检索结果-南通市图书馆

Comparison of QT Correction Methods in the Pediatric Population of a Community Hospital: A Retrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Congenital Heart Disease 2024年第1期19卷 107-121页

作者： Koren Hyogene Kwag Ibrahim Kak Ying Li Walid Khass alec McKechnie Oksana Nulman Brande Brown Manoj Chhabra Department of Pediatrics New York Presbyterian Brooklyn Methodist HospitalBrooklyn11215USA Department of Population Health sciences Division of BiostatisticsWeill Cornell MedicineNew York10065USA

Objective:Accurate measurement of QT interval,the ventricular action potential from depolarization to repolarization,is important for the early detection of Long QT *** most effective QT correction(QTc)formula has yet to be determined in the pediatric population,although it has intrinsically greater extremes in heart rate(HR)and is more susceptible to errors in *** authors of this study compare six dif-ferent QTc methods(Bazett,Fridericia,Framingham,Hodges,Rautaharju,and a computer algorithm utilizing the Bazett formula)for consistency against variations in HR and RR ***:Descriptive Retrospective *** included participants from a pediatric cardiology practice of a community hospital who had an ECG performed in *** participants were healthy patients with no past medical history and no regular ***:ECGs from 95 participants from one month to 21 years of age(mean 9.7 years)were included with a mean HR of 91 beats per minute(bpm).The two-sample paired t-test or Wilcoxon signed-rank test assessed for any difference between QTc methods.A statistically signiﬁcant difference was observed between every combination of two QTc *** spearman’s rank correlation analysis explored the QTc/HR and QTc/RR relationships for each *** method was most independent of HR and RR with the lowest absolute value of correlation coefﬁ*** and Computer had moderate correlations,while Framingham and Rautaharju exhibited strong *** were positive for Bazett and Computer,reﬂecting results from prior studies demonstrating an over-correction of Bazett at higher *** the linear QTc/HR regression analysis,Bazett had the slope closest to zero,although Computer,Hodges,and Fridericia had comparable ***,Fridericia had the linear QTc/RR regression coefﬁcient closest to *** Bland-Altman method assessed for bias and the limits of agreement between correction *** an

关键词： Corrected QT interval QT prolongation long QT syndrome electrocardiogram retrospective study bazett fridericia framingham hodges rautaharju computer algorithm

Mixed iridium-nickel oxides supported on antimony-doped tin oxide as highly efficient and stable acidic oxygen evolution catalysts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Materials Futures 2024年第1期3卷 165-180页

作者： Jonathan Ruiz Esquius alec P LaGrow Haiyan Jin zhipeng Yu Ana Araujo Rita Marques Adélio Mendes Lifeng Liu Clean Energy Cluster International Iberian Nanotechnology LaboratoryAv.Mestre JoséVeigaBraga 4715-330Portugal Carbon science and Technology Institute INCAR-CSICFrancisco Pintado Fe 26Oviedo 33011Spain scientific Imaging section Okinawa Institute of Science and Technology Graduate UniversityKunigami-gunOkinawa 904-0412Japan songshan Lake Materials Laboratory Dongguan 523808People’s Republic of China Laboratory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal Associate Laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoRua Dr Roberto FriasPorto 4200-465Portugal.

Proton exchange membrane(PEM)water electrolysis represents a promising technology for green hydrogen production,but its widespread deployment is greatly hindered by the indispensable usage of platinum group metal catalysts,especially iridium(Ir)based materials for the energy-demanding oxygen evolution reaction(OER).Herein,we report a new sequential precipitation approach to the synthesis of mixed Ir-nickel(Ni)oxy-hydroxide supported on antimony-doped tin oxide(ATO)nanoparticles(IrNiyO_(x)/ATO,20 wt.%(Ir+Ni),y=0,1,2,and 3),aiming to reduce the utilisation of scarce and precious Ir while maintaining its good acidic OER *** tested in strongly acidic electrolyte(0.1 M HClO_(4)),the optimised IrNi1Ox/ATO shows a mass activity of 1.0 mAµgIr^(−1) and a large turnover frequency of 123 s^(−1) at an overpotential of 350 mV,as well as a comparatively small Tafel slope of 50 mV dec^(−1),better than the IrOx/ATO control,particularly with a markedly reduced Ir loading of only 19.7µgIr cm^(−2).Importantly,IrNi1O_(x)/ATO also exhibits substantially better catalytic stability than other reference catalysts,able to continuously catalyse acidic OER at 10 mA cm^(−2) for 15 h without obvious *** in-situ synchrotron-based x-ray absorption spectroscopy confirmed that the Ir^(3+)/Ir^(4+)species are the active sites for the acidic ***,the performance of IrNi1Ox/ATO was also preliminarily evaluated in a membrane electrode assembly,which shows better activity and stability than other reference *** IrNi1Ox/ATO reported in this work is a promising alternative to commercial IrO_(2) based catalysts for PEM electrolysis.

关键词： mixed oxides oxygen evolution reaction polymer electrolyte membrane antimony doped tin oxide membrane electrode assembly

Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Military Medical Research 2024年第1期11卷 50-79页

作者： shuai Liu Jiang-Ming Yu Yan-Chang Gan Xiao-zhong Qiu zhe-Chen Gao Huan Wang shi-Xuan Chen Yuan Xiong Guo-Hui Liu si-En Lin alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA zigong Affiliated Hospital of southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic scaffold Biosynthesis Natural biomaterial Tissue engineering

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

在线全文

学校读者我要写书评

暂无评论

Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.strong Yuxiao sun Lei Guo Conan Juan alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA section of Plastic surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

在线全文

学校读者我要写书评

暂无评论

锈河染红最后的荒野

环球科学 2024年第3期 40-49页

作者：亚历克·卢恩吕昀斐(译) 不详

那是美国阿拉斯加州科伯克谷国家公园七月一个多云的下午。我们所在的地方距离最近的村庄95千米,距离公路也有400千米远。事实上,这座公园是美国最大的一片荒野保护区,没有哪一处比这里的自然环境受到的破坏更少了。

关键词：荒野自然环境公园保护区距离

Recent emergence and outbreak of rotavirus gastroenteritis in samoa:A scoping review of risk factors,containment measures and public health preparedness

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2021年第11期14卷 479-485页

作者： Lawal Olatunde Olayemi Vicky Yemoh alec Ekeroma school of Medicine Faculty of Health Sciences National University of Samoa

Diarrheal diseases have been known to cause death in many children below the age of five years,and rotavirus infection represents a major health problem in the world today,particularly in developing *** recent outbreak of rotavirus gastroenteritis in samoa led to the introduction of her debut national immunization program on rotavirus vaccination for *** the introduction of anti-viral and anti-emetic drugs as of the containment approaches towards the virus,risk factors,preventive measures and public health preparedness against rotavirus infection are poorly understood in *** review aims to use available evidence on rotavirus literature to elucidate and map preventive strategies for the recently emerged rotavirus infections in *** conducted a search strategy using online medical literature databases and retrieval systems.A designated set of keywords such as rotavirus,gastroenteritis,outbreak,risk factors,containment measures,vaccination and samoa were inserted in electronic databases to retrieve *** databases included Pub Med,Google scholar,MEDLINE,scinapse,and EBsCO *** from this review addressed the impact of rotavirus infection,associated threats and other preventive *** useful health frameworks in pursuing possible methods such as improved water quality,exclusive breast feeding,improved laboratory diagnostics and outbreak surveillance,may be essential in addressing alternate approaches towards containment of the disease in samoa and other Pacific Island Countries and Territories.

关键词： Rotavirus Gastroenteritis Outbreak Risk factors Containment measures Vaccination Pacific Island Countries and Territories samoa

Potato farmers’ preference for agricultural insurance in China: An investigation using the choice experimental method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2020年第4期19卷 1137-1148页

作者： HUANG ze-ying alec zUO sUN Jun-mao GUO Yan-zhi Institute of Food and Nutrition Development Ministry of Agriculture and Rural AffairsBeijing 100081P.R.China Centre for Global Food and Resources University of AdelaideAdelaide 5005Australia

Potato insurance plays an important role in transferring agricultural risks to promote the potato staple strategy. Understanding farmers’ real preferences for potato insurance attributes is important to improve the potato insurance. In this study, a choice experiment was designed with attributes such as peril, minimum compensation ratio for production loss, types of crops covered by insurance, annual premium per mu after subsidy, and complexity of claims procedures. We constructed a mixed logit model based on a questionnaire survey of 362 potato farmers’ choices of insurance attributes from 24 villages in Dingxi City of Gansu Province using random sampling. The results show that:(1) farmers prefer agricultural insurance with widely perils including output price drop and input cost risk;(2) farmers who have suffered plant disease and insect and pest damage are willing to pay a high premium for the insurance with a high compensation ratio and several types of crops covered;full-time farmers and large-scale farmers preferred insurance products with low complexity of claims procedures. Therefore, new potato insurance design could be considered specifically for different farmer groups such as those who had previous disaster experiences, and large-or small-scale farm operations.

关键词： agricultural insurance choice experimental method potato attributes preferences

Ray transfer matrix perturbation for an optical component with aberration

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2012年第8期10卷 11-13页

作者： Jerry T.Barretto Clark Kendrick C.Go stein alec C.Baluyot Department of Physics School of Science and EngineeringAteneo de Manila University Department of Mathematics School of Science and EngineeringAteneo de Manila University

The perturbation theory of matrices is applied to ray transfer matrices （RTMs） to describe an optical component with aberration. A quantitative description of the perturbation extent corresponding to aberration strength is provided using condition numbers and absolute errors for the perturbed RTM. An application to a single small aberration is presented, and the results are compared with those of the diffraction theory of aberrations.

关键词： 080.0080 Geometric optics 080.2720 Mathematical methods (general) 080.2730 Matrix methods in paraxial optics

Concurrent optic disc pit and retinal cavernous hemangioma

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2017年第1期10卷 168-170页

作者： alec L Amram Renata Picciani Jaafar El-Annan Department of Ophthalmology and Visual sciences University of Texas Medical BranchGalvestonTexas 77555USA

We present, to the authors＇ knowledge, the first reported case of an optic disc pit （ODP） and retinal cavernous hemangioma （RCH） in the same eye in addition to a review of both clinical entities. An ODP is a rare... 详细信息

关键词： ODP Concurrent optic disc pit and retinal cavernous hemangioma Figure