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Characteristics of normal human retinal pigment epithelium cells with extremes of autofluorescence or intracellular granule count

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Annals of Eye Science 2021年第1期6卷 11-19页

作者： Katharina Bermond Andreas Berlin Ioana-Sandra Tarau Christina Wobbe Rainer Heintzmann Christine A.curcio Kenneth R.Sloan Thomas Ach Department of Ophthalmology University Hospital WürzburgWürzburgGermany Department of Ophthalmology Ludwigshafen HospitalLudwigshafenGermany Leibniz Institute of Photonic Technology JenaGermany Institute of Physical Chemistry and Abbe Center of Photonics Friedrich-Schiller University JenaJenaGermany Department of Ophthalmology University of Alabama at BirminghamBirminghamALUSA Department of Ophthalmology University Hospital BonnBonnGermany

Background:Cells of the retinal pigment epithelium(RPE)accumulate different kinds of granules(lipofuscin,melanolipofuscin,melanosomes)within their cell bodies,with lipofuscin and melanolipofuscin being autofluorescent after blue light *** amounts of lipofuscin granules within the RPE have been associated with the development of RPE cell death and age-related macular degeneration(AMD);however,this has not been confirmed in histology so ***,based on our previous dataset of RPE granule characteristics,we report the characteristics of RPE cells from human donor eyes that show either high or low numbers of intracellular granules or high or low autofluorescence(AF)***:RPE flatmounts of fifteen human donors were examined using high-resolution structured illumination microscopy(HR-SIM)and laser scanning microscopy(LSM).Autofluorescent granules were analyzed regarding AF phenotype and absolute number of *** addition,total AF intensity per cell and granule density(number of granules per cell area)were *** the final analysis,RPE cells with total granule number below 5th or above the 95th percentile,or a total AF intensity±1.5 standard deviations above or below the mean were included,and compared to the average RPE cell at the same *** are presented as mean±standard ***:Within 420 RPE cells examined,42 cells were further analyzed due to extremes regarding total granule *** addition,20 RPE cells had AF 1.5 standard deviations below,28 RPE cells above the mean local AF *** granules predominate in RPE cells with low granule content and low AF *** cells with high granule content have nearly twice(1.8 times)as many granules as an average RPE ***:In normal eyes,outliers regarding autofluorescent granule load and AF intensity signals are rare among RPE cells,suggesting that granule deposition and subsequent AF follows intrinsic control mechanisms at a cellul

关键词： Retinal pigment epithelium(RPE) granules autofluorescence(AF) lipofuscin melanolipofuscin melanosomes

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IP世界的语音安全

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软件世界 2006年第7期 65-65页

作者： Joseph curcio Avaya公司

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Case of obscure-overt gastrointestinal bleeding after pediatric liver transplantation explained by endoscopic ultrasound

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World Journal of Gastrointestinal Endoscopy 2012年第12期4卷 571-574页

作者： Gabriele curcio Marta Di Pisa Roberto Miraglia Pieralba Catalano Luca Barresi Ilaria Tarantino Antonino Granata Marco Spada Mario Traina Department of Gastroenterology Liver Transplantation Unit Department of Radiology Liver Transplantation Unit Department of Pediatric Liver Transplantation Unit

Portal hypertension,which is a common finding in children awaiting liver transplantation,is also found after ***'s reported the case of a 6-year-old girl,transplanted for biliary atresia,who had a severe obscure-overt bleeding presenting with *** esophagogastroduodenoscopy showed several duodenal small,bulging lesions,with some red *** the lesions,a depressed area of 2cm,covered with mixed hyperemic and white mucosa,was *** better evaluate these lesions,we performed an endoscopic ultrasonography(EUS) that showed multiple,round hypoechoic areas 0.5-5mm in diameter,compatible with duodenal varices,and several periduodenal anechoic lesions compatible with collaterals.A consecutive computed tomography scan showed a stenosis of the portal vein anastomosis confirmed with a transhepatic portography,which was successfully treated with balloon *** further episodes of bleeding were observed during the *** case report suggests that EUS is safe and feasible in young children when using echoendoscopes designed for use in *** further studies are needed to validate the employment of this technique in the management and follow-up of pediatric portal hypertension.

关键词： Obscure bleeding Pediatric Endoscopic ultrasound Liver transplantation Gastrointestinal

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胰腺的膀胱的损害: 内视镜的超声形态学和内视镜的超声罚款针渴望帮助怎么开诊断难题

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World Journal of Gastrointestinal Endoscopy 2012年第6期4卷 247-259页

作者： Luca Barresi Ilaria Tarantino Antonino Granata Gabriele curcio Mario Traina Unit of Gastroenterology and Digestive Endoscopy Mediterranean Institute for Transplantation and Advanced Specialized Therapies90146 PalermoItaly

Cystic lesions of the pancreas are being diagnosed with increasing frequency,covering a vast spectrum from benign to malignant and invasive *** investigations can be done to discriminate between benign and non-evolutive lesions from those that require *** the moment,there is no single test that will allow a correct diagnosis in all *** ultrasound(EUS) morphology,cyst fluid analysis and cytohistology with EUS-guided fine needle aspiration can aid in this difficult diagnosis.

关键词： Pancreatic cystic lesions Endoscopic ultrasound Endoscopic ultrasound fine needle aspiration

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盖住的自我有为避免 stent 赶出的胰腺的 pseudocyst 的在内的闪耀的塑料的可扩充的金属性的 stent

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World Journal of Gastrointestinal Endoscopy 2012年第4期4卷 148-150页

作者： Ilaria Tarantino Marta Di Pisa Luca Barresi Gabriele curcio Antonino Granata Mario Traina Department of Gastroenterology and Digestive Endoscopy Mediterranean Institute for Transplantation and Advanced Specialized Therapies ISMETT/University of Pittsburgh Medical Center 90100 Palermo Italy

Endoscopic ultrasound-guided drainage has recently been recommended for increasing the drainage rate of endoscopically managed pancreatic fluid collections and decreasing the morbidity associated with conventional endoscopic trans-mural drainage. The type of stent used for endoscopic drainage is currently a major area of interest. A covered self expandable metallic stent (CSEMS) is an alternative to conventional drainage with plastic stents because it offers the option of providing a larger-diameter access fi stula for drainage, and may increase the fi nal success rate. One problem with CSEMS is dislodgement, so a metallic stent with flared or looped ends at both extremities may be the best option. An 85-year-old woman with severe comorbidity was treated with percutaneous approach for a large (20 cm) pancreatic pseudocyst with corpuscolated material inside. This approach failed. The patient was transferred to our institute for EUS-guided transmural drainage. EUS confi rmed a large, anechoic cyst with hyperechoic material inside. Because the cyst was large and contained mixed and corpusculated fluid, we used a metallic stent for drainage. To avoid migration of the stent and potential mucosal growth above the stent, a plastic prosthesis (7 cm, 10 Fr) with flaps at the tips was inserted inside the CSEMS. Two months later an esophagogastroduodenoscopy was done, and showed patency of the SEMS and plastic stents, which were then removed with a polypectomy snare. The patient experienced no further problems.

关键词： Pancreatic pseudocyst Self expandable metallic stent

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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