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Cellular & Molecular Immunology 2018年第4期15卷 353-366页

作者： Laura Gómez-Jaramillo Raquel Romero-García Gema Jiménez-Gómez Lisa Riegle Ana Belén Ramos-Amaya JoséAntonio Brieva Marie Kelly-Worden Antonio Campos-caro Unidad de Investigación Hospital Universitario Puerta del MarCádizSpain Department of Biology Ball State UniversityMuncieINUSA

The production and secretion of antibodies by human plasma cells(PCs)are two essential processes of humoral *** secretion process relies on a group of proteins known as soluble N-ethylmaleimide-sensitive factor attachment protein receptors(SNAREs),which are located in the plasma membrane(t-SNAREs)and in the antibody-carrying vesicle membrane(v-SNARE),and mediate the fusion of both *** have previously shown that SNAP23 and STX4 are the t-SNAREs responsible for antibody ***,using human PCs and antibody-secreting cell lines,we studied and characterized the expression and subcellular distribution of vesicle associated membrane protein(VAMP)isoforms,demonstrating that all isoforms(with the exception of VAMP1)are expressed by the referenced ***,the functional role in antibody secretion of each expressed VAMP isoform was tested using *** results show that VAMP2 may be the v-SNARE involved in vesicular antibody *** further support this conclusion,we used tetanus toxin light chain to cleave VAMP2,conducted experiments to verify co-localization of VAMP2 in antibody-carrying vesicles,and demonstrated the coimmunoprecipitation of VAMP2 with STX4 and SNAP23 and the in situ interaction of VAMP2 with *** together,these findings implicate VAMP2 as the main VAMP isoform functionally involved in antibody secretion.

关键词： exocytosis human immunoglobulin plasma cells VAMP proteins

High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis

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World Journal of Gastroenterology 2008年第10期14卷 1549-1552页

作者： Aldo Spadaro Vincenza Tortorella Carmela Morace Agostino Fortiguerra Paola Composto Caterina Bonfiglio Angela Alibrandi Carmelo Luigiano Giuseppe De caro Antonino Ajello Oscar Ferraù Maria Antonietta Freni Department of Medicine and Pharmacology University Hospital Messina 98125 Italy Department of Statistics University oMessina Messina 98125 Italy

AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity.

关键词： D-dimers Liver cirrhosis Ascites Hepatocellular carcinoma Hyperfibrinolysis

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CAD-CAM系统与旋压加工

锻压技术 1989年第5期14卷 55-57页

作者： Mrs TRIOULEYRE CAMPANA caro FELIX 张士宏巴黎国立材料技术大学

一、前言虽然我们对CAD-CAM系统叙述较多,但是运用这个系统並不是在所有情况下都是满意的。实际上,CAD-CAM的概念与产品、工艺和加工过程等的严格定义有牵连,另外,许多应用也与切削加工有关。在这种情况下,选择工艺与确定加工过程虽不... 详细信息

一、前言虽然我们对CAD-CAM系统叙述较多,但是运用这个系统並不是在所有情况下都是满意的。实际上,CAD-CAM的概念与产品、工艺和加工过程等的严格定义有牵连,另外,许多应用也与切削加工有关。在这种情况下,选择工艺与确定加工过程虽不是特别复杂,但会忽略某些问题。对于旋压加工,CAD-CAM系统需要解决下列问题:

关键词：旋压 CAD-CAM系统

Acalculous cholecystitis due to Salmonella enteritidis

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World Journal of Gastroenterology 2008年第41期14卷 6408-6409页

作者： Maria Lourdes Ruiz-Rebollo Gloria Sánchez-Antolín Félix García-Pajares Maria Antonia Vallecillo-Sande Pilar Fernández-Orcajo Rosario Velicia-Llames Agustín caro-Patón Gastroenterology Unit Hospital Río Hortega

Acute acalculous cholecystitis (AAC) is defi ned as an acute infl ammation of the gallbladder in the absence of stones. We herein report a case of a young man who developed AAC after a Salmonella enteritidis gastroint... 详细信息

关键词： Cholecystitis Young adult Infectious Salmonella enteritidis

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编组作业的优化方法

铁道运输与经济 1997年第7期19卷 22-24页

作者： caro.,G 陈立平德国柏林工业大学工程博士

阐述在编组站中灵活使用编组线的必要性和可能性，提出灵活使用编组线的优化算法，并简要介绍相应的计算机软件程序，以及比较固定与灵活使用编组线的不同结果。

关键词：编组作业优化方法编组线铁路编组站计算

Yield Response to Deficit Irrigation and Partial Root-Zone Drying in Processing Tomato （Lycopersicon esculentum Mill,）

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Journal of Agricultural Science and Technology(A) 2012年第2期2卷 209-219页

作者： Eugenio Nardella Marcella Michela Giuliani Giuseppe Gatta Antonio De caro Department of Agro-environmental Sciences Chemistry and Crop Protection （DiSACD） University of Foggia Foggia 71122 Italy

Due to the global expansion of irrigated areas and the limited availability of irrigation water, it is necessary to optimize water use in order to maximize crop yields under water deficit conditions. To evaluate the yield response of two processing tomato hybrids （Ercole and Genius） grown under different irrigation treatments, a field trial was conducted during the 2008 growing season in Southern Italy. Three irrigation treatments were used： the restitution of 70% of maximum evapotranspiration （ETc） both under ＂Deficit Irrigation＂（70DI） and ＂Partial Root-zone Drying＂（70PRD） strategies; full irrigated （FI： 100% ETc）. The two water deficit irrigation treatments （DI and PRD） showed stomatal conductance values lower than FI treatment and saved a substantial amount of water maintaining reasonable marketable yield. Moreover, PRD strategy showed slightly higher ＂Water Use Efficiency＂（WUE） values than DI. Finally, ＂yield response factor＂（Ky） showed always values less than unity, indicating the possibility to adopt, within certain limited condition, both DI and PRD in field-grown processing tomato cultivated in Southern Italy. In conclusion, in our experimental conditions, deficit irrigation practices seem to be acceptable relatively to processing tomato yield aspects and Ky could be promoted as a useful indicator for irrigation in water deficit conditions.

关键词： Tomato deficit irrigation partial root-zone drying WUE Ky.

Design of Calibration Experiments for Identification of Manipulator Elastostatic Parameters

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Journal of Mechanics Engineering and Automation 2012年第9期2卷 531-542页

作者： Alexandr Klimchik Anatol Pashkevichl Yier Wu Stephane caro Benoit Furet Ecole des mines de Nantes Nantes 44300 France Research Institute of Communications and Cybernetics of Nantes (1RCCyN) Nantes 44300 France National Centre for Scientific Research (CNRS) Paris 75016 France Department of Mechanical Engineering and Manufacturing University of Nantes Carquefou 44475 France

The paper is devoted to the elastostatic calibration of industrial robots, which is used for precise machining of large-dimensional parts made of composite materials. In this technological process, the interaction between the robot and the workpiece causes essential elastic deflections of the manipulator components that should be compensated by the robot controller using relevant elastostatic model of this mechanism. To estimate parameters of this model, an advanced calibration technique is applied that is based on the non-linear experiment design theory, which is adopted for this particular application. In contrast to previous works, it is proposed a concept of the user-defined test-pose, which is used to evaluate the calibration experiments quality. In the frame of this concept, the related optimization problem is defined and numerical routines are developed, which allow generating optimal set of manipulator configurations and corresponding forces/torques for a given number of the calibration experiments. Some specific kinematic constraints are also taken into account, which insure feasibility of calibration experiments for the obtained configurations and allow avoiding collision between the robotic manipulator and the measurement equipment. The efficiency of the developed technique is illustrated by an application example that deals with elastostatic calibration of the serial manipulator used for robot-based machining.

关键词： Industrial robot elastostatic calibration experiment design industry-oriented performance measure test-pose basedapproach.

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亚历山大健身技巧

亚历山大健身技巧

Interactions between Superplasticizer and Release Agents at the Concrete/Formwork Interface

2004年

作者：（英）Robert Macdonald （英）caro Ness 庄则豪杨婷译

本书由4部分组成。介绍了费德里克·麦特里亚斯·亚历山大及其研究的成果；讲述了人体的结构和功能，介绍了如何在日常生活中实践亚历山大技巧的克制和引导原则等内容。

关键词：健身运动(学科: 基本知识) 健身运动

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Materials Sciences and Applications 2012年第6期3卷 384-389页

作者： Samir Bouharoun Yannick Vanhove Chafika Djelal Pascale De caro Isabelle Dubois Centre de Recherche Lafarge Rue du Montmurier St Quentin Fallavier France Laboratoire Génie Civil et géo-Environnement (LGCgE)—Lille Nord de France IUT de Béthune Rue de l’Université Béthune France Université de Toulouse INP LCA (Laboratoire de Chimie Agro-Industrielle) ENSIACET Allée Emile Monso Toulouse France

Improving the knowledge of rheological and tribological characteristics of fresh concrete is important to contribute to the progress of construction sites and the final quality of the work. The objective of this study is to identify the effect of a superplasticizer based on polycarboxylic ether on the tribological behavior of fresh concrete at the concrete/formwork and concrete/oil/formwork interfaces. Friction tests on fresh concrete were carried out using a plan/plan tribometer. In order to study the behavior of the superplasticizer close to the formwork, three concretes with 30% of paste and different dosage of superplasticizer were formulated. The results show that the increase of the dosage of superplasticizer reduces the friction stress. The properties of the superplasticizer generate a deflocculating action of concrete grains and lead to a stabilisation of the soap-oil micellae present in the vicinity of the formwork. Thus, the efficiency of superplasticizer depends on the quantity of fines, on the quantity of soap formed and so, on the release agent formulation.

关键词： Tribology Concrete/Formwork Interface Concrete/Oil/Formwork Interface Superplasticizer Release Agent Physicochemical

Predictive value of bleeding risk scores in elderly patients with atrial fibrillation and oral anticoagulation

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老年心脏病学杂志:英文版 2023年第9期20卷 684-692页

作者： Pablo Domínguez-Erquicia Sergio Raposeiras-Roubín Emad Abu-Assi Andrea Lizancos-Castro Jose A Parada-Barcia AndréGonzález-García Ana Ledo-Piñeiro Vanesa Noriega-caro Carla Iglesias-Otero AndrésÍñiguez-Romo Department of Cardiology University HospitalÁlvaro CunqueiroVigoSpain Health Research Institute Galicia Sur VigoSpain

BACKGROUND The predictive value of bleeding risk scores for atrial fibrillation in older patients is not as well *** goal of this study was to evaluate the predictive value of HASBLED,ORBIT and ATRIA for major bleeding(MB)and intracranial hemorrhage(ICH)in patients≥75 years with atrial fibrillation and oral anticoagulation(OAC).METHODS A retrospective unicenter study including patients≥75 years with atrial fibrillation(AF)and OAC.A total of 7613 patients≥75 years with AF and OAC included between 2014 and 2018(registry:NCT04364516).We analyzed the discriminative value of HASBLED,ATRIA and ORBIT scores for bleeding endpoints(major bleeding as primary endpoint and intracerebral hemorrhage as secondary).Cox regression was used to predict major bleeding with each scale and also for searching other variables potentially predictor of major *** discrimination was assessed using Harrell’s *** was assessed with goodness-of-fit test proposed by Gronnesby and *** During a mean follow up of 4.0 years(IQR:2.4–5.7 years),729 patients developed MB(2.61 per 100 patients/year)and 243 patients developed ICH(0.85 per 100 patients/year).Three scores showed a low discrimination for major bleeding,being ORBIT the best(HASBLED C statistic=0.557;ATRIA C statistic=0.568;ORBIT C statistic=0.595)and also a low discrimination for ICH(HASBLED C statistic=0.509;ATRIA C statistic=0.522;ORBIT C statistic=0.526).Among the variables that are part of the scores and other baseline characteristics,after multivariable adjustment only sex(male),dementia,prior admission for bleeding,anemia and liver disease were found as a predictors of *** In older patients under oral anticoagulation with atrial fibrillation,the risk scores HASBLED,ATRIA and ORBIT showed a weak discrimination for major bleeding and intracranial ***,other better alternatives should be evaluated for this purpose.

关键词： patients bleeding fibrillation