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Effect of different anesthetic mixtures——ketamine-xylazine, ketamine-acepromazine and tiletamine-zolazepam——on the physiological and blood biochemistry parameters of male rhesus monkeys(Macaca mulatta) at different ages

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Animal Models and Experimental Medicine 2019年第2期2卷 83-97页

作者： Braulio Hernández‐Godínez Herlinda Bonilla Jaime Adrián Poblano Marcela Arteaga‐Silva Ameyalli Medina Hernández Armando contreras‐Uribe alejandra ibanez-contreras Posgrado en Ciencias Biológicas y de la Salud Unidad Iztapalapa Universidad Autónoma Metropolitana Ciudad de México México Investigación Biomédica Aplicada (INBIOMA) S.A.S. de C.V. Ciudad de México México Alimentos y Camas Zoosanitarias (ACAZOO) S. de R.L. Ciudad de México México Departamento Biología de la Reproducción Unidad Iztapalapa Universidad Autónoma Metropolitana Ciudad de México México Laboratorio de Neurofisiología Cognoscitiva Instituto Nacional de Rehabilitación Ciudad de México México

Background: Anesthetic agents are commonly utilized in the handling of non‐human primates for prevent the stress caused in physical exploration or physical restrain. For this reason, the objective of this work was to describe the effect of age and dissociative anesthetics (ketamine and tiletamine), and their combinations with acepromazine, xylazine and zolazepam, on the physiological and blood biochemical parameters in Macaca mulatta. Methods: Eighty male Macaca mulatta were divided into four experimental groups depending on the anesthetic mixture applied. Each group of 20 males was divided into five sub‐groups according to age. Physiological parameters were recorded every five minutes during a 30‐minute period. A blood sample was drawn to analyze blood biochemistry. Results: Statistical analyses revealed significant differences in the physiological parameters between the ketamine‐acepromazine and ketamine‐xylazine groups compared to the control group. The analysis of blood biochemistry found significant differences by age and by anesthetic mixture among all groups. Conclusion: These findings contribute to standardizing this animal model in biological research.

关键词： acepromazine anesthesia blood biochemistry ketamine Macaca mulatta physiologic parameters tiletamine xylazine zolazepam

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Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents

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Neural Regeneration Research 2024年第4期19卷 846-854页

作者： Willian Orlando Castillo-Ordoñez Nohelia Cajas-Salazar Mayra alejandra Velasco-Reyes Facultad de Ciencias Naturales-Exactas y de la Educación Departamento de Biología.Universidad del Cauca Departamento de Estudios Psicológicos Universidad Icesi

Alzheimer’s disease is a progressive neurodegenerative disorder and the most common cause of dementia that principally affects older *** factors,such as oxidative stress,an increase in acetylcholinesterase activity,mitochondrial dysfunction,genotoxicity,and neuroinflammation are present in this syndrome,which leads to *** pathologies such as Alzheimer’s disease are considered late-onset diseases caused by the complex combination of genetic,epigenetic,and environmental *** are two main types of Alzheimer’s disease,known as familial Alzheimer’s disease(onset<65 years)and late-onset or sporadic Alzheimer’s disease(onset≥65 years).Patients with familial Alzheimer’s disease inherit the disease due to rare mutations on the amyloid precursor protein(APP),presenilin 1 and 2(PSEN1 and PSEN2)genes in an autosomaldominantly fashion with closely 100%*** contrast,a different picture seems to emerge for sporadic Alzheimer’s disease,which exhibits numerous non-Mendelian anomalies suggesting an epigenetic component in its ***,the fundamental pathophysiological mechanisms driving Alzheimer’s disease are interfaced with epigenetic ***,the dynamic nature of epigenetics seems to open up new avenues and hope in regenerative neurogenesis to improve brain repair in Alzheimer’s disease or following injury or stroke in *** recent years,there has been an increase in interest in using natural products for the treatment of neurodegenerative illnesses such as Alzheimer’s *** epigenetic mechanisms,such as DNA methylation,non-coding RNAs,histone modification,and chromatin conformation regulation,natural compounds appear to exert neuroprotective *** we do not purport to cover every in this work,we do attempt to illustrate how various phytochemical compounds regulate the epigenetic effects of a few Alzheimer’s disease-related genes.

关键词： Alzheimer’s disease epigenetics genes methylation natural products

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Oligo-carrageenan kappa increases C, N and S assimilation, auxin and gibberellin contents, and growth in Pinus radiata trees

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Journal of Forestry Research 2015年第3期26卷 635-640页

作者： Silvia Saucedo Rodrigo A. contreras alejandra Moenne University of Santiago of Chile Santiago Chile Facultad de Ciencias Agrarias Universidad Te'cnica Estatal de Quevedo 63 Quevedo Ecuador

Oligo-carrageenans （OCs） obtained from pure carrageenans extracted from marine red algae stimulate growth by enhancing photosynthesis and basal metabolism in tobacco plants and Eucalyptus trees. In addition, OCs stimulate secondary metabolism, increasing the level of metabolites involved in defense against pathogens. In this work, we analyzed the effect of OC kappa on the increase in height, in activities of basal metabolism enzymes in- volved in carbon, nitrogen and sulphur assimilation, ribu- lose 1,5 biphosphate carboxylase/oxygenase （rubisco）, glutamate dehydrogenase （GDH） and O-acetylserine thiol- lyase （OASTL）, and in the level of growth-promoting hormones, the auxin indole acetic acid （IAA） and the gibberellin GA3, in pine （Pinus radiata） trees treated with OC kappa at concentrations of 1 and 5 mg mL-1 and cultivated for 9 months without additional treatment. Pines treated with OC kappa at 1 mg mL-1 showed a similar increase in height but displayed a higher increased in total chlorophyll, activities of rubisco, GDH and OASTL and level of IAA and GA3 than those treated with OC kappa at 5 mg mL-1. Thus, OC kappa stimulates growth and basal metabolism and increases the level of growth-promoting hormones in pine trees, mainly at 1 mg mL-1.

关键词： Auxin Basal metabolism C, N and Sassimilation Gibberellin Oligo-carrageenan kappaPinus radiata

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Vegetation Response To Soil And Morphological Properties In An Arid Region Alluvial Fan Landscape. Pre-Andes Of San Juan， Argentina

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Journal of Earth Science 2024年

作者： FLORES Daniel Germán OCA?A Raúl Emmanuel MELIáN Edgardo ORTEG Andrés ESPER ANGILLIERI María Yanina PITTALUGA María alejandra CIGEOBIO (CONICET-UNSJ) Av.José I.de la Roza y Meglioli Gabinete de Geología Ambiental， INGEO， Universidad Nacional de San Juan， Av.José I.de la Roza y Meglioli

The Monte Desert is characterized by a great diversity of landforms created with fluvial， alluvial which the vegetation patterns are related to. The present work has the following objectives: 1: determine whether topographical attributes， surface characteristics， soil properties and vegetation patterns vary between alluvial landforms， and 2: define whether morphometric， soil and surface properties influence vegetation patterns along alluvial landscape. Morphometric data were obtained by processing a 5 m digital elevation model. The coverage of rock fragments， fine sediments and mulch was quantified. Observations and descriptions of the soil profiles were restricted to the uppermost 50 cm. Vegetation properties were calculated using a Point Quadrat Method. The relationship between variables was evaluated through multivariate statistical analysis. The main results show the presence of 45 plant species distributed in 19 families， where shrubs are dominant. The wind effect， topographic wetness and dissection of the landscape are limiting factors of diversity. The coverage of superficial rock fragments influence vegetation coverage through the distribution and availability of rainwater. Furthermore， the different soil textures reveal that the silt content favors an increase in vegetation coverage. The presence of V horizon could condition the installation and development of vegetation in the early stages of growth.

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Uremic Bleeding in 2 Patients with Dieulafoy’s Lesion: Case Report and Literature Review

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Open Journal of Gastroenterology 2024年第5期14卷 167-173页

作者： Gustavo Adolfo Hernández Valdez Diana Estefanía Ibarra García Juan Antonio contreras Escamilla Janette alejandra Gamiño Gutierrez Francisco Manuel Tonatiuh Carrillo Beltran Ulises Solis Gomez Jocelyn Nataly Quintero Meléndez Ivan Alejandro Medina Jimenez Marco Antonio González Villar Jorge Rojas Morales Department of Internal Medicine ISSSTE APP General Hospital of Tepic Tepic Nayarit Mexico Hospital Civil de Guadalajara Fray Antonio Alcalde Guadalajara Jalisco M&#233xico

Dieulafoy’s lesions are rare vascular malformations of the gastrointestinal tract. A Dieulafoy’s lesion is an aberrant vessel that does not reduce in caliber when it extends from the submucosa to the mucosa. Damage to this artery can cause severe and intermittent arterial bleeding from small vascular stumps that are difficult to visualize. Furthermore, these catastrophic bleeding episodes frequently result in hemodynamic instability and the need for transfusion of multiple blood products. Recently, uremic syndrome has been identified as a risk factor for gastric mucosal lesions. We present two clinical cases of acute digestive bleeding due to Dielafoy lesion with chronic kidney disease as the main cause, where two different therapies were performed endoscopically. We concluded with the results of our patients that the best therapy was the application of the hemostatic hemoclip on the injury vs the injection with adrenaline on the wound site. Uremia is identified as a risk factor for upper gastrointestinal bleeding in patients with pre-existing Dieulafoy’s lesion, as well as a higher incidence of new bleeding.

关键词： Dieulafoy’s Lesion Gastrointestinal Bleeding Endoscopy Endoscopy Hemostatic Clips Kidney Disease Adrenaline Thermal Coagulation Dieulafoy

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Effects of Phytoremediation on Soil Contaminated with Pb and Cd in Tolerant Bacterial Populations

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Journal of Environmental Science and Engineering(A) 2024年第4期13卷 122-127页

作者： alejandra Vásquez María Montes Melissa Cervantes María Alvarado Pedro García Victor Aguilar Department of Environmental Engineering Institute for EngineeringUniversity of VeracruzBoca del RioVer.94294Mexico Department Chemical Engineering Faculty of Chemical SciencesUniversity of VeracruzBoca del RíoVer.94294Mexico Faculty of Environmental Engineering Popular Autonomous University of the State of PueblaBarrio de Santiago 72410PueblaPueMexico Department of Administration Open Education SystemUniversity of VeracruzBoca del RioVer.94294Mexico

Bacterial populations isolated from treated soil,artificially contaminated with lead(Pb)and cadmium(Cd)and undergoing a phytoremediation process were studied to determine their potential application in soil *** physicochemical parameters evaluated in the soil varied *** bacterial strains were selected from each polluted soil to test tolerance and growth in contaminated *** concentrations of heavy metals tested were 1,000 ppm for lead and 850 ppm for *** strains were morphologically identified through Gram *** strains showing the most significant growth in both contaminants were then selected to verify their tolerance to different concentrations of heavy *** results demonstrated that the selected bacteria have high tolerance to Pb,resisting inhibition up to 2,000 *** contrast,strains exposed to cadmium tended to slow their growth as the concentration increased.

关键词： Lead cadmium soil bacteria remediation

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Competencies in Computer Security and Resolution of Technological Problems in Higher Education Students

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Journal of Computer and Communications 2024年第4期12卷 171-185页

作者： Esteban Pérez Flores alejandra Aldrette Malacara Sandra R. Murillo Cano Vittorio Zanella Palacios Facultad de Ciencias Administrativas Universidad Aut&#243noma de Baja California Mexicali M&#233xico Decanato de Ingenierí as Universidad Popular Aut&#243noma Del Estado de Puebla Puebla M&#233xico

Starting from the importance of preserving our information and protecting our devices against attacks on their vulnerabilities, this article aims to establish the level of knowledge in computer security and problem-solving of students at a university in northwest Mexico. This research has a quantitative approach where the European Framework of Digital Competencies for Citizenship was used as a reference to identify and establish the level of the competencies that were evaluated. The IKANOS Test was used as a data collection tool. The results show that students know the importance of keeping their devices safe and how valuable the information found on them is. On the other hand, the results also show a considerable percentage of students who do not have the knowledge and are at a basic level of knowledge to solve technical problems with their devices.

关键词： Digital Literacy Cybersecurity DigComp Digital Skills Data Protection

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The W3C Data Catalog Vocabulary,Version 2:Rationale,Design Principles,and Uptake

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Data Intelligence 2024年第2期6卷 457-487页

作者： Riccardo Albertoni David Browning Simon Cox alejandra N.Gonzalez-Beltran Andrea Perego Peter Winstanley Istituto di Matematica Applicata e Tecnologie Informatiche"Enrico Magenes" Consiglio Nazionale delle Ricerche(IMATI-CNR)GenoaItaly Independent Consultant United Kingdom LandandWater CSiROMelbourneAustralia Scientific Computing Rutherford Appleton LaboratoryScience and Technology Facilities CouncilHarwell Cam-pusOx110QXUnited Kingdom European Parliament Luxembourg Semantic Arts Fort CollinsCO80524USA

DCAT is an RDF vocabulary designed to facilitate interoperability between data catalogs published on the *** its first release in 2014 as a W3C Recommendation,DCAT has seen a wide adoption across communities and domains,particularly in conjunction with implementing the FAIR data principles(forfindable,accessible,interoperable and reusable data).These implementation experiences,besides demonstrating the fitness of DCAT to meet its intended purpose,helped identify existing issues and ***,over the last few years,additional requirements emerged in data catalogs,given the increasing practice of documenting not only datasets but also data services and *** paper illustrates the new version of DCAT,explaining the rationale behind its main revisions and extensions,based on the collected use cases and requirements,and outlines the issues yet to be addressed in future versions of DCAT.

关键词： Data Catalogs Interoperability Discoverability FAIR data

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Exclusive breastfeeding greater than 50%, success of education in a university hospital in Bogotá: Case-control study

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World Journal of Clinical Pediatrics 2024年第1期13卷 23-30页

作者： Marcela Murillo Galvis Sofia Ortegon Ochoa Clara Eugenia Plata García Maria Paula Valderrama Junca Dayanna alejandra Inga Ceballos Daniel Mauricio Mora Gómez Claudia M Granados Martin Rondón Department of Pediatrics Hospital Universitario San IgnacioBogotá110111Colombia Department of Clinical Epidemiology and Biostatistics Pontifica Universidad JaverianaBogotá110111Colombia

BACKGROUND Maintenance rates of exclusive breastfeeding(EBF)worldwide are low,thus,one of the objectives of the summary of policies on breastfeeding(BF)in world nutrition goals for 2025 are that at least 50%of infants under six months of age receive EBF that *** Objective of this study is to document the rates of EBF in children born in San Ignacio University Hospital(HUSI)and identify factors associated with *** To document the percentages of EBF in those that were born at HUSI and identify factors associated to their *** This is a study of cases and controls in an analytic,retrospective cohort that took children born alive between January 2016 and January 2019 at HUSI located in the city of Bogotá,*** Receiving information about BF at HUSI was able to maintain EBF up until 4 mo(OR=1.65;95%CI:1.02-2.66).The presence of gynecologic and obstetric comorbidities(OR=0.32;95%CI:0.12-0.83),having mastitis(OR=0.56;95%CI:0.33-0.94),and receiving information from mass media(OR=0.52;95%CI:0.31-0.84)are factors associated with not maintaining *** Receiving education at a Women-and Child-Friendly Institution was the only significant factor to achieve EBF until 4 mo,with a frequency greater than the one reported in the country,which matches multiple studies where counseling and individualized support on BF achieve this *** about BF and early detection of obstetric/gynecologic complications must be strengthened among the healthcare staff in charge of mothers during ***,strategies must be promoted to continue BF such as creating milk banks with the objective of increasing BF rates even when mothers return to work.

关键词： Breastfeeding Women-and Child-Friendly Institutional Strategy Strategies Adherence Education

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Portal Venous Thrombosis and Splenic Hemangioma, Secondary to Acute Pancreatitis: Case Report

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Open Journal of Gastroenterology 2024年第1期14卷 11-17页

作者： Gustavo Adolfo Hernández Valdez Harvey Yair Zamora Veliz Estefany Gilberty Mendoza Verdin Quitzia Mayanim Rentería Fonseca Itzel Velázquez Viniegra Janette alejandra Gamiño Gutierrez Diana Rita Velázquez Jimenez Florencio Favian Andrade Luis Fernando Baez Bustos Jorge Morales Rojas María Jacqueline Martínez Tejeda Graciela Gaddy Robles Martínez Juan Antonio contreras Escamilla Departamento de Medicina Interna ISSSTE Tepic General Hospital APP Tepic Nayarit México General Surgery Department ISSSTE Tepic General Hospital APP Tepic Nayarit México Hospital Civil Fray Antonio Alcalde Guadalajara Jalisco México

We present an unusual case of portal vein thrombosis with a splanchnic hemangioma secondary to acute biliary pancreatitis. We report a 45-year-old patient, who has systemic arterial hypertension in treatment, was admitted for abdominal pain in the epigastrium, with irradiation to the right hypochondrium, accompanied by nausea and vomiting of 10 occasions of bile content, physical examination with pain in the right hypochondrium, Murphy positive. We have laboratory studies with a lipase of 788, so a diagnosis of pancreatitis is made with an etiology to be determined. The laboratories suggestive of acute biliary pancreatitis (lipase 788.71);an imaging study was subsequently performed (ultrasonography) with the result of stone in the common bile duct. A laparoscopy was performed with relative improvement, so he was discharged and returned 20 days after surgery due to abdominal pain of the same intensity in the left hypochondrium. Ending his hospitalization with a splenectomy for splenic hemangioma with portal vein thrombosis.

关键词： Pancreatitis Esplenic Hemangioma Esplenectomy Portal Vein Thrombosis Surgery

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