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History of Infection Prior to Hematopoietic Stem Cell Transplant in the Recipient as a Risk Factor to Develop Acute Graft versus Host Disease

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Journal of Cancer Therapy 2019年第4期10卷 327-335页

作者： Alberto Olaya-Vargas Iván Castorena-Villa Martin Pérez-García Gerardo lop.z-Hernández Nideshda Ramírez-Uribe Haydeé Salazar-Rosales Hematopoietic Stem Cell Transplant and Cell Therapy Program National Institute of Pediatrics (INP) Mexico City México Hematopoietic Stem Cell Transplantand Cell TherapyProgram Hospital Infantil de México Federico Gomez Instituto Nacional de Salud México City México

Background: Acute graft-versus-host disease (aGVHD) is the most frequent and severe complication after allogeneic hematopoietic stem cell transplantation (HSCT). Objective: To determine if a history of prior infection in the allogeneic HSTC recipient is a risk factor to develop aGVHD. Methods: A retrospective cohort study based on data collected from the Department of Hematopoietic Stem Cell Transplantation at the Instituto Nacional de Pediatría (INP) from January 1998 to December 2016 was performed to identify if prior infection was a predictive risk factor for aGVHD. Results: 27 patients developed aGVHD (36.4%). Median time to aGVHD presentation was 82 days (9 to 273 days). Most patients developed grade III aGVHD. Following the multivariate analysis peripheral blood > bone marrow (OR 12.3;p 8.3 × 106/kg (OR 7.1;p = 0.05), peripheral blood (OR: 11.4;p < 0.001), infection 3 months prior to allogeneic transplant (OR: 4.5;p < 0.03) and CMV infection in the recipient (OR: 4.68;p Conclusions: Either bacterial infection or CMV infection in the recipient was significant risk factor within the aGVHD recipients;it is important to consider these factors for patients that are going to receive an allogeneic HSCT.

关键词： Allogeneic HSCT Complications Acute GVHD HSCT Infections

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PHYSICAL MODELLING OF ISOTHERMAL DIE FORGING PROCESS OF Ti-ALLOY STRUCTURAL AIR-FRAME PART WITH ETYPE CROSS-SECTION AND VARYING THICKNESS RIB

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Acta Metallurgica Sinica(English Letters) 2000年第1期13卷 401-405页

作者： z. K. Yao H. z. Cuo M. Wang F. Lan and P. F. Feng (Northwestern Polytechnical University, Xi’ an 710072, China)

Isothermal flashless die forging process of Ti - alloy structural air - frame part with varying thickness rib has been modelled in this *** results of present study show that a upside - down trapezoid rib would be formed and buckling would occure as blank is reduced,if the thickness of billet is maller than or equal to the thickness of rib. During modelling process of structural air frame part with E type cross - section rib, the saddle or lap would be formed finally at the middle of transverse rib between ribs with increase in *** metal is allowed to flow out at confluence of longitudinal and transverse rib, the lop defect would be eliminated,, but a pipe cavity is obvious on corresponding loca- tion of blank. of defect formation depends on distance of metal flow ,friction,temperature homoge- neity of the blank and complexity of the part.

关键词： Ti alloy air-frame part physical modelling

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他莫昔芬可治疗多巴胺激动剂抵抗性高泌乳血症患者的促性腺激素功能减退性性腺功能低下

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世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 23-23页

作者： lop.z Departamento opez J.M. Oestreicher E. 李跃萍 Dr.Facultad de Medicina P. Universidad Cat'olica de Chile Lira 85 Santiago Chile

Objective: To determine the response to tamoxifen in a woman with hypogonadotropic hypogonadism induced by hyperprolactinemia resistant to dopamine agonist drugs. Design: Case report. Setting: Academic fertility center. Patient(s): A young woman with persistent amenorrhea, symptomatic hypogonadotropic hypogonadism, and hyperprolactinemia. Intervention(s): Tamoxifen was administered in addition to bromocriptine. Main Outcome Measure(s): Measurements of follicle-stimulating hormone, estradiol, prolactin, and progesterone. Result(s): Recovery of gonadal-hypothalamic-pituitary axis. Conclusion(s): Tamoxifen can revert the effects of chronic hypogonadotropic hypogonadism induced by hyperprolactinemia resistant to dopamine agonists.

关键词：促性腺激素他莫昔芬性腺功能低下激动剂抵抗性多巴血症卵泡刺激素溴隐亭持续性

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隐蔽巩膜切开术作为滤过性青光眼手术

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 40-41页

作者： Wirbelauer C. Fischer-Schieβl E. zllner F. Pham D.T. 韩静 Klinik für Augenheilkunde Vivantes Klinikum NeukllnRudower Str.48D-12351 BerlinGermany Dr.

Background:Covered sclerotomy was developed as a minimally invasive modification of filtering glaucoma *** this prospective study the clinical results are compared after one *** and Methods:58 eyes with advanced glaucoma were studied.32 eyes had a covered sclerotomy(ST)and 26 had an ST with viscoelastic filling of the anterior chamber in order to reduce the postoperative hypotony rate(ST+ H).The ST procedure consisted in the preparation of a 4 mm corneoscleral tunnel incision with a T-shaped 1.75 mm wide perforation and radial transection of the tunnel ***:The preoperative intraocular pressure(IOP)was on average 30± 8.5 mmHg(ST)and 26± 8.3 mmHg(ST+ H).After 1 year the IOP decreased significantly(P < 0.05)to 17± 3.7 mmHg(ST)and 17± 2.9 mmHg(ST+ H).The mean IOP reduction was 37%(ST)and 30%(ST+ H).Revisions were required in 37%(ST)and 15%(ST+ H)of the *** postoperative hypotony rate was 34% in both *** number of morphologically functional filtering blebs was 60%(ST)and 70%(ST+ H)after one ***:The covered sclerotomy required minimal surgical manipulations of the conjunctiva and *** 1 year a significant reduction of the IOP was ***,the occurrence of bleb scarring could not be lowered compared to *** further modifications with the primary application of antimetabolites are planned.

关键词：巩膜切开术滤过性青光眼手术术后低眼压青光眼滤过术巩膜隧道切口手术操作前瞻性研究

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