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American Journal of Plant Sciences 2014年第15期5卷 2426-2430页

作者： Awad f. farah Samia M. Ibrahim Department of Biology Faculty of Education University of Sirt Sirt Libya Department of Science Faculty of Education University of Holy Quraan Omdurman Sudan

four solanaceous plant species, namely hot pepper (Capsicum frutescensL.), potato (Solanum tuberosumL.), tobacco (Nicotiana tabacumL.) and tomato (Lycopersicon esculentumMiller) were anatomically screened for compatibility/incompatibility to field dodder (Cuscuta campestrisYuncker, Cuscutaceae). The development of field dodder haustorium within stem tissues of the studied solanaceous plants was found to depend on the latter’s response to the former’s penetration. In hot pepper and tobacco, which showed a positive response, the haustorium was well developed and its searching hyphae established connections with their vascular tissues. However, potato and tomato showed a negative response and acquired different defense mechanisms against the parasitism of field dodder. In both of them, the field dodder haustorium and/or its searching hyphae exhibited distorted appearance and failed to establish connection with their vascular tissues. Thus, the tested solanaceous plant species could be classified as either compatible (hot pepper and tobacco) or incompatible (potato and tomato) hosts to field dodder.

关键词： Compatible or Incompatible Hosts field Dodder Haustorium Searching Hyphae Solanaceous Plant Species

Therapeutic drug monitoring in inflammatory bowel disease:The dawn of reactive monitoring

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World Journal of Gastroenterology 2021年第37期27卷 6231-6247页

作者： farah Albader Petra Anna Golovics Lorant Gonczi Talat Bessissow Waqqas Afif Peter Laszlo Lakatos Department of Internal Medicine McGill UniversityMontreal H3G1A4QuebecCanada Division of Gastroenterology Hungarian Defence ForcesMedical CentreBudapest H-1062Hungar Division of Gastroenterology McGill UniversityMontreal H3G 1A4QuebecCanada first Department of Medicine Semmelweis UniversityBudapest H-1083Hungary Division of Gastroenterology McGill University Health CentreMontreal H3G 1A4QuebecCanada

Inflammatory bowel disease(IBD)is a chronic condition that significantly affects the quality of life of its *** drugs have been the mainstay treatment in the management of IBD patients but despite their significant contribution,there remains a proportion of patients that do not respond or lose response to *** drug monitoring(TDM)involves measuring levels of serum drug concentrations and anti-drug *** of biologic drugs initially emerged to understand treatment failure in other immune mediated inflammatory *** was then introduced in IBD to rationalize primary non-response or secondary loss of response,given that low serum drug concentrations or the formation of anti-drug antibodies are variably associated with treatment *** aim of this narrative review is to provide an overview regarding the current use of TDM in clinical practice and to present the evidence available regarding its use in both proactive and reactive clinical settings in preventing and managing treatment *** review also presents the existing evidence regarding the association of various clinical outcomes with specific thresholds of drug concentrations,in everyday practice.A narrative review of published articles and conference abstracts regarding the use of TDM in IBD management,through an electronic search using PubMed and *** has proven to be superior and more cost effective in guiding management of patients with treatment failure compared to empiric dose escalation or change in *** a trend towards an association between clinical outcomes and drug concentrations,proactive TDM based strategies have not been shown to achieve clear benefit in long-term *** the clinical setting,TDM has proven to be useful in managing IBD patients,and its use in the reactive setting,as an additional tool to help manage patients with treatment failure,is being promoted as newer guidelines and consensus groups implement

关键词： Therapeutic drug monitoring Inflammatory bowel disease Biologic therapies Loss of response Reactive Proactive

Intimate hygiene practices and reproductive tract infections: A systematic review

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Gynecology and Obstetrics Clinical Medicine 2022年第3期2卷 129-135页

作者： Alaa Daher Obey Albaini Lauren Siff Stephanie farah Karl Jallad Department of Obstetrics and Gynecology American University of Beirut Medical CenterBeirutLebanon Department of Clinical Research Lebanese American University Medical CenterGilbert and Rose-Marie Chagoury School of MedicineBeirutLebanon Virginia Commonwealth University School of Medicine VirginiaUSA Lebanese American University Medical Center Gilbert and Rose-Marie Chagoury School of MedicineBeirutLebanon

Introduction:Worldwide,women perform a variety of vaginal practices to enhance their intimate hygiene and sexual ***:To conduct a systematic review to assess the different kinds of intimate hygiene practices and their association with reproductive tract infections and ***:PubMed,Medline and The Cochrane Library were *** observational and interventional studies targeting the urogenital infections and their association with hygiene practices were *** criteria included studies that assessed the knowledge and attitudes towards intimate hygiene practices rather than their relation to *** design of this systematic review complied with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis(PRISMA).Results:fifteen articles were *** practices were found to be associated with reproductive tract *** absorbent material used during menstruation increased the risk of Candida infection with an adjusted proportional reported ratio(aPRR)of 1.54(95%CI 1.2–2.0),but no association with bacterial vaginosis or trichomonas vaginalis infection was *** or vaginal washing during menstruation with water only showed a higher association with symptoms of urogenital infections when compared with washing with both soap and water during *** reusable pads inside the house and storing them inside the toilet was found to be associated with a higher candida infection ***,bathing in sitting position during menstruation,not drying the genital area or using cloth for drying it,and not paying attention to hand washing,were all associated with a higher risk of genital ***,postpartum use of native homemade vaginal preparations might be a risk factor for ascending vaginal infections,and the use of inappropriate material for menstrual blood absorption was associated with secondary ***:Several hygiene pract

关键词： Intimate hygiene practice Reproductive tract infection Sexually transmitted infection Vaginal douching

Typical atrial flutter from blunt cardiac injury:an atypical cause

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Journal of Geriatric Cardiology 2021年第2期18卷 155-157页

作者： Naji Maaliki fadi Kandah aleem Azal Ali James farah Temitope Akinjogbin francesco franchi Internal Medicine University of Florida College of Medicine-JacksonvilleFloridaUSA General Surgery University of Florida College of Medicine-JacksonvilleFloridaUSA Division of Cardiology University of Florida College of Medicine-JacksonvilleFloridaUSA

Atrial flutter(AfL)is a detrimental cardiac arrhythmia caused by multiple pathologic *** unsuspecting cases,however,may be an inciting *** them is blunt cardiac injury(BCI),characterized by nonpenetrating mediastinal trauma,leading to arrhythmias due to myocardial tissue *** is a rare sequela of BCI that has seldom been *** present a case of a healthy 50-year-old lady who was incidentally diagnosed with AfL in the setting of BCI.

关键词： cardiac injury atypical

Role of the cation-chloride-cotransporters in the circadian system

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Asian Journal of Pharmaceutical Sciences 2021年第5期16卷 589-597页

作者： Shihan Salihu Nur farah Meor Azlan Sunday Solomon Josiah Zhijuan Wu Yun Wang Jinwei Zhang Institute of Biomedical and Clinical Sciences Medical SchoolCollege of Medicine and HealthUniversity of ExeterHatherly LaboratoriesExeter EX44PSUK Department of Neurology Institutes of Brain ScienceState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitute of Biological ScienceZhongshan HospitalFudan UniversityShanghai 200032China

The circadian system plays an immense role in controlling physiological processes in our *** suprachiasmatic nucleus (SCN) supervises this system,regulating and harmonising the circadian rhythms in our *** neurons present in the SCN are GABAergic *** GABA is considered the main inhibitory neurotransmitter of the CNS,recent studies have shown that excitatory responses were recorded in this *** responses are enabled by an increase in intracellular chloride ions[Cl;];*** chloride (Cl;) levels in GABAergic neurons are controlled by two solute carrier 12 (SLC12)cation-chloride-cotransporters (CCCs):Na^(+)/K^(+)/Cl^(-)co-transporter (NKCC1) and K^(+)/Cl^(-)cotransporter (KCC2),that respectively cause an influx and efflux of Cl^(-).Recent works have found altered expression and/or activity of either of these co-transporters in SCN neurons and have been associated with circadian *** this review,we summarize and discuss the role of CCCs in circadian rhythms,and highlight these recent advances which attest to CCC’s growing potential as strong research and therapeutic targets.

关键词： GABAergic Na^(+)-K^(+)-2Cl^(-)cotransporter 1(NKCC1) K^(+)-2Cl^(-)cotransporter 2(KCC2) WNK3-SPAK/OSR1,Chloride(Cl^(-)) homoostasis Suprachiasmatic nucleus(SCN) Circadian rhythms

Antioxidant activity profiling by spectrophotometric methods of aqueous methanolic extracts of Helichrysum stoechas subsp. rupestre and Phagnalon saxatile subsp. saxatile

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Chinese Journal of Natural Medicines 2014年第6期12卷 415-422页

作者： farah Haddouchi Tarik Mohammed Chaouche Riadh Ksouri faten Medini fatima Zohra Sekkal Abdelhafid Benmansour Laboratory of Natural Products Department of Biology Faculty of Sciences Abou Bekr Belkad University Laboratory of Plant Adaptation to Abiotic Stresses Biotechnologic Center in Borj-Cedria Technopol (CBBC) Department of Biotechnology Faculty of Natural Science and Life Abdelel Hamid Ibn Badiss University Mostaganem 27000 Algeria

AIM: The aqueous methanolic extracts of two plants from Algeria, Helichrysum stoechas subsp. rupestre and Phagnalon saxatile subsp. saxatile, were investigated for their antioxidant activity. METHOD: Total phenolics, flavonoids, and tannins were determined by spectrophotometric techniques..In vitro antioxidant and radical scavenging profiling was determined by spectrophotometric methods, through: Total antioxidant capacity, and radical scavenging effects by the DPPH and ABTS methods, reducing and chelating power, and blanching inhibition of the β-carotene. RESULTS: All of the extracts showed interesting antioxidant and radical scavenging activity. The highest contents in phenolics, tannins, and the highest total antioxidant capacity as gallic acid equivalents of 97.5 ± 0.33 mg GAE/g DW was obtained for the flowers of H. stoechas subsp. rupestre extract in the phosphomolybdenum assay. An extract of the leafy stems of P. saxatile subsp. saxatile revealed the highest content of flavonoids, and the highest antioxidant activity by the radical scavenging and β-carotene assays when compared with standards. The best activity was by the scavenging radical DPPH with an IC50 value of 5.65 ± 0.10 μg·mL-1. CONCLUSION: The studied medicinal plants could provide scientific evidence for some traditional uses in the treatment of diseases related to the production of reactive oxygen species(ROS) and oxidative stress.

关键词： Helichrysum stoechas subsp.rupestre Phagnalon saxatile subsp.saxatile Phenolic compounds Antioxidant activity

Measuring Global Warming: Global and Hemisphere Mean Temperature Anomalies Predictions Using Sliced functional Time Series (SfTS) Model

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Open Journal of Applied Sciences 2019年第5期9卷 316-334页

作者： farah Yasmeen Karachi University Karachi Pakistan

In this study, the sliced functional time series (SfTS) model is applied to the Global, Northern and Southern temperature anomalies. We obtained the combined land-surface air and sea-surface water temperature from Goddard Institute for Space Studies (GISS), NASA. The data are available for Global mean, Northern Hemisphere mean and Southern Hemisphere means (monthly, quarterly and annual) since 1880 to present (updated through March 2019). We analyze the global surface temperature change, compare alternative analyses, and address the questions about the reality of global warming. We detected the outliers during the last century not only in global temperature series but also in northern and southern hemisphere series. The forecasts for the next twenty years are obtained using SfTS models. These forecasts are compared with ARIMA, Random Walk with drift and Exponential Smoothing State Space (ETS) models. The comparison is made on the basis of root mean square error (RMSE), mean absolute percentage error (MAPE) and the length of prediction intervals.

关键词： Temperature Series Hemispheric Temperature Temperature Anomalies Global Warming Weather Prediction Sliced functional Time Series Outliers

An Improved Method for Preparation of Uniform and functional Mitochondria from fresh Liver

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Journal of Clinical and Translational Hepatology 2019年第1期7卷 46-50页

作者： Nagham Khouri farah Xiaocong Liu Catherine H.Wu George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Background and Aims:As the major energy source for mammalian cells,mitochondria have been the subject of numerous ***,the isolation and purification of healthy mitochondria,especially from fresh tissue,remains *** most popular methods and kits involve various centrifugation steps which require substantial time and equipment but do not consistently provide pure preparations of functional *** aim of this study was to determine whether methods could be devised to improve the purity and yield of functional mitochondria from fresh ***:fresh mouse liver was homogenized,and cells *** size analysis,quantitation of mitochondrial DNA,mitochondrial oxygen consumption,and purity of mitochondria(by electron microscopy)were measured in samples after various purification steps and significant differences ***:A two-step procedure consisting of centrifugation followed by filtration through 1.2μand 0.8μfilters resulted in uniform mitochondrial preparations with diameters between 520-540 nm,and approximately 5-times more pure *** mitochondria thus obtained had oxygen consumption and sensitivities to mitochondrial inhibitors that were indistinguishable from those purified by centrifugation *** microscopy confirmed the presence of more uniform and 4-5 times greater concentrations of mitochondria compared to centrifugation ***:A two-step procedure consisting of sequential centrifugation followed by filtration is a rapid method for the production of highly purified,uniform and functional mitochondria.

关键词： Mitochondria Isolation filtration Purified Uniform functional

Performance of the hybrid growth sequencing batch reactor(HG-SBR) for biodegradation of phenol under various toxicity conditions

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Journal of Environmental Sciences 2019年第1期31卷 64-72页

作者： NikAthirah Yusoff Soon-An Ong Li-Ngee Ho Yee-Shian Wong farah Naemah Mohd Saad Wanfadhilah Khalik Sin-Li Lee School of Environmental Engineering University Malaysia Perlis School of Materials Engineering University Malaysia Perlis

Hybrid growth microorganisms in sequencing batch reactors have proven effective for treating the toxic compound phenol, but the toxicity effect under different toxicity conditions has rarely been discussed. Therefore, the performance of the HG-SBR under toxic, acute and chronic organic loading can provide the overall operating conditions of the system. Toxic organic loading(TOL) was monitored during the first 7 hr while introducing50 mg/L phenol to the system. The system was adversely affected with the sudden introduction of phenol to the virgin activated sludge, which caused a low degradation rate and high dissolved oxygen consumption during TOL. Acute organic loading(AOL) had significant effects at high phenol concentrations(600, 800 1000 mg/L). The specific oxygen uptake rate(SOUR) gradually decreased to 4.9 mg O_2/(g MLVSS·hr) at 1000 mg/L of phenol compared to 12.74 mg O_2/(g MLVSS·hr) for 200 mg/L of phenol. The HG-SBR was further monitored during chronic organic loading(COL) over 67 days. The effects of organic loading were more apparent at 800 mg/L and 1000 mg/L phenol concentrations, as the removal range was between 22%–30% and 18%–46% respectively, which indicated the severe effects of COL.

关键词： Toxic organic loading Acute organic loading Chronic organic loading Phenol Sequencing batch reactor

Distribution of different hepatitis C virus genotypes in patients with hepatitis C virus infection

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World Journal of Gastroenterology 2010年第16期16卷 2005-2009页

作者： farah Bokharaei Salim Hossein Keyvani Afsaneh Amiri fatemeh Jahanbakhsh Sef idi Ramin Shakeri farhad Zamani Virology Department Iran University of Medical Sciences GI and Liver Disease Research Centre Iran University of Medical Sciences Digestive Disease Research Centre Tehran University of Medical Sciences

AIM:To investigate the presence of mixed infection and discrepancy between hepatitis C virus(HCV) genotypes in plasma,peripheral blood mononuclear cells(PBMCs),and liver biopsy ***:from September 2008 up to April 2009,133 patients with chronic hepatitis C referred to firouzgar Hospital for initiation of an antiviral therapy were recruited in the *** milliliters of peripheral blood was collected from each patient and liver biopsy was performed in those who gave consent or had *** genotyping was done using INNO-LiPATM HCV in serum,PBMCs,and liver biopsy specimens and then conf irmed by sequencing of 5'-UTR ***:The mean age of patients was 30.3 ± 17.1 *** transfusion was seen in 124(93.2%) of *** HCV genotypes were found in 3(2.3%) of 133 plasma samples,9(6.8%) of 133 PBMC samples,and 8(18.2%) of 44 liver biopsy *** is notable that the different genotypes found in PBMCs were not the same as those found in plasma and liver biopsy ***:Our study shows that a signif icant proportion of patients with chronic hepatitis C are affected by multiple HCV genotypes which may not be detectable only in serum of patients.

关键词： Chronic hepatitis C virus infection Mixed hepat itis C virus infection Peripheral blood mononuclear cells Hepatocyte