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How to choose the most appropriate technique for the single-stage treatment of cholecysto-choledocolithiasis?

Gastroenterology Report 2019年第4期7卷 258-262,I0001,I0002页

作者： aldo Bove Paolo Panaccio Raffaella di Renzo Gino Palone Marco Ricciardiello Sara Ciuffreda Giuseppe Bongarzoni Department of Medicine Dentistry and BiotechnologyUniversity‘G.D’Annunzio’Via dei VestiniChietiItaly

Background:We utilized transcystic clearance and intra-operative papillotomy through a rendezvous technique for the treatment of *** goal of this study was to evaluate the reliability of pre-operative parameters to address the most suitable surgical ***:A total of 180 patients affected by calculi of the gallbladder and bile duct underwent the single-stage *** to several pre-operative parameters,141 patients had to supposedly undergo transcystic clearance of the bile duct,while 39 patients had to be treated with the rendezvous *** patients were treated with the sequential procedure:first,we tried the transcystic procedure and,if there was a failure,we used a rendezvous *** prospectively analysed each group based on a series of variables such as sex,age,operative time,success rate of proposed treatment,conversion rate,post-operative complications and hospital ***:Transcystic clearance was successful in 134 out of 141 patients(95.0%),while 2 patients needed to undergo a laparo-endoscopy procedure(failure).Thirty-five out of 39 patients(89.7%)obtained common bile-duct(CBD)clearance through the rendezvous technique,while 1 patient obtained clean-up through the simple transcystic procedure(failure).Five out of 141 patients with transcystic clearance and 3 out of 39 patients with the rendezvous technique underwent laparotomy CBD clearance with conversion rates of 3.5%and 7.7%,***-operative complications showed similar percentages for both ***,the surgical time turned out to be longer for the rendezvous ***:The one-stage procedure for the treatment of cholecysto-choledocolithiasis was possible in 94%of the cases utilizing a surgical technique selected according to the patient’s case *** pre-operative parameters,such as jaundice,CBD diameters and stone diameters,have certified their reliability as good predictors of the most suitable

关键词： Common bile-duct stone transcystic laparoscopic bile-duct clearance laparoscopic common bile-duct exploration rendezvous intra-operative endoscopic retrograde cholangiography

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differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo diana Simón Johnny di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Zero Sequence Voltage and Current Control in Four-wire Grids-fed by Grid-forming Inverters

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CSEE Journal of Power and Energy Systems 2023年第6期9卷 2272-2279页

作者： Zixian Zhu Wei Chen vito Giuseppe Monopoli the College of Electrical And Information Engineering Hunan UniversityChangshaChina the College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhouChina the Department of Electrical and Information Engineering Bari PolytechnicBariItaly

Low voltage three-phase four-wire AC distribution grids may experience high neutral current,mainly caused by asymmetrical distribution of single-phase loads in three *** neutral current will not only increase line losses but also result in neutral potential *** the LV AC distribution grid established by a grid-forming inverter(e.g.,uninterruptible power supply and solid-state-transformer),it also suffers from the same neutral current ***,this paper comparatively studies several neutral current control approaches and their impacts on grid voltage balance,which is required by grid ***,this paper proposes an optimal neutral current control approach,which can obtain maximum neutral current suppression with less impact on grid voltage *** correctness of the theoretical analysis is validated through both simulation and experimental results.

关键词： LV AC grid neutral current reduction grid-forming inverter three-phase four-wire system

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A Bioinspired Robot Growing like Plant Roots

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Journal of Bionic Engineering 2023年第5期20卷 2044-2058页

作者： Giovanni Bianchi aldo Agoni Simone Cinquemani Department of Mechanics Politecnico di MilanoVia La Masa 1Milano20156LombardiaItaly

Plants are usually considered static organisms,but they can perform a wide range of movements that can be a source of inspiration for *** roots’growing motion is the most noteworthy since they are excellent diggers that can move in unstructured environments and navigate past ***,root growth has a high energy efficiency since it penetrates the soil at its tip,adding new material without displacing the already grown portion,minimizing the energy dissipation due to friction and lowering the inertia.A robot inspired by the growth of roots could be used in search and rescue or environmental *** design of a soft robot inspired by root growth is presented in this *** robot body consists of a cylindrical plastic membrane folded inside *** robot body is inflated,and its tip is everted,expanding its length as air is blown from the *** straps are placed on the membrane’s exterior surface to keep it *** head is positioned inside the tip,which houses the mechanism that controls the growth *** consists of housing for two balloons that are selectively inflated,and their expansion applies pressure on the exterior surface,opening the Velcro straps and determining the growth *** robot was constructed,and a kinematic model of its motion in the plane was created and compared with experimental *** error in predicting the turning angle is only 5%,and the resulting predicted position differs on average by 55 mm on a total length of 850 mm.

关键词： Soft robot Pneumatic actuation Bioinspired robot Growing robot Plant root

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Fluorescence image-guided lymphadenectomy using indocyanine green and near infrared technology in robotic gastrectomy

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Chinese Journal of Cancer Research 2018年第5期30卷 568-570页

作者： Jacopo Desiderio Stefano Trastulli AlessANDro Gemini Domenico di Nardo Giorgio Palazzini Amilcare Parisi vito D'ANDrea Department of digestive Surgery St.Mary's HospitalTerni Department of Surgical Sciences "La Sapienza" University of Rome

In recent years, some researchers have tried to find a way to improve the surgical identification of the lymphatic drainage routes and lymph node stations during radical gastrectomy, thus starting a new research frontier in this field called ＂navigation surgery＂. Among the different reported solutions, the introduction of the indocyanine green （ICG） has drawn attention for its characteristics, a fluorescence dye that can be detected in the near infrared spectral band （NIR）. A fluorescence imaging technology has been integrated in the latest version of the Da Vinci robotic system and surgeons have extensively reported their experiences in colorectal and hepato-biliary surgery for tumors, vascular and lymphatic structures visualization. However, up to date, the combined use of fluorescence imaging and robotic technology has not been adequately investigated during lymphadenectomy in gastric cancer.

关键词： Gastric cancer fluorescence guided surgery robotic surgery

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Resveratrol as an Anti-inflammatory Agent in Coronary Artery disease:A Systematic Review,Meta-Analysis and Meta-Regression

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Chinese Journal of Integrative Medicine 2024年第10期30卷 927-937页

作者： vito A.Damay Ignatius Ivan Department of Cardiovascular Medicine Universitas Pelita HarapanTangerangBanten15811Indonesia Jakarta Varices Clinic Jakarta12210Indonesia

Background:Resveratrol is a non-flavonoid polyphenol that shows promise in reducing proinflammatory factors and maintaining endothelial function,which hints at its potential role in slowing atherosclerosis and preventing acute coronary ***:To study the cardioprotective effects of resveratrol on inflammatory mediators and endothelial function in patients with coronary artery disease(CAD).Methods:A thorough search was conducted in databases(Cochrane Library,Pro Quest,Pub Med,LILACS,Science direct,Springer,Taylor&Francis,CNKI,Wanfang,and Weipu)until September 24,*** vasopro-inflammatory mediators,endothelial function and outcomes related to cardiovascular events were *** and abstracts were assessed,and bias was evaluated with Cochrane Ro B *** of results was explored by metaregression,certainty of evidence was assessed by the GRADE system,and conclusive evidence was enhanced by trial sequence ***:Ten randomized controlled trials and 3 animal studies investigated resveratrol's impact on inflammatory mediators and endothelial *** primary prevention studies,meta-analysis showed a significant reduction(95%CI:–0.73 to–0.20;P=0.0005)in tumor necrosis factor-α(TNF-α)expression with resveratrol,demonstrating a dose-dependent *** significant difference was observed in interleukin-6(IL-6)expression with P=0.58 for primary prevention and P=0.57 for secondary *** endothelial nitric oxide synthase(e NOS)expression was significantly increased after resveratrol pre-treatment following CAD *** prevention studies yielded no significant results;however,meta-regression identified associations between age,hypertension,and lower doses with the extent of TNF-α*** certainty of evidence supported TNF-αreduction,while evidence for IL-6 reduction and e NOS elevation was deemed ***:Resveratrol reduces TNF-αin individuals at risk for CAD,specifically 15 mg per ***

关键词： anti-inflammation coronary artery disease nitric oxide resveratrol systematic review

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Metal-Halide Perovskite Submicrometer-Thick Films for Ultra-Stable Self-Powered direct X-Ray Detectors

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Nano-Micro Letters 2024年第9期16卷 410-431页

作者： Marco Girolami Fabio Matteocci Sara Pettinato Valerio Serpente Eleonora Bolli Barbara Paci Amanda Generosi Stefano Salvatori aldo di Carlo Daniele M.Trucchi CNR‑ISM Consiglio Nazionale delle RicercheIstituto di Struttura della MateriaSede Secondaria di MontelibrettiDiaTHEMA LabStrada Provinciale 35D900010 MontelibrettiRomeItaly CHOSE–Centre for Hybrid and Organic Solar Energy Department of Electronic EngineeringUniversity of Rome“Tor Vergata”Via del Politecnico 100133 RomeItaly Faculty of Engineering Universita degli Studi Niccolo CusanoVia don Carlo Gnocchi 300166 RomeItaly SpecXLab CNR‑ISMConsiglio Nazionale Delle RicercheIstituto di Struttura Della MateriaArea della Ricerca di Tor VergataVia del Fosso del Cavaliere 10000133 RomeItaly

Metal-halide perovskites are revolutionizing the world of X-ray detectors,due to the development of sensitive,fast,and cost-effective ***-powered operation,ensuring portability and low power consumption,has also been recently demonstrated in both bulk materials and thin ***,the signal stability and repeatability under continuous X-ray exposure has only been tested up to a few hours,often reporting degradation of the detection *** it is shown that self-powered direct X-ray detectors,fabricated starting from a FAPbBr_(3)submicrometer-thick film deposition onto a mesoporous TiO_(2)scaffold,can withstand a 26-day uninterrupted X-ray exposure with negligible signal loss,demonstrating ultra-high operational stability and excellent *** structural modification is observed after irradiation with a total ionizing dose of almost 200 Gy,revealing an unexpectedly high radiation hardness for a metal-halide perovskite thin *** addition,trap-assisted photoconductive gain enabled the device to achieve a record bulk sensitivity of 7.28 C Gy^(−1)cm^(−3)at 0 V,an unprecedented value in the field of thin-film-based photoconductors and photodiodes for“hard”***,prototypal validation under the X-ray beam produced by a medical linear accelerator for cancer treatment is also introduced.

关键词： Metal-halide perovskite thin films direct X-ray detectors Self-powered devices Operational stability Medical linear accelerator

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企业网络地位对数据资产信息披露的影响研究

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工业技术经济 2025年第1期44卷 75-84页

作者：何地赵唱庞铭辽宁大学经济学部亚澳商学院沈阳110136 大连财经学院会计学院大连116122

随着数据资产作为重要战略资源的价值日益凸显,数据资产信息披露已经成为学术界和实业界共同关注的重要议题。本文基于2009~2023年A股上市公司数据,实证检验了企业网络地位对数据资产信息披露的影响及作用机制。研究结果发现,企业网络... 详细信息

随着数据资产作为重要战略资源的价值日益凸显,数据资产信息披露已经成为学术界和实业界共同关注的重要议题。本文基于2009~2023年A股上市公司数据,实证检验了企业网络地位对数据资产信息披露的影响及作用机制。研究结果发现,企业网络地位对其数据资产信息披露水平具有正向影响。机制分析结果表明,客户集中度在企业网络地位对其数据资产信息披露水平的影响中发挥调节作用,即客户集中度越低,企业网络地位对其数据资产信息披露水平的影响越强。异质性分析结果发现,对于非国有企业、多阶(长链)结构和小规模企业而言,企业网络地位对数据资产信息披露的影响效果尤为明显。本文揭示了企业网络地位影响数据资产信息披露的微观机制,为我国完善数据要素市场制度以及促进数字经济高质量发展提供了政策启示。

关键词：企业网络地位数字资产信息披露客户集中度文本分析法信号传递理论数字经济数字化转型企业竞争力

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Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study

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World Journal of Gastroenterology 2018年第41期24卷 4652-4662页

作者： Cristiano Pagnini vito Domenico Corleto Michela Martorelli Claudio Lanini Giancarlo D'Ambra Emilio di Giulio Gianfranco Delle Fave Department of digestive and Liver disease School of Medicine and PsychologyS.Andrea HospitalSapienza University

AIM To investigate the adhesion and anti-inflammatory effects of Lactobacil us rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture *** For the ex vivo experiment, a total of 98 patients (68 UC patients and 30 normal subjects) were included. Endoscopic biopsies were collected and incubated with and without LGG or LGG-conditioned media to evaluate the mucosal adhesion and anti-inflammatory effects [reduction of tumor necrosis factor alpha (TNFα) and interleukin (IL)-17 expression] of the bacteria, and extraction of DNA and RNA for quantification by real-time (RT)-PCR occurred after the incubation. A dose-response study was performed by incubating biopsies at "regular", double and 5 times higher doses of LGG. For the in vivo experiment, a total of 42 patients (20 UC patients and 22 normal controls) were included. Biopsies were taken from the colons of normal subjects who consumed a commercial formulation of LGG for 7 d prior to the colonoscopy,and the adhesion of the bacteria to the colonic mucosa was evaluated by RT-PCR and compared with that of control biopsies from patients who did not consume the formulation. LGG adhesion and TNFα and IL-17 expression were compared between UC patients who consumed a regular or double dose of LGG supplementation prior to *** In the ex vivo experiment, LGG showed consistent adhesion to the distal and proximal colon in normal subjects and UC patients, with a trend towards higher concentrations in the distal colon, and in UC patients, adhesion was similar in biopsies with active and quiescent inflammation. In addition, bioptic samples from UC patients incubated with LGG conditioned media (CM) showed reduced expression of TNFα and IL-17 compared with the corresponding expression in controls (P < 0.05). Incubation with a double dose of LGG increased mucosal adhesion and the anti-inflammatory effects (P < 0.05). In the in vivo expe

关键词： Lactobacillus rhamnosus GG Ulcerative colitis Probiotic Adhesion Cytokines

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数字赋能乡村公共文化事业高质量发展——以乡村图书馆建设为例

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三峡大学学报（人文社会科学版） 2025年第1期47卷 65-71页

作者：卢迪曲阜师范大学马克思主义学院山东济宁273100

数字赋能乡村公共文化事业高质量发展是全面推进乡村振兴战略的基本要求,也是逐步实现人民群众精神文化生活共同富裕的题中之义。乡村图书馆是乡村公共文化服务体系的重要组成部分,在数字赋能过程中要以民需导向的服务理念、技术支撑的... 详细信息

数字赋能乡村公共文化事业高质量发展是全面推进乡村振兴战略的基本要求,也是逐步实现人民群众精神文化生活共同富裕的题中之义。乡村图书馆是乡村公共文化服务体系的重要组成部分,在数字赋能过程中要以民需导向的服务理念、技术支撑的转型升级、人文铸魂的角色定位、数字乡村的建设助力作为建设的数智图景,同时在基础设施、智慧人才、数字素养、长效机制等方面存在着发展的现实梗阻。因此,在数字赋能乡村图书馆建设过程中要从推进数字化基础设施建设、加强智慧人才的人力储备、全方位提升乡村数字素养、优化数字转型的顶层设计这四个方面入手。

关键词：数字赋能乡村公共文化乡村图书馆

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