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Comparison of gene expression between normalcolon mucosa and colon carcinoma by means of messenger RNA differential display

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World Journal of Gastroenterology 1999年第6期5卷 533-534页

作者： Wang L Lu W Chen YG Zhou XM Gu jr Shanghai Med Univ Dept Gastroenterol Huashan Hosp Shanghai 200040 Peoples R China Shanghai Canc Inst Natl Lab Oncogene & Related Genes Shanghai 200032 Peoples R China

INTRODUCTIONMessenger RNA differential display technique, developed by Dr. Liang in 1992[1], is a powerful new tool for identifying and cloning differentially expressed genes in a certain type of cell line, tissue or a special developing stage. Using this method, large amounts of molecular biological information can be obtained easily and quickly. In our study, this technique was used to compare genes expressed differentially between normal colon mucosa and colon carcinomas, in order to understand the molecular biological basis of colon cancer.

关键词： colonic mucosa colonic neoplasms RNA, messenger gene expression

Cerebral air embolism complicating transbronchial lung biopsy: A case report

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World Journal of Clinical Cases 2021年第32期9卷 9911-9916页

作者： Vladimir Herout Kristian Brat Svatopluk Richter Ivan Cundrle jr Department of Respiratory Diseases University Hospital BrnoBrno 62500Czech Republic Department of Respiratory Diseases Faculty of MedicineMasaryk UniversityBrno 62500Czech Republic International Clinical Research Center Brno 60200Czech Republic Department of Radiology and Nuclear Medicine University Hospital BrnoBrno 62500Czech Republic Department of Anesthesiology and Intensive Care St.Anne's University HospitalBrno 60200Czech Republic Department of Anesthesiology and Intensive Care Faculty of MedicineMasaryk UniversityBrno 60200Czech Republic

BACKGROUND In this case report we describe an extremely rare case of cerebral air embolism following transbronchial lung biopsy(TBLB).Only a few cases of this rare complication were described *** bronchologist should recognize this severe adverse *** recognition of this complication is mandatory in order to initiate supportive measures and consider hyperbaric oxygen *** SUMMARY In this case report we describe an extremely rare case of cerebral air embolism following *** a few cases of this rare complication were described *** patient had an incidental finding of lung tumour and pulmonary *** air embolism developed during bronchoscopy procedure,immediately after the third trans-bronchial lung biopsy sample and caused cerebral ischaemia of the right hemisphere and severe left-sided *** timely initiation of hyperbaric oxygen therapy hemiplegia didn´t resolve and the patient died several weeks *** air embolism is an extremely rare complication of *** condition should be considered in case the patient remains unresponsive or presents with acute neurological symptoms in the postintervention period since early recognition,diagnosis and hyperbaric oxygen therapy initiation are key factors determining the patient´s *** Within this report,we conclude that air/gas embolism is an extremely rare complication after TBLB,which should be considered in case the patient remains unresponsive or presents with acute neurological symptoms in the postintervention period after *** current gold standard for diagnosis is computed tomography scan of the *** recognition of this complication we suggest immediate hyperbaric oxygen therapy,if available.

关键词： Transbronchial lung biopsy Cerebral air embolism Ischemic stroke Bronchoscopy Hyperbaric oxygen therapy Case report

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World Journal of Gastroenterology 2007年第38期13卷 5151-5153页

作者： GL Gupte S Mahadevan jr Clarke H Alton SV Beath Liver Unit Birmingham Children's Hospital Steelhouse Lane B4 6NH United Kingdom Department of Respiratory Medicine Birmingham Children's Hospital Steelhouse Lane B4 6NH United Kingdom Department of Radiology Birmingham Children's Hospital Steelhouse Lane B4 6NH United Kingdom Liver Unit Birmingham Children’s Hospital Steelhouse Lane B4 6NH United Kingdom

Sirolimus is an immunosuppressant with expanding use in pediatric organ transplantation, dermatology and rheumatology. We report two cases of children who developed asthma like symptoms and were diagnosed with interstitial lung disease, which responded to discontinuation of sirolimus. Pediatricians should be aware about the pulmonary side effects of sirolimus.

关键词： Sirolimus Pulmonary toxicity Interstitial lung disease Asthma Small bowel transplantation Intestinal transplantation Organ transplantation

Mediastinal tuberculous lymphadenitis presenting as an esophageal intramural tumor: A very rare but important cause for dysphagia

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World Journal of Gastroenterology 2007年第45期13卷 6104-6108页

作者： APA Pimenta jr Preto AMF Gouveia E Fonseca MML Pimenta Servio de CirurgiaGeral Porto Medical School and Hospital de So Joo PortoPortugal Institute of Molecular Pathology andImmunology of the University of Porto Porto Portugal Servio de CirurgiaGeral Porto Medical School and Hospital de So Joo PortoPortugal Pathology Department Porto Medical School andHospital de So Joo Porto Portugal Institute of Molecular Pathology andImmunology of the University of Porto Porto Portugal Radiology Department Porto Medical School andHospital de So Joo Porto Portugal

Dysphagia associated with esophageal mechanical obstruction is usually related to malignant esophageal diseases. Benign lesions are rarely a cause for this type of dysphagia, and usually occur either as an intramural tumor or as an extrinsic compression. Mediastinal tuberculous lymphadenitis is rare in adults, and even more rarely causes dysphagia. We report two cases of dysphagia in adult patients caused by mediastinal tuberculous lymphadenitis, presenting radiologicaUy and endoscopically as an esophageal submucosal tumor. Based on the clinical and imaging diagnosis, the patients underwent a right thoracotomy, and excision of the mass attached to and compressing the esophagus. Pathological examination of the specimens showed a chronic granulomatous inflammation with caseous necrosis, which was consistent with tuberculous lymphadenitis.

关键词： Dysphagia Tuberculous lymphadenitis Esophageal tumor Uncommon dysphagia Esophagealbenign lesion

Paleoecological Response of Corals to the End-Triassic Mass Extinction： An Integrational Analysis

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Journal of Earth Science 2018年第4期29卷 879-885页

作者： George D Stanley jr Hannah M E Shepherd Autumn J Robinson University of Montana Paleontology Center Missoula MT 59812 USA

The end-Triassic （also Triassic-Jurassic） mass extinction severely affected life on planet Earth 200 million years ago. Paleoclimate change triggered by the volcanic eruptions of the Central Atlantic Magmatic Province （CAMP） caused a great loss of marine biodiversity, among which 96% coral genera were get lost. However, there is precious little detail on the paleoecology and growth forms lost between the latest Triassic extinction and the Early Jurassic recovery. Here a new pilot study was conducted by analyzing corallite integration levels among corals from the latest Triassic and Early Jurassic times. Integration levels in corals from the Late Triassic and Early Jurassic were determined through both the Paleobiology Database as well as from a comprehensive museum collection of fossil corals. Results suggest that in addition to a major loss of diversity following the end-Triassic mass extinction, there also was a significant loss of highly integrated corals as clearly evidenced by the coral data from the Early Jurassic. This confirms our hypothesis of paleoecological selectivity for corals following the end-Triassic mass extinction. This study highlights the importance of assigning sim- ple to advanced paleoecological characters with integration levels, which opens a useful approach to understanding of mass extinction and the dynamics of the recovery.

关键词： coral loss integration level end-Triassic mass extinction paleoecology

Lophozonia tree cavities used for nesting by Slender-billed Parakeets(Enicognathus leptorhynchus)in the central valley of southern Chile:a potentially vanishing keystone resource

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Chinese Birds 2017年第1期8卷 25-36页

作者： Thomas H.White jr. Jaime E.Jiménez Puerto Rican Parrot Recovery Program United States Fish and Wildlife ServiceBox 1600Rio GrandePR 00745USA Sub-Antarctic Biocultural Conservation Program Department of Biological SciencesUniversity of North TexasDentonTX 76201USA Sub-Antarctic Biocultural Conservation Program Department of Philosophy and ReligionUniversity of North TexasDentonTX 76201USA Omora Etnobotanical Park Universidad de MagallanesPuerto WilliamsChile

Background: The Slender-billed Parakeet(Enicognathus leptorhynchus) is a psittacine endemic to southern Chile and an obligate secondary cavity-nester. In the central valley of southern Chile, most(94%) of the known Slender-billed Parakeet nests have occurred in large, mature southern beech(Lophozonia obliqua) trees(locally known as "pellines"). As relicts of the original old-growth forests of southern Chile, most pellines have been lost due to extensive landclearing throughout the region, potentially threatening long-term persistence of the Slender-billed ***: We conducted our study in the central valley of southern Chile, near the city of Osorno during three consecutive nesting seasons(November–January, 2008–2011). Nest trees used by Slender-billed Parakeets were located by direct observation of parakeet activities and through interviews with local residents, some of whom were former parrot nest poachers. Nest cavities were accessed, inspected and measured using single-rope climbing techniques. We report means, standard errors, 95% confidence intervals and ranges for 11 cavity-related variables. We also report clutch sizes encountered in active nests, and age estimates of nest trees based on known growth rates of Lophozonia trees in southern Chile. Linear regressions were used to evaluate potential relationships between cavity-related variables and clutch ***: We located and measured 38 Lophozonia tree cavities used for nesting by Slender-billed Parakeets. Compared to those used by other psittacines, nest trees were relatively large, averaging 30.4 breast height of 134.5 ter ± 1.1 m in height with a mean diameter at ± 4.7 cm. Based on estimated annual diameincrement, ages of nest trees ranged from approximately 209–485 years. Nest cavities entrances averaged 12.5 ± 0.9 m in height above ground level. Cavity entrance widths averaged 51.0 ± 13.3 cm(vertical) by 11.5 ± 0.7 cm(horizontal). Cavity entrance orientations were apparently random, with

关键词： Conservation Deforestation Habitat loss Lophozonia obliqua Pellines Psittacidae Regeneration

Cancer chemoprevention through dietary avonoids: what's limiting?

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Chinese Journal of Cancer 2017年第10期36卷 455-467页

作者： Haneen Amawi Charles R. Ashby jr Amit K. Tiwari Department of Pharmacology and Systems Therapeutics College of Pharmacy and Pharmaceutical Sciences University of Toledo Toledo OH 43560USA Pharmaceutical Sciences College of Pharmacy St. John’s UniversityQueens NY 11432 USA Department of Pharmacology and Experimental Therapeutics College of Pharmacy and Pharmaceutical Sciences University of Toledo Toledo OH 43614 USA

Flavonoids are polyphenols that are found in numerous edible plant species. Data obtained from preclinical and clinical studies suggest that specific flavonoids are chemo-preventive and cytotoxic against various cancers via a multitude of mechanisms. However, the clinical use of flavonoids is limited due to challenges associated with their e ective use, including(1) the isolation and purification of flavonoids from their natural resources;(2) demonstration of the e ects of flavonoids in reducing the risk of certain cancer, in tandem with the cost and time needed for epidemiological studies, and(3) numerous pharmacokinetic challenges(e.g., bioavailability, drug–drug interactions, and metabolic instability). Currently, numerous approaches are being used to surmount some of these challenges, thereby increasing the likelihood of flavonoids being used as chemo-preventive drugs in the clinic. In this review, we summarize the most important challenges and e orts that are being made to surmount these challenges.

关键词： Flavonoids Chemoprevention Silybin Silymarin Natural product drug development Pharmacokinetic challenges

The Electrochemical Investigation of MEH-PPV in Ionic Liquid

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Chinese Chemical Letters 2000年第10期11卷 919-920页

作者： Yang, CH He, GF Zheng, jr Qiao, J Li, YF Chinese Acad Sci Inst Chem Ctr Mol Sci Lab Organ Solids Beijing 100080 Peoples R China

The electrochemical properties of MEH-PPV were: studied in ionic liquid([bmim](+)[PF6](-)) by cyclic voltammetry, chronoamperometry and AC impedance measurements. Both p- and n-doping of MEH-PPV were observed in the cyclic voltammograms, The chronoamperometric and AC impedance results indicate that the p-doping of MEH-PPV was controlled by the linear diffusion of counterions.

关键词： MEH-PPV electrochemistry ionic liquid

Andropause and the development of cardiovascular disease presentationmore than an epi-phenomenon

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Journal of Geriatric Cardiology 2011年第1期8卷 35-43页

作者： Emst R. Schwarz Anita Phan Robert D. Willix jr Cedars Sinai Heart Institute Cedars Sinai Medical Center 8700 Beverly Boulevard Suite 6215 Los Angeles CA 90048 USA Cenegenics Medical Institute 851 Rampart Blvd. Las Vegas NV 89145 USA

Andropause refers to a generalized decline of male hormones, including testosterone and dehydroepiandrosterone in middle-aged and aging men. This decline in hormones has been associated with changes such as depression, loss of libido, sexual dysfunction, and changes in body composition. Aging has been associated with an abundance of concomitant diseases, in particular cardiovascular diseases, and although andropause is correlated to aging, a causal relationship between reduction of androgens and the development of chronic diseases such as atherosclerosis and heart failure has not been convincingly established yet. On the other hand, increasing data has emerged that revealed the effects of low levels of androgens on cardiovascular disease progression. As an example, low levels of testosterone have been linked to a higher incidence of coronary artery disease. Whether hormone replacement therapy that is used for andropausal men to alleviate symptoms of ＂male menopause＂ can halt progression of cardiovascular disease, remains controversially discussed, primarily due to the lack of well-designed, randomized controlled trials. At least for symptom improvement, the use of androgen replacement therapy in andropausal men may be clinically indicated, and with the appropriate supervision and follow up may prove to be beneficial with regard to preservation of the integrity of cardiovascular health at higher ages.

关键词： andropause age androgen testosterone heart disease heart failure hormone therapy