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Congenital extrahepatic portosystemic shunt complicated by the development of hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 552-557页

作者： Ruchi Sharma Abid Suddle alberto quaglia Praveen Peddu John Karani Thomas Satyadas Institute of Liver Studies King's College Hospital Department of Radiology King's College Hospital Central Manchester University Hospital Manchester Royal Infirmary

Congenital extrahepatic portosystemic shunt,also known as Abernethy malformation, is a rare congenital malformation. It causes shunting of blood through a communication between the portal and systemic veins such as a patent ductus venous. We report 3 cases of Abernethy malformation complicated by the development of hepatocellular carcinoma. Additionally, we comprehensively reviewed all previously reported cases and highlighted common features that may help in early diagnosis and appropriate *** with Abernethy malformation may have an increased propensity to develop hepatocellular carcinoma. All 5 previously reported cases, plus the three of our patients, have a type 1（complete） shunt suggesting a role for absent portal blood flow in the pathogenesis of hepatocellular carcinoma. Congenital extrahepatic portosystemic shunt should be sought for in cases with raised serum ammonia, hepatic encephalopathy or hepatocellular carcinoma in the absence of cirrhosis.

关键词： Abernethy malformation congenital extrahepatic portosystemic shunt congenital absence of portal vein patent ductus venosus hepatocellular carcinoma

Pigmented well-differentiated hepatocellular neoplasm with β-catenin mutation

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Hepatobiliary & Pancreatic Diseases International 2015年第6期14卷 660-664页

作者： Lara Neves Souza Rodrigo Bronze de Martino Richard Thompson Sandra Strautnieks Nigel D Heaton alberto quaglia Institute of Liver Studies King's College Hospital Department of Gastroenterology Discipline of Liver and Gastrointestinal TransplantationHospital das ClínicasUniversity of S?o Paulo

ABSTRACT： According to the most recent WHO classification of hepatocellular adenomas, a small percentage of inflammatory hepatocellular adenomas presents with mutation in the β-catenin gene and are at higher risk of malignant transformation. It has been recognized that adenoma-like hepatocellular neoplasms with focal atypia, or in unusual clinical context present with similar cytogenetic and immunohistochemistry characteristics to well-differentiated hepatocellular carcino- mas.

关键词： hepatocellular adenoma hepatocellular carcinoma β-catenin glutamine synthetase diethylstilbestrol

Role of monocytes and macrophages in experimental and human acute liver failure

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World Journal of Gastroenterology 2010年第15期16卷 1811-1819页

作者： Lucia A Possamai Charalambos Gustav Antoniades Quentin M Anstee alberto quaglia Diego Vergani Mark Thursz Julia Wendon Antiviral Centre 10th Floor QEQM building St Mary’s Hospital Imperial College London Institute of Liver Studies King’s College Hospital

Acute liver failure (ALF) is a devastating clinical syndrome characterised by progressive encephalopathy, coagulopathy, and circulatory dysfunction, which commonly leads to multiorgan failure and death. Central to the pathogenesis of ALF is activation of the immune system with mobilisation of cellular effectors and massive production of cytokines. As key components of the innate immune system, monocytes and macrophages are postulated to play a central role in the initiation, progression and resolution of ALF. ALF in humans follows a rapidly progressive clinical course that poses inherent difficulties in delineating the role of these pivotal immune cells. Therefore, a number of experimental models have been used to study the pathogenesis of ALF. Here we consider the evidence from experimental and human studies of ALF on the role of monocytes and macrophages in acute hepatic injury and the ensuing extrahepatic manifestations, including functional monocyte deactivation and multiple organ failure.

关键词： Monocyte Macrophage Acute liver failure Inflammation Monocyte chemoattractant protein-1/ chemokine (C-C motif) receptor-2 Cytokine

Fat or fillers:The dilemma in eyelid surgery

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World Journal of Clinical Cases 2024年第17期12卷 2951-2965页

作者： Giovanni Miotti Luca De Marco Davide quaglia Martina Grando Carlo Salati Leopoldo Spadea Caterina Gagliano Mutali Musa Pier Luigi Surico Pier Camillo Parodi Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna“Kore”Enna 94100Italy Eye Clinic Catania University San Marco Hospital Viale Carlo Azeglio CiampiCatania 95121Italy Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Africa Eye Laser CentreKm 7Benin 300105Nigeria Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States

The aging of the periocular region has always aroused great interest.A fresh,young,and attractive sight determined an ever-greater attention to surgical and non-surgical techniques to obtain this *** particular,the change in the concept of a young look,considered then“full”,led to the increasing use of surgical(fat grafting)or medical(hyaluronic acid)filling *** rejuvenation became increasingly popular in the field of cosmetic treatments,with a focus on achieving a youthful and refreshed *** the various techniques available,the choice between using fat grafting or fillers presented a clinical *** particular,what surgery considered of fundamental importance was a long-lasting result over *** the other hand,aesthetic medicine considered it fundamental not to have to resort to invasive *** what was the reality?Was there one path better than the other,and above all,was there a better path for patients?The minireview aims to explore the physiopathology,diagnosis,treatment options,prognosis,and future studies regarding this *** analyzed the literature produced in the last 20 years comparing the two *** literature reveals advancements in biomaterials,stem cell research and tissue engineering held promise for further enhancing the field of eyelid *** choice between fat grafting and fillers in eyelid cosmetic treatments presented a clinical *** physiopathology,accurately diagnosing eyelid aging,exploring treatment options,assessing prognosis,and conducting future studies were essential for providing optimal care to patients seeking eyelid rejuvenation.

关键词： Stem cells Adipose stem cell Ocular therapy Oculoplastics Regenerative

Air-coupled PMUTs array with residual stresses:experimental tests in the linear and non-linear dynamic regime

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International Journal of Smart and Nano Materials 2020年第4期11卷 387-399页

作者： Gianluca Massimino Borka Lazarova Fabio quaglia alberto Corigliano Department of Civil and Environmental Engineering Politecnico Di Milano MilanItaly Analog MEMS&Sensors Group STMicroelectronicsCornaredoItaly

The mechanical characterization of a 4×4 air-coupled array of Piezoelectric Micromachined Ultrasonic Transducers(PMUTs)is *** experimental campaign consists of three set of experi-mental tests,namely:topography measurements,small signal dynamic measurements,and vibrometry in the non-linear dynamic *** behavior of three different kinds of PMUT are *** differ according to the thermo-electrical treatment that has been applied to the piezoelectric *** presence of the fabrication induced residual stresses is investigated and the treat-ment effect is evaluated in terms of the initial deflected *** results reported in this paper represent an experimental mechanical investigation useful for the design of PMUT structures with advanced functionalities in the linear and non-linear regime.

关键词： acoustic-structure interaction array experimental characterization non-linear dynamics Piezoelectric Micromachined Ultrasonic Transducers(PMUTs) ultrasound

Static balancing of planar articulated robots

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Frontiers of Mechanical Engineering 2015年第4期10卷 326-343页

作者： quaglia Zhe YIN Department of Mechanical and Aerospace Engineering Politecnico diTorino Torino 10129 Italy

Static balancing for a manipulator＇s weight is necessary in terms of energy saving and performance improvement. This paper proposes a method to design balancing devices for articulated robots in industry, based on robotic dynamics. Full design details for the balancing system using springs are presented from two aspects： One is the optimization for the position of the balancing system; the other is the design of the spring parameters. As examples, two feasible balancing devices are proposed, based on different robotic structures： The first solution consists of linkages and springs; the other consists of pulleys, cross mechanisms and （hydro-） pneumatic springs. Then the two solutions are compared. Pneumatic, hydro-pneumatic and mechanical springs are discussed and their parameters are decided according to the requirements of torque compensation. Numerical results show that with the proper design using the methodology presented in this paper, an articulated robot can be statically balanced perfectly in all configurations. This paper therefore provides a design method of the balancing system for other similar structures.

关键词： robotics static balancing pneumatic spring,mechanical spring torque compensation

Helicobacter pylori:a foodborne pathogen?

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World Journal of Gastroenterology 2018年第31期24卷 3472-3487页

作者： Nicoletta C quaglia Angela Dambrosio Department of Emergency and Organ Transplantation Section of Veterinary Clinic and Animal ProductionUniversity of Bari "Aldo Moro"

Helicobacter pylori(H. pylori) is an organism that is widespread in the human population and is sometimes responsible for some of the most common chronic clinical disorders of the upper gastrointestinal tract in humans, such as chronic-active gastritis, duodenal and gastric ulcer disease, low-grade B-cell mucosa associated lymphoid tissue lymphoma of the stomach, and gastric adenocarcinoma, which is the third leading cause of cancer death worldwide. The routes of infection have not yet been firmly established, and different routes of transmission have been suggested, although the most commonly accepted hypothesis is that infection takes place through the faecal-oral route and that contaminated water and foods might play an important role in transmission of the microorganism to humans. Furthermore, several authors have considered H. pylori to be a foodborne pathogen because of some of its microbiological and epidemiological characteristics. H. pylori has been detected in drinking water, seawater, vegetables and foods of animal origin. H. pylori survives in complex foodstuffs such as milk, vegetables and ready-to-eat foods. This review article presents an overview of the present knowledge on the microbiological aspects in terms of phenotypic characteristics and growth requirements of H. pylori, focusing on the potential role that foodstuffs and water may play in the transmission of the pathogen to humans and the methods successfully used for the detection of this microorganism in foodstuffs and water.

关键词： Helicobacter pylori Viable but nonculturable state Foodborne pathogen Food Water Animal reservoirs Culture methods Molecular methods

Alpine tundra species phenology is mostly driven by climate-related variables rather than by photoperiod

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Journal of Mountain Science 2020年第9期17卷 2081-2096页

作者： quaglia Elena RAVETTO ENRI Simone PEROTTI Elisa PROBO Massimiliano LOMBARDI Giampiero LONATI Michele Department of Agricultural Forest and Food SciencesUniversity of TorinoLargo Paolo Braccini 210095Grugliasco(To)Italy Grazing Systems AgroscopeRoute de Duillier 501260NyonSwitzerland

The study of plant phenology has frequently been used to link phenological events to various factors,such as temperature or *** the high-alpine environment,proper timing of the phenological cycle has always been crucial to overcome harsh conditions and potential extreme events(*** frosts)but little is known about the response dynamics of the vegetation,which could shape the alpine landscape in a future of changing *** tundra vegetation is composed by an array of species belonging to different phytosociological optima and with various survival strategies,and snowbed communities are a relevant expression of such an extreme-climate adapted *** set eight permanent plots with each one in a snowbed located on the Cimalegna plateau in Northwestern Italy and then we selected 10 most recurring species among our plots,all typical of the alpine tundra environment and classified in 3different pools:snowbed specialists,grassland species and rocky debris *** 3 years we registered the phenophases of each species during the whole growing season using an adaptation of the BBCH *** later focused on the three most biologically relevant phenophases,i.e.,flower buds visible,full flowering,and beginning of seed *** important season-related variables were chosen to investigate their relationship with the phenological cycle of the studied species:(i)the Day Of Year(DOY),the progressive number of days starting from the 1 st of January,used as a proxy of photoperiod,(ii)Days From Snow Melt(DFSM),selected to include the relevance of the snow dynamics,and(iii)Growing Degree Days(GDD),computed as a thermal *** analysis highlighted that phenological development correlated better with DFSM and GDD than with ***,models showed that DOY was always a worse predictor since it failed to overcome interannual variations,while DFSM and marginally GDD were better suited to predict the phenological development of most of the species,desp

关键词： Alpine plants Climate change Growing degree days Italian Alps Salix herbacea Snowbed vegetation

Heterozygous nucleotide-binding oligomerization domain-2 mutations affect monocyte maturation in Crohn's disease

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World Journal of Gastroenterology 2007年第46期13卷 6191-6196页

作者： Marilena Granzotto Elisa Fabbro Massimo Maschio Stefano Martelossi Sara quaglia alberto Tommasini Gianni Presani Alessandro Ventura Institute for Child Health Burlo Garofolo Trieste 34137Italy Department of Sciences of Reproduction and Development University of TriesteTriesteItaly Supported by the Italian Ministry of HealthNo.150/03

瞄准：在 Crohn 的疾病(CD ) 调查单核白血球的函数病人并且相关这与联系疾病的核苷酸绑定 oligomerization domain-2 (NOD2 ) 基因变体。方法：从 47 个连续地提交的 CD 病人和 9 健康供血者的单核白血球与 interleukin (IL ) 是有教养... 详细信息

瞄准：在 Crohn 的疾病(CD ) 调查单核白血球的函数病人并且相关这与联系疾病的核苷酸绑定 oligomerization domain-2 (NOD2 ) 基因变体。方法：从 47 个连续地提交的 CD 病人和 9 健康供血者的单核白血球与 interleukin (IL ) 是有教养的 -4 和 granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) ，并且与脂肪的多糖(LPS ) 或 muramyldipeptide (MDP ) 刺激了， NOD2 的通常认为的 ligand。结果：我们发现从 CD 病人的单核白血球区分了在试管内到成熟树枝状的房间(DC ) ，由免疫显型和形态学决定了。NOD2 遗传型在所有题目被估计，并且我们观察到在 NOD2 的不成熟、刺激 LPS 的 DC 上的高 CD86 表示变异 CD 病人，作为与 wtNOD2 CD 病人和控制相比。由对比，导致到成熟， MDP 源于变异 NOD2 的题目的 DC 的 CD86 表示层次比得上正常题目的那些。在耐心房间的文化的 IL-12p70 的数量与 MDP 比在在 LPS 治疗，然而并非术后疗法以后的控制大。结论：我们的结果建议在 NOD2 基因与变化从病人获得的 DC 显示高 CD86 表示描绘的激活的显型，但是当与终端相比区别分阶段执行时，有减少的回答到 MDP。我们推测单核白血球的改变的区别可能导致在发炎和单核白血球的杀死的能力之间的不平衡，并且可能与 CD 的致病相关。

关键词：克罗恩氏病树突细胞核苷酸症状