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Late-onset hypogonadism： beyond testosterone

Asian Journal of Andrology 2015年第2期17卷 236-238,I0008页

作者： Carlo Foresta aldo E Calogero Francesco Lombardo Andrea Lenzi Alberto Ferlin Department of Medicine and Centre for Human Reproduction Pathology University of Padova Padova 35128 Italy Department of Medical and Pediatric Sciences Section of Endocrinology Andrology and Internal Medicine University of Catania Catania 95123 Italy Department of Experimental Medicine Section of Medical Pathophysiology and Endocrinology Sapienza University of Rome Rome 00185 Italy

Late-onset hypogonadism is defined as a combination of low testosterone （T） levels and typical symptoms and signs. A major area of uncertainty is whether T concentrations are always really sufficient to fully reflect Leydig cell （dys）function. Mild testicular alteration could be diagnosed only by additional biochemical markers, such as luteinizing hormone （LH） and 25-hydroxyvitamin D levels. These markers help in identifying the so-called ＂subclinical＂ hypogonadism （normal T, high LH levels）. Patients with hypogonadism have frequently low levels of 25-hydroxyvitamin D due to impairment of the hydroxylating enzyme CYP2R1 in the testis. However, no data have been published dealing with the best treatment option （cholecalciferol - the Vitamin D precursor, or calcidiol - 25-hydroxylated form of Vitamin D） in these patients. We studied 66 patients with classic hypogonadism （total T [TT] 〈12 nmol I-~, LH 〉 8 IU 1-1）（n = 26） and subclinical hypogonadism （TT 〉 12 nmol I-＊, LH 〉 8 IU I-~）（n = 40） and low 25-hydroxyvitamin D （〈50 nmol I-1）. Subjects received cholecalciferol （5000 IU per week）（n = 20） or calcidiol （4000 IU per week）（n -- 46）, and 25-hydroxyvitamin D and parathyroid hormone （PTH） were evaluated after 3 months of therapy. Supplementation with calcidiol significantly increased 25-hydroxyvitamin D and significantly decreased PI＂H levels in both groups of men with hypogonadism （primary, n = 16 and subclinical, n = 30）, whereas supplementation with cholecalciferol did not modify their levels. This study shows for the first time that the administration of the 25-hydroxylated form of Vitamin D （calcidiol）, and not the administration of the precursor cholecalciferol, restores 25-hydroxyvitamin D levels in subjects with hypogonadism.

关键词： insulin-like factor 3 late-onset hypogonadism male hypogonadism testosterone Vitamin D

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Does alcohol have any effect on male reproductive Function？ A review of literature

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Asian Journal of Andrology 2013年第2期15卷 221-225,I0006页

作者： Sandro La Vignera Rosita A Condorelli Giancarlo Balercia Enzo Vicari aldo E Calogero Section of Endocrinology Andrology and Internal Medicine Department of Medical and Pediatric Sciences University of Catania Catania 95123 Italy Department of tnternat Medicine and Applied Biotechnologies Politechnic University of Marche Ancona 60100 Italy

Although alcohol is widely used, its impact on the male reproductive function is still controversial. Over the years, many studies have investigated the effects of alcohol consumption on sperm parameters and male infertility. This article reviews the main preclinical and clinical evidences. Studies conducted on the experimental animal have shown that a diet enriched with ethanol causes sperm parameter abnormalities, a number of alterations involving the reproductive tract inhibition, and reduced mouse oocyte in vitro fertilization rate. These effects were partly reversible upon discontinuation of alcohol consumption. Most of the studies evaluating the effects of alcohol in men have shown a negative impact on the sperm parameters. This has been reported to be associated with hypotestosteronemia and low-normal or elevated gonadotropin levels suggesting a combined central and testicular detrimental effect of alcohol. Nevertheless, alcohol consumption does not seem to have much effect on fertility either in in vitro fertilization programs or population-based studies. Finally, the genetic background and other concomitant, alcohol consumption-related conditions influence the degree of the testicular damage. In conclusion, alcohol consumption is associated with a deterioration of sperm parameters which may be partially reversible upon alcohol consumption discontinuation.

关键词： alcohol HPT hypothalamic-pituitary-testicular axis male infertility reproductive function sperm parameters spermatogenesis teratozoospermia

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Performance of Slope Behavior Indicators in Unsaturated Pyroclastic Soils

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Journal of Mountain Science 2015年第6期12卷 1434-1447页

作者： Luciano PICARELLI Emilia DAMIANO Roberto GRECO aldo MINARDO Lucio OLIVARES Luigi ZENI Department of Civil Engineering Design Home Building and Environment Seconda Università di Napoli Department of Industrial and Information Engineering Seconda Università di Napoli

Landslide risk is increasing in many parts of the world due to growth of population and infrastructures. Therefore, an effort has to be made in developing new and cheap sensors for areas susceptible of landslides to continuously control the slope behaviour, until approaching failure conditions. The paper reported experimental data from smallscale physical models about the performance of Time Domain Reflectometry(TDR) and optical fibres, which act as the indicators of the incoming failure of slopes covered by unsaturated granular soils. Obtained results appear encouraging, since both sensors provide continuous information about the state of the slope, in terms of water content profiles and ongoing deformations, induced by rainwater infiltration, even immediately before the triggering of a fast landslide.

关键词： Unsaturated granular soils Slope monitoring Rapid landslide Optical fibre Time Domain Reflectometry Probe

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Gallium containing bioactive materials: A review of anticancer, antibacterial, and osteogenic properties

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Bioactive Materials 2022年第11期7卷 125-146页

作者： Fatih Kurtuldu Nurshen Mutlu aldo R.Boccaccini Dusan Galusek FunGlass Alexander Dubcek University of TrencínStudentska 291150TrencínSlovakia Institute of Biomaterials Department of Material Science and EngineeringUniversity of Erlangen-Nuremberg91058ErlangenGermany Joint Glass Centre of the IIC SAS TnUAD and FChFT STUStudentska 291150TrencínSlovakia

The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis,to influence blood clotting,and to induce anti-cancer and anti-bacterial ***-doped biomaterials prepared by various techniques include melt-derived and sol-gel-derived bioactive glasses,calcium phosphate bioceramics,metals and *** this review,we summarize the recently reported developments in antibacterial,anti-cancer,osteogenesis,and hemostasis properties of Ga-doped biomaterials and briefly outline the mechanisms leading to Ga biological *** key finding is that gallium addition to biomaterials has great potential for treating bone-related diseases since it can be efficiently transferred to the desired region at a controllable ***,it can be used as a potential substitute for antibiotics for the inhibition of infections during the initial and advanced phases of the wound healing *** is also used as an anticancer agent due to the increased concentration of gallium around excessive cell proliferation(tumor)***,we highlight the possibility to design different therapeutic approaches aimed at increasing the efficiency of the use of gallium containing bioactive materials for multifunctional applications.

关键词： Antibacterial Bioactive materials Cancer treatment Hemostasis Osteogenesis

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FSH dosage effect on conventional sperm parameters:a meta-analysis of randomized controlled studies

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Asian Journal of Andrology 2020年第3期22卷 309-316页

作者： Rossella Cannarella Sandro La Vignera Rosita A Condorelli Laura M Mongioi aldo E Calogero Department of Clinical and Experimental Medicine University of CataniaCatania 95123Italy.

Follicle-stimulating hormone(FSH)represents a therapeutic option in normogonadotropic patients with idiopathic *** aim of this review was to evaluate the possible dose-and drug-dependent efficacy of FSH treatment on conventional sperm *** performed a comprehensive systematic review via a meta-analysis of all available randomized controlled trials,in which FSH administration was compared with placebo or no treatment when administered to normogonadotropic patients with idiopathic *** the 971 articles that were retrieved,5 were fin ally included,in eluding a total of 372 patie nts and 294 ***,FSH treatment was effective in ameliorating the sperm concentration,total count,progressive motility,but not normal *** the basis of the weekly dosage,the studies were classified into those using low(175-262.5 IU per week),intermediate(350-525 IU per week),and high(700-1050 IU per week)*** low doses,FSH improved only sperm *** intermediate doses,FSH ameliorated sperm concentration and *** sperm count and progressive motility showed a trend toward the *** high doses,FSH increased sperm concentration,total sperm count,and progressive *** morphology showed a trend toward the ***,both highly purified FSH(hpFSH)and recombinant human FSH(rhFSH)improved sperm concentration,total sperm count,progressive motility,but not *** different efficacy was observed between these two *** meta-analysis provides evidence in favor of high FSH *** FSH efficacy was not related to the preparation type(recombinant vs highly purified).Further studies are needed to evaluate the effectiveness of Iong-standing treatment regimes.

关键词： follicle-stimulati ng hormone male in fertility oligozoospermia sperm concen tration sperm count

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Modelling an Efficient URL Phishing Detection Approach Based on a Dense Network Model

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Computer Systems Science & Engineering 2023年第11期47卷 2625-2641页

作者： A.aldo Tenis R.Santhosh Department of Computer Science and Engineering Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatoreTamil NaduIndia

The social engineering cyber-attack is where culprits mislead the users by getting the login details which provides the information to the evil server called *** deep learning approaches and the machine learning are compared in the proposed system for presenting the methodology that can detect phishing websites via Uniform Resource Locator(URLs)*** legal class is composed of the home pages with no inclusion of login forms in most of the present modern solutions,which deals with the detection of ***,the URLs in both classes from the login page due,considering the representation of a real case scenario and the demonstration for obtaining the rate of false-positive with the existing approaches during the legal login pages provides the test having *** addition,some model reduces the accuracy rather than training the base model and testing the latest *** addition,a feature analysis is performed on the present phishing domains to identify various approaches to using the phishers in the campaign.A new dataset called the MUPD dataset is used for ***,a prediction model,the Dense forward-backwards Long Short Term Memory(LSTM)model(d−FBLSTM),is presented for combining the forward and backward propagation of LSMT to obtain the accuracy of 98.5%on the initiated login URL dataset.

关键词： Cyber-attack URL phishing attack attention model prediction accuracy

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Application of AVO attributes for gas channels identification, West offshore Nile Delta, Egypt

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Petroleum Research 2020年第2期5卷 112-123页

作者： Amir Ismail Hatem Farouk Ewida Mohammad Galal Al-Ibiary aldo Zollo Department of Physics“E.Pancini” University of Naples‘Federico II’Italy Department of Geology Faculty of ScienceHelwan UniversityCairoEgypt Exploration General Manager PERENCO North Sinai Petroleum CompanyCairoEgypt

The offshore part of the Nile Delta is considered one of the most prolific provinces for gas production andfor future petroleum exploration. Amplitude Variation with Offset (AVO) analysis supported by composite logs considered as one of the best-advanced techniques enables the interpreter to understand theseismic data. It is used to generate a new view of the output results, especially for the identification of gaszones as gas channels by using pre-stack AVO attributes that based on the intercept product gradient(A*B) and the Scaled Poisson’s Ratio Change. Free gas, regardless of the percentage show obvious AVOanomaly. Well log data, including gamma-ray, resistivity, and Vp sonic logs are used in the seismic data towell tie and in the generation of the synthetic seismogram. Seismic data conditioning processes withcheck-shot correction is performed to improve the resolution of the reflection events and signal to noiseratio. AVO attributes technique, as a direct hydrocarbon indicator, including AVO gradient analysis andAVO crossplot separate the gas levels in the sand-shale sequences. The identified gas-bearing zonesconsistent with well log data responses. As the main conclusion, we show the visual evidence for the gasbearing zones by interpreting different AVO responses due to the changes in fluid and rock types.

关键词： AVO attributes Offshore Nile Delta Gas channels Gas bearing sand zones AVO crossplots

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T-cells in myocardial infarction:Culprit instigators or mere effectors?

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World Journal of Cardiology 2018年第10期10卷 123-126页

作者： Luca Liberale aldo Bonaventura Fabrizio Montecucco Center for Molecular Cardiology University of ZürichSchlieren 8952Switzerland First Clinic of Internal Medicine Department of Internal MedicineUniversity of GenoaGenoa 16132Italy

Immune system activation and dysfunction characterize the early phase of reperfusion after a myocardial infarction(MI). Despite initially neglected, adaptive immunity has been recently showed to play an important role in this setting. In fact, the immune system can recognize sequestered antigens released by the necrotic tissue, initiating a deleterious autoimmune vicious circle leading to worse outcome. In their recent work, Angelini et al shed the light on a new feature of post-MI which involves two "old players" of post-ischemic myocardial injury: CD31 and matrix metalloproteinase(MMP)-9. Specifically, the authors showed that an enhancement of MMP-9 release could determine the cleavage of inhibitory CD31 from CD4+ T-cells surface in patients with Acute Coronary Syndromes(ACS). These findings open the room for new studies investigating the role of MMP9 in other pathological processes associated with a reduction of CD31 functionality, such as plaque instability and rupture. Of interest, in the case of a causative role for CD31 shedding in ACS would be confirmed, there might be a potential role for the administration of CD31 protein or analogue compounds to blunt post-ischemic cardiac inflammation and improve ACS outcome.

关键词： Matrix metalloproteinase Lymphocytes Autoimmunity Inflammation Myocardial infarction Adaptive immunity

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To metabolomics and beyond:a technological portfolio to investigate cancer metabolism

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1721-1742页

作者： Federica Danzi Raffaella Pacchiana Andrea Mafficini Maria TScupoli aldo Scarpa Massimo Donadelli Alessandra Fiore Department of Neurosciences Biomedicine and Movement SciencesSection of BiochemistryUniversity of VeronaVeronaItaly Department of Diagnostics and Public Health University of VeronaVeronaItaly Department of Neurosciences Biomedicine and Movement SciencesBiology and Genetics SectionUniversity of VeronaVeronaItaly ARC-NET Research Centre University and Hospital Trust of VeronaVeronaItaly

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support tumour initiation, progression,metastasis and resistance to therapies. These reprogrammed activities include a complete rewiring of the bioenergetic, biosyntheticand redox status to sustain the increased energetic demand of the cells. Over the last decades, the cancer metabolism field hasseen an explosion of new biochemical technologies giving more tools than ever before to navigate this complexity. Within a cell ora tissue, the metabolites constitute the direct signature of the molecular phenotype and thus their profiling has concrete clinicalapplications in oncology. Metabolomics and fluxomics, are key technological approaches that mainly revolutionized the fieldenabling researchers to have both a qualitative and mechanistic model of the biochemical activities in cancer. Furthermore, theupgrade from bulk to single-cell analysis technologies provided unprecedented opportunity to investigate cancer biology at cellularresolution allowing an in depth quantitative analysis of complex and heterogenous diseases. More recently, the advent offunctional genomic screening allowed the identification of molecular pathways, cellular processes, biomarkers and noveltherapeutic targets that in concert with other technologies allow patient stratification and identification of new treatmentregimens. This review is intended to be a guide for researchers to cancer metabolism, highlighting current and emergingtechnologies, emphasizing advantages, disadvantages and applications with the potential of leading the development ofinnovative anti-cancer therapies.

关键词： metabolism qualitative beyond

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Effects of basic traditional Chinese diet on body mass index,lean body mass,and eating and hunger behaviours in overweight or obese individuals

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Journal of Traditional Chinese Medicine 2016年第4期36卷 456-463页

作者： Frida Leonetti aldo Liguori Filomena Petti Susanna Rughini Laura Silli Stefano Liguori Sergio Bangrazi Department of Clinical Science La SapienzaUniversityRome 00185Italy Department of Anatomic HistologicForensic Medicine and Locomotor System SciencesLa Sapienza UniversityRome 00185Italy Department of Studies and Research Paracelso InstituteRome 00153Italy

OBJECTIVE:To compare the effects of a basic traditional Chinese diet with a Western standard diet on body mass index(BMI),lean body mass(LBD),and eating and hunger ***:A sample of 284 patients were randomized into 2 groups:group A(n = 142) followed a basic traditional Chinese diet(BCTD) and group B(n =142) followed a Western standard diet(WSD).Both diets were set at approximately 1200 *** patients enrolled were compared before treatment and 6 weeks after treatment,and then follow-ups were made at 1 year and 5 ***:In the BCTD group,BMI decreased by0.46 kg/m2 and LBM by 0.25 kg,versus respectively0.28 kg/m2 and 0.41 kg in the WSD *** of eating self-assessment,hunger measurement and psychophysical indices of health were also in favour of the ***:Outcomes show that the BCTD has a better effect on BMI and LBM,as well as over the medium/long term,and provides stronger psychophysical support to obese patients.

关键词： Obesity Overweight Cardiovascular diseases Diabetes mellitus Dietetics Diet Body mass index

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