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Recovery and reuse of abandoned buildings for student housing:A case study in Catania,Italy

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Frontiers of Architectural Research 2018年第4期7卷 510-520页

作者： Stefano Cascone Gaetano sciuto Department of Civil Engineering and Architecture University of CataniaCataniaItaly

Over the past 15 years, housing supply for university students has increased significantly given the considerable attention provided by national institutions on the issue of student housing. In Italy, however, only approximately 4% of students live in university residences. Since 2001, interventions on existing buildings have accounted for approximately 60% of the overall measures proposed for new university residences; these interventions comprise most of the available public economic resources. The possibility of recovering and reusing existing buildings for university residences is remarkable for the city of Catania because most of the students are enrolled in university courses located within the historic city center. Moreover, abandoned buildings are currently a significant part of the city׳s architectural heritage. This research aims to develop an articulated and integrated set of frameworks to support the various phases of the design process for recovering and then reusing existing buildings as university residences. The proposed approach applies existing dimensional standards and environmental sustainability principles to a constructed building using traditional techniques.

关键词： University residences Historic center Recovery Reuse Refurbishment Retrofit

Predictive factors for anastomotic leakage after laparoscopic colorectal surgery

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World Journal of Gastroenterology 2018年第21期24卷 2247-2260页

作者： Antonio sciuto Giovanni Merola Giovanni D De Palma Maurizio Sodo Felice Pirozzi Umberto M Bracale Umberto Bracale Department of Abdominal Surgery Casa Sollievo della Sofferenza Research Hospital Department of General Surgery Casa di Cura Villa Berica Department of Gastroenterology Endocrinology and Endoscopic SurgeryUniversity Hospital of Naples Federico Ⅱ Department of Public Health University of Naples Federico Ⅱ

Every colorectal surgeon during his or her career is faced with anastomotic leakage(AL); one of the most dreaded complications following any type of gastrointestinal anastomosis due to increased risk of morbidity, mortality, overall impact on functional and oncologic outcome and drainage on hospital resources. In order to understand and give an overview of the AL risk factors in laparoscopic colorectal surgery, we carried out a careful review of the existing literature on this topic and found several different definitions of AL which leads us to believe that the lack of a consensual, standard definition can partly explain the considerable variations in reported rates of AL in clinical studies. Colorectal leak rates have been found to vary depending on the anatomic location of the anastomosis with reported incidence rates ranging from 0 to 20%, while the laparoscopic approach to colorectal resections has not yet been associated with a significant reduction in AL incidence. As well, numerous risk factors, though identified, lack unanimous recognition amongst researchers. For example, the majority of papers describe the risk factors for left-sided anastomosis, the principal risk being male sex and lower anastomosis, while little data exists defining AL risk factors in a right colectomy. Also, gut microbioma is gaining an emerging role as potential risk factor for leakage.

关键词： Laparoscopic colorectal surgery Colorectal surgery Anastomotic leakage Laparoscopy Risk factor Rectal cancer Diverting stoma

A scalable decentralized system for fair token distribution and seamless users onboarding

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Blockchain(Research and Applications) 2022年第1期3卷 40-48页

作者： Francesco Bruschi Manuel Tumiati Vincenzo Rana Mattia Bianchi Donatella sciuto Politecnico di Milano Milano20133Italy KNOBS srl Milan20121Italy

Tokens are digital,transferable,and programmable assets and one of the most promising tools offered by *** could enable a wide range of applications,from down to earth to *** of the main issues in achieving wide adoption of tokens is onboarding:main platforms require users to deal with specific tools such as wallets,transaction fees,key generation,and *** most common solution to offer a familiar experience to naive users are custodial intermediaries,which have the important drawback of centralizing the process,and keeping users away from the advantages of selfsovereign assets *** this paper,we present a process for the distribution of digital tokens to end users,exploiting“physical”objects for initial *** process is aimed at making the onboarding of users not yet accustomed to blockchain tools and concepts as easy as possible,in a secure and decentralized way.

关键词： Blockchain Tokens Onboarding Wallets

Pros and Cons in Therapeutic Evaluation of Paraoxonase 1 in Nerve Agent Toxicity

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Journal of Life Sciences 2013年第9期7卷 935-940页

作者： Manojkumar Valiyaveettil Yonas Alamneh Bhupendra P. Doctor Alfred M. sciuto Madhusoodana P.Nambiar Blast-Induced Neurotrauma Branch Center for Military Psychiatry and Neuroscience Walter Reed Army Institute of ResearchSilver Spring MD 20910 USA Analytical Toxicology Division US Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground MD21010 USA

PON 1 （Paraoxonase 1） has been proposed as an efficient catalytic bioscavenger to combat against OP （organophosphate） and CWNA （chemical warfare nerve agent） toxicity. Unlike stoichiometric bioscavengers such as butyrylcholinesterase, catalytic bioscavengers are cost effective with the advantage of eliminating all the OPs/CWNAs at low doses. Analysis of catalytic bioscavenger efficacy of PONI showed promising results by various group of researchers. Still, there are large numbers of grey areas which are not addressed so far. One of the major areas of interest is the pharmacokinetic analysis of infused PON 1 in multiple animal models. It is shown that previous studies in mice significantly increased half-life of PONI, while recent studies in guinea pigs from our group showed reduced half-life of PON1. Similar results were reported by other research groups in guinea pigs and non-human primates. The short half-life of exogenously administered PON1 in multiple animal models may be due to poor association of PON1 with its endogenous carrier, high density lipoprotein or lower doses of PON 1 or a reflection of species difference. These observations warrant the significance of thorough pharmacokinetic analysis of infused PON 1 and the development of alternative approaches for successful utility of PON 1 as an efficient medical countermeasure against OP/CWNA toxicity.

关键词： Paraoxonase 1 catalytic bioscavenger chemical warfare nerve agents pharmacokinetics protective efficacy

Responsibility of hepatitis C virus in the development of hepatocellular carcinoma:From molecular alterations to possible solutions

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World Journal of Hepatology 2018年第6期10卷 448-451页

作者： Gaetano Bertino Giulia Malaguarnera Evelise Frazzetto Alice sciuto Gaetano Inserra Guido Nicola Zanghì Michele Malaguarnera Hepatology Unit Department of Clinical and Experimental MedicineUniversity of CataniaPoliclinico“G.Rodolico”Catania 95123Italy Research Center“the Great Senescence” University of CataniaCatania 95100Italy Department of Biomedical and Biotechnological Science University of CataniaCatania 95100Italy Department of Clinical and Experimental Medicine University of CataniaCatania 95123Italy Department of Surgery Policlinico Vittorio Emanuele University HospitalUniversity of CataniaCatania 95100Italy

There are several causes of hepatocellular carcinoma(HCC), but certainly the hepatitis C virus(HCV) is one of the most common. The HCV is able to contribute, both directly and indirectly, to the development of HCC. Determining early HCV clearance before an advanced liver disease develops, is absolutely necessary as this prevents the initiation of the cascade of events induced by HCV that may result in the development of HCC. The early treatment of the infection and the clearance of HCV represents today, in the age of the direct antiviral agents(DAAs), an extraordinary opportunity for true prevention of the development of HCV-related HCC.

关键词： Hepatitis C virus Hepatocellular carcinoma Inflammation Fibrosis Insulin-resistance Oxidative stress Direct acting antivirals