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Robust Latent Factor Analysis for Precise Representation of High-dimensional and Sparse Data

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IEEE/CAA Journal of Automatica Sinica 2021年第4期8卷 796-805页

作者： di Wu Xin Luo the Chongqing Key Laboratory of Big Data and Intelligent Computing Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714 the Chongqing School University of Chinese Academy of SciencesChongqing 400714China

High-dimensional and sparse(HiDS)matrices commonly arise in various industrial applications,e.g.,recommender systems(RSs),social networks,and wireless sensor *** they contain rich information,how to accurately represent them is of great significance.A latent factor(LF)model is one of the most popular and successful ways to address this *** LF models mostly adopt L2-norm-oriented Loss to represent an HiDS matrix,i.e.,they sum the errors between observed data and predicted ones with *** L2-norm is sensitive to outlier ***,outlier data usually exist in such *** example,an HiDS matrix from RSs commonly contains many outlier ratings due to some heedless/malicious *** address this issue,this work proposes a smooth L1-norm-oriented latent factor(SL-LF)*** main idea is to adopt smooth L1-norm rather than L2-norm to form its Loss,making it have both strong robustness and high accuracy in predicting the missing data of an HiDS *** results on eight HiDS matrices generated by industrial applications verify that the proposed SL-LF model not only is robust to the outlier data but also has significantly higher prediction accuracy than state-of-the-art models when they are used to predict the missing data of HiDS matrices.

关键词： High-dimensional and sparse matrix L1-norm L2 norm latent factor model recommender system smooth L1-norm

Natural history of untreatable hepatocellular carcinoma:A retrospective cohort study

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World Journal of Hepatology 2012年第9期4卷 256-261页

作者： Giuseppe Cabibbo Marcello Maida Chiara Genco Pietro Parisi Marco Peralta Michela Antonucci Giuseppe Brancatelli Calogero Cammà Antonio Craxì vito di Marco Section of Gastroenterology Department of Internal Medicine and Biomedical SpecialistUniversity of PalermoPalermo 90127Italy Department of Biopathology and Biomedical Methodologies University of PalermoPalermo 90127Italy Department of Oncology Division of General Surgery and OncologyUniversity of PalermoPalermo 90127Italy Department of Radiology DIBIMEFUniversity of PalermoPalermo 90127Italy

AIM: To investigate the clinical course of untreatable hepatocellular carcinoma (HCC) identified at any stage and to identify factors associated with mortality. METHODS: From January 1999 to December 2010, 320 out of 825 consecutive patients with a diagnosis of HCC and not appropriate for curative or palliative treatments were followed and managed with supportive therapy. Cirrhosis was diagnosed by histological or clinical features and liver function was evaluated according to Child-Pugh score. The diagnosis of HCC was performed by Ultra-Sound guided biopsy or by multiphasic contrast-enhanced computed tomography or gadolinium-enhanced magnetic resonance imaging. Data were collected for each patient including all clinical, laboratory and imaging variables necessary for the outcome prediction staging systems considered. HCC staging was performed according Barcelona Clinic Liver Cancer (BCLC) and Cancer of the Liver Italian Program scores. Follow-up time was defined as the number of months from the diagnosis of HCC to death. Prognostic baseline variables were analyzed by multivariate Cox analysis to identify the independent predictors of survival. RESULTS: Seventy-five per cent of patients had hepatitis C. Ascites was present in 169 patients (53%), while hepatic encephalopathy was present in 49 patients (15%). The Child-Pugh score was class A in 105 patients (33%), class B in 142 patients (44%), and class C in 73 patients (23%). One hundred patients (31%) had macroscopic vascular invasion and/or extra-hepatic spread of the tumor. A single lesion > 10 cm was observed in 34 patients (11%), while multinodular HCC was present in 189 patients (59%). Thirty nine patients (12%) were BCLC early (A) stage, 55 (17%) were BCLC intermediate (B) stage, 124 (39%) were BCLC advanced (C) stage, and 102 (32%) were end-stage BCLC (D). At the time of this analysis (July 2011), 28 (9%) patients were still alive. Six (2%) patients who were lost during follow-up were censored at the last vi

关键词： Hepatocellular carcinoma Liver Cancer Survival Prognosis Natural history

The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： di Wu Yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

Optimal predictive sliding-mode guidance law for intercepting near-space hypersonic maneuvering target

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Chinese Journal of Aeronautics 2022年第4期35卷 320-331页

作者： Bolun ZHANG di ZHOU School of Astronautics Harbin Institute of TechnologyHarbin 150001China

The design of optimal guidance law for intercepting a near-space hypersonic maneuvering target with bounded inputs is considered. Firstly, a maneuvering model for near-space hypersonic aircraft is given. Then, the aircraft acceleration prediction can be obtained using this model with two neural networks. By using the target acceleration prediction, which is taken into account when calculating the Zero Effort Miss(ZEM), an optimal sliding-mode guidance law is proposed to fulfill the guidance task. An adaptive sliding-mode switch term is designed to deal with actuator saturation and prediction errors. Finally, numerical simulations show that the proposed guidance law can reduce the energy consumption and the terminal acceleration command of the interceptor effectively.

关键词： Adaptive sliding-mode control Near-space hypersonic aircraft Neural networks Optimal control Predictive guidance law

Combining oncolytic virus and radiation therapy for cancer management

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 459-475页

作者： vito Filbert Jayalie Sri Mutya Sekarutami Department of Radiation Oncology Faculty of Medicine Universitas Indonesia-Dr.Cipto Mangunkusumo HospitalJakarta 10430Indonesia

Cancer has caused a tremendous burden in developing *** virus(OV)therapy is an emerging modality with the potential to be a single or combination agent with radiation therapy(RT).Following entry of OV to the cell,OV will replicate and assemble before exiting from tumor *** of OV can be done by modifying the capsid,genome,and chemical material of *** will induce double-strand breaks,and further integration of OV with DNA damage response pathway will interact with the MRE11-Rad50-Nbs1 complex to regulate the mobilization of E4 open reading frame 6,protein phosphatase 2A,poly(ADP-ribose)polymerase,apoptosis-inducing factor,and topoisomerase-IIβ-binding protein *** of DNA-dependent protein kinase catalytic subunits via human simplex virus-1-infected cell polypeptide 0 will inhibit DNA *** and RT have a synergistic interaction to cause viral oncolysis and upregulation of immune *** the clinical setting,most studies have demonstrated that OV is a safe treatment with less ***,OV+RT resulted in longer median survival(62.4 vs.37.7 weeks)in malignant glioma.

关键词： Oncolytic virus radiation therapy cancer developing country

Strong convergence rate of principle of averaging for jump-diffusion processes

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Frontiers of Mathematics in China 2012年第2期7卷 305-320页

作者： di LIU Department of Mathematics Michigan State University East Lansing MI 48824 USA

We study jump-diffusion processes with two well-separated time scales. It is proved that the rate of strong convergence to the averaged effective dynamics is of order O（ε1/2）, where s 〈〈 1 is the parameter measuring the disparity of the time scales in the system. The convergence rate is shown to be optimal through examples. The result sheds light on the designing of efficient numerical methods for multiscale stochastic ,dynamics.

关键词： Stochastic differential equation time scale separation averaging ofperturbations

Advances in soil erosion research:Mechanisms,modeling and applications-A special issue in honor of *** Nearing

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International Soil and Water Conservation Research 2023年第4期11卷 589-591页

作者： Viktor Polyakov Claire Baffaut vito Ferro Scott Van Pelt Southwest Watershed Research Center USDA-ARS2000 E Allen RdTucsonAZ85718USA Cropping Systems and Water Quality Research Unit USDA-ARS241 Ag Engineering BuildingUniversity of MissouriColumbiaMO65211USA Department of Agricultural Food and Forest SciencesUniversity of PalermoViale Delle ScienzeBuilding 490128PalermoItaly Cropping Systems Research Laboratory USDA-ARS38104th StLubbockTX79401USA

*** Long-term sustainability of soils is one of the critical challenges facing *** erosion is an intrinsic geomorphological pro-cess,which if accelerated can threaten natural ecosystems and agri-culture through loss of productivity,sedimentation,and associated *** efforts to mitigate these problems require changes in management practices and large *** puts special emphasis on understanding physical processes driving soil erosion,developing techniques for accurate estimation of erosion rates and its on-site and off-site impacts,as well as devel-oping new modeling,prediction,and management tools.

关键词： soil erosion driving

Holographic Duals of Quark Gluon Plasmas with Unquenched Flavors

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Communications in Theoretical Physics 2012年第3期57卷 364-386页

作者： Francesco Bigazzi aldo Cotrone Javier Mas Daniel Mayerson Javier Tarrio dipartimento di Fisica e Astronomia Universita' di Firenze Via G.Sansone 1 I-50019 Sesto Fiorentino (Firenze)Italyand INFNSezione di PisaLargo B.Pontecorvo356127 PisaItaly dipartimento di Fisica Universita' di Torino and INFN Sezione di Torino Via P.Giuria 1 I-10125 TorinoItaly Departamento de F' sica de Part' culas Universidade de Santiago de Compostela and Instituto Galego de F' sica de Altas Enerx' as (IGFAE) E-15782 Santiago de CompostelaSpain Institute for Theoretical Physics University of AmsterdamScience Park 904Postbus 944851090 GL AmsterdamThe Netherlands Institute for Theoretical Physics Universiteit Utrecht3584 CEUtrechtThe Netherlands

We review the construction of gravitational solutions holographically dual to N=1 quiver gauge theories with dynamical flavor *** focus on the D3-D7 construction and consider the finite temperature,finite quark chemical potential case where there is a charged black hole in the dual *** physical outputs of the model include its thermodynamics (with susceptibilities) and general hydrodynamic properties.

关键词： AdS/CFT correspondence quark-gluon plasma flavor physics finite baryon density

Male accessory gland inflammation prevalence in type 2 diabetic patients With symptoms possibly reflecting autonomic neuropathy

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Asian Journal of Andrology 2014年第5期16卷 761-766,I0010,I0011页

作者： Rosita A Condorelli Enzo Vicari aldo E Calogero Sandro La Vignera Department of Medical and Pediatric Sciences Section of Endocrinology Andrology and Internal Medicine University of Catania Catania Italy

Male accessory gland inflammation or infection （MAGI） is a potentially underdiagnosed complication of type 2 diabetes （DM2）; specifically, we reported in a recent study that the frequency of MAGI was 43% among DM2 patients. In previous studies, we have demonstrated that diabetic autonomic neuropathy （DAN） is associated with a peculiar ultrasound characterization of the seminal vesicles （SVs） in DM2 patients. The aim of the present study was to evaluate the frequency of MAGI in two different categories of DM2 patients （i.e. patients with and without symptoms that possibly reflect DAN） and the respective ultrasound characterizations. Sixty DM2 patients with a mean （± s.e.m.） age of 42.0 ± 6.0 years （range： 34-47 years） were classified according to the presence or the absence of symptoms that could possibly reflect DAN （group A： DM2 with symptoms possibly reflecting DAN, n = 28 patients and group B： DM2 without symptoms possibly reflecting DAN, n = 32 patients）. The patients in Group A exhibited a significantly higher frequency of MAGI compared with those in group B patients （P 〈 0.05）; moreover, the Group A patients exhibited a significantly higher frequency of ultrasound signs suggestive of vesiculitis （P 〈 0.05）. Finally, the concentrations of lymphocytes but not the concentrations of the leukocytes in the semen were significantly higher （P 〈 0.05） in group A compared with group B.

关键词： diabetic neuropathy male accessory gland inflammation or infection male infertility