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Distribution and space use of seed-dispersing rodents in central Pyrenees:implications for genetic diversity,conservation and plant recruitment

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Integrative Zoology 2018年第3期13卷 307-318页

作者： Jon URGOITI alberto muñoz Josep Maria ESPELTA Raúl BONAL CREAF Cerdanyola del VallésCataloniaSpain Department of Didactics of Experimental Sciences Faculty of EducationUniversity Complutense of MadridMadridSpain Forest Research Group INDEHESAUniversity of ExtremaduraPlasenciaSpain DITEG Research Group University of Castilla-La ManchaToledoSpain Research group of Genetic and Cultural Biodiversity Research centre for Cinegetic Resources(CSIC-UCLM-JCCM)Ciudad RealSpain

The function and conservation of many forest ecosystems depend on the distribution and diversity of the community of rodents that consume and disperse *** habitat preferences and interactions are especially relevant in alpine systems where such granivorous rodents reach the southernmost limit of their distribution and are especially sensitive to global *** analyzed the community of granivorous rodents in the Pyrenees,one of the southernmost mountain ranges of *** species were identified by DNA with particular attention to the Apodemus species,which are prominent seed-dispersing rodents in *** confirmed for the first time the presence of the yellow-necked mouse,Apodemus flavicollis,in central Pyrenees,a typical Eurosiberian species that reaches its southernmost distribution limit in this *** also found the wood mouse,Apodemus sylvaticus,a related species more tolerant to Mediterranean *** rodents were spatially segregated by *** was rare at high altitudes,which might cause the genetic differentiation between populations of the different valleys reported *** also found other seed consumers like dormice,Elyomis quercinus,and voles,Myodes glareolus,with marked habitat *** suggest that population isolation among valleys may increase the genetic diversity of rodents,like *** also highlight the potential threat that global warming may represent for species linked to high-altitude refuges at the southern edge of its distribution,like Apodemus ***,we discuss how this threat may have a dimension in the conservation of alpine forests dispersed by these rodent populations.

关键词： DNA analysis Pyrenees rodents seed dispersal vegetation structure

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Effects of fire history on animal communities:a systematic review

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Ecological Processes 2022年第1期11卷 248-258页

作者： Tania Marisol González Juan David González‑Trujillo alberto muñoz Dolors Armenteras Laboratorio de Ecología del Paisaje y Modelación de Ecosistemas ECOL‑MOD Departamento de BiologíaFacultad de CienciasUniversidad Nacional de ColombiaEdificio 421111321 BogotáColombia Departamento de Biología Facultad de CienciasUniversidad Nacional de ColombiaEdificio 421111321 BogotáColombia Departamento de Didáctica de Ciencias Experimentales Sociales y MatemáticasFacultad de EducaciónUniversidad Complutense de Madrid28040 MadridSpain CREAF 08193 Cerdanyola del VallèsCataloniaSpain

Fire is a natural agent with a paramount role in ecosystem functioning and biodiversity ***,it can also act as a negative force against many *** some knowledge of the interactions of fire and vegetation,there is no clear understanding of how different components of fire regimes(i.e.,severity,history,or frequency)influence known patterns of animal ***,we performed a systematic review on the global responses of arthropods,birds,mammals,reptiles,and amphibians to different fire ***,we focused on assessing how fire severity,history,and frequency modulate the effect of fire on the richness and abundance of faunal *** conducted a systematic review of 566 papers retrieved from the Scopus *** also scrutinized all the documents included in the meta‑analysis of Pastro et al.(Pastro et *** Ecol Biogeogr 23:1146–1156,2014).Our selection criteria excluded studies without data on species richness or *** also excluded studies without adequate controls and those without information about the fire regime of the study *** careful examination,we used data from 162 studies to perform a quantitative meta‑*** the 162 studies meeting our selection criteria,nearly 60%of the studies are from North America,25%from Australia,11%from Europe,and 4%from the *** to the ecological role of fire,90%of the studies were carried out in fire‑dependent ecosystems(i.e.,conifer forests,natural savannas,pastures).Finally,40%of the studies analyzed birds,22%mammals,and 20%*** meta‑analysis of the available evidence indicates that fire history is an important modulator of animal richness and *** negative or positive,animal responses depended on the time since the last fire *** that short‑term studies may not capture such a long‑term effect on fauna,this translates to more challenges at implementing fire management *** or not we can

关键词： Amphibians Arthropods Birds Fire regime components Mammals Reptiles

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Extensive pollen immigration and no evidence of disrupted mating patterns or reproduction in a highly fragmented holm oak stand

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Journal of Plant Ecology 2014年第4期7卷 384-395页

作者： Joaquín Ortego Raúl Bonal alberto muñoz JoséMiguel Aparicio Grupo de Investigación de la Biodiversidad Genética y Cultural Instituto de Investigación en Recursos Cinegéticos-IREC(CSICUCLMJCCM)Ronda de Toledo s/nE-13005 Ciudad RealSpain Departamento de Ecología Evolutiva Museo Nacional de Ciencias Naturales(CSIC)C/JoséGutiérrez Abascal 2E-28006 MadridSpain Departamento de Didáctica de las Ciencias Experimentales Facultad de EducaciónUniversidad Complutense de MadridC/Rector Royo Villanova s/nE-28040 MadridSpain Centre de Recerca Ecològica i Aplicacions Forestals(CREAF) Cerdanyola del VallèsE-08193 BarcelonaSpain

Aims Forest fragmentation and reduced tree population densities can poten-tially have negative impacts on mating patterns,offspring genetic diversity and reproductive *** aim of the present study is to test these hypotheses comparing an extremely fragmented,low tree density(~0.02 trees/ha)holm oak(Quercus ilex l.)stand from Central spain with a nearby high tree density stand(~50 trees/ha).Methods We genotyped adult trees and seeds from the low-density stand(436 seeds from 15 families)and the high-density stand(404 seeds from 11 families)using nine microsatellite *** these data,we performed paternity analyses,determined pollen flow,mating patterns and pollen pool structure,and estimated progeny genetic diversity in both *** also studied seed set and production and performed a pollen supplementation experiment to determine whether reduced tree density has limited foreign pollen *** Findings We have found extensive pollen immigration(>75%)into the low tree density stand and monte Carlo simulations revealed that pollen moves larger distances than expected from null models of random *** patterns and differentiation of pollen pools were similar in the high-density stand and the low-density stand but we found higher inter-annual differentiation of pollen pools in the *** genetic diversity and self-fertilization rates did not dif-fer between the low-density stand and the high-density *** set rates were significantly lower in the low-density stand than in the high-density stand and experimental cross-pollen supplementation evidenced that foreign pollen availability is indeed a limiting factor in the ***,seed crops did not differ between the low-density stand and the high-density stand,indicating that limitation of foreign pollen is not likely to be of great concern in terms of reduced seed production and potential *** forest regeneration due to other ecological and human fac

关键词： forest fragmentation genetic diversity paternity analyses pollen dispersal pollen pool structure selfing tree density

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Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy

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World Journal of Gastroenterology 2021年第28期27卷 4639-4652页

作者： alberto E muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero Sección Hepatología Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoFacultad de MedicinaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina Instituto de Investigaciones en Salud Pública Facultad de OdontologíaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1122Argentina Unidad Clínica Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoInvestigador Asociado del Gobierno de la Ciudad Autónoma de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina

This review summarizes the safety and efficacy of statins in patients with *** to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in *** most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver *** is the most serious and potentially life-threatening *** has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle ***,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle *** to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something *** these effects,statins could prevent liver-related morbidity and mortality in cirrhotic *** studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and *** few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic *** large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival *** these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies ***,it is advisable to per

关键词： Cirrhosis Liver disease Statins Safety Efficiency

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Gallbladder perforation with fistulous communication

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1191-1201页

作者： Alejandro Quiroga-Garza Neri Alejandro Alvarez-Villalobos Milton alberto muñoz-Leija Mariano Garcia-Campa Hermilo Jeptef Angeles-Mar Guillermo Jacobo-Baca Rodrigo Enrique Elizondo-Omana Santos Guzman-Lopez Human Anatomy Department Universidad Autonoma de Nuevo LeonSchool of MedicineMonterrey 64460Nuevo LeonMexico General Surgery Division Hospital de Traumatología y Ortopedia No.21Instituto Mexicano del Seguro SocialMonterrey 64000Nuevo LeonMexico Plataforma INVEST Medicina UANLKER Unit Mayo Clinic Universidad Autonoma de Nuevo LeonSchool of MedicineMonterrey 64460Nuevo LeonMexico Family Medicine Division Instituto Mexicano del Seguro SocialMonterrey 64000Nuevo LeonMexico Surgery Division Hospital General de Zona No.6Instituto Mexicano del Seguro SocialMonterrey 64000Nuevo LeonMexico

BACKGROUND The management of gallbladder perforation(GBP)with fistulous communication(Neimeier type I)is *** To recommend management options for GBP with fistulous *** A systematic review of studies describing the management of Neimeier type I GBP was performed according to the PRISMA *** search strategy was conducted in Scopus,Web of Science,MEDLINE,and EMBASE(May 2022).Data extraction was obtained for patient characteristics,type of intervention,days of hospitalization(DoH),complications,and site of fistulous *** A total of 54 patients(61%female)from case reports,series,and cohorts were *** most frequent fistulous communication occurred in the abdominal *** from case reports/series had a similar proportion of complications between open cholecystectomy(OC)and laparoscopic cholecystectomy(LC)(28.6 vs 12.5;P=0.569).Mortality was higher in OC(14.3 vs 0.0;P=0.467)but this proportion was given by only one *** were higher in OC(mean 26.3 d vs 6.6 d).There was no clear association between higher rates of complications of a given intervention in cohorts,and no mortality was *** Surgeons must evaluate the advantages and disadvantages of the therapeutic *** and LC are adequate options for the surgical management of GBP,with no significant differences.

关键词： Gallbladder perforation Open cholecystectomy Laparoscopic cholecystectomy Fistulous communication

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Interstitial lung disease in rheumatoid arthritis:Current concepts in pathogenesis,diagnosis and therapeutics

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World Journal of Rheumatology 2015年第1期5卷 1-22页

作者： Eva M Olivas-Flores David Bonilla-Lara Jorge I Gamez-Nava alberto D Rocha-muoz Laura Gonzalez-Lopez Hospital General Regional 180 Instituto Mexicano del Seguro Social (IMSS) Centro Universitario de Ciencias de la Salud (CUCS) Universidad de Guadalajara Hospital de Especialidades Centro Medico Nacional de Occidente Instituto Mexicano del Seguro Social (IMSS) Hospital General Regional 110 Departamento de Medicina Interna-Reumatologia Instituto Mexicano del Seguro Social (IMSS)

Rheumatoid arthritis(RA) is the most common chronic autoimmune inflammatory joint disease. RA-associated interstitial lung disease(RA-ILD) is a major extraarticular complication and causes symptoms that lead to a deterioration in the quality of life, high utilization of health resources, and an increased risk of earlier mortality. Early in the course of RA-ILD, symptoms are highly variable, making the diagnosis difficult. Therefore, a rational diagnostic strategy that combines an adequate clinical assessment with the appropriate use of clinical tests, including pulmonary function tests and high-resolution computed tomography, should be used. In special cases, lung biopsy or bronchioalveolar lavage should be performed to achieve an early diagnosis. Several distinct histopathological subtypes of RA-ILD are currently recognized. These subtypes also have different clinical presentations, which vary in therapeutic response and prognosis. This article reviews current evidence about the epidemiology of RA-ILD and discusses the varying prevalence rates observed in different studies. Additionally, aspects of RA-ILD pathogenesis, including the role of cytokines and other molecules such as autoantibodies, as well as the evidence linking several drugs used to treat RA with lung damage will be discussed. Some aspects of the clinical characteristics of RA-ILD are noted, and diagnostic strategies are reviewed. Finally, this article analyzes current treatments for RA-ILD, including immunosuppressive therapies and biologic agents, as well as other therapeutic modalities. The prognosis of this severe complication of RA is discussed. Additionally, this paper examines updated evidence from studies identifying an association between drugs used for the treatment of RA and the development of ILD.

关键词： Rheumatoid arthritis Interstitial lung disease Pathogenesis Diagnosis Therapeutic

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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p38γand p38δas biomarkers in the interplay of colon cancer and inflammatory bowel diseases

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Cancer Communications 2022年第9期42卷 897-901页

作者： Pilar Fajardo Maria Taskova Miguel A.Martín-Serrano Jonas Hansen Sofie Slott Anna K.Jakobsen Marie-Louise Wibom Beñat Salegi alberto muñoz Antonio Barbachano Arpita Sharma John Mark Gubatan Aida Habtezion Juan J.Sanz-Ezquerro Kira Astakhova Ana Cuenda Department of Immunology and Oncology National Centre of Biotechnology/Consejo Superior de Investigaciones CientíficasDarwin 3Madrid 28049Spain PhD Programme in Molecular Bioscience Doctoral SchoolUniversidad Autónoma de MadridMadrid 28049Spain Department of Chemistry Technical University of Denmark2800 Kongens LyngbyDenmark Adolphe Merkle Institute University of FribourgChemin des Verdiers 41700 FribourgSwitzerland Stanford School of Medicine StanfordCA 94305USA Instituto de Investigaciones Biomédicas“alberto Sols” Consejo Superior de Investigaciones CientíficasUniversidad Autónoma de MadridMadrid 28029Spain Centro de Investigación Biomédica en Red-Cáncer Instituto de Salud Carlos IIIMadrid 28029Spain Instituto de Investigación Sanitaria del Hospital Universitario La Paz Madrid 28029Spain Department of Medicine Division of Gastroenterology and HepatologyStanford University School of MedicineStanfordCA 94305USA Department of Molecular and Cellular Biology Centro Nacional de Biotecnología/Consejo Superior de Investigaciones CientíficasDarwin 3Madrid 28049Spain

Dear Editor,Colorectal cancer(CRC)is the second leading cause of cancer death according to the World Health *** with inflammatory bowel disease(IBD),ulcerative colitis(UC)or Crohn’s disease(CD)are at increased risk of developing colitis-associated CRC(CAC)[1];however,our understanding of the inflammationcancer interplay at the molecular level is still limited.

关键词： inflammatory death p38 CRC

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Final Results of a Phase II Study of Bevacizumab, Cisplatin and Pemetrexed as First-Line Therapy for Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer

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Journal of Cancer Therapy 2016年第7期7卷 455-463页

作者： Guillermo López Vivanco Eider Azkona Sergio Carrera Aintzane Sancho Itziar Rubio Juan Manuel Mañé Begoña Calvo Unai Aresti Aitziber Buque Inés Marrodán alberto muñoz Servicio de Oncología Médica Hospital de Cruces Bilbao Spain

Background: Efficacy and safety data for cisplatin and pemetrexed plus bevacizumabinnon squamousnon non-small cell lung cancer (NSCLC) are still limited. Nevertheless, either bevacizumab plus platinum doublet or pemetrexed plus platinum is approved options for first line therapy. Predictive factors for bevacizumab are needed. KRAS is one of the most common oncogenic drivers in lung cancer. Its prognostic and predictive value in NSCLC is under investigation. Patients and methods: This trial evaluates the addition of bevacizumab 7.5 mg/kg to cisplatin 75 mg/m2 plus pemetrexed 500 mg/m2 as first line treatment in stage IV non-squamous NSCLC patients. Maintenance bevacizumab was received as monotherapy until progressive disease, unacceptable toxicityor consent with drawal. The primary objective was progression free survival (PFS). Secondary objectives included overall survival (OS), safety, global objective responses and the determination of KRAS mutation at baseline. Results: From March 2009 to March 2012, 31 patients were enrolled. Mean age was 59.19 (standard deviation (SD) 8.53). From all the patients included in this trial, 67.70% were men. KRAS was wild type in 19 patients (58.06%);in 7 (22.58%) was mutated and was unknown in 6 patients (19.35%). Median PFS for KRAS mutated patients was 4 months, whereas for the KRAS wild type it was 7.9 months (P = 0.0031). Median OS was 4 months for the KRAS population, and 16.1 months for the KRAS wild type (P = 0.0032). Twenty four patients (77.42%) experienced at least a grade 3 - 4 adverse event. The most common grade 3 - 4 toxicity was asthenia. Conclusions: Both PFS and OS were statistically longer for the KRAS wild type patients compared with the KRAS mutated population (P = 0.0031). Median OS was shorter than the reported in previous trials with bevacizumab. Nevertheless, focussing on the OS for KRAS wild type patients, this achieves a result or 16.1 months. Therefore, this would be a consistent dat

关键词： Non-Small-Cell Lung Cancer Bevacizumab Pemetrexed Predictive Biomarker KRAS

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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Neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri alberto Javier Ramos Laboratorio de Neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRNAs or lncRNA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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