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Organic Chemistry Frontiers 2022年第2期9卷 462-470页

作者： Daniel Carretero-Molina Francisco Javier Ortiz-López Tetiana Gren Daniel Oves-Costales Jesús Martín Fernando Román-Hurtado Tue sparholt Jorgensen Mercedes de la Cruz Caridad Díaz Francisca Vicente Kai Blin Fernando Reyes Tilmann Weber Olga Genilloud Fundación medina Centro de Excelencia en Investigación de Medicamentos Innovadores en AndalucíaAvda.del Conocimiento 3418016 ArmillaGranadaSpain The Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKemitorvetbuilding 2202800 Kgs.LyngbyDenmark

Gargantulides B and C,two new and highly complex 52-membered glycosylated macrolactones,were isolated from Amycolatopsis *** CA-230715 during an antibacterial screening *** structures of these giant macrolides were elucidated by 2D NMR spectroscopy and shown to be related to gargantulide A,although containing additional β-glucopyranose and/orα-arabinofuranose monosaccharides separately attached to their *** sequencing allowed the identification of a strikingly large 216 kbp biosynthetic gene cluster,among the largest type Ⅰ PKs clusters described so far,and the proposal of a previously unreported biosynthetic pathway for gargantulides *** absolute configurations of gargantulides B and C were assigned based on a combination of NMR and bioinformatics analysis of ketoreductase and enoylreductase domains within the multimodular type Ⅰ *** addition,the absolute stereochemistry of gargantulide A has now been revised and *** B and C display potent antibacterial activity against a set of drug-resistant Gram-positive bacteria and moderate activity against the clinically relevant Gram-negative pathogen Acinetobacter baumannii.

关键词： absolute membered backbone

酒精性肝硬化患者血清一氧化氮及非对称二甲基精氨酸的浓度

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 60-60页

作者： Lluch P. Torondel B. medina P. 黎一兵 servicio de Hepatologa Hosp.Clnico UniversitarioDepto.Med.Univ.ValenciaB.ValenciaSpain

Background/Aims The liver plays a prominent role in the metabolism of asymmetric dimethyl-L-arginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthase. This study was designed to determine whether plasma levels of ADMA and NO production are altered in patients with compensated and decompensated alcoholic cirrhosis. Methods Plasma levels of L-arginine, ADMA, symmetric dimethylarginine (sDMA) and NO (nitrite plus nitrate, NOx) were measured in nine patients with compensated alcoholic cirrhosis (Child-Pugh A) and 11 patients with advanced cirrhosis (Child-Pugh B-C). seven healthy volunteers served as controls. Results ADMA and NOx concentrations in decompensated cirrhosis were higher than in the compensated group and control group (ADMA: 1.12± 0.08 vs.0.58± 0.05 and 0.58± 0.07μ mol/l, respectively; Ps. 37.42± 3.91 and 40.43± 5.30μ mol/l, respectively;Ps a positive correlation between the clinical score of the patients and concentrations of ADMA(r2=0.547, PsDMA and L-arginine levels were not significantly different between the three groups. Conclusions The results suggest that hepatocellular damage is a main determinant of elevated ADMA concentration in advanced alcoholic cirrhosis. By inhibiting NO release from vascular endothelium, ADMA might oppose the peripheral vasodilation caused by excessive NO production in severe cirrhosis.

关键词：酒精性肝硬化血清一氧化氮失代偿性血管舒张精氨酸临床评分合成酶抑制剂 sDMA 非对称肝细胞

Associations between Vitamin D and Type 2 Diabetes Mellitus: The Role of Vitamin D Receptor and Binding Protein

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Journal of Diabetes Mellitus 2020年第4期10卷 222-235页

作者： Eman s. Arafat Inass M. Taha shahad W. Kattan Nouf Abubakr Babteen Iman Fawzy Medical Biochemistry and Molecular Biology Departement Faculty of Medicine Menoufia University Al-Minufya Egypt Medicine Department College of Medicine Taibah University Medina KSA Medical Laboratory Department College of Applied Medical Science Taibah University Yanbu KSA Biochemistry Department Faculty of Science University of Jeddah Jeddah KSA Mansoura Central Laboratories Ministry of Health Mansoura Egypt

Background: Type 2 diabetes mellitus (T2DM) is a chronic disease that is characterized by β-cell dysfunction and resistance for insulin. Vitamin D is necessary for insulin secretion so it is a crucial factor in the d... 详细信息

strong>Background:strong> Type 2 diabetes mellitus (T2DM) is a chronic disease that is characterized by β-cell dysfunction and resistance for insulin. Vitamin D is necessary for insulin secretion so it is a crucial factor in the development of T2DM. This study was done to investigate the association between serum 25-hydroxy Vitamin D [25(OH)3D], VDR (Vitamin D receptor) and VDBP (Vitamin D binding protein) with type 2 diabetic patients compared to control subjects.strong> subjects and Methods:strong> This study carried out 110 female patients who were previously diagnosed with type 2 diabetes and 110 age, sex and weight matched as controls. All participants were subjected to full history taking, clinical examination and assessment of fasting blood glucose, HbA1c , lipid profile, 25-hydroxy Vitamin D [25(OH)3D], VDR and VDBP. strong>Results:strong> Results showed that the level of 25(OH)3D was significantly lower in diabetic group compared to controls and was significantly negatively correlated with glycated hemoglobin, serum total cholesterol and low density lipoprotein cholesterol in type 2 DM. Decreasing Vitamin D level was significantly associated with decreasing VDR. No significant association was found between Vit D and VDBP levels. strong>Conclusions:strong> Vitamin D deficiency is frequent in diabetic patients and associated with poor control and outcome. This suggests a role of Vitamin D in the pathogenesis and control of T2DM. serum VDBP in diabetes may be independent to the level of 25(OH)3D and needs further studies.

关键词： Diabetes Mellitus Type 2 25-Hydroxy Vitamin D Vitamin D Receptor Vitamin D Binding Protein

Application of Medicinal Plants on Menopause symptoms

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Journal of Pharmacy and Pharmacology 2021年第7期9卷 245-255页

作者： Yosvany Urquiola Martínez Ana Elena Rodríguez Cadalso Regina de Caridad Rodríguez Muñoz Viviana silvia Rodríguez Jiménez Marelys medina Barroso Ramón Florencio Duarte Chaviano Filial of Medical sciences Elena Fernández de Castro Unit Trinidad 62600Sanctis Spíritus.Cuba

Objectives:To relate the symptoms of menopause and the use of medicinal ***:it was carried out a study that applied the qualitative method,by means of a bibliographical and documental revision in sources of digital data of wide reach(Google,sciELO,DOAJ,Latindex and sCOPUs).It was kept in mind the quality and the present ***:It was based on the search of articles in Virtual the Library in Health(spanish:BVs)and using the key words:menopause,medicinal plants,phytotherapy,menopause symptoms.

关键词： Menopause medicinal plants phytotherapy menopause symptoms.

A TEM study of Cobalt-Base Alloy Prototypes Fabricated by EBM

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Lumbar-sacral Plexus Block Anesthesia versus General Anesthesia for Total Hip Arthroplasty: Case Control study

Materials sciences and Applications（材料科学与应用期刊） 2011年第5期

作者： sara M. Gaytan Larry E. Murr Diana A. Ramirez Brenda I. Machado Edwin Martinez Daniel H. Hernandez Jose L. Martinez Francisco medina Ryan B. Wicker

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PathoDNA, an Advanced Diagnostic for Lyme Disease & Co-Infections Utilizing Next Generation DNA sequencing with Greater sensitivity and selectivity than ELIsA/Western Blot

Open Journal of Anesthesiology（麻醉学期刊） 2021年第9期

作者： Perales Caldera Eduardo González Lumbreras Aniza surinam Uribe Campo Giselle Andrea Fernández soto José Rodrigo medina de la Rosa Edoardo DíazBorjónEfraín Bravo Reyna Carlos César

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中国乌头的研究 ⅩⅣ.紫草乌碱甲的化学结构的研究

Advances in Infectious Diseases（传染病进展） 2021年第4期

作者： Robert schettig Ruth Tan-Lim Daniel Warren Zachary Poteet Rory sears Michael Hummel Connor Coffin Kendra Quart Christopher Aussems Ronald Matthias Jr. David medina Matthew Klein Gayle Roberts John C.Oertle III Dino Prato

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化学学报 1987年第11期45卷 1101-1106页

作者：蒋山好洪山海周炳南朱元龙朱任宏郑培菊汪明中国科学院上海药物研究所上海中药研究所复旦大学测试中心复旦大学测试中心上海

从云南紫草乌（Aconitum delavayi Franch）中所得的紫草乌碱甲（delavaconitine）是具有麻醉作用的新的二萜类生物碱,其分子式应更正为C29H39O6N.经水解、乙酰化、热解和异构化等化学反应及紫外光谱、红外光谱、质谱及1H和13C核磁共振... 详细信息

从云南紫草乌（Aconitum delavayi Franch）中所得的紫草乌碱甲（delavaconitine）是具有麻醉作用的新的二萜类生物碱,其分子式应更正为C29H39O6N.经水解、乙酰化、热解和异构化等化学反应及紫外光谱、红外光谱、质谱及1H和13C核磁共振的测定,确定它的化学结构为1;其水解产物紫草乌碱甲胺醇（delavaconine）经X射线衍射测定,进一步证实了1的化学结构.

关键词：化学结构水解产物核磁共振质谱红外光谱核自旋共振粒子谱 IR 光谱 ppm 紫草乌相对丰度基峰烷氧基甲氧基

Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs

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Asian Pacific Journal of Tropical Medicine 2013年第9期6卷 673-681页

作者： Lin Zhang Anjaneya s.Ravipati sundar R Koyyalamudi sang Chul Jeong Narsimha Reddy John Bartlett Paul T.smith Mercedes de la Cruz Maria Cndida Monteiro ngeles Melguizo Ester Jimnez Francisca Vicente school of science and Health University of Western SydneyLocked Bag 1797Penrith South DCNSW 1797Australia Fundación medina Centro de Excelencia en Investigación de Medicamentos Innovadores en AndalucíaParque Tecnológico de Ciencias de la SaludAvda.de Conocimiento 3E-18016 ArmillaGranadaSpain

Objective:To evaluate in ritro antimicrobial activities of selected 58 ethno-medicinal plant extracts with a view to assess their therapeutic ***:A total of 58 traditional Chinese medicinal plants were carefully selected based on the literature review and their traditional *** antimicrobial activities of ethanol extracts of these medicinal plants were tested against fungi(Aspergillus funigaius),yeast(Candida albicans),gram-negative(Acirelobacter haumannii and Pseudornnruis aeruginosa)and gram-positive bacteria(staphglococcus aureus).The activities were tested at three different concentrations of 1.00,0.10 and 0.01 mg/*** data was analysed using Gene data screener ***:The measured antimicrobial activities indicated that out of the 58 plant extracts,15 extracts showed anti-fungal activity and 23 extracts exhibited anti-bacterial *** plant extracts have exhibited both anti-bacterial and anti-fungal *** instance,Eucommia ulmoides,Pohgonum cuspidcrtum,Poria cocas and Uncaria rhineophylla showed activity against both bacterial and fungal strains,indicating their broad spectrum of ***:The results revealed that the ethanol extracts of 30 plants out of the selected 58 possess significant antimicrobial *** is interesting to note that the findings from the current study are consistent with the traditional use.A clear correlation has also been found between the antimicrobial activity and the flavonoid content of the plant extracts which is in agreement with the *** results presented here can be used to guide the selection of potential plant species for the isolation and structure elucidation of novel antimicrobial compounds in order to establish the structure-activity *** in turn is expected to lead the way to the discovery of novel antimicrobial agents for therapeutic use.

关键词： Anti-fungal activity Anti-bacterial activity Ethanol extract Chinese medicinal herb