检索结果-南通市图书馆

Computational Molecular Bioscience 2018年第3期8卷 122-148页

作者： alberto cabrera Leonor Huerta Hernández Daniel Chávez José L. Medina-Franco Departamento de Farmacia Facultad de Química Universidad Nacional Autónoma de México México City México Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México México City México Centro de Graduados e Investigación en Química del Instituto Tecnológico de Tijuana Tijuana México

As follow-up of our past publication?[1], we propose that quinolones (as part of the pyridinone family) are capable to increase the number of interactions with HIV reverse transcriptase (RT) or integrase (IN) by adding a halogen in position C-8 of aromatic portion of the quinolones. This addition could help with the activity of dual inhibitors of RT and IN. In this work, we add a chlorine atom with the rationale to identify in the docking simulations a halogen interaction with the oxygen in the near aminoacids in the binding pockets of RT and IN enzymes. Our docking studies started with RT and 320 structures. Later, we took 73 structures with good results in docking with RT. The structures that we choose contain ester or acids groups in C-3 due the structural similarity with groups in charge to interact with the Mg++ ions in Elvitegravir. In conclusion, we obtained 14 structures that could occupy the allosteric pocket of RT and could inhibit the catalytic activity of IN, for this reason could be dual inhibitors. A major perspective of this work is the synthesis and testing of the potential dual inhibitors designed.

关键词： Reverse Transcriptase Integrase Quinolone Dual Inhibitor Docking

Molecular Modeling of Potential Dual Inhibitors of HIV Reverse Transcriptase and Integrase

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computational Molecular Bioscience 2018年第1期8卷 1-41页

作者： alberto cabrera Leonor Huerta Hernández Daniel Chávez José L. Medina-Franco Departamento de Farmacia Facultad de Química Universidad Nacional Autónoma de México Mexico City Mexico Instituto de Investigaciones Biomedicas Universidad Nacional Autónoma de México Mexico City Mexico Centro de Graduados e Investigaciónen Químicadel InstitutoTecnológico de Tijuana Tijuana B.C. Mexico

With the goal of suggesting dual inhibitors of HIV reverse transcriptase (RT) and integrase (IN), herein we report the molecular docking of an initial set of 556 compounds related to the pyridinone class. Docking with multiple crystallographic structures of HIV-1 RT led to 160 potential binders of RT interacting with key amino acid residues at the enzyme’s allosteric site. Compounds selected from the docking with RT were further docked with a crystallographic structure of HIV-1 IN. A total of 31 structures had the potential to make contacts with Mg2+ ions located in a small space between DNA and IN. Interactions with Mg2+ ions are relevant because they participate in the stabilization of the IN-DNA complex. In conclusion, 31 compounds synthetically accessible are proposed as dual inhibitors of RT and IN. It is hypothesized that the suggested compounds will inhibit RT by occupying the allosteric site for NNRTIs and will inhibit the catalytic activity of IN by destabilizing the IN-DNA complex. The main perspective of this work is the synthesis and biological testing of the candidate molecules.

关键词： AIDS Antiviral Computer-Aided Drug Design Docking Polypharmacology

A computer vision system for early detection of anthracnose in sugar mango(Mangifera indica)based on UV-A illumination

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Information Processing in Agriculture 2023年第2期10卷 204-215页

作者： Leonardo Ramırez alberto Carlos Eduardo cabrera Ardila Flavio Augusto Prieto Ortiz Facultad de Ingenierı´a Universidad Nacional de ColombiaBogota´D.C.111321Colombia

The present work describes the development of a computer vision system for the early detection of anthracnose in sugar mango based on Ultraviolet A illumination(UV-A).Anthracnose,a disease caused by the fungus Colletotrichum sp,is commonly found in the fruit of sugar mango(Mangifera indica).It manifests as surface defects including black spots and is responsible for reducing the quality of the ***,it decreases its commercial *** more detail,this study poses a system that begins with image acquisition under white and ultraviolet ***,it proposes to analyze the Red,Green and Blue color information(R,G,B)of the pixels under two types of illumination,using four different methods:RGB-threshold,RGB-Linear Discriminant Analysis(RGBLDA),UV-LDA,and *** analysis produces an early semantic segmentation of healthy and diseased areas of the mango *** results showed that the combination of the linear discriminant analysis(LDA)and UV-A light(called UV-LDA method)in sugar mango images allows early detection of ***,this method achieves the identification of the disease one day earlier than by an expert with respect to the scale of anthracnose severity implemented in this work.

关键词： Sugar mango Anthracnose LDA UV-A light Grading Image processing

Influence of oxidation of automatic transmission fluids (ATFs) and sliding distance on friction coefficients of a wet clutch in the running-in stage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Friction 2021年第2期9卷 401-414页

作者： Leonardo Israel FARFAN-cabrera Ezequiel alberto GALLARDO-HERNÁNDEZ Manuel VITE-TORRES Jesús Gilberto GODÍNEZ-SALCEDO Tecnologico de Monterrey Escuela de Ingeniería y CienciasAve.Eugenio Garza Sada 2501Monterrey 64849México Instituto Politécnico Nacional SEPI-Escuela Superior de Ingeniería Mecánica y EléctricaUnidad ZacatencoGrupo de TribologíaCol.LindavistaCiudad de México 07738México Instituto Politécnico Nacional ESIQIEIPNCol.LindavistaCiudad de México 07738México

In this paper,the influence of oxidation of automatic transmission fluids(ATFs)and sliding distance on the friction coefficients of a wet clutch in approached running-in conditions was *** ATFs were oxidized by a laboratory process approaching oxidation occurred in actual *** was evaluated by means of increase in carbonyl compounds and depletion of zinc dialkyldithiophosphates(ZDDPs)***,the changes in kinematic viscosity and viscosity index were ***-ondisk tests were conducted to replicate the actual sliding contact in a wet *** pin specimens were cut from friction material composite plates and the disks were actual steel separators both from an automotive wet *** coefficient, μ,was measured at progressive sliding velocity,ν,to obtain μ–νcurves at 26 and 100°*** μ–νtests were consecutively run using the same pair of specimens and *** cumulative sliding distance for each μ–νtest generated surface flattening using the *** friction coefficients of the wet clutch increased due to the ATFs oxidation meanwhile the dm/dv values decreased in most *** suggests that ATF oxidation can enhance torque capacity of the wet clutch,but it could reduce anti-shudder *** sliding distance improved the slopes in the μ–νresults using fresh ATFs meanwhile it generated a slope decrease by using aged ATFs.

关键词： wet clutch friction oil oxidation automatic transmission fluid(ATF)

Kinematics ofmandibular advancement devices(MADs):Why do some MADs move the lower jaw backward duringmouth opening?

在线全文

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2024年第5期7卷 637-650页

作者： Juan A.cabrera Alex Bataller Sergio Postigo Marcos García Mechanical Engineering Department University of Malaga29071 MalagaSpain

Mandibular advancement devices(MADs)are widely used treatments for obstructive sleep *** function by advancing the lower jaw to open the upper *** increase patient comfort,most patients allow the mouth to be ***,not all systems maintain the lower jaw in a forward position during mouth opening,which results in the production of a retrusion that favors the collapse of the upper ***,the kinematic behavior of the mechanism formed by the mandible-device assembly depends on jaw *** means that,during mouth opening,some devices cause lower jaw protrusion in some patients,but cause its retraction in *** this study,we report the behavior of well-known devices currently on *** do so,we developed a kinematic model of the lower jawdevice *** validated for all devices analyzed using a high-resolution camera *** results show that some of the devices analyzed here did not produce the correct behavior during patient mouth opening.

关键词： Mandibular advancement devices Lower jaw kinematics Sleep apnea

On the installation of an in situ large-scale vertical SEALing (VSEAL) experiment on bentonite pellet-powder mixture

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2023年第9期15卷 2388-2401页

作者： Nadia Mokni Justo cabrera Frédéric Deleruyelle Institut de Radioprotection et de SûretéNucléaire(IRSN) PSE-ENV/SEDRE/LETISFontenay-aux-Roses92260France

Recently,the Institute for Radiological protection and Nuclear Safety(IRSN)has launched VSEAL(Vertical SEALing)project to investigate the impact of gas migration on the long-term performance of bentonite based vertical sealing systems(VSS).The first VSEAL in situ test was emplaced in IRSN’s Underground Research Laboratory(URL)in Tournemire(France)in 2019 and was equipped with 76 wired and wireless *** test is still in progress,but the collected set of data provides already valuable information of the hydro-mechanical behavior of VSS during *** swelling core consists of a mixture of highdensity pellets and powder of MX80 bentonite in a ratio of 80/20(in dry mass).An innovative method was adopted to drill a 1-m diameter and w10-m deep shaft in order to minimize the rock perturbation at the *** a specific protocol was adopted to install the bentonite mixture together with a careful characterization of the core during construction,VSEAL 1 constitutes the unique in situ sealing test with a well-known initial structural distribution of the pellets and the *** heterogeneities occurred within the experiment during the installation process:a damaged zone developed around the shaft walls due to the interruption of the installation operations caused by COVID19 lockdown in France;a technological gap with a variable thickness between the last pellets layer and the top confining lid and a heterogeneous distribution of the bentonite powder at some layers inducing large inter pellets voids close to the bentonite-rock *** injected water volume,relative humidity,water content and swelling pressure in both radial and axial directions were *** of the results showed that the presence of installation-induced heterogeneities led to the generation of preferential flow paths that influenced the swelling pressure evolution at radial and axial directions.

关键词： Bentonite pellet-powder mixture Heterogeneities Technological gap Seals In situ test

Re-engineering artificial muscle with microhydraulics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2017年第1期3卷 278-285页

作者： Jakub Kedzierski Eric Holihan Rafmag cabrera Isaac Weaver Massachusetts Institute of Technology Lincoln Laboratory LexingtonMA 02420USA

We introduce a new type of actuator,the microhydraulic stepping actuator(MSA),which borrows design and operational concepts from biological muscle and stepper *** offer a unique combination of power,efficiency,and scalability not easily achievable on the *** actuator works by integrating surface tension forces produced by electrowetting acting on scaled droplets along the length of a thin *** muscle,MSAs have liquid and solid functional components and can displace a large fraction of their *** 100μm pitch MSA presented here already has an output power density of over 200 W kg^(−1),rivaling the most powerful biological muscles,due to the scaling of surface tension forces,MSA’s power density grows quadratically as its dimensions are reduced.

关键词： artificial muscle electrowetting linear actuator microactuator microsystem microhydraulic stepping actuator

Nodal user’s demand response based on incentive based programs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2017年第1期5卷 79-90页

作者： Nestor GONZáLEZ-cabrera Guillermo GUTIéRREZ-ALCARAZ Instituto Tecnolo´gico Superior de Irapuato Irapuato 36620Mexico Instituto Tecnolo´gico de Morelia Morelia 58120Me´xico

This paper describes a practical approach to identify nodal price compensation payment for nodal consumers willing to reduce their energy consumption(consumers’ demand response). The implementation of a nodal reliability service pricing is based on contingency assessment of N-2 order for transmission lines. A representative annualized demand curve is used to reflect the system’s operation condition by seasons. Such curve is used to access the nodal reliability impact trough a whole year in order to determine back-payments(incentive payment) to users for service interruption. The IEEE_RTS 24 nodes system is used to implement the proposed approach.

关键词： Nodal demand response Demand side management Reliability assessment Incentive based programs(IBP)

The Public Role of the Social and Human Sciences After the Crisis of Modernity

在线全文

学校读者我要写书评

暂无评论

Fudan Journal of the Humanities and Social Sciences 2019年第1期12卷 15-26页

作者： Miguel A.cabrera University of La Laguna Ap.45638200 La LagunaTenerifeSpain

The current crisis of modernity has far-reaching implications for the public role of the social and human *** crisis has made it clear that the central theoretical premises and concepts used by social scientists until now are not reflections of phenomena and processes which really exist,but components of the modern imaginary or *** a consequence,social scientists5 ambition of being experts and guides of human practice has been seriously undermined and their social function should be completely reconsidered and *** now on,the function of social scientists cannot be to provide people with an objective knowledge about *** a situation marked by the theoretical and epistemological disenchantment of modernity,their public role should be to help denaturalize and deconstruct any statement,practice,institution,or power relation with claims of being objectively founded.

关键词： Social scientists,role Crisis of modernity Knowledge Modern imaginary Deconstruction

Using single cell transcriptomics to study the complexity of human retina

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第11期15卷 2045-2046页

作者： Daniel Urrutia-cabrera Raymond Ching-Bong Wong Centre for Eye Research Australia Department of Surgery(Ophthalmology)University of MelbourneMelbourneAustralia

The human retina is a specialized multilayered structure composed of numerous cell *** process of vision relies on a robust network integrated by rod photoreceptors,cone photoreceptors,bipolar cells,horizontal cells,amacrine cells and retinal ganglion cells,which detect,process and relay the visual information to the ***,structural and metabolic support is provided by Muller glia,retinal astrocytes and *** 200 genes have been implicated in inherited retinal diseases(RetNet:https://***/retnet/).However,in many cases,the retinal cell types that express these disease-associated genes remain to be *** complexity of the human retina represents a major challenge for the molecular profiling of all retinal cell *** previous studies utilised bulk RNA-seq to profile the whole human adult retina,which only analysed the averaged gene expression levels across all retinal cell *** such,knowledge of the transcriptome profile in specific cell types within the retina would help us to unravel the heterogeneity of retinal cells,advance understanding of the pathogenesis of inherited retinal diseases,and to develop gene therapies that could improve treatment options.

关键词： diseases specialized retina