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Mechanistic modeling of copper corrosions in data center environments

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Building Simulation 2024年第3期17卷 483-492页

作者： Rui Zhang Jianshun Zhang Roger schmidt Jeremy L.Gilbert Department of Mechanical and Aerospace Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buildings and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA SyracuseCoE-New York Center of Excellence in Environmental and Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Department of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

Air-side economizers are increasingly used to take advantage of“free-cooling”in data centers with the intent of reducing the carbon footprint of ***,they can introduce outdoor pollutants to indoor environment of data centers and cause corrosion damage to the information technology *** evaluate the reliability of information technology equipment under various thermal and air-pollution conditions,a mechanistic model based on multi-ion transport and chemical reactions was *** model was used to predict Cu corrosion caused by Cl_(2)-containing pollutant *** also accounted for the effects of temperature(25℃and 28℃),relative humidity(50%,75%,and 95%),and *** also identified higher air temperature as a corrosion barrier and higher relative humidity as a corrosion accelerator,which agreed well with the experimental *** average root mean square error of the prediction was 13.7Å.The model can be used to evaluate the thermal guideline for data centers design and operation when Cl_(2)is present based on pre-established acceptable risk of corrosion in data centers’environment.

关键词： chloride pollutant mixture copper corrosion model data center temperature relative humidity synergistic effect

Transfer learning from synthetic data for open-circuit voltage curve reconstruction and state of health estimation of lithium-ion batteries from partial charging segments

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Energy and AI 2024年第3期17卷 80-97页

作者： Tobias Hofmann Jacob Hamar Bastian Mager Simon Erhard Jan Philipp schmidt Chair of Systems Engineering for Electrical Energy Storage University of BayreuthWeiherstraße 26Bayreuth95448BavariaGermany BMW Group Petuelring 130Munich80809BavariaGermany

Data-driven models for battery state estimation require extensive experimental training data,which may not be available or suitable for specific tasks like open-circuit voltage(OCV)reconstruction and subsequent state of health(SOH)*** study addresses this issue by developing a transfer-learning-based OCV reconstruction model using a temporal convolutional long short-term memory(TCN-LSTM)network trained on synthetic data from an automotive nickel cobalt aluminium oxide(NCA)cell generated through a mechanistic model *** data consists of voltage curves at constant temperature,C-rates between C/30 to 1C,and a SOH-range from 70%to 100%.The model is refined via Bayesian optimization and then applied to four use cases with reduced experimental nickel manganese cobalt oxide(NMC)cell training data for higher use *** TL models’performances are compared with models trained solely on experimental data,focusing on different C-rates and voltage *** results demonstrate that the OCV reconstruction mean absolute error(MAE)within the average battery electric vehicle(BEV)home charging window(30%to 85%state of charge(SOC))is less than 22 mV for the first three use cases across all *** SOH estimated from the reconstructed OCV exhibits an mean absolute percentage error(MAPE)below 2.2%for these *** study further investigates the impact of the source domain on TL by incorporating two additional synthetic datasets,a lithium iron phosphate(LFP)cell and an entirely artificial,non-existing,cell,showing that solely the shifting and scaling of gradient changes in the charging curve suffice to transfer knowledge,even between different cell chemistries.A key limitation with respect to extrapolation capability is identified and evidenced in our fourth use case,where the absence of such comprehensive data hindered the TL process.

关键词： Lithium-ion battery State of health estimation Transfer learning OCV curve Partial charging Synthetic data

A complete reference genome for the soybean ***

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Plant Communications 2024年第2期5卷 19-22页

作者： Yicheng Huang Dal-Hoe Koo Yizhou Mao Eliot M.Herman Jianwei Zhang Monica A.schmidt National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Wheat Genetics Resource Center Department of Plant PathologyKansas State UniversityManhattanKS 66506USA BIO5 Institute School of Plant SciencesUniversity of ArizonaTucsonAZ 85721USA

Dear Editors,Soybeans are a global commodity for their edible protein and vegetable *** global population is predicted to be 9.7 billion by 2050(UN,2022),with a concomitant drastic increase in protein *** already 2.4 billion people suffering from food insecurity(FAO et al.,2023),there is an urgent need to meet future production demands for plant-based proteins.

关键词： commodity soybean urgent

Temporally Preserving Latent Variable Models:Offline and Online Training for Reconstruction and Interpretation of Fault Data for Gearbox Condition Monitoring

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Journal of Dynamics, Monitoring and Diagnostics 2024年第2期3卷 156-177页

作者： Ryan Balshaw P.Stephan Heyns Daniel N.Wilke Stephan schmidt Center for Asset Integrity Management Department of Mechanical and Aeronautical EngineeringUniversity of PretoriaPretoriaSouth Africa

Latent variable models can effectively determine the condition of essential rotating machinery without needing labeled *** models analyze vibration data via an unsupervised learning *** preservation is necessary to obtain an informative latent manifold for the fault diagnosis *** a temporalpreserving context,two approaches exist to develop a condition-monitoring methodology:offline and *** latent variable models,the available training modes are not *** many traditional methods use offline training,online training can dynamically adjust the latent manifold,possibly leading to better fault signature extraction from the vibration *** study explores online training using temporal-preserving latent variable *** online training,there are two main methods:one focuses on reconstructing data and the other on interpreting the data *** are considered to evaluate how they diagnose faults over *** two experimental datasets,the study confirms that models from both training modes can detect changes in machinery health and identify faults even under varying ***,the complementarity of offline and online models is emphasized,reassuring their versatility in fault *** the implications of the training approach and the available model formulations is crucial for further research in latent variable modelbased fault diagnostics.

关键词： Condition monitoring unsupervised learning latent variable models temporal preservation training approaches

Advancing Evaluation of Microplastics Thresholds to Inform Water Treatment Needs and Risks

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Environment & Health 2024年第7期2卷 441-452页

作者： Omar S.Chowdhury Philip J.schmidt William B.anderson Monica B.Emelko Department of Civil and Environmental Engineering University of Waterloo200 University Avenue WestWaterlooON N2L 3G1Canada

Although human health impacts of microplastics are not well understood,concern regarding chemical contaminants retained on or within them is *** water providers are increasingly asked about these risks,but strategies for evaluating them and the extent of treatment needed to manage them are currently *** can potentially induce health effects if the concentration of contaminants adsorbed to them exceeds predetermined drinking water guidelines(e.g.,Maximum Contaminant Levels).The risk posed by microplastics due to adsorbed contaminants is difficult to determine,but a worst-case scenario can be evaluated by using adsorption ***,a“Threshold Microplastics Concentration”(TMC)framework is developed to evaluate whether waterborne microplastic concentrations can potentially result in the intake of regulated contaminants on/in microplastics at levels of human health concern and identify treatment targets for managing associated health *** the TMC does not indicate an immediate health risk;it informs the need for detailed risk assessment or further treatment evaluation to ensure particle removal targets are ***,the TMC concept and framework provide an updateable,science-based screening tool to determine if there is a need for detailed risk assessment or treatment modification due to waterborne microplastics in supplies used for potable water production.

关键词： drinking water treatment chemical contaminants adsorption capacity risk management maximum contaminant level

The NORE1A/RASSF5 Tumor Suppressor Forms a Complex with GSK-3β to Regulate β-Catenin

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Journal of Biosciences and Medicines 2024年第8期12卷 60-75页

作者： M. Lee schmidt Howard Donninger Geoffrey J. Clark Department Pharmacology and Toxicology University of Louisville Louisville USA US Worldmeds LouisvilleUSA Department of Medicine University of Louisville Louisville USA Experimental Therapeutics Program James Graham Brown Cancer Center University of Louisville Louisville USA

NORE1A (RASSF5) is a tumor suppressor of the RASSF family that is often down-regulated in human tumors. NORE1A has multiple roles in controlling cellular homeostasis, one of them being regulating levels of β-catenin by binding and modulating the ubiquitin ligase substrate recognition factor β-TrCP. β-catenin is a major executor of the Wnt pathway. The ubiquitin SCF-β-TrCP ligase complex acts on a phospho-degron site in β-catenin that can be phosphorylated by GSK-3β. We now show that in addition to binding β-TrCP, NORE1A also promotes the phosphorylation of the β-catenin phospho-degron by complexing with the kinase GSK-3β. Indeed, NORE1A enhances the formation of a GSK-3β/β-TrCP complex. A structural mutant of NORE1A that retains β-TrCP binding but will no longer interact with GSK-3β inhibits the β-catenin degrading action of NORE1A. The GSK-3β interaction with NORE1A plays an important role in the biology of NORE1A as a GSK-3β inhibitor blocks NORE1A induced senescence. Thus, we identify a new role for the tumor suppressor NORE1A: The regulation of GSK-3β. GSK-3β has many other substrates including multiple transcription factors and co-activators such as p53 and the Hippo component TAZ. The work implies that NORE1A may be able to influence all of them via this new kinase scaffolding interaction.

关键词： RAS NORE1A RASSF5 GSK-3β Beta Catenin HIPPO

Concise Synthesis of Lactococcus garvieae Lipoteichoic Acids Through an Additive-Modulated Preactivation Protocol and the Immunological Studies

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CCS Chemistry 2024年第2期6卷 403-414页

作者： Tianlu Li Tong Li Yue Yang Haoru Zhuang Jianwu Lv Ning Zhou Miaomiao Zhang Fengshan Wang Yiqun Geng Richard R.schmidt Peng Peng National Glycoengineering Research Center Shandong Key Laboratory of Carbohydrate Chemistry and GlycobiologyNMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate Based MedicineShandong UniversityQingdao 266237 State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050 Department of Chemistry University of KonstanzD-78457 Konstanz

Lipoteichoic acids(LTAs)are macroamphiphiles composed of alditol,lipid,phosphate,and carbohydrate *** to their inherent complexity,it is a severe challenge to access LTAs with structural integrity from natural sources for biological or immunological ***,we describe the first total synthesis of Lactococcus garvieae LTA(type II LTA),containing five distinct 1,2-cis gluco/galactopyranosidic linkages,via a novel additive-modulated O-glycosyl trichloroacetimidate preactivation glycosidation *** strategy features(1)high glycosidation yields and excellent 1,2-cis stereoselectivities independent of the donor anomeric configuration,(2)common and inexpensive reagents as promoters and additives,(3)application to standard glycosyl imidate donors without resorting to participating protection,and(4)general application to reactive and less reactive glycosyl ***,via the precise stereocontrolled construction of three galactopyranosidic and two glucopyranosidic bonds on a multigram scale,a series of structurally well-defined LTA molecules were successfully *** evaluation of these type II synthetic LTAs showed a structure–activity relationship in the stimulation of a proinflammatory response.

关键词： 1,2-cis glycosidation stereoselectivity lipoteichoic acid total synthesis additive-modulated trichloroacetimidate glycosidation immune response

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语法惊异——论语言戏剧化的认知情感机制

当代语言学 2024年第3期26卷 317-335页

作者：井茁俄勒冈大学东亚语言文学系

在日常生活中,戏剧化的语言呈现令人惊的事件、表达强烈的情感体验。那么戏剧化的语言有哪些特征?其戏剧性又从何而来呢?继“戏剧化语言”这一概念提出以来,汉语语言学界对相关现象的研究不断深入,不仅分析了语言戏剧性在汉语词汇句法... 详细信息

在日常生活中,戏剧化的语言呈现令人惊的事件、表达强烈的情感体验。那么戏剧化的语言有哪些特征?其戏剧性又从何而来呢?继“戏剧化语言”这一概念提出以来,汉语语言学界对相关现象的研究不断深入,不仅分析了语言戏剧性在汉语词汇句法上的表现,而且从戏曲审美和戏剧语言的角度发掘、论述了汉语特有的戏剧化模式与手段。这些研究成果进一步深化拓展了语言主观性研究的理论视野。同时,戏剧化语言作为一个理论构建还有待进一步界定和锤炼。本文拟从信息的情感认知层面探讨语言的戏剧性和戏剧化机制,提出“语法惊异”这一理论构建,即创造性的语法逾矩所产生的惊异情感认知体验在语言体系中的凝结、更新、再创造。我们认为,语法惊异作为戏剧性语言的心理基础,在理论上补充了先前提出的以认知显著性和情感表达力为标志的戏剧化语言命题。文章以汉语、英语和德语为例,从语法惊异的视角阐释语言戏剧性的具身性,并探讨语言类型学特征对语法惊异编码的制约。

关键词：戏剧化语法惊异主观构建具身性类型学

Prevalence and Risk Factors for Chronic Obstructive Pulmonary Disease Among Adults Aged 50 and Above-10 CKB Study Areas,China,2020–2021

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China CDC weekly 2024年第43期6卷 1126-1131页

作者： Wei Yu Yongbing Lan Dianjianyi Sun Pei Pei Ling Yang Yiping Chen Huaidong Du Yingcai Yang Dan schmidt Junshi Chen Zhengming Chen Jun Lyu Liming Li Canqing Yu Department of Epidemiology&Biostatistics School of Public HealthPeking UniversityBeijingChina Peking University Center for Public Health and Epidemic Preparedness&Response BeijingChina Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijingChina Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxfordUnited Kingdom Shinan District Center for Disease Control and Prevention Qingdao CityShandong ProvinceChina China National Center for Food Safety Risk Assessment BeijingChina State Key Laboratory of Vascular Homeostasis and Remodeling Peking UniversityBeijingChina.

What is already known about this topic?The prevalence of COPD in Chinese individuals aged 50 years and above was obviously higher than that in younger adults,but the risk factors for this age group were *** is added by this report?The prevalence was estimated at 12.8%and 5.7%for males and females over 50 in 2020–2021,with confirmed risk factors of cigarette smoking,a family history of respiratory diseases,respiratory symptoms,and a history of cough or respiratory diseases during *** are the implications for public health practice?The findings may help clinicians and the public identify individuals at high risk of COPD and take targeted measures in a timely manner.

关键词： respiratory diseases prevalence