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Clinical assessment and management of liver fibrosis in nonalcoholic fatty liver disease

World Journal of Gastroenterology 2020年第39期26卷 5919-5943页

作者： alejandro Campos-Murguía Astrid Ruiz-Margáin JoséA González-Regueiro Ricardo U Macías-rodríguez Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico

Non-alcoholic fatty liver disease(NAFLD)is among the most frequent etiologies of cirrhosis worldwide,and it is associated with features of metabolic syndrome;the key factor influencing its prognosis is the progression of liver *** review aimed to propose a practical and stepwise approach to the evaluation and management of liver fibrosis in patients with NAFLD,analyzing the currently available *** the assessment of NAFLD patients,it is important to identify clinical,genetic,and environmental determinants of fibrosis development and its *** properly detect fibrosis,it is important to take into account the available methods and their supporting scientific evidence to guide the approach and the sequential selection of the best available biochemical scores,followed by a complementary imaging study(transient elastography,magnetic resonance elastography or acoustic radiation force impulse)and finally a liver biopsy,when *** help with the selection of the most appropriate method a Fagan′s nomogram analysis is provided in this review,describing the diagnostic yield of each method and their post-test probability of detecting liver ***,treatment should always include diet and exercise,as well as controlling the components of the metabolic syndrome,+/-vitamin E,considering the presence of sleep apnea,and when available,allocate those patients with advanced fibrosis or high risk of progression into clinical *** final end of this approach should be to establish an opportune diagnosis and treatment of liver fibrosis in patients with NAFLD,aiming to decrease/stop its progression and improve their prognosis.

关键词： Non-alcoholic fatty liver disease Liver fibrosis Clinical assessment Diagnosis Treatment Test accuracy

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Deposition of carbon nanotubes onto glass fibers using ultrasound standing waves

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Frontiers of Materials Science 2021年第3期15卷 471-475页

作者： Julio alejandro rodrÍguez-GONZÁLEZ Carlos RUBIO-GONZÁLEZ Alfonso PÉREZ-SÁNCHEZ Centro de Ingeniería y Desarrollo Industrial Departamento de EnergíaAv.Pie de la Cuesta#702Col.Desarrollo San PabloC.P.76125QuerétaroQroMexico

Carbon nanotubes(CNTs)are special types of carbon nanostructures with exceptional physical and mechanical properties such as high elastic modulus,high electrical and thermal conductivities,as well as high surface area and large aspect ratios[1].Given their tubular structure and size,CNTs are conceptualized as one-dimensional nanostructures with a crystalline structure of carbon sp2 hybridization formed by carbon–carbon covalent bonds[1].

关键词： carbon fibers exceptional

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Non-human primate pluripotent stem cells for the preclinical testing of regenerative therapies

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Neural Regeneration Research 2022年第9期17卷 1867-1874页

作者： Ignacio rodríguez-Polo Rüdiger Behr Research Platform Degenerative Diseases German Primate Center-Leibniz Institute for Primate ResearchGöttingenGermany German Center for Cardiovascular Research(DZHK) Partner Site GöttingenGöttingenGermany

Non-human primates play a key role in the preclinical validation of pluripotent stem cell-based cell replacement *** stem cells used as advanced therapy medical products boost the possibility to regenerate tissues and organs affected by degenerative ***,the methods to derive human induced pluripotent stem cell and embryonic stem cell lines following clinical standards have quickly developed in the last 15 *** the preclinical validation of cell replacement therapies in non-human primates,it is necessary to generate non-human primate pluripotent stem cell with a homologous quality to their human ***,pluripotent stem cell technologies have developed at a slower pace in non-human primates in comparison with human cell *** recent years,however,relevant progress has also been made with non-human primate pluripotent stem *** review provides a systematic overview of the progress and remaining challenges for the generation of non-human primate induced pluripotent stem cells/embryonic stem cells for the preclinical testing and validation of cell replacement *** focus on the critical domains of(1)reprogramming and embryonic stem cell line derivation,(2)cell line maintenance and characterization and,(3)application of non-human primate pluripotent stem cells in the context of selected preclinical studies to treat cardiovascular and neurodegenerative disorders performed in non-human primates.

关键词： embryonic stem cells induced pluripotent stem cells non-human primates pluripotent stem cells preclinical regeneration reprogramming translational research

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Plyometric exercise and bone health in children and adolescents: a systematic review

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World Journal of Pediatrics 2017年第2期13卷 112-121页

作者： alejandro Gómez-Bruton (A)ngel Matute-Llorente alejandro González-Agüero JoséA.Casajús Germán Vicente-rodríguez Growth ExerciseNutrition and Development(GENUD)Research GroupUniversity of ZaragozaZaragozaSpain Faculty of Health and Sport Sciences(FCSD) Department of Physiatry and NursingUniversity of ZaragozaRonda Misericordia 522001-HuescaSpain Growth ExerciseNutrition and Development(GENUD)Research GroupUniversity of ZaragozaZaragozaSpain

Background:Many jumping interventions have been performed in children and adolescents in order to improve bone-related variables and thus,ensure a healthy bone development during these periods and later in *** systematic review aims to summarize and update present knowledge regarding the effects that jumping interventions may have on bone mass,structure and metabolism in order to ascertain the efficacy and durability (duration of the effects caused by the intervention) of the *** sources:Identification of studies was performed by searching in the database MEDLINE/PubMed and *** studies were identified by contacting clinical experts and searching bibliographies and *** terms included 'bone and bones','jump*','weight-bearing','resistance training' and 'school intervention'.The search was conducted up to October *** studies that had performed a specific jumping intervention in under 18-year olds and had measured bone mass were *** extraction of articles was done by 2 authors using predefined data ***:A total of 26 studies were included in this ***-four studies found positive results as subjects included in the intervention groups showed higher bone mineral density,bone mineral content and bone structure improvements than *** two studies found no effects on bone mass after a 10-week and 9-month ***,those studies that evaluated the durability of the effects found that some of the increases in the intervention groups were maintained after several ***:Jumping interventions during childhood and adolescence improve bone mineral content,density and structural properties without side *** type of interventions should be therefore implemented when possible in order to increase bone mass in early stages of life,which may have a direct preventive effect on bone diseases like osteoporosis later in fife.

关键词： adolescents bone mineral density intervention jumping osteoporosis

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The adaptive value of grass traits in response to grazing

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Journal of Plant Ecology 2018年第2期11卷 248-255页

作者： Valerie Cayssials Claudia rodríguez Instituto de Ecología y Ciencias Ambientales Facultad de CienciasUniversidad de la RepúblicaIguá4225CP 11400MontevideoUruguay

Aims Grazing is associated with several plant traits that may confer resist-ance to ***,cross-species analyses do not allow for the differentiation between adaptive evolution and common *** this study,we evaluated the effect of grazing on 5 mor-phological traits in 41 native grasses growing in natural grasslands of Uruguay and investigated whether such effects are independent of *** We used data of grass species from 17 paired,grazed and ungrazed plots located in different regions of natural grass-lands of *** each species,we calculated the Grazing Response index(GRi)and estimated the culm length,blade length,blade width,blade length/width ratio and caryopsis *** values were calculated as the mean of the maximum and minimum values reported in a public *** assessed the relationship between the GRi and the morphologi-cal traits using cross-species correlations,and we re-examined the correlations using phylogenetically controlled comparative *** Findings Culm length and blade length were significantly correlated with the *** with higher culms and longer blades diminished their cover under *** association remained significant after statistical control of phylogenetic relatedness among *** contrast,blade width,blade length/width ratio and caryopsis length did not show any significant relationship with the *** studies in temperate grasslands recognized that several plant traits respond to grazing but were rarely evaluated in a phylogenetic *** results are consistent with the idea that grazing is a selective force with a clear effect on the evolution of grass stature,selecting smaller plants with shorter blades.

关键词： grasslands plant height leaf length PiCs Uruguay

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Gromov Hyperbolicity of Riemann Surfaces

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Acta Mathematica Sinica,English Series 2007年第2期23卷 209-228页

作者： José M.rodríguez EVa TOURIS Departamento de Matemáticas Universidad Carlos Ⅲ de MadridAvenida de la Universidad 3028911 LeganésMadridSpain

We study the hyperbolicity in the Gromov sense of Riemann surfaces. We deduce the hyperbolicity of a surface from the hyperbolicity of its ＂building block components＂. We also prove the equivalence between the hyperbolicity of a Riemann surface and the hyperbolicity of some graph associated with it. These results clarify how the decomposition of a Riemann surface into Y-pieces and funnels affects the hyperbolicity of the surface. The results simplify the topology of the surface and allow us to obtain global results from local information.

关键词： Gromov hyperbolicity hyperbolic Riemann surface

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The movement dynamics of autotomized lizards and their tails reveal functional costs of caudal autotomy

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Integrative Zoology 2020年第6期15卷 511-521页

作者： Irene FERNÁNDEZ-rodrÍguez Florentino BRAÑA Department of Organisms and Systems Biology(Zoology) University of OviedoOviedoSpain Research Unit of Biodiversity(UMIB UO/CSIC/PA)University of OviedoMieresSpain

Autotomy has evolved independently several times in different animal *** frequently involves immediate functional costs,so regeneration evolved in many instances to restore the functionality of that body *** autotomy is a widespread antipredator strategy in lizards,although it may affect energy storage,locomotion dynamics,or survival in future encounters with ***,we assessed the effect of tail loss on the locomotor performance of wall lizards(Podarcis muralis),as well as the recovery of locomotor functionality of lizards with regenerated tails,and the movement dynamics of shed tails that were either intact or having regenerated *** loss had no effect on locomotion over unhindered spaces,possibly due to compensation between a negative effect on the stride of front limbs,and a positive effect of losing mass and friction *** found a clear negative impact of tail loss on locomotion in spaces with interspersed obstacles,in which tailed lizards jumped larger distances when leaving the ***,lizards that used the tail to push off the ground were able to approach the obstacles from further,so that the tail seemed to be useful when used during *** fully restores lizard’s locomotor capacities,but tail antipredator value,as indicated by the intensity of post-autotomic movements,is only partially *** these results,we propose that,together with the recovery of post-autotomy antipredator capacities,the restoration of the organismal locomotor performance may have been an important,yet frequently neglected factor in the evolution of lizard’s regeneration ability.

关键词： autotomy locomotor performance regeneration tail wall lizard

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Changes in microhabitat, but not allelopathy, affect plant establishment after Acacia dealbata invasion

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Journal of Plant Ecology 2017年第4期10卷 610-617页

作者： Paula Lorenzo Jonatan rodríguez Luís González Susana rodríguez-Echeverría Centre for Functional Ecology(CFE) Department of Life SciencesUniversity of CoimbraCalçada Martim de Freitas3000-456 CoimbraPortugal Facultade de Bioloxía Departamento de Bioloxía Vexetal e Ciencia do SoloUniversidade de VigoAs Lagoas-Marcosende s/n36310PontevedraSpain

Aims The tree legume Acacia dealbata Link is an aggressive Australian invader that severely affects abiotic and biotic compartments of eco-systems *** invasive species outcompetes native plant communities through direct competition,changes in microhabitat and soil properties under the canopy and the release of allelopathic ***,these effects are usually studied separately and under controlled *** objective of this study was to evaluate the combined effect of these modifications exerted by *** on the establishment of native and invasive species in the *** A full factorial experiment was performed in order to test the com-bined effect of microhabitat,soil type and allelopathy on the establish-ment of the invasive *** and three native species in the field(North-West Spain).We sowed seeds of native or invasive species in pots with different soil type(soil collected under *** or Pinus pinaster),allelopathy status(soil treated or untreated with activated car-bon)and microhabitat(under the canopy of *** or ***).The number and total biomass of established plants were evaluated after 8 *** abiotic properties were determined in all *** Findings The establishment of native and invasive species was signifi-cantly affected by the microhabitat,with a higher number of seedlings under the native forest(***).The establishment of *** seedlings was also significantly promoted by its own soil.A negligible effect of allelopathy was detected on the establishment and growth of both invasive and native *** conclude that(i)the main factor affecting seedling establish-ment was microhabitat rather than changes in soil properties or allelopathy,(ii)soil modifications by *** promote the establishment of its own seedlings,contributing to the progress of invasion and(iii)allelochemicals released by *** do not seem to play a key role for the establishment of native

关键词： plant invasion microhabitat soil changes allelopathy plant establishment

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Kainate receptors in the CA2 region of the hippocampus

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Neural Regeneration Research 2023年第2期18卷 320-321页

作者： Yuniesky Andrade-Talavera Antonio rodríguez-Moreno Laboratorio de Neurociencia Celulary Plasticidad Departamento de FisiologíaAnatomía y Biología CelularUniversidad Pablo de OlavideSevillaSpain

The hippocampus is involved in important brain functions such as learning and memory,spatial navigation,fear processing,and social behavior(Dudek et al,2016).The most prominent areas of the hippocampus are typically denoted as the dentate gyrus and the three areas of the cornu ammonis(CA1,CA2,and CA3).Discovered by Lorente de Nó(1934),the CA2 region of the hippocampus is a relatively small area interposed between CA3 and CA1 that forms the nexus linking the input of the entorhinal cortex to the output of CA1(Chevaleyre and Siegelbaum,2010).

关键词： CA2 cortex linking

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Citation distributions and research evaluations:The impossibility of formulating a universal indicator

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Journal of Data and Information Science 2024年第4期9卷 24-48页

作者： Alonso rodríguez-Navarro Department of Biotechnology-Plant Biology Polytechnic University of MadridMadrid 28040Spain

Purpose:To analyze the diversity of citation distributions to publications in different research topics to investigate the accuracy of size-independent,rank-based *** top percentile-based indicators are the most common indicators of this type,and the evaluations of Japan are the most evident ***/methodology/approach:The distributions of citations to publications from countries and journals in several research topics were analyzed along with the corresponding global publications using histograms with logarithmic binning,double rank plots,and normal probability plots of log-transformed numbers of ***:Size-independent,top percentile-based indicators are accurate when the global ranks of local publications fit a power law,but deviations in the least cited papers are frequent in countries and occur in all journals with high impact *** these cases,a single indicator is *** of the proportions of uncited papers are the best way to predict these *** limitations:This study is fundamentally analytical,and its results describe mathematical facts that are *** implications:Respectable institutions,such as the OECD,the European Commission,and the *** Science Board,produce research country rankings and individual evaluations using size-independent percentile indicators that are misleading in many *** misleading evaluations should be discontinued because they can cause confusion among research policymakers and lead to incorrect research ***/value:Studies linking the lower tail of citation distribution,including uncited papers,to percentile research indicators have not been performed *** present results demonstrate that studies of this type are necessary to find reliable procedures for research assessments.

关键词： Scientometrics Research assessment Research indicators Citation distribution Rank analysis

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