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抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)

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环境与职业医学 2014年第2期31卷 151-157页

作者： Nicholas J.Ashbolt alejandro amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇张伊人操仪 U.S.Environmental Protection Agency Office of Research and Development Unilever-Safety and Environmental Assurance Centre Department of Biological and Environmental Sciences Gothenburg University Veterinary Medicines Directorate Department of Plant and Environmental Sciences University of Copenhagen The Canberra Hospital and Canberra Clinical School Australian National University ECT Oekotoxikologie GmbH Fl?rsheim/Main Public Health Agency of Canada European Centre for Environment and Human Health Exeter University Medical School Knowledge Spa Royal Cornwall Hospital Federal Office of Consumer Protection and Food Safety Department 3: Veterinary Drugs Environment Canada Saskatoon Institute for Biomedicine The Sahlgrenska Academy University of Gothenburg Department of Population Medicine University of Guelph Environment Health and Safety GlaxoSmithKline Umweltbundesamt Federal Environment Agency MB Consult Limited Southampton University of Bradford Brixham Environmental Laboratory Pfizer Animal Health VMRD Agriculture and Agri-Food Canada London Ontario Canada

[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性... 详细信息

[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生"热点区域"的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的"热点区域"中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。

关键词：抗生素耐药性健康风险评估环境评估人类健康基因转移剂量反应决策分析方法耐药性细菌

amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Stochastic Contrast Measures for SAR Data: A Survey

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雷达学报（中英文） 2019年第6期8卷 758-781页

作者： alejandro C.Frery La CCAN–Laboratório de Computa??o Científica e Análise Numérica Universidade Federal de Alagoas

“Contrast”is an generic denomination for“difference”.Measures of contrast are a powerful tool in image processing and analysis,e.g.,in denoising,edge detection,segmentation,classification,parameter estimation,change detection,and feature *** present a survey on techniques that aim at measuring the contrast between(i)samples of SAR imagery,and(ii)samples and models,with emphasis on those that employ the statistical properties of the data.

关键词： Contrast Divergence Entropy Geodesic distance Statistics Synthetic Aperture Radar(SAR)

Physiology of bile secretion

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World Journal of Gastroenterology 2008年第37期14卷 5641-5649页

作者： alejandro Esteller Department of Physiology and Pharmacology University of Salamanca Campus Miguel de UnamunoED Salamanca 37007 Spain

The formation of bile depends on the structural and functional integrity of the bile-secretory apparatus and its impairment, in different situations, results in the syndrome of cholestasis. The structural bases that permit bile secretion as well as various aspects related with its composition and flow rate in physiological conditions will first be reviewed. Canalicular bile is produced by polarized hepatocytes that hold transporters in their basolateral (sinusoidal) and apical (canalicular) plasma membrane. This review summarizes recent data on the molecular determinants of this primary bile formation. The major function of the biliary tree is modification of canalicular bile by secretory and reabsorptive processes in bileduct epithelial cells (cholangiocytes) as bile passes through bile ducts. The mechanisms of fluid and solute transport in cholangiocytes will also be discussed. In contrast to hepatocytes where secretion is constant and poorly controlled, cholangiocyte secretion is regulated by hormones and nerves. A short section dedicated to these regulatory mechanisms of bile secretion has been included. The aim of this revision was to set the bases for other reviews in this series that will be devoted to specific issues related with biliary physiology and pathology.

关键词： Hepatocytes Cholangiocytes Bile flow Bile acid Transport

Chronic epididymitis and Grade III varicocele and their associations with semen characteristics in men consulting for couple infertility

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Asian Journal of Andrology 2018年第4期20卷 360-365页

作者： alejandro Oliva Luc Multigner Center for Interdisciplinary Studies National University of Rosario Rosario 2000 Argentina University of Rennes Inserm EHESP Irset (Institut de recherche en sante environnement et travail) UMR_S 1085 Rennes F-35000 France

Chronic epididymitis and varicocele are frequently observed genital disorders in men consulting for couple infertility, but their impact on semen characteristics at the time of infertility consultation is still a matter of debate. We investigated 652 male partners of couples who had their first infertility consultation between 1999 and 2015 in Argentina. Men with chronic epididymitis （n = 253）, Grade III varicocele （n = 106）, and both conditions （n = 125） were compared with a control group （n = 168） composed of men without these disorders or any other recognized causes of male infertility. We showed that men who presented isolated chronic epididymitis were more likely to have high percentages of low sperm motility and abnormal sperm morphology as well as a high number of white blood cells. Men with isolated Grade III varicocele had low sperm production and motility and an increased percentage of abnormal sperm morphology. Finally, men who simultaneously presented chronic epididymitis with Grade III varicocele had a low sperm motility and increased percentage of abnormal sperm morphology as well as a high number of white blood cells. Physical examination of the genital organs may identify common disorders, potentially involved as causal factors of patient＇s infertility. These disorders are associated with specific seminal profiles that should help in identifying the best treatment from the available therapeutic options, effectiveness, safety, and allowing as much as possible natural conception.

关键词： couple subfertility epididymitis male factor infertility semen quality varicocele

Selectivity in feeding preferences and ranging patterns in spider monkeys Ateles geoffroyi yucatanensis of northeastern Yucatan peninsula, Mexico

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Current Zoology 2013年第1期59卷 125-134页

作者： Carmen SCHERBAUM alejandro ESTRADA Department of Animal Ecology and Tropical Biology Biozentrum University of Wiirzburg Germany Estacion de Biologia Tropical Los Tuxtlas Instituto de Biologfa Universidad Nacional Aut6noma de M6xico Apartado Postal94 San Andres Tuxtla Veracruz M6xico C. P. 95700

The spider monkey, a fruit specialist and important seed dispersal agent in the Neotropics, is an endangered primate due to habitat loss, hunting and the pet trade. Spider monkeys have been the subject of a few studies in Central and South ame- rica, but little is known about the diet and ranging for this primate in southern Mexico. Here we report the results of a six-month long study （October 2010 to March 2011） of the feeding preferences and ranging patterns of the Yucatan spider monkey Ateles geoffroyi yucatanensis living in the ＂Ya＇ax＇che＂ reserve by the Caribbean coast in northeast Yucatan peninsula. Focal animal and scan sampling as well as GPS tracking were used to document spider monkey feeding behavior, location of food trees and ranging in the reserve. The spider monkeys used 36 species of plants （94% trees; n = 432） and six non tree morphospecies as a source of food. Six tree species accounted for 〉~80% of total feeding time and for 74% of all trees used. Fruits accounted for 59% of total feeding time, followed by leaves （35%）, palm piths （5%） and other plant parts （1%）. Total range used by the monkeys was esti- mated at 43% of semievergreen rainforest habitat available （ca 40ha）. Range use was not random with segments showing light, moderate and heavy use; the use of different areas of their range varied monthly and was closely linked to the spatial dispersion of the trees used for food [Current Zoology 59 （1）： 125-134, 2013].

关键词： Primates Frugivory Neotropics Conservation Seed dispersal

Vee-tail conceptual design criteria for commercial transport aeroplanes

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Chinese Journal of Aeronautics 2019年第3期32卷 595-610页

作者： alejandro SANCHEZ-CARMONA Cristina CUERNO-REJADO Faculty of Aerospace Engineering Department of Aircraft and Spacecraft Technical University of Madrid (Universidad Poltécnica de Madrid)

Vee-tail configuration is an unconventional tail configuration for commercial transport aviation, the use of which could suppose reductions on CO2 emissions. The conceptual design criteria have been selected inspired on the certification requirements established by the aviation regulation in force. They are static stability in cruise, control after Critical Engine Failure(CEF),control in crosswind landing, and trim in these three conditions. The study is carried out through a combination of semi-empirical techniques and Vortex-Lattice Methods(VLM) and thus this analyses the consequences of applying these criteria to a reference aeroplane substituting its conventional tail by a parametrised Vee-tail configuration. The Vee-tail is defined by four parameters:span, root chord, taper ratio and dihedral angle. The results of the study establish a relation between the parameters in order to accomplish the proposed conceptual design criteria. To sum up, minimum and maximum limits are obtained for dihedral angle depending on the combination of the rest of parameters. In addition, a design restriction to the yawing trailing-edge tail control is reached when the results are analysed, demonstrating that its minimum size must be between 60%and 80% of the half-span of the tail, depending on the Vee-tail geometry.

关键词： Commercial transport aeroplane Conceptual aircraft design Tail design requirements Unconventional tail design Vee-tail

A CONTRIBUTION TO THE SCIENTIFIC FOUNDATIONS OF SYSTEMS ENGINEERING： SOLUTION SPACES AND REQUIREMENTS

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Journal of Systems Science and Systems Engineering 2017年第5期26卷 549-589页

作者： alejandro Salado Roshanak Nilchiani Dinesh Verma Grado Department of Industrial and Systems Engineering Virginia Tech Blacksburg VA 24061 USA School of Systems and Enterprises Stevens Institute of Technology Hoboken N J 07030 USA

Some researchers have suggested that scientific foundations expressed in a mathematical form are needed to thrust the success of systems engineering as a discipline on its own merit. In order to contribute the development of such systems science, this paper investigates from a foundational standpoint the relationships between stakeholder needs, system requirements, and sets of systems. Various theorems and corollaries are proposed and mathematically proven. The theoretical elements are presented as a foundation for the development of a science for requirements engineering. The proposed foundations are finally tested to mathematically describe, in a rigorous and precise manner, qualities of good requirements, which are otherwise traditionally defined using vague narrative. By showcasing practical examples of the theoretical aspects, the paper is intended to serve as a bridge between practitioners and theorists.

关键词： Systems science systems theory requirements engineering mathematical formulation,requirements qualities formal concepts