检索结果-南通市图书馆

Journal of Cancer Therapy 2013年第6期4卷 34-43页

作者： Vermont P. Dia Elvira Gonzalez de mejia Department of Food Science and Human Nutrition University of Illinois at Urbana-Champaign Urbana USA

Lunasin is a bioactive peptide originally isolated from soybean and has demonstrated chemopreventive and anti-cancer properties against skin, colon and breast cancers. The objective of the study was to evaluate the capability of intraperitoneally and orally-administered soybean-derived peptide lunasin to inhibit KM12L4 human colon cancer cell metastasis in a mouse model. Intraperitoneal (i.p.) injection of lunasin (4 mg/kg bw/day) reduced the number of liver metastasis by 50% (P = 0.047) and the liver weight/body weight ratio by 23% (P = 0.039). Oral administration of lunasin reduced the number of liver metastasis by 56% (8 mg/kg bw/day, P = 0.293) and 94% (20 mg/kg bw/day, P = 0.247). Immunohistochemical staining of the liver-tissue section showed that lunasin at 20 mg/kg bw dose did not significantly reduce the expression of proliferating cell nuclear antigen, increased the expression of proapoptotic Bax by 2.7-fold but also increased the expression of the antiapoptotic Bcl-2 by 3.8-fold. Regarding epigenetic markers, H3K18 was not significantly affected by either oral dose while H4K8 was dose dependently increased by 2.3-fold (P = 0.001, 8 mg/kg bw) and 2.7-fold (P s of administration used leading to digestion of lunasin when given by oral gavage. In conclusion, lunasin reduced colon cancer metastasis in vivo;however, more studies are needed to determine the oral dose of lunasin and prevent colon cancer metastasis.

关键词： Lunasin Colon Cancer Metastasis Apoptosis Histones

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

横风大雨对高速列车绕流的影响

横风大雨对高速列车绕流的影响

作者： NESTOR DAVID mejia 北京交通大学

学位级别：硕士

随着社会的发展,对交通运输工具的安全、高速、及运载力的要求日益增加。高速铁路是供乘客使用的轨道交通,其运行速度比普通速度的铁路交通有着显著的提高。在安全运行的条件下,其速度可达400-450km/h。然而,横风、大雨等自然现象会对... 详细信息

随着社会的发展,对交通运输工具的安全、高速、及运载力的要求日益增加。高速铁路是供乘客使用的轨道交通,其运行速度比普通速度的铁路交通有着显著的提高。在安全运行的条件下,其速度可达400-450km/h。然而,横风、大雨等自然现象会对高速列车的安全行驶起到负面影响。本文旨在通过研究现代化高速运载工具,从而对经济、环境及技术的可行性的研究提供依据。高速列车的空气动力学特性不仅与其运行效益紧密相关,还与安全性,以及在极端天气条件和其他外部因素下的运行性能密切相关。一些学者研究了横风和大雨对高速列车气动力的影响,但仍然需要进一步的深入研究。本研究的目的在于：1)分析安全行驶的速度范围及其特性;2)研究大雨对高速列车的影响,加深对这项对安全至关重要的因素的认识;3)分析表面压强分布及其对几何设计和运行性能的影响;4)对数值模拟结果进行分析,并与其他研究者在相关研究中提及的概念与理论框架进行验证。在此背景下,现有的知识与研究为进一步的研究提供了基础与依据。本文涉及空气动力学、流体力学、流体动力学、数值分析、计算流体动力学和多相流分析的理论与计算,列车车身绕流考虑了横向风的作用和雨的作用。采用多相流混合模型理论、realizable k-∈湍流模型、多面体网格和标准壁面函数对各项参数进行分析。使用高端台式电脑客户端,数值模拟计算软件使用ANSYS WORKBENCH-FLUENT,结构设计使用整合了Autodesk Inventor与Nx7.5的标准CAD平台。本研究使用了三组不同大小的网格,其单元数量分别为：1824488;2285764;和3555243。这三个有限元组的选择是根据计算和时间的限制确定的。列车的性能一部分是由它的结构决定的,还有很重要的一部分是由外部条件决定的,例如横风和雨。在研究横风影响时,选取以下速度：24m/s,20m/s,16m/s,10m/s,4m/s。参照邵雪明等人的相关研究,降雨量取60mm/h,每滴雨速度5m/s。考虑到网格设计理论与模型,使用y+壁面函数,在列车模型的重要部分,如车头和车尾,y+取30-60;考虑到计算能力的限制,列车其他部分y+选取120-200。通过研究,本文得到以下结论： ●由于数值模拟的计算时间与计算条件有限,圆柱形计算域与多面体网格对本文的数值模拟最为合适。 ·最大压强和最小压强分别分布在车头和车尾。 ·阻力、升力、侧向力、滚动力矩和偏航力矩在横风和大雨的环境下显著增大。 ·高速列车系统在大雨条件下运行是不安全的,其出轨和倾覆的可能性很高。 ●在使用CFD进行数值模拟计算时,为避免结果失真,例如出现回流和残差过大,计算区域的大小、松弛因子、以及离散方法的选择至关重要。

关键词：计算流体动力学空气动力学高速列车横风雨多相流

Ileal angiomyolipoma manifested by small intestinal intussusception

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第11期15卷 1398-1400页

作者： Chang Ho Lee Jong Hun Kim Doo Hyun Yang Yong Hwang Myoung Jae Kang Young Kon Kim Min ro Lee Department of Surgery Chonbuk National University Medical SchoolJeonju 561-180 South Korea Department of Pathology Chonbuk National University Medical SchoolJeonju 561-180 South Korea Department of Radiology Chonbuk National University Medical SchoolJeonju 561-180South Korea

Angiomyolipomas(AMLs),a form of benign mesenchymal hamartoma,arise primarily in the kidneys of patients with or without tuberous ***-renal AMLs are very rare and are most commonly found in the liver. AMLs of the small intestine are exceedingly ***, a case of a 28-year-old man,who presented with ileal intussusception caused by ileal AML is *** clinicopathological and immunohistochemical findings of ileal AMLs are discussed and the literature on small intestinal AMLs is reviewed.

关键词： Angiomyolipoma Intussusception Hamartoma Ileum Colectomy

UNILATERAL EIGENVALUE ProBLEMS FOR NONLINEARLY ELASTIC PLATES: AN APProACH VIA PSEUDO-MONOTONE OPERATORS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2000年第2期21卷 147-152页

作者： LILIANA GRATIE(Faculty of Engineering-Braila, Dunarea de Jos University of Galati, Calarasilor 29, Braila 6100, romania.) E-mail: gratie@starnets.ro Faculty of Engineering-Braila Dunarea de Jos University of Galati Calea Calarasilor 29 Braila 6100 Romania

This paper considers a class of variational inequalities that model the buckling of a von Karman plate clamped on a part of its boundary and lying on a fiat rigid support. The existence and bifurcation results of D. Goeleven, V. H. Nguyen and M. Thera[6] rely on the Leray- Schauder degree. Using the topological degree for pseudo-monotone operators of type (S+), the author establishes a more general existence result for such unilateral eigenvalue problems.

关键词： Variational inequalities Topological degree Generalized monotone operators Unilateral eigenvalue problem Nonlinearly elastic plates

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

开拓标签新市场

印刷技术 2001年第5B期 110-111页

作者： Bradley,ro

Label Innovations公司经理菲利浦说,从单张纸胶印转为柔印后,生产成本至少降低了30%该公司为了印刷纸盒,添置了一台新设备--Edale B系列柔印机.该机采用水墨印刷,有5个色组.为增加产品光泽,最后一个机组装有UV干燥装置,用于上光,可印刷... 详细信息

Label Innovations公司经理菲利浦说,从单张纸胶印转为柔印后,生产成本至少降低了30%该公司为了印刷纸盒,添置了一台新设备--Edale B系列柔印机.该机采用水墨印刷,有5个色组.为增加产品光泽,最后一个机组装有UV干燥装置,用于上光,可印刷380～420g/m2的纸板.

关键词：标签印刷机柔版印刷

基于文化差异的秘鲁中资企业人力资源绩效管理研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于文化差异的秘鲁中资企业人力资源绩效管理研究

作者： mejia Gamboa Brenda Nairobi 东北农业大学

学位级别：硕士

经济全球化使各国之间的联系更加紧密,导致企业国际化的发展。在这个跨文化交流的时代,越来越多的跨国企业正在快速增长,给中秘企业在不同地理和文化背景下带来了许多管理挑战和机遇。此外,这些企业的竞争格局也受到了独特政策背景影响... 详细信息

经济全球化使各国之间的联系更加紧密,导致企业国际化的发展。在这个跨文化交流的时代,越来越多的跨国企业正在快速增长,给中秘企业在不同地理和文化背景下带来了许多管理挑战和机遇。此外,这些企业的竞争格局也受到了独特政策背景影响下的不同发展趋势的塑造。因此,本研究旨在探索和分析中秘企业中人力资源绩效管理(HRPM)的有效利用,这成为本研究的核心关注点。本文深入探讨了在秘鲁经营的中国企业特定跨文化背景下的HRPM的复杂性,同时考虑到文化多样性的影响。本研究将通过六个主要部分进行详尽的考察。本文的开篇部分是引言,其中包括研究背景和研究意义的阐述,以及关于中国企业的HRPM的综合文献回顾,强调文化差异。此外,本部分还详述了本研究所采用的研究思路、方法和创新方法,并考虑了它们的意义。第二部分首先对本研究所涉及的相关概念进行准确定义,以建立研究的理论框架,并进行深入分析。第三部分:本部分重点关注在秘鲁成立的中国企业中跨文化HRPM的现状。它全面分析了中国企业在秘鲁的发展和现状,包括中秘贸易发展概况、投资的地理和行业分布、中国对秘鲁投资的新兴趋势、中国和企业文化的历史背景,以及中国和秘鲁企业的文化特点。在此基础上,本部分深入探讨了中国资助企业在秘鲁的HRPM的现状。第四部分:本部分进行实证研究,调查文化差异对中国企业在秘鲁的HRPM的影响。第五部分:本部分针对文化差异,提出了增强中国企业在秘鲁的HRPM的具体措施和建议。它从三个关键方面进行改进。最后一部分给出了研究的结论和展望。本研究运用绩效管理的相关理论和方法,以文化差异作为背景,研究中国企业在秘鲁的HRPM的现状。通过进行实证分析,旨在找出现有问题,并提供基于研究结果的实际改进措施。本研究为在秘鲁的中国企业的管理者提供了有价值的见解,有助于将这些见解应用于类似企业的运营和发展方面。

关键词：人力资源绩效管理跨文化中国秘鲁

A case of colohepatic penetration by a swallowed toothbrush

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第15期12卷 2464-2465页

作者： Min ro Lee Yong Hwang Jong Hun Kim Department of Surgery Chonbuk National University Medical School San 2-20 Geumam-dongDeokjin-guJeonjuJeonbuk 561-180South Korea Research Institute of Clinical MedicineChonbuk National University Medical SchoolSan 2-20 Geumam-dongDeokjin-guJeonjuJeonbuk 561-180South Korea Department of Surgery Chonbuk National University Medical School San 2-20 Geumam-dongDeokjin-guJeonjuJeonbuk 561-180South Korea

Although foreign body ingestion is relatively common,toothbrush swallowing is rare. We report a case of a swallowed toothbrush which passed through the ileocecal valve and perforated the proximal transverse colon,then... 详细信息

关键词： Toothbrush Colohepatic penetration

Socioeconomic, environmental, and geographic factors and US lung cancer mortality, 1999-2009

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2017年第1期5卷 3-12页

作者： Maria C.mejia de Grubb Barbara Kilbourne Katy Kilbourne Michael Langston Lisa Gittner roger J.Zoorob robert Levine Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA Sociology Department Tennessee State UniversityNashvilleTNUSA Department of Family and Community Medicine Meharry Medical CollegeNashvilleTNUSA Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTNUSA Department of Political Science Texas Tech University College of Arts and SciencesLubbockTXUSA

Background:The American Cancer Society estimates that about 25%of all US cancer deaths will be due to lung cancer-more than from cancers of the colon,breast,and prostate ***:We ascertained county-level age-adjusted and age-specific death rates and 95%confidence intervals from the Centers for Disease Control and Prevention Compressed Mortality *** regression analyses were used to estimate the strength and direction of relationships between county poverty,smoking,fine particulate matter(PM2.5)air pollution,and US Census divisions and race-and sex-specific lung cancer ***:Poverty,smoking,and particulate matter air pollution were positively and signifi-cantly related to lung cancer deaths among white men,but of these,only poverty and smoking were significantly associated with lung cancer deaths among white *** in the South Atlantic,East South Central,and West South Central US Census divisions at the time of death was significantly associated with lung cancer deaths for both white men and white *** with white men,poverty and smoking were associated with lung cancer deaths among black men,but of these,only adult smoking had a statistically significant association among black ***:The results support the need for further research,particularly in high-risk areas,to better differentiate factors specific to race and sex and to understand the impact of local risk factors.

关键词： Lung cancer mortality geographic risk factors environmental hot spot

Preliminary assessment of nasopharyngeal carcinoma incidence in the Philippines: a second look at published data from four centers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2014年第3期33卷 159-164页

作者： Mario Paulus Cesar B.Sarmiento Michael Benedict A.mejia Department of Radiation Oncology Benavides Cancer InstituteUniversity of Santo Tomas Hospital

In endemic regions such as southern China and Southeast Asia, the annual incidence of nasopharyngeal carcinoma(NPC) ranges from 3 to 30 per 100,000. In the Philippines, the estimated incidence in 2010 was 1.2 per 100,000. However, this rate is based on data collected from registries covering only two regions in the country. Here, we report the findings from our study to better approximate the incidence of NPC in the Philippines. Between September 1, 2011 and August 31, 2012, data were collected from 49 patients from 4 different institutions—University of Santo Tomas, Makati Medical Center, Philippine Oncology Center Corporation, and Cardinal Santos Memorial Medical Center—using a NPC screening questionnaire. Crude incidence was 0.09 per 100,000. Age-standardized incidences using Segi and WHO standards were 2.08 and 1.79 per 100,000, respectively. Of the 49 patients, 31 were males and 18 were females, and 71% of patients were between 30 and 59 years old. WHO types II and III represented 22% and 78% of the subjects, respectively, and 75.5% of cases were locally advanced(stages III–IVB). Although the age-standardized incidence from the 4 institutions was numerically higher than the published age-standardized incidence(2.07 per 100,000 vs. 1.2 per 100,000), two-proportion z-test showed no significant difference between them(P = 0.68). A more concerted effort is needed for a better approximation of the country's NPC disease burden.

关键词： Nasopharyngeal carcinoma incidence Philippines

Temporal trends in colorectal cancer incidence among Asian American populations in the United States, 1994-2013

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2017年第1期5卷 56-64页

作者： Haijun Wang Maria C.mejia de Grubb Sandra J.Gonzalez Mohamad Sidani Jianping Ma roger J.Zoorob Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA Shenzhen Nanshan Center for Chronic Disease Control ShenzhenGuangdongChina

Objective:To investigate the incidence and trends in colorectal cancer(CRC)among Asian American populations in the United ***:CRC incidence data from 1994 through 2013 were obtained from 13 Surveillance,Epidemiology,and End Results ****Stat and IBM SPSS Statistics were ***:The age-adjusted incidence of CRC among Asian Americans decreased from 45.6 per 100,000 in 1994 to 33.0 per 100,000 in 2013,with the annual percent change being−1.8%(Proximal site were more *** patients presented with localized and regional ***,80 years or older,in situ stage,and some geo-graphic areas such as Connecticut and California experienced significant incidence decreases in the 20-year observation ***:Although CRC incidence has declined among Asian American populations in the United States in the past 2 decades,there are persistent differences by age and geographic *** research is needed to guide the design and implementation of tailored strategies to reduce CRC outcome differences across Asian American populations.

关键词： Colorectal cancer proximal colon distal colon rectal cancer incidence trend