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Disordered eating behaviors in type 1 diabetic patients

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World Journal of Diabetes 2011年第11期2卷 189-195页

作者： alejandra Larraaga Ricardo V García-Mayor María F Docet Eating Disorders Unit University Hospital of Vigo Nutrition Section University Hospital of Vigo

Patients with type 1 diabetes mellitus are at high risk for disordered eating behaviors (DEB). Due to the fact that type 1 diabetes mellitus is one of the most common chronic illnesses of childhood and adolescence, the coexistence of eating disorders (ED) and diabetes often affects adolescents and young adults. Since weight management during this state of development can be especially diff icult for those with type 1 diabetes, some diabetics may restrict or omit insulin, a condition known as diabulimia, as a form of weight control. It has been clearly shown that ED in type 1 diabetics are associated with impaired metabolic control, more frequent episodes of ketoacidosis and an earlier than expected onset of diabetes-related microvascular complications, particularly retinopathy. The management of these conditions requires a multidisciplinary team formed by an endocrinologist/diabetologist, a nurse educator, a nutritionist, a psychologist and, frequently, a psychiatrist. The treatment of type 1 diabetes patients with DEB and ED should have the following compo- nents: diabetes treatment, nutritional management and psychological therapy. A high index of suspicion of the presence of an eating disturbance, particularly among those patients with persistent poor metabolic control, repeated episodes of ketoacidosis and/or weight andshape concerns are recommended in the initial stage of diabetes treatment, especially in young women. Given the extent of the problem and the severe medical risk associated with it, more clinical and technological research aimed to improve its treatment is critical to the future health of this at-risk population.

关键词： Anorexia nervosa Bulimia nervosa Eating disorders not otherwise specified Disordered eating behaviors Type 1 diabetes

New 5-Alkenyl Resorcinols from <i>Lithraea molleoides</i>(Vell). Eng.

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American Journal of Plant Sciences 2020年第6期11卷 861-868页

作者： alejandra Catalano Beatriz Lantaño Lucas Fabián Paula López Universidad de Buenos Aires Facultad de Farmacia y Bioquímica Cátedra de Farmacognosia Ciudad Autónoma de Buenos Aires Argentina CONICET Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA) Cuidad Autónoma de Buenos Aires Argentina Universidad de Buenos Aires Facultad de Farmacia y Bioquímica Cátedra de Química Orgánica Cuidad Autónoma de Buenos Aires Argentina Universidad de Buenos Aires Facultad de Farmacia y Bioquímica Cátedra de Química Medicinal Cuidad Autónoma de Buenos Aires Argentina

Lithraea molleoides (Anacardiaceae) is a tree that grows in South America including Southern Brazil, Southern, and Eastern Bolivia, Southern Paraguay, Northern, and Central Argentina. Infusions, decoctions, or tinctures from its aerial parts (leaves, buds, and young stems) are employed in ethnomedicine mainly against respiratory, and digestive inflammations and illnesses. Antibacterial, antiviral, antioxidant, anti-inflammatory, and antinociceptive activities, among others, have been reported for L. molleoides. Many of its biological activities have been associated with the reported presence of 5-alkenyl resorcinols. Alkyl/alkenyl catechols and alkyl/alkenyl resorcinols are very common in members of the Anacardiaceae family and several activities have been attributed to them. This work describes the isolation and the structural elucidation of three new 5-alkenyl resorcinols isolated from Lithraea molleoides reported in nature for the first time.

关键词： Lithraea molleoides 5-Alkenyl Resorcinol (Z Z)-5-(Pentadeca-6 9-Dienyl)-Resorcinol (Z Z)-5-(Trideca-5 8-Dienyl)-Resorcinol (Z)-5-(Heptadec-6-Enyl)-Resorcinol

巴拿马水域内船舶造成的碰撞损害赔偿责任——以巴拿马法律为视角

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巴拿马水域内船舶造成的碰撞损害赔偿责任——以巴拿马法律为视角

作者： alejandra ESTEPHANIA VILLARREAL ARROCHA（安德拉）大连海事大学

学位级别：硕士

本文对巴拿马碰撞法律法规,尤其是与海上碰撞事故中确定碰撞责任和碰撞损害赔偿相关的法律法规,进行了详细的研究。本文分析了一般情况下巴拿马管辖权对船舶碰撞案件的适用及范围,并明确了在巴拿马法律体系中没有确定船舶碰撞事故责任... 详细信息

本文对巴拿马碰撞法律法规,尤其是与海上碰撞事故中确定碰撞责任和碰撞损害赔偿相关的法律法规,进行了详细的研究。本文分析了一般情况下巴拿马管辖权对船舶碰撞案件的适用及范围,并明确了在巴拿马法律体系中没有确定船舶碰撞事故责任分担和责任主体的规定也是现存的问题之一。除此之外,本文还对如何通过比较法研究借鉴国外法律体系中确定船舶碰撞案件中责任主体的法律规定进行了阐述,并明确建立一个能够确定碰撞责任并确保责任主体支付到期赔偿的法律制度具有重要意义。本文还探讨了船舶碰撞案件中的民事责任,即对民事注意义务进行了阐述,对过失、损害以及因果关系等具体问题进行了分析。据预测,一般情况下船舶碰撞风险是主要风险之一,这一风险致使司法机关需要对由哪一方承担此次海事事故所造成的损害赔偿责任展开司法调查。本文选题源于修订和完善巴拿马法律以确定碰撞事故中谁是责任主体、谁来赔偿以及如何赔偿的需求。为了满足这一需求,本文对巴拿马现行法律进行分析,并将其与其他国家的法律进行比较研究。本文建议修改《巴拿马商事海商法》,在其中增加在船舶碰撞案件中确定碰撞责任主体以及责任比例的条款。因为这些条款有助于在碰撞发生时确定碰撞过失、责任以及责任主体,并为碰撞事故的裁判提供一个框架。这表明本文对此领域的研究具有重要意义。然而,还需要完善巴拿马船舶碰撞法规,以确定碰撞发生时的责任主体。

关键词：责任主体碰撞规则碰撞责任赔偿碰撞损害民事责任

Enzyme-Linked Immunosorbent Assays Using the Recombinant gp51 and p24 of Bovine Leukemia Virus for Immunodetection of the Disease

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Open Journal of Animal Sciences 2017年第3期7卷 241-253页

作者： alejandra Larsen Santiago Corva Javier Panei Christoph Geisler Eduardo Mortola Faculty of Veterinary Science National University of La Plata La Plata Argentina CONICET (CCT-La Plata) La Plata Argentina Department of Immunology Faculty of Veterinary Sciences National University of La Plata La Plata Argentina d Department of Molecular Biology University of Wyoming Laramie WY USA

Enzyme-linked immunosorbent assay (ELISA) is often used to test bovine leukemia virus (BLV) infection. However, commercially available kits test in South America detect only antibodies against the gp51 protein. With the aim to improve the sensitivity of the test, we developed here a two-step indirect dual ELISA test that included both proteins p24 and gp51, expressed and produced in E. coli and baculovirus expression system respectively. Two hundred ten BLV sera, stated as double positive or double negative by the combination of commercial agar gel immunodiffusion (AGID) assay and a gp51-ELISA test, were tested with our in house dual rp24/rgp51 ELISA. Firstly, we checked the purified, optimized and standardized proteins as antigen by the checkerboard technique, and set up our in house ELISA test. The concordance correlation coefficient (CCC) and coefficient of variation (CV) intraplate repeatability levels were within the values established by the international standards. The statistical analysis demonstrated the value of sera correctly ranked highest (93.48%), and for 0.3 cutoff, the sensitivity was 95.65% and the specificity 91.30%. In conclusion, the rp24/rgp51 ELISA developed and standardized here demonstrated to have good analytical characteristics to be considered for screening of BLV.

关键词： Bovine Leukemia Virus Indirect Dual ELISA Recombinant Antigens

Embryo and Endosperm Phytochemicals from Polyembryonic Maize Kernels and Their Relationship with Seed Germination

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Phyton-International Journal of Experimental Botany 2022年第5期91卷 929-941页

作者： J.David García-Ortíz Rebeca González-Centeno María alejandra Torres-Tapia J.A.Ascacio-Valdés JoséEspinoza-Velázquez Raúl Rodríguez-Herrera Food Research Department School of ChemistryAutonomous University of CoahuilaSaltillo25280México Plant Breeding Department Universidad Autonoma Agraria Antonio Narro(UAAAN)Saltillo25315México

Because of the growing worldwide demand for maize grain,new alternatives have been sought for breeding of this cereal,e.g.,development of polyembryonic varieties,which agronomic performance could positively impact the grain yield per unit area,and nutritional *** objectives of this study were to(1)determine the phytochemicals present in the embryo and endosperm of grain from maize families with high,low,and null polyembryony frequency,which were planted at different locations,and(2)state the relationship between these compounds and seed *** extracted phytochemicals from corn were identified by *** results showed that the genotype with the highest presence of phytochemicals was the brachytic population with high polyembryony called“BAP”,which also required less water during the germination *** number of phytochemicals in both embryo and endosperm tissues was not related to the sowing location where they came from or the type of *** number of different phytochemicals depended on the grain tissue from where they were *** chemical compounds found in the different maize tissues were related to the development of the plant,either in roots or nibs because these are mainly associated with the lignin synthesis.

关键词： Zea mays L HPLC-MS locations kernels phytochemicals

The Genome of Cucurbita argyrosperma (Silver- Seed Gourd) Reveals Faster Rates of Protein- Coding Gene and Long Noncoding RNA Turnover and Neofunctionalization within Cucurbita

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Molecular Plant 2019年第4期12卷 506-520页

作者： Josue Barrera-Red on do Enrique Ibarra-Laclette alejandra Vazquez-Lobo Yocelyn T. Gutierrez-Guerrero Guillermo Sanchez de la Vega Daniel Pinero Salvador Montes-Hernandez Rafael Lira-Saade Luis E. Eguiarte Departamento de Ecologia Evolutiva Instituto de Ecologia Universidad Nacional Aut6noma de Mexico Circuito Exterior s/n Anexo al Jardin Bot合nico 04510 Ciudad de Mexico Mexico Departamento de Estudios Moleculares Avanzados Instituto de Ecologia A.C. Carretera Antigua a Coatepec No. 351 Col. El Haya. C.P. Xalapa Veracruz 91070 Mexico Centro de Investigaciones en Biodiversidad y Conservacion Universidad Autdnoma del Estado de Morelos Av. Universidad 1001 Col. Chamilpa Cuernavaca Morelos 62209 Mexico Campo Experimental Bajio Instituto Nacional de In vestigaciones Forestales Agricolas y Pecuarias (INIFAP) Km 6.5 Carretera Celaya-San Miguel de Allen de Celaya Guanajuato 38110 Mexico UBIPRO Facultad de Estudios Superiores Iztacala Universidad Nacional Autdnoma de Mexico Av. de los Barrios #1 Col. Los Reyes Iztacala Tlanepantla Edo. de Mex 54090 Mexico

Whole-genome duplications are an important source of evolutionary novelties that change the mode and tempo at which genetic elements evolve within a genome. The Cucurbita genus experienced a wholegenome duplication around 30 million years ago, although the evolutionary dynamics of the coding and noncoding genes in this genus have not yet been scrutinized. Here, we analyzed the genomes of four Cucurbita species, in eluding a newly assembled genome of Cucurbita argyrosperma, and compared the gene con tents of these species with those of five other members of the Cucurbitaceae family to assess the evolutionary dynamics of protein-coding and long intergenic noncoding RNA (lincRNA) genes after the genome duplication. We report that Cucurbita genomes have a higher protein-coding gene birth-death rate compared with the genomes of the other members of the Cucurbitaceae family. C. argyrosperma gene families associated with pollination and transmembrane transport had significantly faster evolutionary rates. lincRNA families showed high levels of gene turnover throughout the phylogeny, and 67.7% of the lincRNA families in Cucurbita showed evidence of birth from the neofunctionalization of previously existing protein-coding genes. Collectively, our results suggest that the whole-genome duplication in Cucurbita resulted in faster rates of gene family evolution through the neofunctionalization of duplicated genes.

关键词： Cucurbita argyrosperma, comparative genomics molecular evolution neofunctionalization long noncoding RNA whole-genome duplication

Assessment of the Connection of Antisocial-Criminal Behavior, Corruption and Depression in College Students

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Psychology Research 2017年第3期7卷 131-139页

作者： Iris Xochitl Galicia Moyeda alejandra Sanchez Velasco Francisco Javier Robles Ojeda Universidad Nacional Autonoma de Mexico Iztacala Mexico

Graves’ Disease as a Late Manifestation of Immune Reconstitution Syndrome after Highly Active Antiretroviral Therapy in an HIV-1 Infected Patient

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World Journal of AIDS 2013年第3期3卷 187-191页

作者： Evelin Mingote Agustina Urrutia alejandra Viteri Cristina Faingold Carla Musso Department of Endocrinology and Metabolism Doctor César Milstein Hospital Buenos Aires Argentine

Context: Highly active antiretroviral therapy (HAART) inhibits the HIV replication and consequently increases CD4 levels and decreases viral load. This immune system improvement can trigger various immunological phenomena, entity called Immune Reconstitution Syndrome (IRS). Graves’ disease is a late Immune Reconstitution consequence. Patient: We report the case of a 48 years old man with HIV infection who developed Graves’ disease three years after he was on effective HAART because of the Immune Reconstitution Syndrome. At presentation he had a very low CD4 T-cell count (17 cells/μL). When he started HAART he presented a lipodystrophy syndrome. HAART was changed because of the persistent low CD4-T cells count (less than 100 cell/μL). Afterwards serum lipid levels began to decrease and that was the first manifestation of Graves’ disease, which was diagnosed when CD4 T-cells increased up to 343 cell/μL. Our patient developed Graves’ disease 36 months after initiating effective HAART with protease inhibitors which was coincident with viral suppression and a rise of CD4 T cells. Conclusion: The most immunosuppressed patients with a CD4 T cell count less than 100 cells/μL are at greatest risk for the development of Immune Reconstitution Syndrome after HAART initiation. We conclude that clinicians will have to consider the importance of the early diagnosis of thyroid disease to bring an adequate treatment.

关键词： Graves’ Disease Immune Reconstitution Syndrome Highly Active Antiretroviral Therapy HIV-1 Lipodystrophy Syndrome

Robot-assisted oncologic pelvic surgery with Hugo™robot-assisted surgery system:A single-center experience

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Asian Journal of Urology 2023年第4期10卷 461-466页

作者： Angelo Territo Alessandro Uleri Andrea Gallioli Josep Maria Gaya Paolo Verri Giuseppe Basile Alba Farré alejandra Bravo Alessandro Tedde Óscar Rodríguez Faba Joan Palou Alberto Breda Department of Urology FundacióPuigvertAutonomous University of BarcelonaBarcelonaSpain

Objective To report the outcomes of intra-and extra-peritoneal robot-assisted radical prostatectomy(RARP)and robot-assisted radical cystectomy(RARC)with Hugo™robot-assisted surgery(RAS)system(Medtronic,Minneapolis,MN,USA).Methods Data of twenty patients who underwent RARP and one RARC at our institution between February 2022 and January 2023 were *** primary endpoint of the study was to report the surgical setting of Hugo™RAS system to perform RARP and *** secondary endpoint was to assess the feasibility of RARP and RARC with this novel robotic platform and report the *** Seventeen patients underwent RARP with a transperitoneal approach,and three with an extraperitoneal approach;and one patient underwent RARC with intracorporeal ileal *** intraoperative complications *** docking and console time were 12(interquartile range[IQR]7-16)min and 185(IQR 177-192)min for transperitoneal RARP,15(IQR 12-17)min and 170(IQR 162-185)min for extraperitoneal *** intraoperative complications *** patient submitted to extraperitoneal RARP had a urinary tract infection in the postoperative period that required an antibiotic treatment(Clavien-Dindo Grade 2).In case of transperitoneal RARP,two minor complications occurred(one pelvic hematoma and one urinary tract infection;both Clavien-Dindo Grade 2).Conclusion Hugo™RAS system is a novel promising robotic platform that allows to perform major oncological pelvic *** showed the feasibility of RARP both intra-and extra-peritoneally and RARC with intracorporeal ileal conduit with this novel platform.

关键词： Bladder cancer Prostate cancer Radical cystectomy Radical prostatectomy Robotic surgery