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Effect of fosfomycin,Cynara scolymus extract,deoxynivalenol and their combinations on intestinal health of weaned piglets

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Animal Nutrition 2019年第4期5卷 386-395页

作者： Guadalupe Martinez Susana N.Dieguez Maria B.Fernandez Paggi Maria B.Riccio Denisa S.Perez Gaudio Edgardo Rodriguez Fabian A.Amanto Maria O.Tapia alejandro l.soraci Area Toxicología Departamento de FisiopatologíaFacultad de Ciencias VeterinariasUniversidad Nacional del Centro de la Provincia de Buenos AiresTandilB7000Buenos AiresArgentina Centro de Investigación Veterinaria de Tandil(CIVETAN) UNCPBA-CICPBA-CONICETFacultad de Ciencias VeterinariasCampus UniversitarioTandilB7000Buenos AiresArgentina Consejo Nacional de Investigaciónes Científicas-CONICET Buenos AiresC1425FQBArgentina Comisión de Investigaciónes Científicas de la Provincia de Buenos Aires(CIC-PBA) La PlataB1900Buenos AiresArgentina Area Producción Porcina Departamento de Producción AnimalFacultad de Ciencias VeterinariasUniversidad Nacional del Centro de La Provincia de Buenos AiresTandilB7000Buenos AiresArgentina Area Estadística Sanidad Animal y Medicina PreventivaFacultad de Ciencias VeterinariasUniversiclacl Nacional del Centro de la Provincia de Buenos AiresTandilB7000Buenos AiresArgentina

Weaning is a challenging stage of pig *** undergo environmental,social and dietary changes leading to weaning stress *** order to compensate for the detrimental effects of weaning stress,antibiotics and natural extracts are used as feed additives,sometimes without fully understanding the interactions between them or even with low concentrations of mycotoxins that are frequently present in *** aim of this study was to evaluate the effect of fosfomycin(FOS),Cynara scolymus extract(CSE),deoxynivalenol(DON) and their combined administration on intestinal health of weaned *** experiment was designed as a 2×2×2 factorial arrangement with 3 factors(FOS,CSE and DON treatments),2 levels each(presence and absence) and 3 *** piglets(n=24)were randomly divided in groups to receive the different treatments,namely DON administered in diet(50 μg/kg BW),FOS administered into the drinking water(30 mg/kg BW),CSE administered in diet(15 mg/kg BW) and all their *** 15 d,the animals were euthanized and gastrointestinal tract samples were immediately taken to evaluate gastrointestinal pH,Enterobacteriaceae to lactic acid bacteria(E:l) ratio,volatile fatty acid(VFA) concentrations,disaccharidase(lactase,sucrase and maltase)activity,histology(intestinal absorptive area [IAA] and goblet cells count) and mucus ability to adhere pathogenic Escherichia *** our results,FOS and CSE treatments,individually or combined,produced a lower E:l ratio,an enhanced production of butyrate,increased disaccharidase activity(particularly maltase),and a greater IAA and goblet cells count along with an increase in pathogenic bacteria adherence to intestinal *** did not show interactions with the other factors and its administration produced decreases on VFA,disaccharidase activity and goblet cells *** conclusion,weaning piglets receiving diets containing FOS,CSE or both exhibited evident beneficial intestinal effects compared

关键词： Fosfomycin Cynara scolymus extract Deoxynivalenol Intestinal health Weaned piglets

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael lujan alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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Genome-wide screening and transcriptional profile analysis of desaturase genes in the European corn borer moth

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Insect Science 2012年第1期19卷 55-63页

作者： Bingye Xue alejandro P. Rooney Wendell l. Roelofs Department of Entomology NYSAES-Comell University Geneva NY Crop Bioprotection Research Unit National Centerfor Agricultural Utilization Research Agricultural Research Service U.S. Department of Agricuiture Peoria IL USA

Acyl-coenzyme A （Acyl-CoA） desaturases play a key role in the biosynthesis of female moth sex pheromones. Desaturase genes are encoded by a large multigene family, and they have been divided into five subgroups on the basis of biochemical functionality and phylogenetic affinity. In this study both copy numbers and transcriptional levels of desaturase genes in the European corn borer （ECB）, Ostrinia nubilalis, were investigated. The results from genome-wide screening of ECB bacterial artificial chromosome （BAC） library indicated there are many copies of some desaturase genes in the genome. An open reading frame （ORF） has been isolated for the novel desaturase gene ECB ezi-A11~ from ECB gland complementary DNA and its functionality has been analyzed by two yeast expression systems. No functional activities have been detected for it. The expression levels of the four desaturase genes both in the pheromone gland and fat body of ECB and Asian corn borer （ACB）, O. furnacalis, were determined by real-time polymerase chain reaction. In the ECB gland, All is the most abundant, although the amount of A14 is also considerable. In the ACB gland, A14 is the most abundant and is 100 times more abundant than all the other three combined. The results from the analysis of evolution of desaturase gene transcription in the ECB, ACB and other moths indicate that the pattern of A 11 gene transcription is significantly different from the transcriptional patterns of other desaturase genes and this difference is tied to the underlying nucleotide composition bias of the genome.

关键词： bacterial artificial chromosome (BAC) library desaturase European corn borer G+C sex pheromone

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Exploring the reproductive ecology of the tropical semifossorial snake Ninia atrata

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Zoological Research 2020年第2期41卷 157-171页

作者： Teddy Angarita-Sierra Cesar alejandro lopez-Hurtado Tropical Organism Biology Research Group Universidad Nacional de ColombiaBogota111321Colombia Yoluka ONG Fundacion de Investigacion en Biodiversidad y ConservacionBogota110931Colombia Vicerrectoria de Investigacion Universidad Manuela BeltranBogota110231Colombia

Based on histological analyses and field studies,this research describes the reproductive ecology of a population of Ninia atrata snakes inhabiting an oil palm ***,through a multivariate approach,we explored the main drivers of reproductive output in *** showed that prey abundance and food intake were crucial variables contributing to reproductive *** linear regression models showed that neonates had high sensitivity(R2=55.29%)to extreme changes in climate,which was strongly related to slug and snail abundance variability and microhabitat *** cycles were markedly different between the sexes,being continuous in males and cyclical in *** this variation,reproductive cycles at the population level were seasonal *** recruitment of neonates all year,multiple clutches,high mating frequency,and continuous sperm production characterized the reproductive phenology of *** addition,a significant number of previtellogenic females presented oviductal sperm as well as uterine scars,suggesting a high precocity in the *** main drivers of reproductive output also differed between the *** females,clutch size and secondary follicle variability were highly related to stomach bolus volume,fat body area,and body *** males,height of piles of palm leaves and body mass,rather than intrinsic reproductive traits,were the main drivers of sperm ***,in both cases,the relationship between body mass,prey abundance,and food intake suggests that *** follows the income breeding strategy to compensate for reproductive costs and to maximize fitness.

关键词： Continuous male reproduction Clutch mass Income breeding Iteroparity Spermatogenesis Oogenesis Reproductive effort El Nino-Southern Oscillation(ENSO)

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Exercise and quality of life in cancer

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Journal of Sport and Health Science 2023年第4期12卷 489-490页

作者： Carmen Fiuza-luces Pedro l.Valenzuela alejandro Santos-lozano Ana Ruiz-Casado alejandro lucia Physical Activity and Health Research Group(PaHerg) Research Institute of Hospital 12 de Octubre(‘i+12’)Madrid 28041Spain Department of Systems Biology University of AlcalaMadrid 28871Spain i+HeAlTH Research Group Department of Health SciencesEuropean University Miguel de CervantesValladolid 47012Spain Department of Medical Oncology Hospital Universitario Puerta de Hierro MajadahondaInstituto de Investigacion Sanitaria Puerta de Hierro-Segovia de Arana(IDIPHISA)Madrid 28220Spain Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain

Historically,patients with cancer were told to avoid physical *** dogma has changed over the last 2 decades,with an exponential growth in the number of studies showing not only the safety,but also the benefits of regular physical activity/exercise in the cancer continuum,notably for attenuating treatment-related toxicities and side effects.

关键词： cancer patients showing

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Adenosine to facilitate the clipping of cerebral aneurysms:literature review

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Stroke & Vascular Neurology 2017年第4期2卷 205-210页

作者： Virendra R Desai alejandro l Rosas Gavin W Britz Department of Neurosurgery Houston Methodist Neurological InstituteHouston Methodist HospitalHoustonTexasUSA Department of Anesthesiology and Critical Care Houston Methodist HospitalHoustonTexasUSA

Cerebral aneurysms have a high mortality rate when *** techniques have improved substantially in treating this ***,surgical clip ligation remains the preferred option for some *** techniques are used intraoperatively to assist the surgeon in dissecting the aneurysmal dome free of surrounding tissue and placing a clip around the neck safely and effectively so that no nearby perforating vessels are affected and no residual *** techniques include temporary clip ligation,endovascular balloon occlusion and cardiac *** use is one viable option for induced cardiac arrest leading to a short period of controlled *** predictable course of action,rapid onset and offset and rare incidence of adverse side effects make it an attractive agent in this ***,we provide an introduction to adenosine use,describing its pharmacokinetic properties,indications,contraindications,complications and future directions.

关键词： aneurysm balloon viable

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Collectorless flotation of marmatite with pine oil

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Rare Metals 2017年第2期36卷 147-154页

作者： Zheng-Bin Deng Xiong Tong alejandro lópez Valdivieso Xiao Wang Xian Xie Faculty of land and Resource Engineering Kunming University of Science and TechnologyKunming 650093China State Key laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming 650093China Yunnan Province Engineering Research Center for Reutilization of Metal Tailings Resources Kunming 650093China laboratory of Surface Chemistry Institute of Metallurgy Universidad Autonoma de San Luis PotosiC.P.78210 San Luis PotosiMexico

The interaction between pine oil and marmatite without collectors and activators was investigated by flotation,scanning electron microscope and energy-dispersive spectrometer（SEM-EDS）,infrared（IR） spectroscopy,Zeta potential,and first-principle theory *** flotation results show that marmatite exhibits considerable floatability with the addition of pine ***-EDS results show that carbon atomic ratios on the surface are significantly high,which suggests that the flotation of marmatite is caused by the adsorption of pine *** evidence of the adsorption mechanism was given by IR,and Zeta potential examining pine oil depends on the physical adsorption on the surface *** first-principle theory calculations indicate that pine oil molecule adsorbs on Zn and Fe atom surfaces by ionic bond and covalent bond of adsorption energies of-1.23and-1.51 eV,respectively.P orbital of O atom,s orbital of Zn atom,and d orbital of Fe are the major participants.

关键词： Pine oil Marmatite Collectorless flotation

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New Results on Truncated Elliptical Distributions

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Communications in Mathematics and Statistics 2021年第3期9卷 299-313页

作者： Raul alejandro Moran-Vasquez Silvia l.P.Ferrari Institute of Mathematics University of AntioquiaCalle 67 No.53-108MedellínColombia Department of Statistics University of Sao PauloRua do Matão 1010São Paulo 05508-090Brazil

Truncated elliptical distributions occur naturally in theoretical and applied statistics and are essential for the study of other classes of multivariate *** members of this class are the multivariate truncated normal and multivariate truncated t *** derive statistical properties of the truncated elliptical *** of our results establish new properties of the multivariate truncated slash and multivariate truncated power exponential distributions.

关键词： Elliptical distribution log-concavity Multivariate power exponential distribution Multivariate slash distribution Truncated distribution

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Role of oxygen and ammonium ions in silver leaching with thiosulfate–ammonia–cupric ions

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Rare Metals 2014年第2期33卷 225-229页

作者： Valentin Ibarra-Galvan alejandro lópez-Valdivieso Xiong Tong Yi-Qi Cui Faculty of Chemistry Colima University Minerals Engineering Area Institute of Metallurgy Autonomous University of San Luis Potosi Faculty of land and Resource Engineering Kunming University of Science and Technology

The dissolution of silver with thiosulfate and copper ions was studied in a batch-stirred reactor at 25 °C in the absence and presence of various ammonium ions and oxygen concentrations in the aqueous solution. leaching silver with 4 mg l-1oxygen in the aqueous solution requires high concentration of ammonium and thiosulfate ions. High silver dissolution is achieved at pH of high cupric tetraamine concentration, around pH 9.8, but a high degradation of thiosulfate ions is resulted from their oxidation by the presence of oxygen. When the oxygen concentration is below 1 mg l-1, dissolved silver thiosulfate species are fairly stable and the degradation of thiosulfate ions in the aqueous solution is low. Under these conditions,high silver dissolution is attained using low thiosulfate concentration. At the oxygen concentration of 4 mg l-1,dissolved silver thiosulfate species precipitate out of the aqueous solution significantly affecting silver *** of dissolved silver thiosulfate species occurs because of oxidation of the thiosulfate bonding to the silver.

关键词： Silver Thiosulfate leaching Non-cyanide silver leaching Cupric tetraamine Oxygen

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