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Frontiers of Law in China-Selected Publications from Chinese Universities 2015年第1期10卷 202-208页

作者： GUO Rui alejandro GARCIA JIMENEZ ZUO Zhenbin Harvard Law School and Assistant Professor at School of Law Renmin University of China Beijing 100872 China. School of Law Renmin University of China Beijing 100872 China. Undergraduate student in law at School of Law Renmin University of China Beijing 100872 China

In the age of globalization, national legislations on corporate governance and corporate social responsibility inevitably influence other parts of the world. This has been the dominant reason for many countries to adopt a comparative approach in legislations and judicial practices. In order to better understand globalization and develop a better approach to it from a comparative perspective, Renmin Law School held a conference that gathered scholars from four prominent law schools, namely Geneva University Law Faculty, Harvard Law School, Renmin Law School, and Sydney University Law School, to exchange ideas on corporate governance and corporate social responsibility. As Vice President of Renmin University has said during the opening ceremony, this conference aims to provide the Chinese government and corporations with new ideas and inspirations by sharing the comparative studies of prominent scholars on corporate governance and corporate social responsibility.

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Current concepts in the management of the duplicated thumb

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Plastic and Aesthetic Research 2023年第1期10卷 137-146页

作者： Tanir Moreno alejandro Gimenez William C.Pederson Division of Plastic Surgery Baylor College of MedicineHoustonTX 77030USA

Preaxial polydactyly is a common congenital anomaly of the hand presenting at *** treatment is aimed at creating a functional thumb capable of normal grip and pinch strength with acceptable *** case is unique and presents individual challenges to the hand *** aim of this review is to provide a synopsis of current knowledge and recommended surgical techniques for the duplicated thumb.

关键词： Preaxial polydactyly hand deformities reconstructive surgical procedures thumb duplication congenital anomaly

Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis

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World Journal of Gastroenterology 2015年第45期21卷 12742-12756页

作者： Manuel A Valenzuela Jimena Canales alejandro H Corvalán Andrew FG Quest Laboratorio de Comunicaciones Celulares Centro de Estudios Moleculares de la Célula Programa de Biología Celular y Molecular ICBM Facultad de Medicina Universidad de Chile Cellular Communication Laboratory Center for Molecular Studies of the Cell Advanced Center for Chronic Diseases School of Medicine Universidad de Chile UC-Centro de Investigación en Oncología Pontificia Universidad Católica de Chile Departamento de Hematología-Oncología Facultad de Medicine Pontificia Universidad Católica de Chile

The sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori(H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the mostrelevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and mi RNAs in this context.

关键词： Helicobacter pylori Methylation Gastric cancer Epi

Semantic Segmentation of Sorghum Using Hyperspectral Data Identifies Genetic Associations

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Plant Phenomics 2020年第1期2卷 14-24页

作者： Chenyong Miao alejandro Pages Zheng Xu Eric Rodene Jinliang Yang James C.Schnable Center for Plant Science Innovation University of Nebraska-LincolnLincolnNEUSA Department of Agronomy and Horticulture University of Nebraska-LincolnLincolnNEUSA Quantitative Life Sciences Initiative University of Nebraska-LincolnLincolnNEUSA Department of Mathematics and Statistics Wright State UniversityDaytonOHUSA

This study describes the evaluation of a range of approaches to semantic segmentation of hyperspectral images of sorghum plants,classifying each pixel as either nonplant or belonging to one of the three organ types(leaf,stalk,panicle).While many current methods for segmentation focus on separating plant pixels from background,organ-specific segmentation makes it feasible to measure a wider range of plant *** scored training data for a set of hyperspectral images collected from a sorghum association population was used to train and evaluate a set of supervised classification *** algorithms show acceptable accuracy for this classification *** trained on sorghum data are able to accurately classify maize leaves and stalks,but fail to accurately classify maize reproductive organs which are not directly equivalent to sorghum *** measurements extracted from semantic segmentation of sorghum organs can be used to identify both genes known to be controlling variation in a previously measured phenotypes(e.g.,panicle size and plant height)as well as identify signals for genes controlling traits not previously quantified in this population(e.g.,stalk/leaf ratio).Organ level semantic segmentation provides opportunities to identify genes controlling variation in a wide range of morphological phenotypes in sorghum,maize,and other related grain crops.

关键词： Sorghum classify organs

Feasibility of the 2-point method to determine the load-velocity relationship variables during the countermovement jump exercise

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Journal of Sport and Health Science 2023年第4期12卷 544-552,F0003页

作者： alejandro Pérez-Castilla Rodrigo Ramirez-Campillo John F.T.Fernandes Amador García-Ramos Department of Physical Education and Sport Faculty of Sport SciencesUniversity of GranadaGranada 18011Spain Human Performance Laboratory Department of Physical Activity SciencesUniversidad de Los LagosSantiago 5170000Chile Centro de Investigacion en Fisiologıa del Ejercicio Facultad de CienciasUniversidad MayorSantiago 8580745Chile Higher Education Sport Hartpury UniversityHartpury GL193BEUK Department of Sports Sciences and Physical Conditioning Faculty of EducationUniversidad Catolica de la Santısima ConcepcionConcepcion 4090541Chile

Purpose:This study aimed to examine the reliability and validity of load-velocity(L-V)relationship variables obtained through the 2-point method using different load combinations and velocity ***:Twenty men performed 2 identical sessions consisting of 2 countermovement jumps against 4 external loads(20 kg,40 kg,60 kg,and80 kg)and a heavy squat against a load linked to a mean velocity(MV)of 0.55 m/s(load_(0.55)).The L-V relationship variables(load-axis intercept(L_(0)),velocity-axis intercept(v_(0)),and area under the L-V relationship line(A_(line)))were obtained using 3 velocity variables(MV,mean propulsive velocity(MPV),and peak velocity)by the multiple-point method including(20-40-60-80-load_(0.55))and excluding(20-40-60-80)the heavy squat,as well as from their respective 2-point methods(20-load_(0.55)and 20-80).Results:The L-V relationship variables were obtained with an acceptable reliability(coefncient of variation(CV)≤7.30%;intra-class correlation coefficient>0.63).The reliability of L_(0)and v_(0)was comparable for both methods(CV_(ratio)(calculated as higher value/lower value):1.11-1.12),but the multiple-point method provided Al_(ine)with a greater reliability(CV_(ratio)=1.26).The use of a heavy squat provided the L-V relationship variables with a comparable or higher reliability than the use of a heavy countermovement jump load(CV_(ratio):1.06-1.19).The peak velocity provided the load-velocity relationship variables with the greatest reliability(CV_(ratio):1.15-1.86)followed by the MV(CV_(ratio):1.07-1.18),and finally the *** 2-point methods only revealed an acceptable validity for the MV and MPV(effect size≤0.19;Pearson s product-moment correlation coefficient≥0.96;Lin's concordance correlation coefficient≥0.94).Conclusion:The 2-point method obtained from a heavy squat load and MV or MPV is a quick,safe,and reliable procedure to evaluate the lower-body maximal neuromuscular capacities through the L-V relationship.

关键词： Force-velocity relationship Mean velocity Multiple-point method Peak velocity Velocity-based training

Extending JASAG with data processing techniques for speeding up agricultural simulation applications:A case study with Simugan

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Information Processing in Agriculture 2016年第4期3卷 235-243页

作者： Mathias Longo Mauricio Arroqui Juan Rodriguez Claudio Machado Cristian Mateos alejandro Zunino ISISTAN–CONICET.Tandil(B7001BBO) Buenos AiresArgentina Consejo Nacional de Investigaciones Cientı´ficas y Te´cnicas(CONICET) Argentina Facultad de Ciencias Veterinarias–UNICEN.Tandil(B7001BBO) Buenos AiresArgentina Agencia Nacional de Promocio´n Cientı´fica y Tecnolo´gica(ANPCyT) Argentina

Resource-intensive agricultural simulation applications have increased the need for gridification tools–i.e.,software to transform and scale up the applications using Grid infrastructures–.Previous research has proposed JASAG,a generic gridification tool for agricultural applications,through which the performance of a whole-farm simulation application called Simugan improved ***,JASAG still lacks proper support for efficiently exploiting Grid storage resources,causing significant delays for assembling and summarizing the generated *** this application note,two different data processing techniques in the context of JASAG are presented to tackle this *** was again employed to validate the benefits of these *** using data processing techniques show that the execution time of Simugan was accelerated by a factor of up to 34.34.

关键词： Agricultural simulation applications Grid Computing Gridification JASAG Data processing Simugan

Human pluripotent stem cell-derived extracellular vesicles:From now to the future

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World Journal of Stem Cells 2023年第5期15卷 453-465页

作者： Bruno Moises de Matos Marco Augusto Stimamiglio alejandro Correa Anny Waloski Robert Stem Cells Basic Biology Laboratory Carlos Chagas InstituteCuritiba 81350010ParanáBrazil

Extracellular vesicles(EVs)are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication ***,in various biological contexts,EVs are reported to engage in immune modulation,senescence,and cell proliferation and ***,EVs could be key elements for potential off-the-shelf cell-free *** has been studied regarding EVs derived from human pluripotent stem cells(hPSC-EVs),even though hPSCs offer good opportunities for induction of tissue regeneration and unlimited proliferative *** this review article,we provide an overview of studies using hPSC-EVs,focusing on identifying the conditions in which the cells are cultivated for the isolation of EVs,how they are characterized,and applications already *** topics reported in this article highlight the incipient status of the studies in the field and the significance of hPSC-EVs’prospective applications as PSC-derived cell-free therapy products.

关键词： Pluripotent stem cells Extracellular vesicles Exosome Cell-free therapy

Residential end-uses disaggregation and demand response evaluation using integral transforms

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Journal of Modern Power Systems and Clean Energy 2017年第1期5卷 91-104页

作者： Antonio GABALDóN Roque MOLINA alejandro MARíN-PARRA Sergio VALERO-VERDú Carlos áLVAREZ ETS de Ingenierı´a Industrial Universidad Polite´cnica de CartagenaDr.Fleming s/n30202 CartagenaSpain EPS de Elche Universidad Miguel Herna´ndezElcheSpain Institute for Energy Engineering Universidad Polite´cnica de ValenciaValenciaSpain

Demand response is a basic tool used to develop modern power systems and electricity markets. Residential and commercial segments account for 40%–50% of the overall electricity demand. These segments need to overcome major obstacles before they can be included in a demand response portfolio. The objective of this paper is to tackle some of the technical barriers and explain how the potential of enabling technology(smart meters) can be harnessed, to evaluate the potential of customers for demand response(end-uses and their behaviors) and,moreover, to validate customers’ effective response to market prices or system events by means of non-intrusive methods. A tool based on the Hilbert transform is improved herein to identify and characterize the most suitable loads for the aforesaid purpose, whereby important characteristics such as cycling frequency, power level and pulse width are identified. The proposed methodology allows the filtering of aggregated load according to the amplitudes of elemental loads, independently of the frequency of their behaviors that could be altered by internal or external inputs such as weather or demand response. In this way, the assessment and verification of customer response can be improved by solving the problem of load aggregation with the help of integral transforms.

关键词： Demand response Hilbert transform Load monitoring Instantaneous frequency Aggregation Smart meters

The reaction electronic flux in chemical reactions

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Science China Chemistry 2011年第12期54卷 1982-1988页

作者： CERON María Luisa ECHEGARAY Eleonora GUTIRREZ-OLIVA Soledad HERRERA Barbara TORO-LABB alejandro Laboratorio de Química Teorica Computacional(QTC) Facultad de Química Pontificia Universidad Catolica de Chile

The mechanism of a chemical reaction can be characterized in terms of chemical events that take place during the *** events are bond weakening/breaking and/or bond strengthening/*** reaction electronic flux(REF),a concept that identifies and rationalizes the electronic activity taking place along the reaction coordinate,has emerged recently as a powerful tool for characterizing the mechanism of chemical reactions.A quantitative theory introducing new descriptors for characterizing reaction mechanisms is presented in detail and three illustrative examples are *** nucleophilic substitution reactions the REF indicates that bond breaking or forming events may be leading the electronic activity whereas in the methanol decomposition reaction by copper oxide,the REF allows to discover that consecutive electronic reductions of copper together with bond breaking processes control the course of the reaction.

关键词： reaction mechanisms chemical potential conceptual DFT reaction electronic flux (REF)

Morphometry and subpopulation structure of Holstein bull spermatozoa： variations in ejaculates and cryopreservation straws

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Asian Journal of Andrology 2016年第6期18卷 851-857页

作者： Anthony Valverde Hector Arenan Maria Sancho Jesus Contell Jesus Yaniz alejandro Fernandez Caries Soler Technological Institute of Costa Rica San Carlos Campus S Xenetica Fontao Fontao-Esperante 27210 Lugo Spain R+D Department Proiser R+D Scientific Park University of Valencia 46980 Paterna Spain Department of Animal Production and Food Science Politechnical School of Huesca University of Zaragoza 22071 Huesca Spain Department of Functional Biology and Physical Anthropology University of Valencia 46100 Burjassot Spain

Sperm quality is evaluated for the calculation of sperm dosage in artificial reproductive programs. The most common parameter used is motility, but morphology has a higher potential as a predictor of genetic quality. Morphometry calculations from CASA-Morph technology improve morphological evaluation and allow mathematical approaches to the problem. Semen from 28 Holstein bulls was collected by artificial vagina, and several ejaculates were studied. After general evaluation, samples were diluted, packaged in 0.25 ml straws, and stored in liquid nitrogen. Two straws per sample were thawed, and slides were processed and stained with Diff-Quik. Samples were analyzed by a CASA-Morph system for eight morphometric parameters. In addition to the ＂classical＂ statistical approach, based on variance analysis （revealing differences between animals, ejaculates, and straws）, principal component （PC） analysis showed that the variables were grouped into PC1, related to size, and PC2 to shape. Subpopulation structure analysis showed four groups, namely, big, small, short, and narrow from their dominant characteristics, representing 31.0%, 27.3%, 24.1%, and 17.7% of the total population, respectively. The distributions varied between animals and ejaculates, but between straws, there were no differences in only four animals. This modern approach of considering an ejaculate sperm population as divided into subpopulations reflecting quantifiable parameters generated by CASA-Morph systems technology opens a new view on sperm function. This is the first study applying this approach to evaluate different ejaculates and straws from the same individual. More work must be done to improve seminal dose calculations in assisted reproductive programs.

关键词： cryopreservation Holstein bull sperm morphometry subpopulations