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Will there be a cure for HIV/AIDS? Making the dream a reality

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 441-442页

作者： alcides troncoso Department of Infectious Diseases School of MedicineUniversity of Buenos Aires

It has been more than 30 years since AIDS was introduced in people's daily life, and it is a milestone that causes taboos, myths and prejudices. At that time, a patient told me his feelings, and he was very convincing: "I am horrified of living and afraid of dying." Three decades later, AIDS infection is not a death sentence anymore. First, doctors could make that infected patients did not die from the disease; then, that the medication which kept them alive was not so toxic. And finally, that the treatments were more comfortable. And once at this point, the possibility that the virus may disappear from the body is a more realistic goal than ever. The story of AIDS has changed and, for the first time, we can foresee in the short term the beginning of the end of the pandemic. Now it is not about whether the cure is possible or not, but about when we will have it. This current momentum, so hard to get, should be maintained. We have never been so close to achieving this goal. Although the end of the pandemic is close, this is not enough. It is worrying that some world leaders have absolved themselves of responsibility for not stopping or at least having understood the explosion of the pandemic as if it was a natural disaster. "Zero tolerance for HIV" requires a profound understanding of the stigma and discrimination of the infected people to finally get rid of the epidemic of fear and the devastation that the pandemic caused.

关键词： HIV AIDS Cure Prejudices

Ebola outbreak in West Africa: a neglected tropical disease

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Asian Pacific Journal of Tropical Biomedicine 2015年第4期5卷 255-259页

作者： alcides troncoso Department of Infectious Diseases School of Medicine Buenos Aires University

Neglected tropical diseases(NTDs) are remediable injustices of our times. Poverty is the starting point, and the ultimate outcome, of NTD. Ebola is just one of many NTDs that badly need attention. Ebola exacerbates West Africa's poverty crisis. The virus spreading in Guinea,Liberia and Sierra Leone has led to food shortages and neglect of other devastating tropical illnesses. A health crisis that was ignored for months until it was out of control is now beginning to get the attention required, if not the resources. So far, the world′s nations have contributed far less than the $ 1 billion. The U.N. estimates would need to control the epidemic before it becomes endemic. Past outbreaks of Ebola have flared up in remote, forested communities, disconnected from much of the outside world. But the outbreak in West Africa has not slowed yet, and it worsens there the chances of it spreading to other countries. Ebola draws attention to NTD. Ebola is not only a health emergency, but also it′s a poverty *** current Global Ebola crisis presents a multitude of challenges in terms of our capacity to respond; the future is even less predictable. Ebola outbreak represents inequity in health as the occurrence of health differences considered unnecessary, avoidable, unfair, and unjust, thus adding a moral and ethical dimension to health inequalities. Health equity does not refer only to the fairness in the distribution of health or the provision of health care; rather, it is linked with the larger issues of fairness and justice in social arrangements.

关键词： Ebola Poverty Epidemic Health inequalities

Zoonotic transmission of hepatitis E:Implications for public health worldwide

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Asian Pacific Journal of Tropical Medicine 2009年第4期2卷 77-82页

作者： Analia Paiva Victoria Rebagliati alcides troncoso Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineUniversity of Buenos AiresArgentina

Since the year 1982,the Hepatitis E virus(HEV),enteric transmission,has been widely spread in many tropical and subtropical *** has multiple routes of transmission,such as food or water contaminated with faecal matter,person-to-person transmission or by the ingestion of raw or undercooked *** is important to consider the significance of zoonotic infections propagation,both in endemic areas as well as in developed countries,where there have been some sporadic *** article summarizes the research conducted to date,which supports the zoonotic transmission of HEV,its risks and how they are often underestimated.

关键词： Human zoonosis HEV Public health

Giemsa and Grocott in the recognition of Histoplasma capsulatum in blood smears

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Asian Pacific Journal of Tropical Biomedicine 2013年第5期3卷 418-420页

作者： Javier Bava alcides troncoso Laboratory of Parasitology Infectious Diseases Muniz Hospital Department of Microbiology and Infectious Diseases School of MedicineUniversity of Buenos Aires

Objective:To facilitate the recognition of intracellular yeasts of Histoplasma capsulation and differentiate it from Leishmania amastigotes and other parasites,using the combination of Giemsa and a rapid modification of Grocott stains to peripheral blood smears in a hematological ***:The combination of both stains was applied consecutively(first Grocott and then Giemsa)to previously fixed peripheral blood *** was performed with 400x and 1000x,the latter using immersion ***:The yeasts of Histoplasma capsulatum were observed into the cytoplasm of leukocytes as brownish oval elements,with 3-4μm in ***:The combination of both techniques is a simple and fast method to facilitate recognition of intracellular yeasts and it is different from intracellular parasitic ***,it allows distinguishing the cell elements that are in the microscopic *** may be very helpful in those cases in which the presumptive diagnosis of histoplasmosis has not been established yet and where other more sophisticated methods are not available.

关键词： Histoplasmosis Peripheral blood smear Visceral leishmaniasis HIV

Chromoblastomycosis as a problem of the tropics

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Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 79-80页

作者： Bava Amadeo Javier Rodriguez Rios Elizabeth troncoso alcides Department of Micology La Plata National UniversityBuenos Aires State Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

Chromoblastomycosis can also cause severe but usually superficial lesions on the *** other deep mycosis, this chronic and disabling condition is seen in many tropical regions,including Argentina,where this man was ***... 详细信息

关键词： Chromoblastomycosis Verrucous Lesiones

Leishmaniasis in the knee area

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 330-331页

作者： Bava Amadeo Javier Rossi Maria Laura Seley Celeste troncoso alcides Department of Micology La Plata University Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

Leishmaniasis is a parasitic infection caused by species leishmaniae,which can produce two types of manifestations:visceral and *** south America cutaneous leishmaniasis is more common than visceral leishmaniasis.A case of primary cutaneous leishmaniasis from Bolivia is presented for its *** patient of our case showed an ulcerated lesion of the knee. Montenegro’s intradermal test was ***-stained touch preparation of the skin biopsy revealed amastigotes inside macrophages,consistent with *** patient was treated with meglumine antimoniate intramuscular(20 mg of Sb+/kg/day) three weeks,with complete cicatrization of the lesion.

关键词： Cutaneous leishmaniasis Skin ulcers Leishmania

Neurocysticercosis causing sudden death:a case report

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Asian Pacific Journal of Tropical Medicine 2010年第8期3卷 669-670页

作者： Martinez Fernanda Seley Celeste Marchesi Liliana Fontanarossa Victoria Rodriguez Dominique troncoso alcides Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineBuenos Aires University

We report an acute case of a native man from Bolivia suffered from cephalalgia which rapidly worsened and ended in his sudden and unexpected *** resonance imaging(MRI) of the brain was *** demonstrated on brain MRI scan were consistent with a diagnosis of neurocysticercosis(NCC).An autopsy showed the presence of intraventricular Taenia solium(***) cysts which caused blockage of cerebrospinal fluid and secondary *** to the increasing travel movements of people neurocysticercosis must be considered as a cause of unexplained sudden death.

关键词： Neurocysticercosis Taenia solium Sudden death

Documented outbreaks of botulism:the impact of foodborne transmission

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Asian Pacific Journal of Tropical Medicine 2008年第2期1卷 71-75页

作者： Victoria Rebagliati Sabrina Chianelli Mariela Tornese Laura Rossi alcides troncoso Department of Microbiology and Parasitology School of NutritionBuenos Aires Medical SchoolBuenos AiresArgentina

Botulism is a severe neuroparalytic disease caused by Clostridium botulinums *** the disease is uncommon,causes great concern due to its high rate of mortality;foodbome outbreaks of botulism occur worldwide and require immediate public health and acute care *** study had a review of outstanding outbreaks published;Journals articles related to the *** the outbreaks analysis we found the most involved food products were;fermented fish products in Alaska;home canning food,oil preservation and restaurant sauce in London and USA;home canned vegetables,food airtight packed with inappropriate refrigeration and aerosols in *** conclusion,the diagnosis is based only on clinical findings matching the disease and previous exposure to suspicious *** must be immediately identified as one case suggests an epidemic and should be treated as a public health *** the purpose of the following review is to recognize the associated risks with the consumption of potentially dangerous foods,to help work our way on prevention for every public health professional to be aware of the dangers of this potentially lethal disease.

关键词： foodborne botulism Clostridium botulinum

Pulmonary coinfection by Pneumocystis jiroveci and Cryptococcus neoformans

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Asian Pacific Journal of Tropical Biomedicine 2012年第1期2卷 80-82页

作者： Bava Javier Lloveras Susana Garro Santiago troncoso alcides Laboratory of Parasitology Infectious Diseases Hospital Division of Infectious Diseases Francisco Muniz Hospital Department of Infectious Diseases Tropical MedicineSchool of Medicine.Buenos Aires University

We communicate the diagnosis by microscopy of a pulmonary coinfection produced by Cryptococcus neoformans and Pneumocystis jiroveci,from a respiratory secretion obtained by bronchoalveolar lavage of an AIDS *** review of literature identified this coinfection as unusual *** infections associated with HIV infection are increasingly *** may occur at an early stage of *** concurrent opportunistic infections may occur,coexisting Pneumocystis jiroveci pneumonia(PCP)and disseminated cryptococcosis with cryptococcal pneumonia is *** lungs of individuals infected with HIV are often affected by opportunistic infections and tumours and over two-thirds of patients have at least one respiratory episode during the course of their *** is the leading HIV-associated *** present the case of a man who presented dual Pneumocystis jiroveci and cryptococcal pneumonia in a patient with *** diagnosis of PCP and Cryptococcus requires demonstration of these organisms in pulmonary tissues or *** patients with<200/microliter CD4-lymphocytes,a bronchoalveolar lavage should be *** patient was successfully treated with amphotericin B and trimethoprim *** 1 week the patient showed clinical and radiologic improvement and was discharged 3 weeks later.

关键词： Cryptococcus neoformans Pneumocystis jiroveci Pulmonary coinfection Diagnosis test Opportunistic pathogen Pneumonia Definitive diagnosis