检索结果-南通市图书馆

International Journal of Innovation Studies 2024年第1期8卷 25-44页

作者： Ana Rita Gonçalves Lopes aldina isabel de azevedo correia Alexandra Maria da Silva Braga Center for Research and Innovation in Business Sciences and Information Systems School of Management and TechnologyPolitecnico do PortoRua do Curral-Margaride4610-156 FelgueirasPortugal

To contribute to the empirical literature on innovation in non-profit organizations,this study examines innovation in Private Social Solidarity Institutions with social responses for the elderly in Northern *** enriches the literature by clarifying the concept of innovation applied to non-profit organizations,which represents a perspective different from the business ***,it is important to support the innovation decisionmaking process in similar non-profit *** this study,the population was surveyed through questionnaires based on the PUBLIN research project,which has already been applied in different countries,and the targets were employees of organizations with social responses for the *** sample is small,with 28 respondent institutions and 51 employees,but it is representative,as it includes institutions from all districts in Northern *** study employed a quantitative approach,particularly factor analysis,multiple linear regression,and correlation analyses,using scales already applied in other dimensions of the social sector,to understand the effect of each innovation dimension/determinant on creativity and innovation in nonprofit *** results show that in these organizations with social responses for the elderly,learning orientation,risk-taking,and job satisfaction have a positive impact on innovation.

关键词： determinants of innovation non-profit organizations social responses for the elderly Northern Portugal

Molecular Cloning of PhoR Sensor Domain from Mycobacterium tuberculosis for Structure-Based Discovery of Novel Anti-Tubercular

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Life Sciences 2012年第3期6卷 268-275页

作者： aldina S. Suwanto Ihsanawati Emawati Arifin Giri-Rachman School of Life Sciences and Technology Bandung Institute of Technology Bandung 40132 Indonesia Biochemistry Research Group Faculty of Mathematics and Natural Sciences Bandung Institute of Technology Bandung40132 Indonesia

The emergence of multidrug-resistant strains （MDR-TB） and extensively drug-resistant strains （XDR-TB） has fuelled the quest for novel drugs and drug targets for its successful treatment. One of the potential candidates as novel TB drug target is the PhoR sensor domain, an extracellular domain of PhoR histidine kinase. PhoR sensor domain is part of the two-component system PhoR-PhoP that senses environmental stimuli and relays the signal to control the expression of 78 virulent associated genes in Mycobacterium tuberculosis. 3D structure of the PhoR sensor domain will facilitate the structure based drug discovery of novel anti- tubercular. In this study, we successfully predicted and isolated the gene encoding PhoR sensor domain from Mycobacterium tuberculosis H37Rv, cloned it in pGEM-T vector and subcloned it in pRSET emGFP expression vector. PhoR sensor domain was successfully cloned and would be used for further expression, purification and crystallization studies.

关键词： Sensor domain PhoR tuberculosis two-component system.

Predominance of constitutional chromosomal rearrangements in human chromosomal fragile sites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Genetics 2013年第2期3卷 8-13页

作者： Ines J.Sequeira Joao T.Mexia Joao Santiago Rita Mamede Elisa Silva Jorge Santos Daniel Faria Jose Rueff aldina Bras department of Mathematics and CMA Faculty of Sciences and TechnologyUniversidade Nova de LisboaCaparicaPortugal department of Genetics and CIGMH Faculty of Medical SciencesUniversidade Nova de LisboaLisbonPortugal

Chromosomal fragile sites (CFSs) are loci or regions susceptible to spontaneous or induced occurrence of gaps, breaks and rearrangements. In this work, we studied the data of 4535 patients stored at deCIPHER (Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources). We mapped fragile sites to chromosomal bands and divided the 23 chromosomes into fragile and non-fragile sites. The frequency of rearrangements at the chromosomal location of clones found to be deleted or duplicated in the array/CGH analysis, provided by deCIPHER, was compared in Chromosomal Fragile Sites vs. non-Fragile Sites of the human genome. The POSSUM Web was used to complement this study. The results indicated 1) a predominance of rearrangements in CFSs, 2) the absence of statistically significant difference between the frequency of rearrangements in common CFSs vs. rare CFSs, 3) a predominance of deletions over duplications in CFSs. These results on constitutional chromosomal rearrangements are evocative of the findings previously reported by others relatively to cancer supporting the current line of evidence and suggesting that a common mechanism can underlie the generation of constitutional and somatic rearrangements. The combination of insights obtained from our results and their interrelationships can indicate strategies by which the mechanisms can be targeted with preventive medical interventions.

关键词： Chromosomal Fragile Sites Constitutional Chromosomal Rearrangements Databases

Leaf Gas Exchange,Photon Capture and Light Harvest in aldina heterophylla along a Vegetation Gradient in the Amazon Rainforest

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2014年第10期5卷 1477-1488页

作者： Joao Victor Figueiredo Cardoso Rodrigues José Francisco de Carvalho Goncalves Federal University of Amazonas Center for Distance EducationManausBrazil Laboratory of Plant Physiology and Biochemistry National Institute for Research in the AmazonManausBrazil

Adaptation along environmental gradients is presumed to induce physiological and biochemical leaf changes in plant species. In this paper, we report how leaf gas exchange, photon capture and light harvest for photosynthesis in aldina heterophylla change along a vegetation gradient from low stature open vegetation on extremely nutrient-poor white sand (Campina, CP), through inter-mediate closet type (Campinarana, CR) to tall closed rain forest (RF). The pigment concentrations did not differ between the CP, CR and RF habitats. The performance index for the photosynthesis (PIABS) of individuals in RF and CP was approximately 30% higher than that in CR individuals. This species showed similar potential rates of photosynthesis in the different vegetation types;however, the dark respiration rates were higher in CP. Our results indicate that the differences in the leaves and soil nitrogen concentrations are not enough to change the levels of gas exchange. Other environmental features may be driving the observed morphological features in this gradient, in particular, the tree height.

关键词： Chloroplast Pigments Dark Respiration Net Photosynthesis Physiological Plasticity Tropical Forest Biomass Accumulation