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Relationship between clinical remission of perianal fistulas in Crohn’s disease and serum adalimumab concentrations:A multicenter cross-sectional study

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World Journal of Gastroenterology 2022年第9期28卷 961-972页

作者： Laura Sirmai Anne-Laure Pelletier Nathalie Gault Camille Zallot Guillaume Bouguen Dominique Bouchard Pascale Roland Nicaise Marine Peyneau Sandrine Sironneau Marcelo De Carvalho Bittencourt Antoine Petitcollin Pedro fernandez Xavier Roblin Laurent Siproudhis Laurent Abramowitz Division of Hepato-Gastroenterology and Digestive Oncology Bichat Claude Bernard University HospitalParis 75018France Division of Hepato-Gastroenterology Hospital Croix Saint SimonParis 75020France Division of Epidemiology Biostatistics and Clinical ResearchUniversity Hospital Center BichatParis 75018France National Institute of Health and Medical Research CIC-EC1425 University Hospital Center BichatParis 75018France Division of Gastroenterology Nancy Regional and University Hospital CenterNancy 54035France Imphy CIC 1414 Group and Division of Gastroenterology and Hepatology University Hospital of RennesPontchaillouRennes 35033France Division of Proctology Hospital BagatelleTalence 33400France Division of Immunology University Hospital Center BichatParis 75018France Inflammation Microbiome and ImmunosurveillanceFaculty of PharmacyUniversitéParis-SaclayChâtenay-Malabry 92290France Division of Radiology Bagatelle Hospital CenterTalence 33400France Division of Immunology Nancy Regional and University Hospital CenterNancy 54000France University of Lorraine CNRS UMR 7365IMoPANancy 54000France Antoine Petitcol Department of Clinical and Biological Pharmacology and Pharmacovigilance Pharmacoepidemiology and Drug Information CenterRennes University HospitalRennes 35700France Division of Radiology University Hospital Center BichatParis 75018France Orangerie Center Le Perreux-sur-Marne 94170France Division of Gastroenterology CHU Saint EtienneSaint-Priest-en-Jarez 42270France Division of Gastroenterology and Hepatology and Proctology University Hospital Center BichatParis 75018France Ramsay GDS Clinique Blomet Paris 75018France

BACKGROUND Crohn’s disease(CD)is complicated by perianal fistulas in approximately 20%of patients.Achieving permanent fistula closure remains a challenge for physicians.An association between serum anti-tumor necrosis factor-αconcentrations and clinical outcomes in patients with CD has been demonstrated;however,little information is available on serum adalimumab(ADA)concentrations and remission of perianal fistulas in such patients.AIM To study the relationship between serum ADA concentrations and clinical remission of CDassociated perianal fistulas.METHODS This cross-sectional study of patients with CD-associated perianal fistulas treated with ADA was performed at four French hospitals between December 2013 and March 2018.At the time of each serum ADA concentration measurement,we collected information about the patients and their fistulas.The primary study endpoint was clinical remission of fistulas defined as the absence of drainage(in accordance with Present’s criteria),with a PDAI≤4,absence of a seton and assessment of the overall evaluation as favorable by the proctologist at the relevant center.We also assessed fistula healing[defined as being in clinical and radiological(magnetic resonance imaging,MRI)remission]and adverse events.RESULTS The study cohort comprised 34 patients who underwent 56 evaluations(patients had between one and four evaluations).Fifteen patients had clinical remissions(44%),four of whom had healed fistulas on MRI.Serum ADA concentrations were significantly higher at evaluations in which clinical remission was identified than at evaluations in which it was not[14(10-16)vs 10(2-15)μg/mL,P=0.01].Serum ADA concentrations were comparable at the times of evaluation of patients with and without healed fistulas[11(7-14)vs 10(4-16)μg/mL,P=0.69].The adverse event rate did not differ between different serum ADA concentrations.CONCLUSION We found a significant association between high serum ADA concentrations and clinical remission of CD-associated perianal fistulas.

关键词： Crohn’s disease Clinical pharmacology Peri-anal disorders Adalimumab

Contribution of Different Agronomic Practices and the Fungus Beauveria bassiana on the Coffee Berry Borer

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Journal of Life Sciences 2013年第9期7卷 980-992页

作者： Alberto fernandez Turro Ernesto Castafieda Hidalgo Francisco simon Ricardo Everton Kort Kamp Fernandes Juana Iris Duran Cos Odisa Baque Fuentes Universidad de Guantanamo UG Km 212 Carretera a Santiago de Cuba Guantanamo 95100 Cuba Instituto Tecnologico del Valle de Oaxaca. Ex Hacienda de Nazareno Xoxocotlan Oaxaca 71230 Mexico Ministerio de la Agricultura. Laboratorio Provincial de Sanidad Vegetal de Santiago de Cuba Carretera a Siboney Santiago de Cuba Cuba Federal University of Goias UFG Carretera 235 Sector Universitario Goiania 74605-050 Brasil

The research was carried out to study the effect of varying certain ecological conditions in the coffee through the implementation of different agronomic practices such as regulation of the shade, ground cover and rehabilitation of plantations on the populations of the coffee berry borer Hypothenemus hampei Ferrari (Coleoptera: Curculionidae), it was also evaluated the influence of these conditions in the introduction and transfer of new variants of application of the fungus Beauveria bassiana (Balsamo) Vuillemin. The results showed that the pest damage was lower under a system of sustainable coffee, designed after the restoration of the population density of coffee, conducting systematic pruning and plant health, sanitation of the forest, shade management to double stratum with scattered light intensity of 60-70% and a combination of systems of denominated handling of weeds (Strip weeding - Ring weeding), it was found that under these conditions the technical effectiveness of the fungus B. bassiana was higher compared with applications made in the trees less enlightened, being more advantageous to spray the foliage four times with a frequency of 40 days from 60 days to peak flowering with positive economic indicators even when used as single biological control strategy against the coffee berry borer.

关键词：球孢白僵菌农艺措施咖啡浆果真菌螟虫散射光强度系统化

C-reactive protein is differentially modulated by co-existing infections,vitamin deficiencies and maternal factors in pregnant and lactating indigenous Panamanian women

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Infectious Diseases of Poverty 2017年第1期6卷 819-832页

作者： Doris Gonzalez-fernandez Emerita del Carmen Pons Delfina Rueda Odalis Teresa Sinisterra Enrique Murillo Marilyn E.Scott Kristine G.Koski School of Dietetics and Human Nutrition Macdonald Campus of McGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3V9Canada Department of Nutritional Health Ministry of HealthAnconPanama CityPanama “Comarca Ngabe-Bugle”Health Region Ministry of HealthSan FelixChiriqui ProvincePanama “Panama Norte”Health Region Ministry of HealthLas Cumbres SquareTransithmian HighwayPanama CityPanama Department of Biochemistry University of PanamaSimon Bolivar Avenue(Transithmian Highway)Panama CityPanama Department of Biochemistry University of PanamaManuel Espinoza Batista and Jose De Fabrega AvenuesPanama CityPanama Institute of Parasitology and Centre for Host-Parasite Interactions Macdonald Campus of McGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3 V9Canada School of Dietetics and Human Nutrition and Centre for Host-Parasite Interactions Macdonald CampusMcGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3 V9Canada

Background:The usefulness of C-reactive protein(CRP)as a non-specific marker of inflammation during pregnancy and lactation is unclear in impoverished populations where co-existing infections and vitamin deficiencies are common.Methods:This cross-sectional study in Panama recruited 120 pregnant and 99 lactating Ngäbe-Buglewomen from 14 communities in rural Panama.Obstetric history,indoor wood smoke exposure,fieldwork,BMI,vitamins A,B_(12),D,and folic acid,and inflammation markers(CRP,neutrophil/lymphocyte ratio(NLR),plateletcrit and cytokines)were measured.Multiple regressions explored both associations of CRP with other inflammatory markers and associations of CRP and elevated CRP based on trimester-specific cut-offs with maternal factors,infections and vitamin deficiencies.Results:CRP was higher in pregnancy(51.4±4.7 nmol/L)than lactation(27.8±3.5 nmol/L)and was elevated above trimester specific cut-offs in 21%of pregnant and 30%of lactating women.Vitamin deficiencies were common(vitamin A 29.6%;vitamin D 68.5%;vitamin B1268%;folic acid 25.5%)and over 50%of women had two or more concurrent deficiencies as well as multiple infections.Multiple regression models highlighted differences in variables associated with CRP between pregnancy and lactation.In pregnancy,CRP was positively associated with greater indoor wood smoke exposure,caries and hookworm and negatively associated with Ascaris and vaginal Lactobacillus and Bacteroides/Gardnerella scores.Consistent with this,greater wood smoke exposure,caries as well as higher diplococcal infection score increased the odds of trimester-elevated CRP concentrations whereas longer gestational age lowered the likelihood of a trimester-elevated CRP.During lactation,folic acid deficiency was associated with higher CRP whereas parity,number of eosinophils and Mobiluncus score were associated with lower CRP.Also,a higher BMI and Trichomonas vaginalis score increased the likelihood of an elevated CRP whereas higher parity and number of eosinophils were associated with lower like

关键词： CRP Intestinal parasites Caries Vaginal infections Folic acid deficiency Wood smoke Neutrophil/lymphocyte ratio Plateletcrit Pregnancy Lactation

Spontaneous immortalization of human dermal microvascular endothelial cells

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World Journal of Stem Cells 2010年第5期2卷 114-120页

作者： Laura DeBusk Suzanne fernandez Douglas W Strand simon W Hayward P Charles Lin Department of Radiation Oncology Vanderbilt University Medical Center Department of Urologic Surgery Vanderbilt University Medical Center Center for Cancer Research National Cancer Institute

AIM:To establish and characterize a spontaneously immortalized human dermal microvascular endothelial cell line,iHDME1.METHODS:We developed a spontaneous immortalization method.This approach is based on the application of optimized culture media and culture conditions without addition of any exogenous oncogenes or carcinogens.Using this approach,we have successfully established a microvascular endothelial cell line,iHDME1,from primary human dermal microvascular endothelial cells.iHDME1 cells have been maintained in culture dishes for more than 50 passages over a period of 6 mo.Using a GFP expressing retrovirus,we generated a GFP-stable cell line(iHDME1-GFP).RESULTS:iHDME1 retain endothelial morphology and uniformly express endothelial markers such as VEGF receptor 2 and VE-cadherin but not α-smooth muscle actin(α-SM-actin) and cytokeratin 18,markers for smooth muscle cells and epithelial cells respectively.These cells retain endothelial properties,migrate in response to VEGF stimulation and form 3-D vascular structures in Matrigel,similar to the parental cells.There is no signif icant difference in cell cycle prof ile between the parental cells and iHDME1 cells.Further analysis indicates enhanced stemness in iHDME1 cells compared to parental cells.iHDME1 cells display elevated expression of CD133 and hTERT.CONCLUSION:iHDME1 cells will be a valuable source for studying angiogenesis.

关键词： Spontaneous immortalization Angiogenesis Endothelial cell

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澳门摩珀斯酒店

建筑实践 2020年第9期3卷 90-109页

作者： Zaha Hadid Patrik Schumacher Viviana Muscettola Michele Pasca di Magliano Michele Salvi Bianca Cheung Maria Loreto Flores Clara Martins Miron Mutyaba Milind Khade Pierandrea Angius Massimo Napoleoni Stefa no lacopini Davide Del Giudice Luciano Letteriello Luis Migue Samanez Cyril Manyara Alvin Triestanto Muhammed Shameel Goswin Rothenthal Santiago fernandez-Achury Vahid Eshraghi Melika Aljukic Virgile simon Bertrand(摄) Ivan Dupont(摄) 无不详哈迪德建筑事务所

澳门新濠天地旗舰酒店摩珀斯酒店于2018年6月15日开业。澳门作为亚洲最受欢迎的娱乐目的地,2017年接待了超过3,200万名游客,并且游客数量连年增加。新濠天地位于澳门路氹城,是一个集赌场、戏院、购物区、餐厅及酒店于一体的综合度假胜... 详细信息

澳门新濠天地旗舰酒店摩珀斯酒店于2018年6月15日开业。澳门作为亚洲最受欢迎的娱乐目的地,2017年接待了超过3,200万名游客,并且游客数量连年增加。新濠天地位于澳门路氹城,是一个集赌场、戏院、购物区、餐厅及酒店于一体的综合度假胜地。扎哈·哈迪德建筑事务所于2012年接受委托建造该酒店,当时项目场地上有一座已经打好地基但没有后续进展的塔楼。建筑师以中国传统玉雕丰富而流畅的造型为灵感,用创新的工程技术和流动性的方式将建筑的公共空间和私密空间融合在一起。建筑形体被构想为一个垂直挤压的矩形体量,建筑中部的一系列虚空间仿佛城市的窗口,将酒店内部的公共空间与城市连接起来,形成具有雕塑感的独特空间形式。

关键词：建筑事务所公共空间扎哈·哈迪德私密空间建筑形体度假胜地工程技术酒店