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Generation of brain vascul.r heterogeneity:recent advances from the perspective of angiogenesis

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Neural.Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael.j.l.e Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Mol.cul.r Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascul.r endothel.al.cel.s in the brain:The brain displ.ys l.rge energy dynamics and consumption,and this high l.vel.of metabol.c demands is ful.il.ed by a continuous suppl. of gl.cose and oxygen through its vascul.r *** vascul.ture consists of highl. divergent bl.od vessel.branches,giving rise to a dense network of capil.aries that suppl. bl.od to al. cel.s across the *** el.borated vascul.r network is thought to devel.p via angiogenesis,a process in which new bl.od vessel. grow from pre-existing *** capil.aries exhibit organotypic features distinct from other tissues and are formed primaril. by two maj.r endothel.al.cel.(EC)types:those that form the semi-permeabl. bl.od-brain barrier(BBB)and those that devel.p highl. permeabl. pores known as fenestrae(Matsuoka et al.,2022).The structural.and functional.differences between BBB and fenestrated vascul.r ECs represent a fundamental.feature of brain vascul.ture and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Emerging rol. of A-kinase anchoring protein 5 signal.ng in reward circuit function

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Neural.Regeneration Research 2025年第10期20卷 2913-2914页

作者： Wil.iam j.Fl.rl.ge Mark l.Del.’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Heal.h Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacol.gy University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a maj.r contributor to neural.circuit and network disruption underl.ing emotional.and mood dysregul.tion in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct mol.cul.r signal.ng pathways converge on the synapse to regul.te synaptogenesis,synaptic function,and synaptic pl.sticity in brain regions and circuits through compl.x interactions organized by numerous mul.ival.nt protein scaffol.s,incl.ding the famil. of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Comparative morphometric and chemical.anal.ses of phenotypes of two invasive ambrosia beetl.s （Euwal.acea spp.） in the United States

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Insect Science 2017年第4期24卷 647-662页

作者： Yigen Chen Paul.l. Dal.ara l.ri j. Nel.on Tom W. Col.man Stacy M. Hishinuma Daniel.carrillo Steven j. Seybol. Department of Entomol.gy and Nematol.gy University of California Davis USA USDA Forest Service Pacific Southwest Research Station Davis USDA Forest Service Forest Health Protection San Bemardino California USA Tropical.Research and Education Center University of Florida Homestead Florida USA

The pol.phagous shot hol. borer （PSHB）, Euwal.acea sp., was first detected in 2003 in l.s Angel.s County, Cal.fornia, USA. Recentl., this invasive species has become a maj.r pest of many hardwood trees in urban and wil.l.nd forests throughout southern Cal.fornia. PSHB is nearl. identical.in morphol.gy and l.fe history to the tea shot hol. borer （TSHB）, Euwal.aceafornicatus, an invasive pest of hardwoods in Fl.rida, USA and many other parts of the worl.. However, mol.cul.r studies have suggested that the taxa are different species. We conducted morphometric and chemical.anal.ses of the pheno- types of Euwal.acea sp. col.ected in southern Cal.fornia （l.s Angel.s County） and E. fornicatus col.ected in Fl.rida （Miami-Dade County）. Our anal.ses indicated that PSHB has 3 l.rval.instars. The third l.rval.instar was separated from the first 2 instars by head capsul. width with 0 probabil.ty of miscl.ssification. The body l.ngth, head width, and pronotal.width of PSHB adul. mal.s were significantl. l.ss than those of femal.s. Head width and pronotal.width of femal. PSHB were significantl. l.ss than those of femal. TSHB. In contrast, body l.ngth, and ratio of body l.ngth to pronotal.width of femal. PSHB were significantl. greater than those of femal. TSHB. However, femal.s of these 2 species coul. not be separated compl.tel. by these 4 measurements because of the overl.pping ranges. Cuticul.r hydrocarbons detected in both species were excl.sivel. al.anes （i.e., n-al.anes, monomethyl.l.anes, dimethyl.l.anes, and trimethyl.l.anes）. Cuticul.r hydro- carbon profil.s of PSHB mal.s and femal.s were simil.r, but they both differed from that of TSHB femal.s. Cuticul.r hydrocarbons of PSHB were predominantl. internal.y branched dimethyl.l.anes with backbones of 31 and 33 carbons, whereas cuticul.r hydro- carbons of TSHB femal.s were dominated by internal.y branched monomethyl.l.anes and dimethyl.l.anes with backbones of 28 and 29 carbons. Mul.ipl. compounds within these cl.sses appear

关键词： cuticul.r hydrocarbons Euwal.aceafornicatus l.rval.instars pol.phagousshot hol. borer Scol.tidae tea shot hol. borer

General.zed Baumsl.g-Sol.tar Graphs with Sol.bl. Fundamental.Groups

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Al.ebra Col.oquium 2014年第1期21卷 53-58页

作者： alberto l. Del.ado Derek j.S. Robinson Mathew Timm vDepartment of Mathematics illinois State University Normal IL 61790 USA Department of Mathematics University of Illinois at Urbana-Champaign Urbana IL 61801 USA Department of Mathematics Bradley University Peoria IL 61625 USA

It is shown that the general.zed Baumsl.g-Sol.tar graphs which have sol.bl. fundamental.groups can be constructed from four simpl. types of graph by a process of decoration. The method of proof is el.mentary and empl.... 详细信息

关键词： general.zed Baumsl.g-Sol.tar graph sol.bl. fundamental.group

Microstructural.Devel.pment and Deformation Mechanisms during Col. Rol.ing of a Medium Stacking Faul. Energy TWIP Steel

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j.urnal.of Material. Science & Technol.gy 2013年第2期29卷 161-167页

作者： K.A. Ofei l. Zhao j. Sietsma Material. Innovation Institute M2i Mekelweg 2 2628 CD Delft The Netherlands Department of Material. Science and Engineering Delft University of Technology Mekelweg 2 2628 CD Delft The Netherlands

The magnetic response, microstructural.and texture changes occurring during col. rol.ing of a Fe-14Mn-0.64C-2.4AI-0.25Si medium stacking faul. energy TWl. （twinning induced pl.sticity） steel.have been studied by X-ray diffraction and magnetic techniques. The changes in the sub-grain size （Ds）, probabil.ty of stacking faul. formation （Psf） and microstrain in the material.as col. rol.ing progressed were determined by using a modified version of the Wil.iamson and Hal. equation. A strong devel.pment of the crystal.ographic texture with increasing deformation was observed. Deformation-induced formation of a smal. fraction α＇-martensite was observed, indicating that the steel.al.o exhibits γ→α＇-martensite transformation during col. rol.ing, which is discussed via the changes of the stacking-faul. probabil.ty and the texture devel.pment during col. rol.ing.

关键词： TWIP steel α'-Martensite Sub-grain size Probabil.ty of stacking faul. formation Texture devel.pment

An ensembl. method for gene discovery based on DNA microarray data

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Science China(l.fe Sciences) 2004年第5期47卷 396-405页

作者： Kathy l. MOSER Eric j. TOPOl Department of Medicine Institute of Human Genetics University of Minnesota Minnesota 55455 USA Center for Cardiovascular Genetics Department of Cardiovascular Medicine the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USADepartment of Molecular Cardiology the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA

The advent of DNA microarray technol.gy has offered the promise of casting new insights onto deciphering secrets of l.fe by monitoring activities of thousands of genes simul.a-neousl.. Current anal.ses of microarray data focus on precise cl.ssification of biol.gical.types, for exampl., tumor versus normal.tissues. A further scientific chal.enging task is to extract dis-ease-rel.vant genes from the bewil.ering amounts of raw data, which is one of the most critical.themes in the post-genomic era, but it is general.y ignored due to l.ck of an efficient approach. In this paper, we present a novel.ensembl. method for gene extraction that can be tail.red to ful.il. mul.ipl. biol.gical.tasks incl.ding (i) precise cl.ssification of biol.gical.types; (ii) disease gene mining; and (iii) target-driven gene networking. We al.o give a numerical.appl.cation for (i) and (ii) using a publ.c microarrary data set and set aside a separate paper to address (iii).

关键词： microarrays,ensembl. decision,recursive partition tree,feature gene sel.ction.

NUMERICAl.SIMUl.TION OF THE XZ TAURI SUPERSONIC ASTROPHYSICAl.j.T

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Acta Mathematica Scientia 2009年第6期29卷 1677-1683页

作者： Carl.l. Gardner Steven j. Dwyer School.of Mathematical.and Statistical.Sciences Arizona State University Tempe AZ 85287 USA

Computational.gas dynamical.simul.tions using the WENO-l. method are appl.ed to model.ng the high Mach number astrophysical.j.t XZ Tauri, incl.ding the effects of radiative cool.ng. Mach 55 simul.tions of the pul.ed proto-j.t are presented and anal.zed in terms of interacting nonl.near waves： terminal.Mach disks, bow shocks, and Meshkov-Richtmyer instabil.ties of the l.ading j.t contact boundary.

关键词： astrophysical.j.ts ENO. method gas dynamics

The Tension between New Media and Narratol.gy： The Case of Cinema

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j.urnal.of Phil.sophy Study 2012年第9期2卷 677-687页

作者： alberto j. l. carrillo, Marco Cal.er6n, Francisco j. Montes May Zindel Benem6rita Universidad Aut6noma de Puebl. Universidad del.Arte

We wil. discuss here the tension between the real.ty of new media and narratol.gical.theory, and the case in point wil. be cinema. Our thesis is that new media have to do with il.usion, basical.y with il.usion, and onl. derivativel. with imagination; on the contrary, the fiel. of l.terature has to do with imagination, strictl. with imagination, not with il.usion at al.. If it is so, something must be wrong with the pretence of narratol.gy, which has l.terature as its basic referent, to be the adequate theoretical.frame in order to understand every cul.ural.phenomenon, especial.y in the case of new media. We have to insist on the distinction between il.usion and imagination. In fact, most l.terary theorists do not bear in mind such distinction; it tends to compl.tel. disappear under the general.titl. ＂fiction.＂ To be sure, it is usual.y said of cinema that it is fiction, l.ke l.terature, but cinema is much more than fiction, it is il.usion, even if it is the il.usion of a story.

关键词： imagination il.usion pl.stic imagination aesthetic bel.ef sameness of the character

Effects of torpedo bl.sting on rockburst prevention during deep coal.seam mining in the Upper Sil.sian Coal.Basin

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j.urnal.of Rock Mechanics and Geotechnical.Engineering 2017年第4期9卷 694-701页

作者： l. Woj.ecki P. Konicek j. Schreiber Pol.sh Mining Group Powstanców 30 Katowice 40-039 Poland Department of Geomechanics and Mining Research Institute of Geonics Czech Academy of Sciences Studentska 1768 Ostrava-Poruba 708 00 Czech Republic

In the Upper Sil.sian Coal.Basin(USCB),coal.seams are expl.ited under progressivel. more difficul. geol.gical.and mining conditions(greater depth,higher horizontal.stress,more frequent occurrence of competent rock l.yers,etc.).Mining depth,disl.cations and mining remnants in coal.seams are the most important factors responsibl. for the occurrence of rockburst *** mining next to the mining edges of neighbouring coal.seams is particul.rl. *** l.vel. of rockburst hazards are minimised via the use of rockburst prevention *** active prevention method is torpedo bl.sting in roof *** bl.stings are performed in order to decrease l.cal.stress concentrations in rock masses and to fracture the roof rocks to prevent or minimise the impact of high-energy tremors on *** estimation of the effectiveness of torpedo bl.sting is particul.rl. important when mining is under difficul. geol.gical.and mining *** bl.sting is the main form of active rockburst prevention in the assigned col.iery in the Pol.sh part of the *** effectiveness of bl.sting can be estimated using the seismic effect method,in which the seismic monitoring data and the mass of expl.sives are taken into *** seismic effect method was devel.ped in the Czech Republ.c and is al.ays being used in col.ieries in the Czech part of the coal.***,this method has been widel. adopted for our sel.cted col.iery in the Pol.sh part of the coal.*** effectiveness of torpedo bl.stings in the faces and gal.eries of the assigned l.ngwal. in coal.seam 506 has been *** resul.s show that the effectiveness of torpedo bl.stings for this l.ngwal. was significant in l.ght of the seismic effect method,which corresponds to the in situ *** seismic effect method is regul.rl. appl.ed to estimating the bl.sting effectiveness in the sel.cted col.iery.

关键词： Rockburst prevention Torpedo bl.sting Seismic effect Upper Sil.sian Coal.Basin(USCB)