liver *** demographics,disease free survival,explant liver characteristics and HCC features(tumour number,cumulative tumour size,vascular invasion and differentiation) were compared between HCV and NASH liver transplant ***:A total of 102 patients with NASH and 283 patients with HCV were *** incidence of HCC in NASH transplant recipients was 16.7%(17/102).The incidence of HCC in HCV transplant recipients was 22.6%(64/283).Patients with NASH-HCC were statistically older than HCV-HCC patients(P < 0.001).A significantly higher proportion of HCV-HCC patients had vascular invasion(23.4% vs 6.4%,P = 0.002) and poorly differentiated HCC(4.7% vs 0%,P < 0.001) compared to the NASH-HCC group.A trend of poorer recurrence free survival at 5 years was seen in HCV-HCC patients compared to NASH-HCC who underwent a Liver transplantation(P = 0.11).CONCLUSION:Patients transplanted for NASH-HCC appear to have less aggressive tumour features compared to those with HCV-HCC,which likely in part accounts for their improved recurrence free survival.

关键词：丙型肝炎病毒肝细胞肝癌酒精性患者病理特点脂肪 NASH 组织学检查

Brent *** Texas Intermediate in the US petro derivatives price formation

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Petroleum Science 2024年第1期21卷 729-739页

作者： alejandro Almeida Antonio A.Golpe Juan Manuel Martín-Alvarez Jose Carlos Vides Universidad Internacional de La Rioja Department of Quantitative Methods for Economics and BusinessLa RiojaSpain University of Huelva Department of Economics and Centro de Estudios Avanzados en FisicaMatematicas y Computacion and ICEIHuelvaSpain Complutense University of Madrid Department of Applied and Structural Economics and History and ICEIMadridSpain

In this paper,we apply the spatial panel model to explore the relationship between the dynamic of two types of crude oil prices(WTI and Brent crude oil)and their refined products over *** the turbulent months of 2011,when Cushing Oklahoma had reached capacity and the crude oil export ban removal in 2015 as breakpoints,we apply this method both in the full sample and the three resultant ***,results suggest our results show that both WTI and Brent display very similar behaviour with the refined ***,when attending to each regime,results derived from the first and third regimes are quite similar to the full sample ***,during the second regime,Brent crude oil became the benchmark in the petrol market,and it influenced the distillate ***,our model can let us determine the price-setters and price-followers in the price formation mechanism through refined *** results possess important considerations to policymakers and the market participants and the price formation.

关键词： Crude oil prices Spatial panel model Refined products Price formation